Liverpool Skylilne

Natural Sciences and Psychology

Dr Gareth Weedall

Dr Gareth Weedall

Telephone: 0151 231 2542

Biography

I am a geneticist with a primary interest in pathogens and their vectors. My research applies bioinformatics and next-generation sequencing (NGS) techniques to study evolutionary genomics and gene expression in these organisms.

I obtained a degree in genetics from the University of Nottingham (2002), where I became fascinated by parasitology and by population genetics. I combined these themes in my PhD research at the London School of Hygiene and Tropical Medicine (2007) on the population and evolutionary genetics of malaria parasites in response to host immunity. I moved to the University of Liverpool in 2008, where I learned the fundamentals of bioinformatics to analyse NGS data. This I applied in a number of projects including one of the first evolutionary genomic studies of the enteric parasite Entamoeba histolytica, the causative agent of amoebic dysentery, and a transcriptomic analysis of the gene expression landscape of the fungus Aspergillus nidulans, which sparked an interest in gene expression and its regulation. During this time I worked closely with Liverpool’s Centre for Genomic Research (CGR) and was head of the CGR bioinformatics group before moving to the Liverpool School of Tropical Medicine in 2014 to apply NGS analysis to understand the population genomics and genetic mechanisms of insecticide resistance in mosquito vectors of human disease. I joined Liverpool John Moores University in 2018 as a lecturer in Genetics.

Degrees

2007, London School of Hygiene & Tropical Medicine, United Kingdom, PhD
2002, University of Nottingham, United Kingdom, BSc

Academic appointments

Lecturer in Genetics, Liverpool John Moores University, 2018 - present

Publications

Journal article

Mackenzie-Impoinvil L, Weedall GD, Lol JC, Pinto J, Vizcaino L, Dzuris N, Riveron J, Padilla N, Wondji C, Lenhart A. 2019. Contrasting patterns of gene expression indicate differing pyrethroid resistance mechanisms across the range of the New World malaria vector Anopheles albimanus PLOS ONE, 14 >DOI >Link

Wilson IW, Weedall GD, Lorenzi H, Howcroft T, Hon C-C, Deloger M, Guillen N, Paterson S, Clark CG, Hall N. 2019. Genetic Diversity and Gene Family Expansions in Members of the Genus Entamoeba GENOME BIOLOGY AND EVOLUTION, 11 :688-705 >DOI >Link

Weedall GD, Mugenzi LMJ, Menze BD, Tchouakui M, Ibrahim SS, Amvongo-Adjia N, Irving H, Wondji MJ, Tchoupo M, Djouaka R, Riveron JM, Wondji CS. 2019. A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy SCIENCE TRANSLATIONAL MEDICINE, 11 >DOI >Link

Chudzicka-Ormaniec P, Macios M, Koper M, Weedall GD, Caddick MX, Weglenski P, Dzikowska A. 2019. The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans. FEMS Microbiology Letters, 366 >DOI >Public Url

Al-Salem WS, Solórzano C, Weedall GD, Dyer NA, Kelly-Hope L, Casas-Sánchez A, Alraey Y, Alyamani EJ, Halliday A, Balghonaim SM, Alsohibany KS, Alzeyadi Z, Alzahrani MH, Al-Shahrani AM, Assiri AM, Memish Z, Acosta-Serrano Á. 2019. Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection Parasites & Vectors, 12 >DOI >Public Url

Wilding CS, Weedall GD. 2018. Morphotypes of the common beadlet anemone Actinia equina (L.) are genetically distinct Journal of Experimental Marine Biology and Ecology, 510 :81-85 >DOI >Public Url

