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Department of Applied Mathematics

Dr Steven Webb

Dr Steven Webb

Telephone: 0151 231 2217

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Biography

Research Interests: Systems Biology; Pharmacokinetics; PBPK modelling; Mathematical and Computational modelling.

Personal Statement: My research is in Mathematical and Systems Biology, particularly in modeling cell-cell interactions, pharmacology, cancer, computational cell biology and infectious diseases. I use a range of computational and mathematical techniques ranging from individual based models, correlation equations, stochastic moment closure systems to ordinary and partial differential equations and numerical analysis.

I obtained my doctorate in Mathematics from Heriot-Watt University in 2000, then did postdoctoral work in Mathematics departments at Minnesota (2000-2001), Loughborough (2001-2004), Nottingham (2004-2005) and in the Department of Animal and Plant Sciences at the University of Sheffield (2005-2007), before taking up a John Anderson Research Lectureship in Mathematical Biology and Medicine at the University of Strathclyde in 2007. I moved to the University of Liverpool to take up a lectureship in Systems Pharmacology in the Centre for Drug Safety Science in Oct 2012 and then, in 2015, I moved to Liverpool John Moores University as a Reader in Applied Mathematics.

Research group webpage: https://sites.google.com/view/webblabuk

Degrees

2000, Heriot-Watt University, United Kingdom, Ph.D., Mathematics
1997, University of Warwick, United Kingdom, M.Math., Master of Mathematics

Academic appointments

Reader in Applied Mathematics, Department of Applied Mathematics, Liverpool John Moores University, 2015 - present
Lecturer in Systems Pharmacology, University of Liverpool, 2012 - 2015
John Anderson Research Lecturer in Mathematics, University of Strathclyde, 2007 - 2012

Postgraduate training

Pg.Cert., Advanced Academic Studies, Member of Higher Education Academy, Glasgow, University of Strathclyde, 2009 - 2011

Publications

Highlighted publications

Leedale J, Colley HE, Gaskell H, Williams DP, Bearon RN, Chadwick AE, Murdoch C, Webb SD. 2019. In silico-guided optimisation of oxygen gradients in hepatic spheroids Computational Toxicology, 12 DOI Publisher Url Public Url

Mason CL, Leedale J, Tasoulis S, Jarman I, Webb SD. 2019. A systems toxicology paracetamol overdose framework: accounting for high-risk individuals Computational Toxicology, 12 DOI Publisher Url Public Url

Sorrell I, Shipley RJ, Regan S, Gardner I, Storm MP, Ellis M, Ward J, Williams D, Mistry P, Salazar JD, Scott A, Webb S. 2019. Mathematical modelling of a liver hollow fibre bioreactor Journal of Theoretical Biology, 475 :25-33 DOI Author Url Publisher Url Public Url

Thaventhiran T, Wong W, Alghanem AF, Alhumeed N, Aljasir MA, Ramsey S, Sethu S, Yeang HXA, Chadwick AE, Cross M, Webb SD, Djouhri L, Ball C, Stebbings R, Sathish JG. 2019. CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 38 :60-69 DOI Author Url Publisher Url Public Url

Kelly R, Leedale J, Calleja D, Enoch S, Harrell A, Chadwick A, Webb S. 2019. Modelling changes in glutathione homeostasis as a function of quinone redox metabolism Scientific Reports, 9 DOI Author Url Publisher Url Public Url

Madden J, Pawar G, Cronin M, Webb S, Tan Y-M, Paini A. 2019. In Silico Resources to Assist in the Development and Evaluation of Physiologically-Based Kinetic Models Compuational Toxicology, 11 :33-49 DOI Publisher Url Public Url

Tomlinson L, Hyndman L, Firman J, Bentley R, Kyffin J, Webb S, McGinty S, Sharma P. 2019. In vitro Liver Zonation of Primary Rat Hepatocytes Frontiers in Bioengineering and Biotechnology, 7 DOI Author Url Publisher Url Public Url

Kelly RA, Leedale J, Harrell A, Beard DA, Randle LE, Chadwick AE, Webb SD. 2018. Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS ONE, 13 :e0207803-e0207803 DOI Author Url Publisher Url Public Url

