Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Mark Murphy

Dr Mark Murphy

Telephone: 0151 231 2885

website
ORCID

Biography

Degrees

2007, Liverpool John Moores University, United Kingdom, PhD Cellular Mechanics
2003, Liverpool John Moores University, United Kingdom, MSc Industrial Biotechnology
2001, Liverpool John Moores University, United Kingdom, BSc Applied Zoology

Academic appointments

Programme Leader Msc Industrial Biotechnology, Liverpool John Moores University, 2015 - present
Lecturer Cell Biology/Biochemistry, Liverpool John Moores University, 2008 - present

Postgraduate training

Post Doctorate, United Kingdom, Liverpool John Moores University, 2007 - 2008

Publications

Journal article

Opoz T, Yasar H, Murphy M, Ekmekci N, Ekmekci B. 2019. Ti6Al4V Surface Modification by Hydroxyapatite Powder Mixed Electrical Discharge Machining for Medical Application International Journal of Advances in Engineering and Pure Sciences, 31 :1-10 DOI Publisher Url Public Url

Yates SA, Murphy MF, Moore SA. 2019. The effect of malondialdehyde is modified by simian virus 40 transformation in human lung fibroblast cells Toxicology, DOI Author Url Public Url

Yates S, Dempster N, Murphy M, Moore SA. 2017. Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography tandem mass spectrometry Rapid Communications in Mass Spectrometry, 31 :762-770 DOI Author Url Public Url

Irving M, Murphy MF, Lilley F, French PW, Burton DR, Dixon S, Sharp MC. 2017. The use of abrasive polishing and laser processing for developing polyurethane surfaces for controlling fibroblast cell behaviour MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 71 :690-697 DOI Author Url Public Url

Fawcett SA, Curran JM, Chen R, Rhodes NP, Murphy MF, Wilson P, Ranganath L, Dillon JP, Gallagher JA, Hunt JA. 2017. Defining the properties of an array of -NH2 modified substrates for the induction of a mature osteoblast/osteocyte phenotype from a primary human osteoblast population using controlled nanotopography and surface chemistry Calcified Tissue International, 100 :95-106 DOI Author Url Publisher Url Public Url

Novosylna O, Doyle A, Murphy MF, Vlasenko D, Negrutskii B, El'skaya A. 2017. Comparison of the ability of mammalian eEF1A1 and its oncogenic variant eEF1A2 to interact with actin and calmodulin Biological Chemistry, 398 DOI Author Url Publisher Url Public Url

Mohammed T, Murphy MF, Lilley F, Burton D, Bezombes F. 2016. The effects of acoustic vibration on fibroblast cell migration Materials Science and Engineering C, DOI Author Url Public Url

Murphy MF, Irving M, Morgan M, Lilley F, French P, Burton D, Moran P. 2016. Machine grinding as an alternative method for creating functional surfaces for controlling cell behaviour The International Journal of Advanced Manufacturing Technology, DOI Author Url Public Url

Zhang G, Deng W, Murphy M, Lilley F, Harvey D, Burton D. 2015. Analysis of Dynamic Cantilever Behaviour in Tapping Mode Atomic Force Microscopy Microscopy Research and Technique, DOI Author Url Public Url

Ross S, Murphy MF, Lilley F, Lalor MJ, Burton DR. 2014. Single-beam three-dimensional optical trapping at extremely low insertion angles via optical fiber optimization OPTICAL ENGINEERING, 53 DOI Author Url Public Url

Histace A, Meziou L, Matuszewsk BJ, Precioso F, Murphy MF, Carreiras F. 2013. Statistical region based active contour using a fractional entropy descriptor: Application to nuclei cell segmentation in confocal microscopy images Annals of BMVA, 2013 :1-14 Publisher Url

Murphy MF, Lilley F, Lalor MJ, Crosby SR, Madden G, Johnston G, Burton DR. 2013. Evaluation of a nonlinear Hertzian-based model reveals prostate cancer cells respond differently to force than normal prostate cells Microscopy Research and Technique, 76 :36-41 DOI

Davies MJ, Seton L, Tiernan N, Murphy MF, Gibbons P. 2011. Towards crystal engineering via simulated pulmonary surfactant monolayers to optimise inhaled drug delivery. Int J Pharm, 421 :1-11 DOI Author Url

Doyle A, Crosby SR, Burton DR, Lilley F, Murphy MF. 2011. Actin bundling and polymerisation properties of eukaryotic elongation factor 1 alpha (eEF1A), histone H2A-H2B and lysozyme in vitro Journal of Structural Biology, 176 :370-378 DOI Author Url

Ahtaiba A, Gdeisat M, Burton D, Lilley F, Murphy M. 2011. A novel approach to the restoration of AFM images by employing an estimated impulse response for the AFM calculated using a square pillar sample Proceedings of the World Congress on Engineering 2011, WCE 2011, 2 :1657-1662

