Research Interests: Systems Biology; Pharmacokinetics; PBPK modelling; Mathematical and Computational modelling.
Personal Statement: My research is in Mathematical and Systems Biology, particularly in modeling cell-cell interactions, pharmacology, cancer, computational cell biology and infectious diseases. I use a range of computational and mathematical techniques ranging from individual based models, correlation equations, stochastic moment closure systems to ordinary and partial differential equations and numerical analysis.
I obtained my doctorate in Mathematics from Heriot-Watt University in 2000, then did postdoctoral work in Mathematics departments at Minnesota (2000-2001), Loughborough (2001-2004), Nottingham (2004-2005) and in the Department of Animal and Plant Sciences at the University of Sheffield (2005-2007), before taking up a John Anderson Research Lectureship in Mathematical Biology and Medicine at the University of Strathclyde in 2007. I moved to the University of Liverpool to take up a lectureship in Systems Pharmacology in the Centre for Drug Safety Science in Oct 2012 and then, in 2015, I moved to Liverpool John Moores University as a Reader in Applied Mathematics.
Research group webpage: https://sites.google.com/view/webblabuk
2000, Heriot-Watt University, United Kingdom, Ph.D., Mathematics
1997, University of Warwick, United Kingdom, M.Math., Master of Mathematics
Madden JC, Webb S, Enoch SJ, Colley HE, Murdoch C, Shipley R, Sharma P, Yang C, Cronin MTD. 2017. In silico prediction of skin metabolism and its implication in toxicity assessment Computational Toxicology, 3 :44-57 >DOI
Storm MP, Sorrell I, Shipley R, Regan S, Luetchford KA, Sathish J, Webb S, Ellis MJ. 2016. Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, >DOI >Link
Eakins R, Walsh J, Randle L, Jenkins RE, Schuppe-Koistinen I, Rowe C, Lewis PS, Vasieva O, Prats N, Brillant N, Auli M, Bayliss M, Webb S, Rees JA, Kitteringham NR, Goldring CE, Park BK. 2015. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome SCIENTIFIC REPORTS, 5 >DOI >Link
Al-Husari M, Murdoch C, Webb SD. 2014. A cellular automaton model examining the effects of oxygen, hydrogen ions and lactate on early tumour growth JOURNAL OF MATHEMATICAL BIOLOGY, 69 :839-873 >DOI >Link
Sorrell I, Shipley RJ, Hearnden V, Colley HE, Thornhill MH, Murdoch C, Webb SD. 2014. Combined mathematical modelling and experimentation to predict polymersome uptake by oral cancer cells NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 10 :339-348 >DOI >Link
Nieminen L, Webb S, Smith MCM, Hoskisson PA. 2013. A Flexible Mathematical Model Platform for Studying Branching Networks: Experimentally Validated Using the Model Actinomycete, Streptomyces coelicolor PLOS ONE, 8 >DOI >Link
Neilson MP, Veltman DM, van Haastert PJM, Webb SD, Mackenzie JA, Insall RH. 2011. Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour PLOS BIOLOGY, 9 >DOI >Link
Neilson MP, Mackenzie JA, Webb SD, Insall RH. 2010. Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell INTEGRATIVE BIOLOGY, 2 :687-695 >DOI >Link
Webb SD, Keeling MJ, Boots M. 2007. Host-parasite interactions between the local and the mean-field: How and when does spatial population structure matter? JOURNAL OF THEORETICAL BIOLOGY, 249 :140-152 >DOI >Link
Byrne HM, Alarcon T, Owen MR, Webb SD, Maini PK. 2006. Modelling aspects of cancer dynamics: a review PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 364 :1563-1578 >DOI >Link
Webb SD, Sherratt JA, Fish RG. 2001. Modelling tumour acidity and invasion Novartis Foundation Symposium, 240 :169-181
Conference Publication (journal proceedings)
Gaskell H, Sharma P, Colley H, Murdoch C, Antoine D, Sathish J, Williams D, Webb S. 2015. Development and characterisation of a functional 3D liver spheroid model TOXICOLOGY LETTERS, 51st Congress of the European-Societies-of-Toxicology (EUROTOX) 238 :S176-S176 >DOI >Link