Pletz J, Ebbrell DJ, Enoch SJ, Firman JW, Madden JC, Webb SD, Cronin MTD. 2018. Development of a Robust In Silico Profiler to Screen for Nephrotoxicity Endpoints TOXICOLOGY LETTERS, 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box 295 :S97-S97 DOI Author Url

Mason C, Leedale J, Tasoulis S, Jarman IH, Antoine D, Webb S. 2018. Systems Toxicology Approach to Identifying Paracetamol Overdose CPT: Pharmacometrics & Systems Pharmacology, 7 :394-403 DOI Author Url Public Url

Leedale J, Sharkey K, Colley H, Norton A, Peeney D, Mason C, Sathish J, Murdoch C, Sharma P, Webb SD. 2018. A combined in vitro/in silico approach to identifying off-target receptor toxicity iScience, DOI Author Url Publisher Url Public Url

Gaskell H, Sharma P, Colley HE, Murdoch C, Williams DP, Webb SD. 2016. Characterization of a functional C3A liver spheroid model Toxicology Research, 5 :1053-1065 DOI Author Url Publisher Url Public Url

Webb SD, Reddyhoff D, Ward J, Williams D, Regan S. 2015. Timescale analysis of a mathematical model of acetaminophen metabolism andtoxicity Journal of Theoretical Biology, 386 :132-146 DOI Author Url Public Url

Eakins R, Walsh J, Randle L, Jenkins RE, Schuppe-Koistinen I, Rowe C, Lewis PS, Vasieva O, Prats N, Brillant N, Auli M, Bayliss M, Webb S, Rees JA, Kitteringham NR, Goldring CE, Park BK. 2015. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports, 5 DOI Author Url Publisher Url Public Url

Sorrell I, Shipley RJ, Hearnden V, Colley HE, Thornhill MH, Murdoch C, Webb SD. 2014. Combined mathematical modelling and experimentation to predict polymersome uptake by oral cancer cells NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 10 :339-348 DOI Author Url

Madden JC, Webb S, Enoch SJ, Colley H, Murdoch C, Shipley R, Sharma P, Yang C. In silico prediction of skin metabolism and its implication in toxicity assessment Computational Toxicology, DOI Public Url

Journal article

Leedale J, Colley HE, Gaskell H, Williams DP, Bearon RN, Chadwick AE, Murdoch C, Webb SD. 2019. In silico-guided optimisation of oxygen gradients in hepatic spheroids Computational Toxicology, 12 DOI Publisher Url Public Url

Mason CL, Leedale J, Tasoulis S, Jarman I, Webb SD. 2019. A systems toxicology paracetamol overdose framework: accounting for high-risk individuals Computational Toxicology, 12 DOI Publisher Url Public Url

Kyffin JA, Cox CR, Leedale J, Colley HE, Murdoch C, Mistry P, Webb SD, Sharma P. 2019. Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid-Overlay Technique. Current Protocols in Toxicology, 81 DOI Author Url Publisher Url Public Url

Sorrell I, Shipley RJ, Regan S, Gardner I, Storm MP, Ellis M, Ward J, Williams D, Mistry P, Salazar JD, Scott A, Webb S. 2019. Mathematical modelling of a liver hollow fibre bioreactor Journal of Theoretical Biology, 475 :25-33 DOI Author Url Publisher Url Public Url

Thaventhiran T, Wong W, Alghanem AF, Alhumeed N, Aljasir MA, Ramsey S, Sethu S, Yeang HXA, Chadwick AE, Cross M, Webb SD, Djouhri L, Ball C, Stebbings R, Sathish JG. 2019. CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 38 :60-69 DOI Author Url Publisher Url Public Url

Kelly R, Leedale J, Calleja D, Enoch S, Harrell A, Chadwick A, Webb S. 2019. Modelling changes in glutathione homeostasis as a function of quinone redox metabolism Scientific Reports, 9 DOI Author Url Publisher Url Public Url

Tomlinson L, Lu ZQ, Bentley RA, Colley HE, Murdoch C, Webb SD, Cross MJ, Copple IM, Sharma P. 2019. Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway Biomedicine and Pharmacotherapy, 112 DOI Author Url Publisher Url Public Url

