Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Laura Randle

Dr Laura Randle

Telephone: 0151 231 2533

Biography

I am currently employed as a senior lecturer within the School of Pharmacy and Biomolecular sciences at Liverpool John Moores University (LJMU), teaching primarily on the biomedical science, biochemistry and forensic related programmes. This requires me to teach a wide variety of topics and skills to a diverse group of students. My integrated approach exploring physiological, pharmacological and toxicological processes allows me to improve our understanding of the chemical and cellular signalling systems involved with human disease process, from the initial contact of the chemical toxin through to pathological outcome. The focus of my research is to further our understanding of the chemical, biochemical and molecular mechanisms of drug-induced liver injury, particularly focusing on cellular defence and hepatoprotective mechanisms.

Degrees

2005, University of Liverpool, United Kingdom, PhD ‘Pharmacological And Physiological Protective Mechanisms In Chemical-Induced Hepatotoxicity.’
2001, University of Liverpool, United Kingdom, BSc (Hons) Pharmacology

Academic appointments

Lecturer/Senior Lecturer in Biomolecular Sciences, Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 2010 - present

Postgraduate training

Wellcome Trust Funded Post Doctoral Researcher, United Kingdom, University of Liverpool, 2007 - 2009
Pfizer Funded Post Doctoral Research Fellow, United Kingdom, University of Liverpool, 2005 - 2006

Publications

Highlighted publications

Eakins R, Walsh J, Randle L, Jenkins RE, Schuppe-Koistinen I, Rowe C, Lewis PS, Vasieva O, Prats N, Brillant N, Auli M, Bayliss M, Webb S, Rees JA, Kitteringham NR, Goldring CE, Park BK. 2015. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome SCIENTIFIC REPORTS, 5 >DOI >Link

Stachulski AV, Baillie TA, Kevin Park B, Scott Obach R, Dalvie DK, Williams DP, Srivastava A, Regan SL, Antoine DJ, Goldring CEP, Chia AJL, Kitteringham NR, Randle LE, Callan H, Castrejon JL, Farrell J, Naisbitt DJ, Lennard MS. 2013. The generation, detection, and effects of reactive drug metabolites Medicinal Research Reviews, 33 :985-1080 >DOI

Goldring CE, Kitteringham NR, Elsby R, Randle LE, Clement YN, Williams DP, McMahon M, Hayes JD, Itoh K, Yamamoto M, Park BK. 2004. Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice Hepatology, 39 :1267-1276 >Link

Journal article

Del Casino A, Valentina L, Rakesh B, Randle LE, Dascombe MJ, Fennell DBJ, Drew MGB, Angus B, Fielding AJ, Ismail FMD. 2018. Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials ChemistrySelect, 3 :7572-7580 >DOI

Fielding AJ, Evans PG, Alizadeh S, Bisby R, Drew MGB, Del Casino A, Dunn JF, Randle LE, Dempster NM, Nahar L, Sarker SD, Cantú Reinhard FG, de Visser SP, Dascombe MJ, Ismail FMD. 2017. Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines Chemistry - A European Journal, >DOI >Link

Eakins R, Walsh J, Randle L, Jenkins RE, Schuppe-Koistinen I, Rowe C, Lewis PS, Vasieva O, Prats N, Brillant N, Auli M, Bayliss M, Webb S, Rees JA, Kitteringham NR, Goldring CE, Park BK. 2015. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome SCIENTIFIC REPORTS, 5 >DOI >Link

Neelima T, Taylor KMG, Saleem I, Randle L, Elsaid Z, Somavarapu S. 2013. Amphotericin polygamma glutamic acid derivatives for the delivery of amikacin to the lung Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 :A-1-A-27 >DOI

Chavan T, Taylor KMG, Saleem IY, Randle LE, Elsaid Z, Somavarapu S. 2013. O-PALMITOYL CHITOSAN-PEG MICELLES FOR AMPHOTERICIN B DELIVERY TO THE LUNG JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 26 :A249-A250 >Link

