Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Mark Murphy

Dr Mark Murphy

Telephone: 0151 231 2885

Publications

Journal Articles

Irving M, Murphy MF, Lilley F, French PW, Burton DR, Dixon S, Sharp MC. 2017. The use of abrasive polishing and laser processing for developing polyurethane surfaces for controlling fibroblast cell behaviour MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 71 :690-697 >DOI >Link

Fawcett SA, Curran JM, Chen R, Rhodes NP, Murphy MF, Wilson P, Ranganath L, Dillon JP, Gallagher JA, Hunt JA. 2017. Defining the Properties of an Array of -NH2-Modified Substrates for the Induction of a Mature Osteoblast/Osteocyte Phenotype from a Primary Human Osteoblast Population Using Controlled Nanotopography and Surface Chemistry CALCIFIED TISSUE INTERNATIONAL, 100 :95-106 >DOI >Link

Novosylna O, Doyle A, Vlasenko D, Murphy M, Negrutskii B, El’skaya A. 2017. Comparison of the ability of mammalian eEF1A1 and its oncogenic variant eEF1A2 to interact with actin and calmodulin Biological Chemistry, 398 >DOI

Yates SA, Dempster NM, Murphy MF, Moore SA. 2017. Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography/tandem mass spectrometry Rapid Communications in Mass Spectrometry, 31 :762-770 >DOI

Mohammed T, Murphy MF, Lilley F, Burton DR, Bezombes F. 2016. The effects of acoustic vibration on fibroblast cell migration MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 69 :1256-1262 >DOI >Link

Murphy MF, Edwards T, Hobbs G, Shepherd J, Bezombes F. 2016. Acoustic vibration can enhance bacterial biofilm formation JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 122 :765-770 >DOI >Link

Irving M, Murphy MF, Morgan MN, Lilley F, French P, Burton DR, Moran P. 2016. Machine grinding as an alternative method for creating functional surfaces for controlling cell behaviour INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY, 87 :1023-1031 >DOI >Link

Deng W, Zhang G-M, Murphy MF, Lilley F, Harvey DM, Burton DR. 2015. Analysis of Dynamic Cantilever Behavior in Tapping Mode Atomic Force Microscopy MICROSCOPY RESEARCH AND TECHNIQUE, 78 :935-946 >DOI >Link

Ross S, Murphy MF, Lilley F, Lalor MJ, Burton DR. 2014. Single-beam three-dimensional optical trapping at extremely low insertion angles via optical fiber optimization OPTICAL ENGINEERING, 53 >DOI >Link

Doyle A, Crosby SR, Burton DR, Lilley F, Johnston G, Perez WB, Kinzy TG, Murphy MF. 2013. Deletion of the TPM1 and MDM20 genes affect the mechanical and structural properties of yeast cells MCB Molecular and Cellular Biomechanics, 10 :275-288

Histace A, Meziou L, Matuszewsk BJ, Precioso F, Murphy MF, Carreiras F. 2013. Statistical region based active contour using a fractional entropy descriptor: Application to nuclei cell segmentation in confocal microscopy images Annals of BMVA, 2013 :1-14

Davies MJ, Kerry TD, Seton L, Murphy MF, Gibbons P, Khoo J, Naderi M. 2013. The crystal engineering of salbutamol sulphate via simulated pulmonary surfactant monolayers. Int J Pharm, 446 :34-45 >DOI >Link

Murphy MF, Lilley F, Lalor MJ, Crosby SR, Madden G, Johnston G, Burton DR. 2013. Evaluation of a nonlinear Hertzian-based model reveals prostate cancer cells respond differently to force than normal prostate cells Microscopy Research and Technique, 76 :36-41 >DOI

Doyle A, Crosby SR, Burton DR, Lilley F, Murphy MF. 2012. The effects of elongation factor 1 alpha (eEF1A) on the organisation of actin and the mechanical properties of yeast cells European Cells and Materials,

Doyle A, Crosby SR, Burton DR, Lilley F, Murphy MF. 2011. Actin bundling and polymerisation properties of eukaryotic elongation factor 1 alpha (eEF1A), histone H2A-H2B and lysozyme in vitro Journal of Structural Biology, 176 :370-378 >DOI

