Liverpool Skylilne

Natural Sciences and Psychology

Dr Alun Hughes

Dr Alun Hughes

Telephone: 0151 231 2335


My research interests are focussed on the mammalian circadian system and aim to address questions regarding the function and synchronisation of circadian oscillators in health and disease. These interests cover a broad spectrum of physiology and neuroscience, encompassing all tiers of organisation from the molecular level to whole animal behaviour and physiology. I have particular interests in the circadian biology of skeletal muscle and adipose tissue, neuropeptide regulation of circadian function and the impact of lifestyle factors such as exercise and diet on circadian biology.


2006, University of Manchester, Manchester, United Kingdom, PhD, Animal Biology
2001, University of Manchester, Manchester, United Kingdom, MRes, Biological Sciences
2000, University of Manchester, Manchester, United Kingdom, BSc, Biology


Journal Articles

Wegner S, Belle MDC, Hughes ATL, Diekman CO, Piggins HD. 2017. Delayed cryptochrome degradation asymmetrically alters the daily rhythm in suprachiasmatic clock neuron excitability Journal of Neuroscience, 37 :7824-7836 >DOI

Timothy JWS, Klas N, Sanghani HR, Al-Mansouri T, Hughes ATL, Kirshenbaum GS, Brienza V, Belle MDC, Ralph MR, Clapcote SJ, Piggins HD. 2017. Circadian Disruptions in the Myshkin Mouse Model of Mania Are Independent of Deficits in Suprachiasmatic Molecular Clock Function Biological Psychiatry, >DOI

Yang N, Williams J, Pekovic-Vaughan V, Wang P, Olabi S, McConnell J, Gossan N, Hughes A, Cheung J, Streuli CH, Meng Q-J. 2017. Cellular mechano-environment regulates the mammary circadian clock Nature Communications, 8 >DOI >Link

Hughes ATL, Croft CL, Samuels RE, Myung J, Takumi T, Piggins HD. 2015. Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC(2)-signaling deficient mice SCIENTIFIC REPORTS, 5 >DOI >Link

Belle MDC, Hughes ATL, Bechtold DA, Cunningham P, Pierucci M, Burdakov D, Piggins HD. 2014. Acute Suppressive and Long-Term Phase Modulation Actions of Orexin on the Mammalian Circadian Clock JOURNAL OF NEUROSCIENCE, 34 :3607-3621 >DOI >Link

Yeung C-YC, Gossan N, Lu Y, Hughes A, Hensman JJ, Bayer ML, Kjaer M, Kadler KE, Meng Q-J. 2014. Gremlin-2 is a BMP antagonist that is regulated by the circadian clock SCIENTIFIC REPORTS, 4 >DOI >Link

Hughes ATL, Piggins HD. 2014. Disruption of daily rhythms in gene expression: The importance of being synchronised BIOESSAYS, 36 :644-648 >DOI >Link

Gossan N, Zeef L, Hensman J, Hughes A, Bateman JF, Rowley L, Little CB, Piggins HD, Rattray M, Boot-Handford RP, Meng Q-J. 2013. The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis ARTHRITIS AND RHEUMATISM, 65 :2334-2345 >DOI >Link

Hughes ATL, Guilding C, Piggins HD. 2011. Neuropeptide Signaling Differentially Affects Phase Maintenance and Rhythm Generation in SCN and Extra-SCN Circadian Oscillators PLOS ONE, 6 >DOI >Link

Guilding C, Hughes ATL, Piggins HD. 2010. CIRCADIAN OSCILLATORS IN THE EPITHALAMUS NEUROSCIENCE, 169 :1630-1639 >DOI >Link

Power A, Hughes ATL, Samuels RE, Piggins HD. 2010. Rhythm-Promoting Actions of Exercise in Mice with Deficient Neuropeptide Signaling JOURNAL OF BIOLOGICAL RHYTHMS, 25 :235-246 >DOI >Link

Guilding C, Hughes ATL, Brown TM, Namvar S, Piggins HD. 2009. A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus MOLECULAR BRAIN, 2 >DOI >Link

Brown TM, Coogan AN, Cutler DJ, Hughes AT, Piggins HD. 2008. Electrophysiological actions of orexins on rat suprachiasmatic neurons in vitro NEUROSCIENCE LETTERS, 448 :273-278 >DOI >Link

Hughes ATL, Piggins HD. 2008. Behavioral responses of Vipr2(-/-) mice to light JOURNAL OF BIOLOGICAL RHYTHMS, 23 :211-219 >DOI >Link

Hughes ATL, Guilding C, Lennox L, Samuels RE, McMahon DG, Piggins HD. 2008. Live imaging of altered period1 expression in the suprachiasmatic nuclei of Vipr2-/- mice JOURNAL OF NEUROCHEMISTRY, 106 :1646-1657 >DOI >Link

Brown TM, Hughes AT, Piggins HD. 2005. Gastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC(2) receptor signaling JOURNAL OF NEUROSCIENCE, 25 :11155-11164 >DOI >Link

Hughes AT, Fahey B, Cutler DJ, Coogan AN, Piggins HD. 2004. Aberrant gating of photic input to the suprachiasmatic circadian pacemaker of mice lacking the VPAC(2) receptor JOURNAL OF NEUROSCIENCE, 24 :3522-3526 >DOI >Link

Zupanc GKH, Clint SC, Takimoto N, Hughes ATL, Wellbrock UM, Meissner D. 2003. Spatio-temporal distribution of microglia/macrophages during regeneration in the cerebellum of adult teleost fish, Apteronotus leptorhynchus: A quantitative analysis BRAIN BEHAVIOR AND EVOLUTION, 62 :31-42 >DOI >Link

Hughes A, Mann D, Pickering-Brown S. 2003. Tau haplotype frequency in frontotemporal lobar degeneration and amyotrophic lateral sclerosis EXPERIMENTAL NEUROLOGY, 181 :12-16 >DOI >Link


Piggins HD, Belle MDC, Baño-Otálora B, Joshi A, Hughes ATL. 2015. Extrinsic and intrinsic regulation of SCN neuronal activity and function Honma KI, Honma S. Circadian Clocks Hokkaido University Press. Sapporo, Japan

Hughes ATL, Piggins HD. 2012. Feedback actions of locomotor activity to the circadian clock Kalsbeek A, Merrow M, Roenneberg T, Foster RG. 199 :305-336 ELSEVIER SCIENCE BV >DOI >Link