Module Leader Research Methods and MPharm (Final Year Project)
|Telephone||+44 (0)151 231 2402|
|Address||James Parsons Building|
Liverpool John Moores University
Mark Cronin is on the academic staff in the School of Pharmacy and Biomolecular Sciences. He has over 20 years expertise in the application of quantitative structure-activity relationships (QSARs) to predict the toxicity and fate of chemicals; in addition to development of strategies (such as integrated testing strategies) to develop alternatives to whole animal testing for toxicity. The alternatives include the whole range of in silico techniques (use of existing data; (Q)SARs; expert systems), data from chemical reactivity (in chemico) assays; and data from in vitro techniques. Research in recent years has centred on the application of these alternatives for regulatory use (e.g. classification and labelling; prioritisation; data gap filling) and for product development. Endpoints currently considered cover all toxicological effects required for regulatory risk assessment including those for human health and environmental effects.
This research effort has resulted in over 200 publications in all areas of the use of (Q)SARs and expert systems to predict toxicity, including three books. Mark has spoken widely on various aspects of predictive toxicology in scientific conferences, symposia as well as invited lectures in industries, regulatory agencies etc. He has received grant funding and performed consultancies from diverse sources including UK government agencies (e.g. Defra), European Union (various framework programmes), the European Commission as well as chemical and personal product industries.
Main areas of research include the application of in silico models for toxicity and ADME effects in various sectors including industrial chemicals, pharmaceuticals, cosmetics and food additives. This includes the development of integrated testing strategies (ITS) for toxicological endpoints. Mark Cronin co-ordinates the EU / Colipa COSMOS project (http://www.cosmostox.eu/). An up todate publications list is available from: http://www.staff.livjm.ac.uk/phamcron/publications.htm
Module leader for Research Methods and the Final Year Project on the Master of Pharmacy programme. Teaches pharmaceutical and physical chemistry, drug design, toxicology and use of computer-aided molecular design.
Various through the OSIRIS, COSMOS, OECD QSAR Toolbox and many others.
Recent Grant Moneys Received and Consultancies European Union 6th and 7th Framework Programme Funding:
- ReProTect Integrated Project 2004-2009
- CAESAR Scientific Support Action 2006-2009
- InSilicoTox Marie Curie Project 2006-2010
- OSIRIS Integrated Project 2007-2011
- eTox IMI Project 2009-2014
- COSMOS Project 2010-2015
- OECD QSAR Toolbox, European Chemicals Agency, Helsinki 2008-2012
- Defra LINK project 2007-2010
- Lhasa Ltd 2007-2010
- Unilever Research 2008-2011
- Leverhulme Academic Exchange 2004-2008
He is currently on the editorial boards of six international peer-reviewed journals, namely: SAR and QSAR in Environmental Research (1999-present); Pesticide Management Science (2001-present); Current Medicinal Chemistry (2006-present); Alternatives to Laboratory Animals (ATLA) (2008-present); International Journal of Molecular Sciences (Molecular Toxicology Section) (2009-present); Molecular Informatics (from 2010)
The applicant has acted on a number of national and international committees. These mainly relate to the promotion of predictive toxicology and reduction of animal testing as well as work with Learned Societies. During the past three years these can be summarised as follows:
- Member of the Organisation of Economic Co-operation and Development (OECD) Working Group on (Quantitative) Structure-Activity Relationships ((Q)SARs), representative of the International Council for Animal Protection in OECD (ICAPO)
- Member of various workshops organised by the European Commission including those by the European ECVAM Task Force on Endocrine Disruption and the ECB Workshop on the Role of Neural Networks in QSAR.
- Member of the ILSI Europe Expert Group on "Chemical risk assessment in absence of adequate toxicological information"
- Member of the International Steering Committee for the 12th, 13th and 14th International Workshop on QSAR in the Environmental Sciences held in 2006 (Lyon, France), 2008 (Syracuse, USA) and 2010 (Montreal, Canada) respectively.