Dr Laura Randle

Conference publication

Gilbert T, Randle L, Diaz-Nieto R, Jones R, Fenwick S, Goldring C, Mallik H. 2022. HPB O06 Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS) British Journal of Surgery, AUGIS 2022 Annual Scientific Meeting Supple DOI Author Url Publisher Url

Mehan A, Migaz N, Parikh N, Truong HV, Lambert DJ, Messham SJ, McKay J, Mahamed N, Brooks SJ, Lloyd M, Morris H, Dempster NM, Randle LE, Burrell HE, Sarker SD, Nahar L, Evans PG, Dascombe MJ, Strashnov N, Edwards G, Drew MGB, Barran P, Ismail FMD. 2015. Purpurogallin-A heme binding component of oak galls BMSS Annual Meeting: Birmingham Publisher Url Public Url

Neelima T, Taylor KMG, Saleem I, Randle L, Somavarapu S. 2011. Amphiphilic polygamma glutamic acid derivatives for delivery of amikacin to the lung Drug Delivery to the Lungs

Yeang HXA, Hamdam J, Al-Huseini L, Goodwin C, Randle L, Melendez A, Park K, Goldring C, Sathish J. 2010. The transcription factor Nrf2 affects dendritic cell maturation and phagocytic function Immunology, 131 :107-107 Author Url

Randle LE, Goldring CEP, Jenkins RE, Denk D, Antoine DJ, Sison RL, Williams DP, Hayes JD, Kitteringham NR, Park BK. 2009. A Biochemical, Toxicological, And Proteomic Analysis Investigating the Effect of Nrf2 Gene Deletion On Paracetamol-induced Hepatoxicity In Vivo Drug Metabolism Reviews, 41 :23-24 Author Url

Goldring CE, Copple I, Jenkins R, Randle L, Chia A, Hayes J, Kitteringham N, Park K. 2008. Activation of the Keap1-Nrf2-Are Cell Defense System by the Reactive Metabolite of Acetaminophen Drug Metabolism Reviews, 40 :95-96 Author Url

Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, Howard M, Gardner I, Blagg J, Park BK. 2007. The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore J Pharmacol Exp Ther, 322 :1208-1220 DOI Author Url Publisher Url

Randle LE, Williams DP, Kitteringham NR, Richard V, Park BK, O'Brien PJ. 2006. Adrenergic modulation of chemical-induced hepatotoxicity DRUG METABOLISM REVIEWS, 9th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX) 38 :166-167 Author Url

Goldring C, Kitteringham N, Jenkins R, Lovatt C, Randle L, Abdullah A, Owen A, Liu X, Butler P, Williams D, Metcalfe P, Berens C, Hillen W, McLellan L, Park BK. 2005. Development of a transactivator in hepatoma cells for regulatable expression of phase I, phase II and defense genes Drug Metabolism Reviews, 37 :17-18 Author Url

Williams DP, O'Donnell C, Randle LE, Goldring CEP, Garcia-Allen C, Johnston G, Kitteringham NR, Pirmohamed M, Smith DA, Park BK. 2003. Transcription factor regulation and gene expression in response to the antipsychotic, clozapine British Journal of Clinical Pharmacology, 55 :446-446 Author Url

Neelima T, Taylor KMG, Saleem IY, Randle LE, Somavarapu S. Amphiphilic polygamma glutamic acid derivatives for delivery of amikacin to the lung Journal of Aerosol Medicine and Pulmonary Drug Delivery, Drug Delivery to the Lungs Author Url

Journal article

Chidlow SJ, Randle LE, Kelly RA. 2022. Predicting physiologically-relevant oxygen concentrations in precision-cut liver slices using mathematical modelling PLOS ONE, 17 DOI Author Url Publisher Url Public Url

Kelly RA, Leedale J, Harrell A, Beard DA, Randle LE, Chadwick AE, Webb SD. 2018. Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS One, 13 DOI Author Url Publisher Url Public Url

Del Casino A, Lukinović V, Bhatt R, Randle LE, Dascombe MJ, Fennell BJ, Drew MGB, Bell A, Fielding AJ, Ismail FMD. 2018. Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials ChemistrySelect, 26 :7572-7580 DOI Author Url Publisher Url Public Url

Fielding AJ, Evans PG, Alizadeh S, Bisby R, Drew MGB, Del Casino A, Dunn JF, Randle LE, Dempster NM, Nahar L, Sarker SD, Cantú Reinhard FG, de Visser SP, Dascombe MJ, Ismail FMD. 2017. Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines Chemistry - A European Journal, DOI Author Url Publisher Url Public Url