Tawfeek H, Khidr S, Samy E, Ahmed S, Murphy M, Mohammed A, Shabir A, Hutcheon G, Saleem I. 2011. Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery Pharmaceutical Research, 28 :2086-2097 Author Url Public Url

Doyle A, Crosby SR, Burton DR, Lilley F, Johnston G, Perez WB, Kinzy TG, Murphy MF. Deletion of the TPM1 and MDM20 Genes Affect the Mechanical and Structural Properties of Yeast Cells Molecular & Cellular Biomechanics, 10 :275-288 DOI Publisher Url

Doyle A, Crosby SR, Burton DR, Lilley F, Murphy MF. The effects of elongation factor 1 alpha (eEF1A) on the organisation of actin and the mechanical properties of yeast cells European Cells and Materials, Publisher Url

Doyle A, Crosby SR, Burton DR, Lilley F, Murphy MF. Actin Bundling and Polymerisation Properties of Eukaryotic Elongation Factor 1 Alpha (eEF1A), Histone H2A-H2B and Lysozyme in vitro Journal of Structural Biology, 176 :370-378 DOI Author Url

Murphy MF, Lalor MJ, Manning FCR, Lilley F, Crosby SR, Randall C, Burton DR. Comparative study of the conditions required to image live human epithelial and fibroblast cells using atomic force microscopy. Microsc Res Tech, 69 :757-765 DOI Author Url

Tawfeek H, Khidr S, Samy E, Ahmed S, Murphy M, Mohammed A, Shabir A, Hutcheon G, Saleem I. Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery Pharmaceutical Research, 28 :2086-2097 DOI Author Url

Murphy MF, Edwards T, Hobbs G, Shepherd J, Bezombes F. Acoustic Vibration Can Enhance Bacterial Biofilm Formation Journal of Bioscience and Bioengineering, DOI Author Url Public Url

Chapters

Turner DC, Kasper AM, Seaborne RA, Brown AD, Close GL, Murphy M, Stewart CE, Martin NRW, Sharples AP. 2019. Exercising Bioengineered Skeletal Muscle In Vitro: Biopsy to Bioreactor Beate Ronning S. Myogenesis: Methods and Protocols vol. 1889 Springer Nature 978-1-4939-8896-9 DOI Author Url Publisher Url Public Url

Conference publication

Opoz TT, Yasar H, Murphy M, Ekmekci N, Ekmekci B. 2018. TI6AL4V SURFACE MODIFICATION BY HYDROXYAPATITE POWDER MIXED ELECTRIC DISCHARGE MACHINING FOR MEDICAL APPLICATION Kilic SE, LOTFISADIGH B. 18th INTERNATIONAL CONFERENCE ON MACHINE DESIGN AND PRODUCTION, 18th INTERNATIONAL CONFERENCE ON MACHINE DESIGN AND PRODUCTION 2 :787-802 Publisher Url Public Url

French PW, Rosowski A, Murphy M, Irving M, Sharp MC. 2015. Laser Induced Micro Plasma Processing of Polymer Substrates for Biomedical Implant Applications Green M. INDUSTRIAL LASER APPLICATIONS SYMPOSIUM (ILAS 2015), 4th Industrial Laser Applications Symposium (ILAS) 9657 DOI Author Url Public Url

Histace A, Bonnefoye E, Garrido L, Matuszewski B, Murphy M. 2014. Active contour segmentation based on approximate entropy: Application to cell membrane segmentation in confocal microscopy BIOSIGNALS - Part of 7th International Joint Conference on Biomedical Engineering Systems and Technologies

Cocks S, Moore SA, Murphy M. Mutation sequencing and atomic force microscopy of fibroblasts treated with malondialdehyde 22nd Biennial congress of the European Association for Cancer Research DOI Author Url

Ahtaiba A, Gdeisat MA, Burton DR, Lilley F, Murphy MF. A novel approach to the restoration of AFM images by employing an estimated impulse response for the AFM calculated using a square pillar sample Proceedings of the World Congress on Engineering 2011, International Conference of Signal and Image Engineering II Author Url

Murphy MF, Cocks S, Moore SA. Malondialdehyde decreases cell viability and damages DNA in human foetal lung fibroblasts NCRI

Moore SA, Cocks S, Murphy M. The effects of malondialdehyde on the cell viability of human foetal lung fibroblasts A89, NCRI 6th Annual Cancer Conference Publisher Url

Johnston G, Madden G, Murphy MF. Characterising The Mechanical Properties Of Normal And Cancer Prostate Cells Using Atomic Force Microscopy LB118, NCRI 6th Annual Cancer Conference Publisher Url

Doyle A, Murphy MF, Crosby SR . The effect of elongation factor 1 alpha eEF1A on the organisation of polymerised actin filaments LB116, NCRI 6th Annual Cancer Conference Publisher Url