Tawfeek H, Khidr S, Samy E, Ahmed S, Murphy M, Mohammed A, Shabir A, Hutcheon G, Saleem I. 2011. Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery Pharmaceutical Research, 28 :2086-2097 >Link

Davies MJ, Seton L, Tiernan N, Murphy MF, Gibbons P. 2011. Towards crystal engineering via simulated pulmonary surfactant monolayers to optimise inhaled drug delivery. Int J Pharm, 421 :1-11 >DOI >Link

Doyle A, Crosby SR, Burton DR, Lilley F, Murphy MF. 2011. Actin Bundling and Polymerisation Properties of Eukaryotic Elongation Factor 1 Alpha (eEF1A), Histone H2A-H2B and Lysozyme in vitro Journal of Structural Biology, 176 :370-378 >DOI

Murphy MF, Lalor MJ, Manning FCR, Lilley F, Crosby SR, Randall C, Burton DR. 2006. Comparative study of the conditions required to image live human epithelial and fibroblast cells using atomic force microscopy. Microsc Res Tech, 69 :757-765 >DOI >Link

Conference Publication (journal proceedings)

French PW, Rosowski A, Murphy M, Irving M, Sharp MC. 2015. Laser Induced Micro Plasma Processing of Polymer Substrates for Biomedical Implant Applications Green M. INDUSTRIAL LASER APPLICATIONS SYMPOSIUM (ILAS 2015), 4th Industrial Laser Applications Symposium (ILAS) 9657 >DOI >Link

Histace A, Bonnefoye E, Garrido L, Matuszewski BJ, Murphy M. 2014. Active contour segmentation based on approximate entropy: Application to cell membrane segmentation in confocal microscopy BIOSIGNALS 2014 - 7th Int. Conference on Bio-Inspired Systems and Signal Processing, Proceedings; Part of 7th Int. Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2014, :270-277

Cocks S, Moore SA, Murphy M. 2012. Mutation sequencing and atomic force microscopy of fibroblasts treated with malondialdehyde 22nd Biennial congress of the European Association for Cancer Research

Murphy MF, Cocks S, Moore SA. 2011. Malondialdehyde decreases cell viability and damages DNA in human foetal lung fibroblasts NCRI

Ahtaiba A, Gdeisat MA, Burton DR, Lilley F, Murphy MF. 2011. A novel approach to the restoration of AFM images by employing an estimated impulse response for the AFM calculated using a square pillar sample Proceedings of the World Congress on Engineering 2011, International Conference of Signal and Image Engineering II >Link

Doyle A, Murphy MF, Crosby SR . 2010. The effect of elongation factor 1 alpha eEF1A on the organisation of polymerised actin filaments LB116, NCRI 6th Annual Cancer Conference

Johnston G, Madden G, Murphy MF. 2010. Characterising The Mechanical Properties Of Normal And Cancer Prostate Cells Using Atomic Force Microscopy LB118, NCRI 6th Annual Cancer Conference

Moore SA, Cocks S, Murphy M. 2010. The effects of malondialdehyde on the cell viability of human foetal lung fibroblasts A89, NCRI 6th Annual Cancer Conference

Burton DB, Murphy MF, Lilley F. 'The formulation of a non-linear Hertzian model in order to assess the mechanical strength of human cells based on data from an atomic force microscope IEEE International Conference on Image processing (ICIP 2011)

Ahtaiba A, Gdeisat MA, Burton DR, Lilley F, Murphy MF, Johnston G. A novel technique for restoration of atomic force microscope images enabling an approximation of AFM impulse response IEEE International Conference on Image processing (ICIP 2011)

Marchant TE, Murphy MF, Madden GP, Moore CJ. Quantifying structure regularity in fluorescence microscopy cell images using a novel multidimensional approximate entropy metric IEEE International Conference on Image processing (ICIP 2011)

Meziou L, Histace A, Precioso F, Matuszewski B, Murphy MF. Confocal microscopy segmentation using active contour based on alpha-divergence IEEE International Conference on Image Processing (ICIP 2011),

