I am a United Kingdom registered Pharmacist and hold a PhD in nanoscale materials characterisation from the Laboratory of Biophysics and Surface Analysis (LBSA), The University of Nottingham. At present, I am employed as a Senior Lecturer in Pharmacy Practice and Pharmaceutics at Liverpool John Moores University (LJMU).
Throughout my professional career, I have had a keen interest in the application of pharmaceutical technology to support the scientific knowledge-base and drive forward patient healthcare. To this end, I completed my doctoral studies at The University of Nottingham on the quantitative assessment of the interaction between inhaled drug particulates and simulated internal lung surfaces. The project was sponsored by AstraZeneca. Here, a number of advanced biophysical techniques were exploited including atomic force microscopy (AFM), inverse gas chromatography (IGC), scanning electron microscopy (SEM) and Langmuir monolayer technology. During the work, an opportunity arose for cross-over involvement with the molecular modelling discipline to further develop experimental understanding. The overarching intention was to better understand mechanisms underpinning drug delivery to the body via the inhaled route.
I have substantial experience of teaching at the Higher Education level. In relation to this point, I completed my Post-Graduate Certificate in Higher Education in 2011, with distinction, and am now registered as a Fellow of the Higher Education Academy. Current teaching responsibilities at LJMU are wide ranging and include lecture, workshop and tutorial delivery.
I lead a number of taught sessions covering aspects such as:
1. Interfacial phenomena
2. Advanced biophysical techniques to enable materials characterisation at the nanoscale
3. Dosage form design and routes of drug administration to the body
4. Materials, approaches and tests to ensure suitable package of pharmaceutical dosage forms
5. Modern day dispensing practices and the appropriate handling and storage of medicines
6. Aseptic manufacture and dispensing
7. Extemporaneous dispensing and related patient advice
8. Ophthalmic products and related patient advice
9. How the diet and lifestyle may be tailored to support healthy living
2005, The University of Nottingham, United Kingdom, Doctor of Philosophy
2001, The University of Nottingham, United Kingdom, Master of Pharmacy
Module Convenor for Pharmaceutical Sterile Products and Microbiological Quality Control, Liverpool John Moores University, 2014 - present
Davies M, Leach A, Riley F. 2018. An Investigation into Drug Partitioning Behaviour in Simulated Pulmonary Surfactant Monolayers with Associated Molecular Modelling Surface and Interface Analysis, :1-1 >DOI
Davies M, Birkett JW, Court O, Mottram A, Zoroaster F. 2018. The Impact of Cannabis Smoke on the Performance of Pulmonary Surfactant under Physiologically Relevant Conditions Surface and Interface Analysis, 50 :188-197 >DOI
Davies M, Leach AG, Fullwood DL, Mistry D, Hope A. 2017. The pH Dependent Interaction between Nicotine and Simulated Pulmonary Surfactant Monolayers with Associated Molecular Modelling Watts J. Surface and Interface Analysis, >DOI
Davies MJ, Birkett JW, Kotwa M, Tomlinson L, Woldetinsae R. 2017. The impact of cigarette/e-cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions Surface and Interface Analysis, 49 :654-665 >DOI
Davies M, Costley E, Ren J, Gibbons P, Kondor A, Naderi M. 2016. On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing Journal of 3D Printing in Medicine, 1 :1-17
DAVIES MJ, KOTADIA A, MUGHAL H, HANNAN A, ALQARNI H. 2015. The attitudes of pharmacists, students and the general public on mHealth applications for medication adherence Pharmacy Practice, 13 :644-644 >DOI
Davies MJ, Collings M, Fletcher W, Mujtaba H. 2014. Pharmacy apps: A new frontier on the digital landscape? Pharmacy Practice, 12 >DOI
Davies M, Collings M, Fletcher W, Mujtaba H. 2014. Pharmacy Apps: a new frontier on the digital landscape? Pharmacy Practice, 12 :453-464
Marigo M, Davies M, Leadbeater T, Cairns DL, Ingram A, Stitt EH. 2013. Application of positron emission particle tracking (PEPT) to validate a discrete element method (DEM) model of granular flow and mixing in the Turbula mixer International Journal of Pharmaceutics, 446 :46-58 >DOI
Davies MJ, Kerry TD, Seton L, Murphy MF, Gibbons P, Khoo J, Naderi M. 2013. The crystal engineering of salbutamol sulphate via simulated pulmonary surfactant monolayers INTERNATIONAL JOURNAL OF PHARMACEUTICS, 446 :34-45 >DOI >Link
Davies MJ, Fleming H, Jones R, Menzie K, Smallwood C, Surendar S. 2013. The inclusion of a business management module within the master of pharmacy degree: A route to asset enrichment? Pharmacy Practice, 11 :109-117 >DOI
Seton L, EHTEZAZI T, DAVIES MJ, SETON L, MORGAN NM, ROSS S, MARTIN GD, HUTCHINGS IM. 2013. Optimizing the primary particle size distributions of pressurized metered dose inhalers by using inkjet spray drying for targeting desired regions of the lungs Drug Development and Industrial Pharmacy, >DOI
Davies MJ, Fleming H, Jones R, Menzie K, Smallwood C, Surendar S. 2013. The inclusion of a business management module within the master of pharmacy degree: a route to asset enrichment? Pharmacy Practice, 11 :109-117
Davies M, Kerry TD, Seton L, Murphy M, Gibbons P, Khoo J, Naderi M. 2013. The crystal engineering of salbutamol sulphate via simulated pulmonary surfactant monolayers International Journal of Pharmaceutcs, 446 :34-45 >DOI
Marigo M, Cairns DL, Davies M, Ingram A, Stitt EH. 2012. A numerical comparison of mixing efficiencies of solids in a cylindrical vessel subject to a range of motions Powder Technology, 217 :540-547 >DOI
Marigo M, Cairns DL, Davies M, Ingram A, Stitt EH. 2011. Developing mechanistic understanding of granular behaviour in complex moving geometry using the Discrete Element Method. Part B: Investigation of flow and mixing in the Turbula® mixer. Powder Technology, 212 :17-24 >DOI
Davies MJ, Seton L, Tiernan N, Murphy M, Gibbons P. 2011. Towards crystal engineering via simulated pulmonary surfactant monolayers to optimise inhaled drug delivery. International Journal of Pharmaceutics, :1-11
Marigo M, Cairns DL, Davies M, Cook M, Ingram A, Stitt EH. 2010. Developing mechanistic understanding of granular behaviour in complex moving geometry using the discrete element method. Part A: Measurement and reconstruction of turbula®mixer motion using positron emission particle tracking CMES - Computer Modeling in Engineering and Sciences, 59 :217-238
George K, Lovelady C, Connolly D, Parmar S, Davies MJ. 2010. Community pharmacy contribution to weight management: Identifying opportunities International Journal of Pharmacy Practice, 18 :7-12 >DOI
Davies MJ, Brindley A, Chen X, