Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Christopher Coxon

Dr Christopher Coxon

Telephone: 0151 904 6344

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Biography

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Dr Christopher R. Coxon is a Senior Lecturer in Medicinal Chemistry within the School of Pharmacy and Biomolecular Sciences (since Oct14). He is a synthetic organic and biological chemist with 10 years doctoral/postdoctoral experience leading the design and preparation of chemical tools to study the function and role of proteins in biology. His research group develops innovative chemical methods to prepare modified (e.g. fluorinated/fluoroarylated, conformationally-constrained) peptides as chemical tools and probes to study i) enzyme mechanisms, ii) the role of proteins in disease, and the use of 19F NMR methods in chemical biology.

Current research projects include:

1. Development of small peptide antagonists of the CGRP-receptor for migraine treatment (Innovate UK/MRC 2017)
2. Microwave synthesis of multicyclic peptides (Royal Society Research Grant (2017))
3. STArMAPPs as a platform for antimicrobial vaccine discovery (LJMU Knowledge Exchange & Innovation (KE&I) funding voucher (2018))
4. STArMAPPs: Multivalent peptides as a new tool for novel antibody generation (Medical Research Council Industry Engagement Fund (2018))
5. The chemical biology and cyclic peptide inhibitors of CypD

Career to-date includes: a) 1st class MChem (Newcastle 2006); b) Completed an interdisciplinary PhD (2010) sponsored through the Cancer Research UK (CRUK) Medicinal Chemistry Training Programme (Northern Institute for Cancer Research, Newcastle University - supervisors: Profs Roger J. Griffin and Bernard T. Golding); c) PDRA position (Durham Oct 10 - Sep 12) in chemical biology with Profs Patrick G. Steel and Robert Edwards; d) A senior PDRA (Oct 12 - Sep 13 Durham Chemistry Dept.) with Dr Steven L. Cobb (SLC); e) Independent researcher /chromatography service manager (Sept 13 - Sept 14, Durham).

Collaborations: CRC collaborates with a number of academics, particularly in biology and structural biology areas; including Professor Lu-Yun Lian (Director, Liverpool NMR Centre for Structural Biology, University of Liverpool), Prof. Martin Noble (Newcastle Cancer Centre), Dr Adam Sharples (Keele University), Dr Sarah Dennison (UCLan). He also works with several biotechnology companies, including Absynth Biologics, Cambridge Research Biochemical, Pharmnovo.

We are always looking for new students to work on exciting projects in our lab. Please send any enquiries via email or Twitter (see above).

Degrees

2010, Northern Institute for Cancer Research, Newcastle University, United Kingdom, PhD
2010, Newcastle University, United Kingdom, MChem

Academic appointments

Lecturer in Medicinal and Natural Products Chemistry, Pharmacy and Biomolecular Sci, Liverpool John Moores University, 2014 - present
Temporary Lecturer, Department of Chemistry, Durham University, 2013 - 2014

Postgraduate training

Senior postdoctoral research associate, United Kingdom, Durham University, 2012 - 2013
Postdoctoral research associate, United Kingdom, Durham University, 2010 - 2012

Publications

Journal article

Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples AP. 2017. The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction Molecular and Cellular Biochemistry, >DOI >Link

Gimenez D, Mooney CA, Dose A, Sandford G, Coxon CR, Cobb SL. 2017. The application of perfluoroheteroaromatic reagents in the preparation of modified peptide systems Org. Biomol. Chem., 15 :4086-4095 >DOI

Gimenez D, Dose A, Robson NL, Sandford G, Cobb SL, Coxon CR. 2017. 2,2,2-Trifluoroethanol as a solvent to control nucleophilic peptide arylation Org. Biomol. Chem., 15 :4081-4085 >DOI

Coxon CR. 2016. Structure-guided design of purine-based probes for selective Nek2 inhibition Oncotarget, >DOI

Coxon CR. 2016. Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines Journal of Medicinal Chemistry, >DOI >Link

Mitcheson DF, Bottrill AR, Carr K, Coxon CR, Cano C, Golding BT, Griffin RJ, Fry AM, Doerig C, Bayliss R, Tobin AB. 2016. A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase Malaria Journal, 15 :1-12 >DOI