Eakins R, Walsh J, Randle LE, Jenkins RE, Schuppe-Koistinen I, Rowe C, Starkey Lewis P, Vasieva O, Prats N, Brillant N, Auli M, Bayliss M, Webb S, Rees JA, Kitteringham NR, Goldring CE, Park BK. 2015. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. Scientific Reports, 5 DOI Author Url Publisher Url Public Url

Stachulski AV, Baillie TA, Kevin Park B, Scott Obach R, Dalvie DK, Williams DP, Srivastava A, Regan SL, Antoine DJ, Goldring CEP, Chia AJL, Kitteringham NR, Randle LE, Callan H, Castrejon JL, Farrell J, Naisbitt DJ, Lennard MS. 2013. The generation, detection, and effects of reactive drug metabolites Medicinal Research Reviews, 33 :985-1080 DOI Author Url Publisher Url

Neelima T, Taylor KMG, Saleem I, Randle L, Elsaid Z, Somavarapu S. 2013. Amphotericin polygamma glutamic acid derivatives for the delivery of amikacin to the lung Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 :A-1-A-27 DOI

Chavan T, Taylor KMG, Saleem IY, Randle LE, Elsaid Z, Somavarapu S. 2013. O-PALMITOYL CHITOSAN-PEG MICELLES FOR AMPHOTERICIN B DELIVERY TO THE LUNG JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 26 :A249-A250 Author Url

Kitteringham N, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Powell H, Sanderson C, Williams S, Higgins L, Yamomoto M, Hayes J, Park BK. 2010. Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. Journal of proteomics, 73 :1612-1631 DOI Author Url Publisher Url

Copple IM, Goldring CE, Jenkins RE, Chia AJL, Randle LE, Hayes JD, Kitteringham NR, Park BK. 2008. The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. Hepatology, 48 :1292-1301 DOI Author Url Publisher Url

Randle LE, Sathish JG, Kitteringham NR, Macdonald I, Williams DP, Park BK. 2008. α 1-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice British Journal of Pharmacology, 153 :820-830 DOI

Randle LE, Sathish JG, Kitteringham NR, Macdonald I, Williams DP, Park BK. 2008. alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. Br J Pharmacol, 153 :820-830 DOI Author Url Publisher Url

Randle LE, Goldring CEP, Benson CA, Metcalfe PN, Kitteringham NR, Park BK, Williams DP. 2008. Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. Toxicology, 243 :249-260 DOI Author Url Publisher Url

Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, Howard M, Gardner I, Blagg J, Park BK. 2007. The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore. J Pharmacol Exp Ther., 3 :1208-1220

Butler PJ, Williams DP, Jones R, Randle LE, Payne A, Howard M, Gardner I, Blagg J, Smith DA, Park BK. 2006. The role of metabolism in furosemide toxicity Drug Metabolism Reviews, 38 :176-177 Author Url

Goldring CEP, Kitteringham NR, Jenkins R, Lovatt CA, Randle LE, Abdullah A, Owen A, Liu XP, Butler PJ, Williams DP, Metcalfe P, Berens C, Hillen W, Foster B, Simpson A, McLellan L, Park BK. 2006. Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes American Journal of Physiology-Cell Physiology, 290 :C104-C115 DOI Author Url Publisher Url

Randle LE, Williams DP, Goldring CEP, Park BK. 2006. Mechanisms of defence during chemical-induced hepatotoxicity Drug Metabolism Reviews, 38 :56-58 Author Url

Randle LE, Williams DP, Kitteringham NR, Richard V, Park BK, O'Brien PJ. 2006. Adrenergic modulation of chemical-induced hepatotoxicity Drug Metabolism Reviews, 38 :28-29 Author Url

Goldring CEP, Kitteringham NR, Lovatt C, Jenkins R, Randle LE, Abdullah A, Owen A, Liu XP, Berens C, Hillen W, Park BK. 2005. Development of doxycycline-regulatable gene expression in hepatoma cells Toxicology, 213 :262-263 Author Url

Butler PJ, Randle LE, Jones R, Macrae P, Blagg J, Smith DA, Williams DP, Park BK. 2004. The role of metabolism in furosemide toxicity Toxicology, 202 :98-99 Author Url

Goldring CE, Kitteringham NR, Elsby R, Randle LE, Clement YN, Williams DP, McMahon M, Hayes JD, Itoh K, Yamamoto M, Park BK. 2004. Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice Hepatology, 39 :1267-1276 DOI Author Url Publisher Url

Randle LE, Greenough CL, Williams DP, Clement YN, Kitteringham NR, Elsby R, Park BK. 2004. Paracetamol-induced hepatotoxicity: Protection by alpha(1)-antagonists Toxicology, 194 :238-239 Author Url

O'Neill PM, Mukhtar A, Stocks PA, Randle LE, Hindley S, Ward SA, Storr RC, Bickley JF, O'Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK. 2003. Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials J Med Chem, 46 :4933-4945 DOI Author Url Publisher Url