Madden J, Pawar G, Cronin M, Webb S, Tan Y-M, Paini A. 2019. In Silico Resources to Assist in the Development and Evaluation of Physiologically-Based Kinetic Models Compuational Toxicology, 11 :33-49 DOI Publisher Url Public Url

Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Harding AL, Mistry P, Webb SD. 2019. Characterisation of a functional rat hepatocyte spheroid model Toxicology in Vitro, 55 :160-172 DOI Author Url Publisher Url Public Url

Tomlinson L, Hyndman L, Firman J, Bentley R, Kyffin J, Webb S, McGinty S, Sharma P. 2019. In vitro Liver Zonation of Primary Rat Hepatocytes Frontiers in Bioengineering and Biotechnology, 7 DOI Author Url Publisher Url Public Url

Kelly RA, Leedale J, Harrell A, Beard DA, Randle LE, Chadwick AE, Webb SD. 2018. Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS ONE, 13 :e0207803-e0207803 DOI Author Url Publisher Url Public Url

Pletz J, Enoch SJ, Jais DM, Mellor CL, Pawar G, Madden JC, Webb S, Tagliati C, Cronin MTD. 2018. A Critical Review of Adverse Effects to the Kidney: Mechanisms, Data Sources and In Silico Tools to Assist Prediction Expert Opinion on Drug Metabolism and Toxicology, DOI Author Url Publisher Url Public Url

Mason C, Leedale J, Tasoulis S, Jarman IH, Antoine D, Webb S. 2018. Systems Toxicology Approach to Identifying Paracetamol Overdose CPT: Pharmacometrics & Systems Pharmacology, 7 :394-403 DOI Author Url Public Url

Leedale J, Sharkey K, Colley H, Norton A, Peeney D, Mason C, Sathish J, Murdoch C, Sharma P, Webb SD. 2018. A combined in vitro/in silico approach to identifying off-target receptor toxicity iScience, DOI Author Url Publisher Url Public Url

Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Mistry P, Webb SD. 2018. Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment TOXICOLOGY IN VITRO, 48 :262-275 DOI Author Url Public Url

Storm MP, Sorrell I, Shipley R, Regan S, Luetchford KA, Sathish J, Webb S, Ellis MJ. 2016. Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture Journal of Visualized Experiments, :e53431-e53431 DOI Author Url Public Url

Gaskell H, Sharma P, Colley HE, Murdoch C, Williams DP, Webb SD. 2016. Characterization of a functional C3A liver spheroid model Toxicology Research, 5 :1053-1065 DOI Author Url Publisher Url Public Url

Webb SD, Reddyhoff D, Ward J, Williams D, Regan S. 2015. Timescale analysis of a mathematical model of acetaminophen metabolism andtoxicity Journal of Theoretical Biology, 386 :132-146 DOI Author Url Public Url

Eakins R, Walsh J, Randle L, Jenkins RE, Schuppe-Koistinen I, Rowe C, Lewis PS, Vasieva O, Prats N, Brillant N, Auli M, Bayliss M, Webb S, Rees JA, Kitteringham NR, Goldring CE, Park BK. 2015. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports, 5 DOI Author Url Publisher Url Public Url

Al-Husari M, Murdoch C, Webb SD. 2014. A cellular automaton model examining the effects of oxygen, hydrogen ions and lactate on early tumour growth JOURNAL OF MATHEMATICAL BIOLOGY, 69 :839-873 DOI Author Url

Sorrell I, Shipley RJ, Hearnden V, Colley HE, Thornhill MH, Murdoch C, Webb SD. 2014. Combined mathematical modelling and experimentation to predict polymersome uptake by oral cancer cells NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 10 :339-348 DOI Author Url

Al-Husari M, Webb SD. 2013. Theoretical Predictions of Lactate and Hydrogen Ion Distributions in Tumours PLOS ONE, 8 DOI Author Url

Al-Husari M, Webb SD. 2013. Acid-mediated tumour cell invasion: a discrete modelling approach using the extended Potts model CLINICAL & EXPERIMENTAL METASTASIS, 30 :793-806 DOI Author Url