Aguilar JA, Ball AT, Coxon CR, Kenwright AM, Lancaster RW, Mosely JA, Mutton MA. 2016. Amorphism and Thermal Decomposition of Salicylsalicylic Acid—A Cautionary Tale Journal of Pharmaceutical Sciences, 105 :3073-3078 >DOI

Tatum NJ, Yufit DS, Cobb SL, Coxon CR. 2015. Synthesis, Ni(II) Schiff base complexation and structural analysis of fluorinated analogs of the ligand (S)-2-[N-(N '-benzylprolyl)amino]benzophenone (BPB) JOURNAL OF FLUORINE CHEMISTRY, 173 :77-83 >DOI >Link

Carbain B, Coxon CR, Lebraud H, Elliott KJ, Matheson CJ, Meschini E, Roberts AR, Turner DM, Wong C, Cano C, Griffin RJ, Hardcastle IR, Golding BT. 2014. Trifluoroacetic acid in 2,2,2-trifluoroethanol facilitates S(N)Ar reactions of heterocycles with arylamines Chemistry (Weinheim an der Bergstrasse, Germany), 20 :2311-2317 >DOI

Webster AM, Coxon CR, Kenwright AM, Sandford G, Cobb SL. 2014. A mild method for the synthesis of a novel dehydrobutyrine-containing amino acid TETRAHEDRON, 70 :4661-4667 >DOI >Link

Carbain B, Coxon CR, Lebraud H, Elliott KJ, Matheson CJ, Meschini E, Roberts AR, Turner DM, Wong C, Cano C, Griffin RJ, Hardcastle IR, Golding BT. 2014. Trifluoroacetic acid in 2,2,2-trifluoroethanol facilitates SNAr reactions of heterocycles with arylamines Chemistry - A European Journal, 20 :2311-2317 >DOI

Lebraud H, Coxon CR, Archard VS, Bawn CM, Carbain B, Matheson CJ, Turner DM, Cano C, Griffin RJ, Hardcastle IR, Baisch U, Harrington RW, Golding BT. 2014. Model system for irreversible inhibition of Nek2: Thiol addition to ethynylpurines and related substituted heterocycles Organic and Biomolecular Chemistry, 12 :141-148 >DOI

Hudson AS, Hoose A, Coxon CR, Sandford G, Cobb SL. 2013. Synthesis of a novel tetrafluoropyridine-containing amino acid and tripeptide TETRAHEDRON LETTERS, 54 :4865-4867 >DOI >Link

Cummins I, Wortley DJ, Sabbadin F, He Z, Coxon CR, Straker HE, Sellars JD, Knight K, Edwards L, Hughes D, Kaundun SS, Hutchings SJ, Steel PG, Edwards R. 2013. Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds Proceedings of the National Academy of Sciences of the United States of America, 110 :5812-5817 >DOI

Blackburn TJ, Ahmed S, Coxon CR, Liu J, Lu X, Golding BT, Griffin RJ, Hutton C, Newell DR, Ojo S, Watson AF, Zaytzev A, Zhao Y, Lunec J, Hardcastle IR. 2013. Diaryl- and triaryl-pyrrole derivatives: Inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions MedChemComm, 4 :1297-1304 >DOI

Poster

Coxon CR. 2015. Perfluoroaryl-stapled peptides: Inhibitors of the p53-MDM2 protein-protein interaction Royal Society of Chemistry, Organic Division, North West Regional Meeting

Conference publication

Islam Y, Leach A, Coxon C, Downing J, Platt M, Pluchino S, Ehtezazi T. Smart micellar systems for brain drug delivery. KTN Biopharmaceutical Formulation Group

Engagement & Impact

Highlighted activities

Award:

Royal Society Research Grant: "Structurally defined 3D peptide architectures as a platform for high value drug discovery and diagnostic scaffolds" (£14,815.00) - Principal Investigator, The Royal Society