Professional activities

Research Grants Awarded:

THE CULTURAL OFFICE OF THE EMBASSY OF THE STATE OF KUWAIT (UK), PhD studentship - ‘Determining the role of metabolic phenotype in the progression of cholangiocarcinomas using human hepatic organoids (HOO) and Precision Cut Tissue Slices (hPCTS).’, Dr Amy Chadwick, The University of Liverpool and Prof. Chris Goldring, The University of Liverpool, Grant value (£): £34’250 (tuition / bench fees) + additional student stipend, Duration of research project: 3 years. 2022

NC3Rs - National Centre for the Reduction, Refinement and Replacement of Animals in Research, Determining the efficacy and safety of cancer chemotherapeutics for cholangiocarcinoma (CCA) using Human Precision Cut Tissue Slices (hPCTS)., Prof Chris Goldring, University of Liverpool, Grant value (£): 74500, Duration of research project: 1 year 6 month. 2021

LJMU Faculty of Engineering and Technology Pump Priming Award, Quantifying the molecular initiating event of Adverse Outcome Pathway 38 predicting liver fibrosis as a function of protein alkylation using hepatic in vitro testing, computational chemistry and mathematical modelling techniques., Dr Ross Kelly, Dr Steve Enoch, Grant value (£): £4722, Duration of research project: 6 months. 2019

LJMU, Elucidating the Metabolic and Toxicological Profile of Novel Bisquinoline Anti-Malarials, FYaz Isamil, Satya Sarker, Grant value (£): PhD Stipend, tuition fees and £4500 consumables, Duration of research project: 3 years. 2015

External collaboration:

https://www.uwmedicine.org/bios/raymond-yeung#about-tab, University of Washington, Raymond Yeung. 2021

https://www.researchgate.net/profile/Hassan_Malik, Aintree University Hospital, Mr Hassan Malik, Consultant Hepatobiliary Surgeon. 2020

https://www.skcin.org/, SKCIN: THE KAREN CLIFFORD SKIN CANCER CHARITY, Marie Tudor. 2017

https://www.rug.nl/staff/p.olinga/research, The University of Groningen, Professor Peter Olinga. 2016

MRC Centre for Drug Safety Science, The University of Liverpool., Prof BK Park Dr CEP Goldring Dr NR Kitteringham Dr DP Williams Dr D Naisbitt. 2005

Other Professional Activity:

NC3Rs SKT grant call in collaboration with University of Liverpool and Aintree University Hospital with external partners from University of Washington, University of Groningen, Revivocell. Successfully passed through first round - Dec 2020 and invited to submit full application, which was submitted 11/11/21 https://www.nc3rs.org.uk/skills-and-knowledge-transfer-grants. 2020

Submitted an application to Biochemical Society's Scientific Outreach Grant Scheme. Unsuccessful this cell.. 2020

Asked to review a FLAIR fellowship 2021 grant application by Royal Society FLR\R1\211995. 2020

PBS Public Engagement Coordinator Jan 2015-present.

Membership of professional bodies:

Full Member, British Pharmacology Society, https://www.bps.ac.uk/. 2020

Member (MRSB), Royal Society of Biology. 2016

Member, British Toxicology Society (BTS).

Fellowships:

Honorary Senior Lecturer, Department of Pharmacology and Therapeutics, Institute of Systems Molecular and Integrative Biology, University of Liverpool. 2019

LJMU Early Career Fellowship, The University of Groningen & The University of Kansas. 2016

FHEA, The Higher Education Academy. 2013

Teaching qualification:

PGCert Learning and Teaching in Higher Education. 2013

SEDA Supporting Learning Award. 2012

External PGR examinations performed:

Univeristy of Liverpool, PhD, Investigation into Nevirapine-Induced Chemical Stress in Murine Models. 2013

External committees:

BTS Local Coordinators Committee, The British Toxicology Society, Member. 2013

Early Career Toxicologist Sub Committee, The British Toxicology Society, Education Representative, http://www.thebts.org/. 2010

Award:

Best Presentation Award for Post Doctoral Research at 11th European Regional ISSX Meeting, The International Society for the study Xenobiotics.. 2009

Best Presentation Award for predoctoral Research at 9th Europena Regional ISSX Meeting., The International Society for the Study of Xenobiotics., http://www.issx.org/. 2006

Winner of Best Young Researcher’s Poster Prize,, Royal Liverpool and Broadgreen University Hospital NHS Trust, R & D Open Day.. 2004

Winner of the drug metabolism section,PGRD Drug Discovery European Postgraduate Poster Symposium., Pfizer Drug Discovery 2003,. 2003