Johnston G, Burton DR, Lilley F, Doyle A, Murphy MF, Madden G, Gdeisat MA, Moore CJ, Marchant T, Matuszewski BJ. Analysis of microscopy reconstructive images for applications in medicine and biology IEEE International Conference on Image Processing (ICIP 2011)

Matuszewski BJ, Murphy MF, Marchant TE, Moore CJ, Histace A, Precioso F. Segmentation of cellular structures in actin tagged fluorescence confocal microscopy images IEEE International Conference on Image Processing

Doyle A, Murphy MF, Gross S, Crosby SR. Characterisation of the bundling properties of eukaryotic elongation factor 1 alpha (eEF1A) on the actin cytoskeleton PO15, Systems Biochemistry

Engagement & Impact

Conference organisation:

Conference name: General Engineering Research Institute, Position: Organiser

Conference name: General Engineering Research Institute Annual Symposium, Position: Organiser and Session Chair

Conference name: General Engineering Research Institute Annual Symposium, Position: Organiser and session chair

Conference name: General Engineering Annual Symposium (GARS), Position: organiser and session chair

Editorial boards:

Publication: International Journal of Diagnostic Imaging, Position: Member of International Editorial Reviewer Board

External collaboration:

Institution: University of Sheffield, Collaborator: Dr Joey Shepherd

Institution: Croda Biotechnology, Collaborator: Dr Tim Miller

Institution: University of Liverpool, Collaborator: Judith Curran

URL: http://molbiosci.rutgers.edu/faculty/kinzy.html, Institution: Robert Wood Johnson Medical School Dept of Biochemistry & Molecular Biology Room R709 Piscataway, NJ 08854 (732) 235-5450 FAX - 5223, Collaborator: Prof Terri Goss Kinzy

Institution: University of Liverpool, Collaborator: Dr Rachel Williams

Institution: the Chrsitie Hospital Manchester, Collaborator: Prof Chris Moore

Institution: Universiy of Nice-Sophia Antipolis, Collaborator: Prof Frédéric Precioso

Institution: University of cergy-Pontoise, Collaborator: Associate Professor Aymeric Histace

Institution: Université de Cergy-Pontoise, Collaborator: Leila Meziou

Institution: NHS, Collaborator: Prof Paul McArthur

URL: http://www.imbg.org.ua/en/dept/translation/lab_pbs/, Institution: Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Collaborator: Dr Boris Negrutskii

Institution: Institute for Electronics, Signal Processing and Communications, Otto von Guericke University Magdeburg, Collaborator: Dr Gerald Krell

Institution: Computing, Engineering & Physical Sciences. Univeristy of Central Lancashire, Collaborator: Dr. Bogdan Matuszewski

URL: http://www.liv.ac.uk/ophthalmology/, Institution: Ophthalmology Research Unit, Univeristy of Liverpool, Collaborator: Prof. Ian Grierson

Industrial connections:

Company: Croda Biotechnology, Position or project: Acoustic Vibration and Biofilms

Company: Biomer Technology Ltd, Position or project: Colloborate on project: Development of novel polymer substrates to control cell growth

Membership of professional bodies:

Fellow, Higher Education Academy

Other invited event:

Title of event: TCES, Location: University of Liverpool, Description: Invited to submit a paper at University of Liverpool Tissue and Cell Engineering Symposium

Title of event: Asylum Research Annual Symposium, Location: University of Oxford, Description: Inviated to talk at conference based around use of atomic force microscopy

Research Grants Awarded:

BBSRC, Enhancing extracellular polysaccharide (EPS) production using low-frequency acoustic vibration, Dr Glyn Hobbs (LJMU), Dr Tim Miller Croda Biotechnology, Grant value (£): £8368, Duration of research project: 6 months

Royal Society - Bilateral travel award for collaboration with Mahidol University Thailand, Mechano-structural modelling of irradiated cancer cells, Grant value (£): £6000, Duration of research project: 12 month

EPSRC, Technology in Radiothepay Feasability Studies, Bogdan Matuszewski, C. Watkins, T. Marchant, G Price, C. Moore, David Burton, Francis Lilley, L Shark, C Frowd, Grant value (£): 250,000

Teaching qualification:

Title of qualification gained: Post Graduate Certificate of Education