EPSRC First Grant Scheme: Tetra-(Polyfluoroaryl)-Porphyrin Templated Multicyclic Peptides: Novel, Functional and Responsive Scaffolds for Miniaturised Biosensors (£101,602) - Principal Investigator, EPSRC, http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/R020299/1

Innovate UK (Technology Strategy Board) - Biomed Catalyst award (£200k) Co-I

Professional activities

Award:

Medical Research Council Industry Engagement Fund: "STArMAPPs: Multivalent peptides as a new tool for novel antibody generation" (£4,976) - Principal Investigator

LJMU Knowledge Exchange & Innovation Funding Voucher: "STArMAPPs as a platform for antimicrobial vaccine discovery" (£9,850) - Principal Investigator

Royal Society Research Grant: "Structurally defined 3D peptide architectures as a platform for high value drug discovery and diagnostic scaffolds" (£14,815.00) - Principal Investigator, The Royal Society

EPSRC First Grant Scheme: Tetra-(Polyfluoroaryl)-Porphyrin Templated Multicyclic Peptides: Novel, Functional and Responsive Scaffolds for Miniaturised Biosensors (£101,602) - Principal Investigator, EPSRC, http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/R020299/1

Innovate UK (Technology Strategy Board) - Biomed Catalyst award (£200k) Co-I

LJMU Fully-Funded PhD Scholarship in Allied Health DTA

Faculty of Science PhD Scholarship 2015, Liverpool John Moores University

Quantitative detection and identification of protein covalent modifications by chemically reactive metabolites (CRMs) via chromatography with fluorescent probes., AstraZeneca open innovation challenge

External collaboration:

https://www.dur.ac.uk/chemistry/staff/profile/?id=5553, Durham University, Dr Steven Cobb

http://www.ncl.ac.uk/nicr/staff/profile/martin.noble, Northern Institute for Cancer Research, Newcastle University, Professor Martin E. Noble

Durham University, Dr Steven L. Cobb

Northern Institute for Cancer Research, Newcastle University, Professor Martin E. Noble

Fellowships:

Fellow of the Higher Education Academy, Durham University

Other invited event:

MERCIA Chemistry meeting, Liverpool John Moores University, Invited to give a research talk

2016 North West Organic Division Regional Meeting, UCLan, Preston, Invited to give a talk on my research

Research Seminar, Department of Chemistry, Nottingham Trent University, Invited to give a talk on my research

Research Seminar, Department of Chemistry, Loughborough University, Invited to give a talk on my research

Research seminar, Bachem UK, Invited talk

Royal Society of Chemistry Chemical Biology and Bioorganic Chemistry Group Meeting 2015, Firbush, Loch Tay, Perthshire, Scotland, I presented current research on 'Perfluoroaryl-stapled peptides: Inhibitors of the p53-MDM2 protein-protein interaction'

Pharmacy and Biomolecular Sciences Research Seminar, Liverpool John Moores University, Talk entitled: “Application of fluorine chemistry in the development of stapled peptides for drug discovery”

RSC North West Organic Division annual meeting, University of Liverpool, Invited to chair a session at the meeting

Royal Society of Chemistry Fluorine Group Meeting 2015, Durham University, Invited to give an oral presentation on my research in the area of fluorine chemistry on the back of a paper recently published in J. Fluor. Chem. Title of talk: Synthesis and structural analysis of fluorinated analogues of nickel (II) complexes used in amino acid synthesis.

Invited talk for Oundle School Science Society, Oundle School, Peterborough, Invited to give a talk to the senior science society VI form students. My talk was entitled, "The Discovery of New Medicines: From Witchcraft to Magic Bullets."

Invited research seminar, Durham University, I was invited to present my recent research with a talk entitled, "Perfluoroaryl-stapled peptides as inhibitors of the p53-MDM2 protein-protein interaction"

The Royal Society of Chemistry 2014 George and Christine Sosnovsky Award in Cancer Therapy, Newcastle University, Invited speaker, giving a talk entitled 'Stabilised Peptides as Chemical Tools in Drug Discovery'. http://www.rsc.org/ScienceAndTechnology/Awards/Sosnovsky/

Teaching qualification:

Fellow of the Higher Education Academy