Doyle A, Murphy MF, Gross S, Crosby SR. Characterisation of the bundling properties of eukaryotic elongation factor 1 alpha (eEF1A) on the actin cytoskeleton PO15, Systems Biochemistry

Matuszewski BJ, Murphy MF, Marchant TE, Moore CJ, Histace A, Precioso F. Segmentation of cellular structures in actin tagged fluorescence confocal microscopy images IEEE International Conference on Image Processing Author Url

Johnston G, Burton DR, Lilley F, Doyle A, Murphy MF, Madden G, Gdeisat MA, Moore CJ, Marchant T, Matuszewski BJ. Analysis of microscopy reconstructive images for applications in medicine and biology IEEE International Conference on Image Processing (ICIP 2011) Author Url

Meziou L, Histace A, Precioso F, Matuszewski B, Murphy MF. Confocal microscopy segmentation using active contour based on alpha-divergence IEEE International Conference on Image Processing (ICIP 2011), DOI Author Url

Marchant TE, Murphy MF, Madden GP, Moore CJ. Quantifying structure regularity in fluorescence microscopy cell images using a novel multidimensional approximate entropy metric IEEE International Conference on Image processing (ICIP 2011) DOI Author Url

Ahtaiba A, Gdeisat MA, Burton DR, Lilley F, Murphy MF, Johnston G. A novel technique for restoration of atomic force microscope images enabling an approximation of AFM impulse response IEEE International Conference on Image processing (ICIP 2011) Author Url

Burton DB, Murphy MF, Lilley F. 'The formulation of a non-linear Hertzian model in order to assess the mechanical strength of human cells based on data from an atomic force microscope IEEE International Conference on Image processing (ICIP 2011) Author Url

Engagement & Impact

Research Grants Awarded:

BBSRC, Enhancing extracellular polysaccharide (EPS) production using low-frequency acoustic vibration, Dr Glyn Hobbs (LJMU), Dr Tim Miller Croda Biotechnology, Grant value (£): £8368, Duration of research project: 6 months. 2016

Royal Society - Bilateral travel award for collaboration with Mahidol University Thailand, Mechano-structural modelling of irradiated cancer cells, Grant value (£): £6000, Duration of research project: 12 month. 2014

EPSRC, Technology in Radiothepay Feasability Studies, Bogdan Matuszewski, C. Watkins, T. Marchant, G Price, C. Moore, David Burton, Francis Lilley, L Shark, C Frowd, Grant value (£): 250,000.

External collaboration:

University of Sheffield, Dr Joey Shepherd. 2015

http://www.liv.ac.uk/ophthalmology/, Ophthalmology Research Unit, Univeristy of Liverpool, Prof. Ian Grierson. 2012

http://molbiosci.rutgers.edu/faculty/kinzy.html, Robert Wood Johnson Medical School Dept of Biochemistry & Molecular Biology Room R709 Piscataway, NJ 08854 (732) 235-5450 FAX - 5223, Prof Terri Goss Kinzy. 2012

University of Liverpool, Dr Rachel Williams. 2012

http://www.imbg.org.ua/en/dept/translation/lab_pbs/, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Dr Boris Negrutskii. 2011

the Chrsitie Hospital Manchester, Prof Chris Moore. 2011

Université de Cergy-Pontoise, Leila Meziou. 2011

University of cergy-Pontoise, Associate Professor Aymeric Histace. 2011

Universiy of Nice-Sophia Antipolis, Prof Frédéric Precioso. 2011

NHS, Prof Paul McArthur. 2010

Computing, Engineering & Physical Sciences. Univeristy of Central Lancashire, Dr. Bogdan Matuszewski. 2009

Croda Biotechnology, Dr Tim Miller.

Institute for Electronics, Signal Processing and Communications, Otto von Guericke University Magdeburg, Dr Gerald Krell.

University of Liverpool, Judith Curran.

Conference organisation:

General Engineering Research Institute, Organiser. 2013

General Engineering Research Institute Annual Symposium, Organiser and Session Chair. 2012

General Engineering Research Institute Annual Symposium, Organiser and session chair. 2010

General Engineering Annual Symposium (GARS), organiser and session chair. 2009

Editorial boards:

International Journal of Diagnostic Imaging, Member of International Editorial Reviewer Board. 2013

Other invited event:

TCES, University of Liverpool, Invited to submit a paper at University of Liverpool Tissue and Cell Engineering Symposium. 2012

Asylum Research Annual Symposium, University of Oxford, Inviated to talk at conference based around use of atomic force microscopy. 2009

Membership of professional bodies:

Fellow, Higher Education Academy. 2011

Teaching qualification:

Post Graduate Certificate of Education. 2011

Industrial connections:

Biomer Technology Ltd, Colloborate on project: Development of novel polymer substrates to control cell growth. 2010

Croda Biotechnology, Acoustic Vibration and Biofilms.