Matthews BJ, Dudchenko O, Kingan SB, Koren S, Antoshechkin I, Crawford JE, Glassford WJ, Herre M, Redmond SN, Rose NH, Weedall GD, Wu Y, Batra SS, Brito-Sierra CA, Buckingham SD, Campbell CL, Chan S, Cox E, Evans BR, Fansiri T, Filipovic I, Fontaine A, Gloria-Soria A, Hall R, Joardar VS, Jones AK, Kay RGG, Kodali VK, Lee J, Lycett GJ, Mitchell SN, Muehling J, Murphy MR, Omer AD, Partridge FA, Peluso P, Aiden AP, Ramasamy V, Rasic G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith ML, Turner J, Weakley AM, Zhao Z, Akbari OS, Black WC, Cao H, Darby AC, Hill CA, Johnston JS, Murphy TD, Raikhel AS, Sattelle DB, Sharakhov IV, White BJ, Zhao L, Aiden EL, Mann RS, Lambrechts L, Powell JR, Sharakhova MV, Tu Z, Robertson HM, McBride CS, Hastic AR, Korlach J, Neafsey DE, Phillippy AM, Vosshall LB. 2018. Improved reference genome of Aedes aegypti informs arbovirus vector control NATURE, 563 :501-+ >DOI >Link

Barnes KG, Weedall GD, Ndula M, Irving H, Mzihalowa T, Hemingway J, Wondji CS. 2017. Genomic Footprints of Selective Sweeps from Metabolic Resistance to Pyrethroids in African Malaria Vectors Are Driven by Scale up of Insecticide-Based Vector Control PLoS Genetics, 13 >DOI >Link >Public Url

Wielgoss S, Didelot X, Chaudhuri RR, Liu X, Weedall GD, Velicer GJ, Vos M. 2016. A barrier to homologous recombination between sympatric strains of the cooperative soil bacterium Myxococcus xanthus ISME JOURNAL, 10 :2468-2477 >DOI >Link

Aboagye-Antwi F, Alhafez N, Weedall GD, Brothwood J, Kandola S, Paton D, Fofana A, Olohan L, Betancourth MP, Ekechukwu NE, Baeshen R, Traore SF, Diabate A, Tripet F. 2015. Experimental Swap of Anopheles gambiae's Assortative Mating Preferences Demonstrates Key Role of X-Chromosome Divergence Island in Incipient Sympatric Speciation PLOS GENETICS, 11 >DOI >Link

Weedall GD, Irving H, Hughes MA, Wondji CS. 2015. Molecular tools for studying the major malaria vector Anopheles funestus: improving the utility of the genome using a comparative poly(A) and Ribo-Zero RNAseq analysis BMC GENOMICS, 16 >DOI >Link

Riveron JM, Chiumia M, Menze BD, Barnes KG, Irving H, Ibrahim SS, Weedall GD, Mzilahowa T, Wondji CS. 2015. Rise of multiple insecticide resistance in Anopheles funestus in Malawi: a major concern for malaria vector control MALARIA JOURNAL, 14 >DOI >Link

Weedall GD, Hall N. 2015. Sexual reproduction and genetic exchange in parasitic protists PARASITOLOGY, 142 :S120-S127 >DOI >Link

Sibthorp C, Wu H, Cowley G, Wong PWH, Palaima P, Morozov IY, Weedall GD, Caddick MX. 2013. Transcriptome analysis of the filamentous fungus Aspergillus nidulans directed to the global identification of promoters BMC GENOMICS, 14 >DOI >Link

Ehrenkaufer GM, Weedall GD, Williams D, Lorenzi HA, Caler E, Hall N, Singh U. 2013. The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation GENOME BIOLOGY, 14 >DOI >Link

Gilchrist CA, Ali IKM, Kabir M, Alam F, Scherbakova S, Ferlanti E, Weedall GD, Hall N, Haque R, Petri WA, Caler E. 2012. A Multilocus Sequence Typing System (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence BMC MICROBIOLOGY, 12 >DOI >Link

Weedall GD, Clark CG, Koldkjaer P, Kay S, Bruchhaus I, Tannich E, Paterson S, Hall N. 2012. Genomic diversity of the human intestinal parasite Entamoeba histolytica GENOME BIOLOGY, 13 >DOI >Link

Wilson IW, Weedall GD, Hall N. 2012. Host-Parasite interactions in Entamoeba histolytica and Entamoeba dispar: what have we learned from their genomes? PARASITE IMMUNOLOGY, 34 :90-99 >DOI >Link