Stachulski AV, Baillie TA, Kevin Park B, Scott Obach R, Dalvie DK, Williams DP, Srivastava A, Regan SL, Antoine DJ, Goldring CEP, Chia AJL, Kitteringham NR, Randle LE, Callan H, Castrejon JL, Farrell J, Naisbitt DJ, Lennard MS. 2013. The generation, detection, and effects of reactive drug metabolites Medicinal Research Reviews, 33 :985-1080 >DOI

Kitteringham N, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Powell H, Sanderson C, Williams S, Higgins L, Yamomoto M, Hayes J, Park BK. 2010. Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. Journal of proteomics, 73 :1612-1631 >DOI

Randle LE, Sathish JG, Kitteringham NR, Macdonald I, Williams DP, Park BK. 2008. α 1-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice British Journal of Pharmacology, 153 :820-830 >DOI

Copple IM, Goldring CE, Jenkins RE, Chia AJL, Randle LE, Hayes JD, Kitteringham NR, Park BK. 2008. The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. Hepatology, 48 :1292-1301 >DOI >Link

Randle LE, Goldring CEP, Benson CA, Metcalfe PN, Kitteringham NR, Park BK, Williams DP. 2008. Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. Toxicology, 243 :249-260 >DOI >Link

Randle LE, Sathish JG, Kitteringham NR, Macdonald I, Williams DP, Park BK. 2008. alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. Br J Pharmacol, 153 :820-830 >DOI >Link

Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, Howard M, Gardner I, Blagg J, Park BK. 2007. The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore. J Pharmacol Exp Ther., 3 :1208-1220

Goldring CEP, Kitteringham NR, Jenkins R, Lovatt CA, Randle LE, Abdullah A, Owen A, Liu XP, Butler PJ, Williams DP, Metcalfe P, Berens C, Hillen W, Foster B, Simpson A, McLellan L, Park BK. 2006. Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes American Journal of Physiology-Cell Physiology, 290 :C104-C115

Randle LE, Williams DP, Kitteringham NR, Richard V, Park BK, O'Brien PJ. 2006. Adrenergic modulation of chemical-induced hepatotoxicity Drug Metabolism Reviews, 38 :28-29

Randle LE, Williams DP, Goldring CEP, Park BK. 2006. Mechanisms of defence during chemical-induced hepatotoxicity Drug Metabolism Reviews, 38 :56-58

Butler PJ, Williams DP, Jones R, Randle LE, Payne A, Howard M, Gardner I, Blagg J, Smith DA, Park BK. 2006. The role of metabolism in furosemide toxicity Drug Metabolism Reviews, 38 :176-177

Goldring CEP, Kitteringham NR, Lovatt C, Jenkins R, Randle LE, Abdullah A, Owen A, Liu XP, Berens C, Hillen W, Park BK. 2005. Development of doxycycline-regulatable gene expression in hepatoma cells Toxicology, 213 :262-263

Randle LE, Greenough CL, Williams DP, Clement YN, Kitteringham NR, Elsby R, Park BK. 2004. Paracetamol-induced hepatotoxicity: Protection by alpha(1)-antagonists Toxicology, 194 :238-239

Goldring CE, Kitteringham NR, Elsby R, Randle LE, Clement YN, Williams DP, McMahon M, Hayes JD, Itoh K, Yamamoto M, Park BK. 2004. Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice Hepatology, 39 :1267-1276 >Link

Butler PJ, Randle LE, Jones R, Macrae P, Blagg J, Smith DA, Williams DP, Park BK. 2004. The role of metabolism in furosemide toxicity Toxicology, 202 :98-99

O'Neill PM, Mukhtar A, Stocks PA, Randle LE, Hindley S, Ward SA, Storr RC, Bickley JF, O'Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK. 2003. Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials J Med Chem, 46 :4933-4945 >DOI >Link

Conference publication

Neelima T, Taylor KMG, Saleem I, Randle L, Somavarapu S. 2011. Amphiphilic polygamma glutamic acid derivatives for delivery of amikacin to the lung Drug Delivery to the Lungs