Dickens D, Webb SD, Antonyuk S, Giannoudis A, Owen A, Raedisch S, Hasnain SS, Pirmohamed M. 2013. Transport of gabapentin by LAT1 (SLC7A5) BIOCHEMICAL PHARMACOLOGY, 85 :1672-1683 DOI Author Url

Webb SD, Keeling MJ, Boots M. 2013. The role of spatial population structure on the evolution of parasites with acquired immunity and demography JOURNAL OF THEORETICAL BIOLOGY, 324 :21-31 DOI Author Url

Al-Husari M, Webb SD. 2013. Regulation of tumour intracellular pH: A mathematical model examining the interplay between H+ and lactate JOURNAL OF THEORETICAL BIOLOGY, 322 :58-71 DOI Author Url

Webb SD, Keeling MJ, Boots M. 2013. A theoretical study of the role of spatial population structure in the evolution of parasite virulence THEORETICAL POPULATION BIOLOGY, 84 :36-45 DOI Author Url

Nieminen L, Webb S, Smith MCM, Hoskisson PA. 2013. A Flexible Mathematical Model Platform for Studying Branching Networks: Experimentally Validated Using the Model Actinomycete, Streptomyces coelicolor PLOS ONE, 8 DOI Author Url

Williams DP, Shipley R, Ellis MJ, Webb S, Ward J, Gardner I, Creton S. 2013. Novel in vitro and mathematical models for the prediction of chemical toxicity TOXICOLOGY RESEARCH, 2 :40-59 DOI Author Url

Best A, Webb S, Antonovics J, Boots M. 2012. Local transmission processes and disease-driven host extinctions THEORETICAL ECOLOGY, 5 :211-217 DOI Author Url

Sorrell I, Webb SD, Shipley RJ, Hearnden VL, Colley HE, Murdoch C. 2012. Modeling polymersome delivery of anticancer therapeutics CANCER RESEARCH, 72 DOI Author Url

Jones EO, Webb SD, Ruiz-Fons FJ, Albon S, Gilbert L. 2011. The effect of landscape heterogeneity and host movement on a tick-borne pathogen THEORETICAL ECOLOGY, 4 :435-448 DOI Author Url

Best A, Webb S, White A, Boots M. 2011. Host resistance and coevolution in spatially structured populations PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 278 :2216-2222 DOI Author Url

Neilson MP, Veltman DM, van Haastert PJM, Webb SD, Mackenzie JA, Insall RH. 2011. Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour PLOS BIOLOGY, 9 DOI Author Url

Davies J, Grinfeld M, Webb SD. 2011. Special Issue: Emerging Modelling Methodologies in Medicine and Biology Introduction THEORY IN BIOSCIENCES, 130 :1-3 DOI Author Url

Neilson MP, Mackenzie JA, Webb SD, Insall RH. 2011. MODELING CELL MOVEMENT AND CHEMOTAXIS USING PSEUDOPOD-BASED FEEDBACK SIAM JOURNAL ON SCIENTIFIC COMPUTING, 33 :1035-1057 DOI Author Url

Neilson MP, Mackenzie JA, Webb SD, Insall RH. 2010. Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell INTEGRATIVE BIOLOGY, 2 :687-695 DOI Author Url

Grinfeld M, Webb SD. 2009. Structural instability in an autophosphorylating kinase switch MATHEMATICAL BIOSCIENCES, 219 :92-96 DOI Author Url

Reinhardt K, Koehler G, Webb S, Childs D. 2007. Field mating rate of female meadow grasshoppers, Chorthippus parallelus, estimated from sperm counts ECOLOGICAL ENTOMOLOGY, 32 :637-642 DOI Author Url

Webb SD, Keeling MJ, Boots M. 2007. Host-parasite interactions between the local and the mean-field: How and when does spatial population structure matter? JOURNAL OF THEORETICAL BIOLOGY, 249 :140-152 DOI Author Url

Webb SD, Owen MR, Byrne HM, Murdoch C, Lewis CE. 2007. Macrophage-based anti-cancer therapy: Modelling different modes of tumour targeting BULLETIN OF MATHEMATICAL BIOLOGY, 69 :1747-1776 DOI Author Url

Webb SD, Keeling MJ, Boots M. 2007. Spatially extended host-parasite interactions: The role of recovery and immunity THEORETICAL POPULATION BIOLOGY, 71 :251-266 DOI Author Url