Weedall GD, Sherrington J, Paterson S, Hall N. 2011. Evidence of Gene Conversion in Genes Encoding the Gal/GalNac Lectin Complex of Entamoeba PLOS NEGLECTED TROPICAL DISEASES, 5 >DOI >Link

Weedall GD, Hall N. 2011. Evolutionary genomics of Entamoeba RESEARCH IN MICROBIOLOGY, 162 :637-645 >DOI >Link

Osier FHA, Weedall GD, Verra F, Murungi L, Tetteh KKA, Bull P, Faber BW, Remarque E, Thomas A, Marsh K, Conway DJ. 2010. Allelic Diversity and Naturally Acquired Allele-Specific Antibody Responses to Plasmodium falciparum Apical Membrane Antigen 1 in Kenya INFECTION AND IMMUNITY, 78 :4625-4633 >DOI >Link

Weedall GD, Conway DJ. 2010. Detecting signatures of balancing selection to identify targets of anti-parasite immunity TRENDS IN PARASITOLOGY, 26 :363-369 >DOI >Link

van Noort SP, Nunes MC, Weedall GD, Hviid L, Gomes MGM. 2010. Immune Selection and Within-Host Competition Can Structure the Repertoire of Variant Surface Antigens in Plasmodium falciparum - A Mathematical Model PLOS ONE, 5 >DOI >Link

Roy SW, Weedall GD, da Silva RL, Polley SD, Ferreira MU. 2009. Sequence diversity and evolutionary dynamics of the dimorphic antigen merozoite surface protein-6 and other Msp genes of Plasmodium falciparum GENE, 443 :12-21 >DOI >Link

Tetteh KKA, Stewart LB, Ochola LI, Amambua-Ngwa A, Thomas AW, Marsh K, Weedall GD, Conway DJ. 2009. Prospective Identification of Malaria Parasite Genes under Balancing Selection PLOS ONE, 4 >DOI >Link

Bray RA, Waeschenbach A, Cribb TH, Weedall GD, Dyal P, Littlewood DTJ. 2009. The phylogeny of the Lepocreadioidea (Platyhelminthes, Digenea) inferred from nuclear and mitochondrial genes: Implications for their systematics and evolution ACTA PARASITOLOGICA, 54 :310-329 >DOI >Link

Weedall GD, Polley SD, Conway DJ. 2008. Gene-Specific Signatures of Elevated Non-Synonymous Substitution Rates Correlate Poorly across the Plasmodium Genus PLOS ONE, 3 >DOI >Link

Weedall GD, Preston BMJ, Thomas AW, Sutherland CJ, Conway DJ. 2007. Differential evidence of natural selection on two leading sporozoite stage malaria vaccine candidate antigens INTERNATIONAL JOURNAL FOR PARASITOLOGY, 37 :77-85 >DOI >Link

Verra F, Chokejindachai W, Weedall GD, Polley SD, Mwangi TW, Marsh K, Conway DJ. 2006. Contrasting signatures of selection on the Plasmodium falciparum erythrocyte binding antigen gene family MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 149 :182-190 >DOI >Link

Polley SD, Weedall GD, Thomas AW, Golightly LM, Conway DJ. 2005. Orthologous gene sequences of merozoite surface protein 1(MSP1) from Plasmodium reichenowi and R. gallinaceum confirm an ancient divergence of P. falciparum alleles MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 142 :25-31 >DOI >Link

Chapters

Harb OS, Boehme U, Crouch K, Ifeonu OO, Roos DS, Silva JC, Silva-Franco F, Svärd S, Tretina K, Weedall G. 2016. Genomics Molecular Parasitology :3-48 Springer Vienna 9783709114155 >DOI

Weedall GD. 2015. The genomics of entamoebae: Insights and challenges Amebiasis: Biology and Pathogenesis of Entamoeba :27-47 9784431551997 >DOI

Conference publication

Weedall GD, Preston BM, Thomas AW, Sutherland CJ, Conway DJ. 2006. Differential evidence of natural selection on two leading sporozoite stage malaria vaccine candidate antigens AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 75 :65-65 >Link