Yeang HXA, Hamdam J, Al-Huseini L, Goodwin C, Randle L, Melendez A, Park K, Goldring C, Sathish J. 2010. The transcription factor Nrf2 affects dendritic cell maturation and phagocytic function Immunology, 131 :107-107

Randle LE, Goldring CEP, Jenkins RE, Denk D, Antoine DJ, Sison RL, Williams DP, Hayes JD, Kitteringham NR, Park BK. 2009. A Biochemical, Toxicological, And Proteomic Analysis Investigating the Effect of Nrf2 Gene Deletion On Paracetamol-induced Hepatoxicity In Vivo Drug Metabolism Reviews, 41 :23-24

Goldring CE, Copple I, Jenkins R, Randle L, Chia A, Hayes J, Kitteringham N, Park K. 2008. Activation of the Keap1-Nrf2-Are Cell Defense System by the Reactive Metabolite of Acetaminophen Drug Metabolism Reviews, 40 :95-96

Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, Howard M, Gardner I, Blagg J, Park BK. 2007. The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore J Pharmacol Exp Ther, 322 :1208-1220 >DOI >Link

Randle LE, Williams DP, Kitteringham NR, Richard V, Park BK, O'Brien PJ. 2006. Adrenergic modulation of chemical-induced hepatotoxicity DRUG METABOLISM REVIEWS, 9th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX) 38 :166-167 >Link

Goldring C, Kitteringham N, Jenkins R, Lovatt C, Randle L, Abdullah A, Owen A, Liu X, Butler P, Williams D, Metcalfe P, Berens C, Hillen W, McLellan L, Park BK. 2005. Development of a transactivator in hepatoma cells for regulatable expression of phase I, phase II and defense genes Drug Metabolism Reviews, 37 :17-18

Williams DP, O'Donnell C, Randle LE, Goldring CEP, Garcia-Allen C, Johnston G, Kitteringham NR, Pirmohamed M, Smith DA, Park BK. 2003. Transcription factor regulation and gene expression in response to the antipsychotic, clozapine British Journal of Clinical Pharmacology, 55 :446-446

Neelima T, Taylor KMG, Saleem IY, Randle LE, Somavarapu S. Amphiphilic polygamma glutamic acid derivatives for delivery of amikacin to the lung Journal of Aerosol Medicine and Pulmonary Drug Delivery, Drug Delivery to the Lungs

Engagement & Impact

Award:

Winner of Best Young Researcher’s Poster Prize,, Royal Liverpool and Broadgreen University Hospital NHS Trust, R & D Open Day.

Winner of the drug metabolism section,PGRD Drug Discovery European Postgraduate Poster Symposium., Pfizer Drug Discovery 2003,

Best Presentation Award for predoctoral Research at 9th Europena Regional ISSX Meeting., The International Society for the Study of Xenobiotics., http://www.issx.org/

Best Presentation Award for Post Doctoral Research at 11th European Regional ISSX Meeting, The International Society for the study Xenobiotics.

External collaboration:

MRC Centre for Drug Safety Science, The University of Liverpool., Prof BK Park Dr CEP Goldring Dr NR Kitteringham Dr DP Williams Dr D Naisbitt

External committees:

BTS Local Coordinators Committee, The British Toxicology Society, Member

Early Career Toxicologist Sub Committee, The British Toxicology Society, Education Representative, http://www.thebts.org/

External PGR examinations performed:

Univeristy of Liverpool, PhD, Investigation into Nevirapine-Induced Chemical Stress in Murine Models

Fellowships:

FHEA, The Higher Education Academy

Membership of professional bodies:

Member, British Toxicology Society (BTS)

Other Professional Activity:

PBS Public Engagement Coordinator Jan 2015-present

Research Grants Awarded:

LJMU, Elucidating the Metabolic and Toxicological Profile of Novel Bisquinoline Anti-Malarials, FYaz Isamil, Satya Sarker, Grant value (£): PhD Stipend, tuition fees and £4500 consumables, Duration of research project: 3 years

Teaching qualification:

SEDA Supporting Learning Award

PGCert Learning and Teaching in Higher Education