Byrne HM, Alarcon T, Owen MR, Webb SD, Maini PK. 2006. Modelling aspects of cancer dynamics: a review PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 364 :1563-1578 DOI Author Url

Webb SD, Owen MR. 2004. Intra-membrane ligand diffusion and cell shape modulate juxtacrine patterning JOURNAL OF THEORETICAL BIOLOGY, 230 :99-117 DOI Author Url

Mantzaris NV, Webb S, Othmer HG. 2004. Mathematical modeling of tumor-induced angiogenesis JOURNAL OF MATHEMATICAL BIOLOGY, 49 :111-187 DOI Author Url

Webb SD, Owen MR. 2004. Oscillations and patterns in spatially discrete models for developmental intercellular signalling JOURNAL OF MATHEMATICAL BIOLOGY, 48 :444-476 DOI Author Url

Webb SD, Sherratt JA. 2004. Oscillatory reaction-diffusion equations with temporally varying parameters MATHEMATICAL AND COMPUTER MODELLING, 39 :45-60 DOI Author Url

Webb SD, Sherratt JA. 2003. A perturbation problem arising from the modelling of soluble Fas ligand in tumour immunology MATHEMATICAL AND COMPUTER MODELLING, 37 :323-331 DOI Author Url

Webb SD, Sherratt JA, Fish RG. 2002. Cells behaving badly: a theoretical model for the Fas/FasL system in tumour immunology MATHEMATICAL BIOSCIENCES, 179 :113-129 DOI Author Url

Webb SD, Sherratt JA, Fish RG. 2001. Modelling tumour acidity and invasion Novartis Foundation Symposium, 240 :169-181 DOI Author Url

Webb SD, Sherratt JA, Fish RG. 1999. Alterations in proteolytic activity at low pH and its association with invasion: A theoretical model CLINICAL & EXPERIMENTAL METASTASIS, 17 :397-407 DOI Author Url

Webb SD, Sherratt JA, Fish RG. 1999. Mathematical modelling of tumour acidity: Regulation of intracellular pH JOURNAL OF THEORETICAL BIOLOGY, 196 :237-250 DOI Author Url

Madden JC, Webb S, Enoch SJ, Colley H, Murdoch C, Shipley R, Sharma P, Yang C. In silico prediction of skin metabolism and its implication in toxicity assessment Computational Toxicology, DOI Public Url

Hyndman L, McKee S, Mottram N, Singh B, Webb S, McGinty S. Mathematical modelling of fluid flow and solute transport to define operating parameters for in vitro perfusion cell culture systems Interface Focus, Public Url

Conference publication

Pletz J, Allen T, Madden J, Cronin MT, Webb S. 2019. A mechanistic model incorporating IVIVE to quantify a proposed AOP on the nephrotoxicity of NSAIDs TOXICOLOGY LETTERS, 55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions 314 :S265-S265 Author Url

Allen T, Currie R, Dyson L, Webb S. 2019. Can inducing Phase II metabolism in the liver perturb thyroid homeostasis enough to cause adverse foetal neurodevelopment? TOXICOLOGY LETTERS, 55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions 314 :S299-S300 Author Url

Pletz J, Ebbrell DJ, Enoch SJ, Firman JW, Madden JC, Webb SD, Cronin MTD. 2018. Development of a Robust In Silico Profiler to Screen for Nephrotoxicity Endpoints TOXICOLOGY LETTERS, 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box 295 :S97-S97 DOI Author Url

Madden J, Pletz J, Webb S, Enoch S, Cronin M. 2017. Identifying potential liver toxicants using in vitro and in silico methods in a weight-of-evidence based approach TOXICOLOGY LETTERS, 53rd Congress of the European-Societies-of-Toxicology (EUROTOX) 280 :S133-S133 DOI Author Url

Gaskell H, Sharma P, Colley H, Murdoch C, Antoine D, Sathish J, Williams D, Webb S. 2015. Development and characterisation of a functional 3D liver spheroid model TOXICOLOGY LETTERS, 51st Congress of the European-Societies-of-Toxicology (EUROTOX) 238 :S176-S176 DOI Author Url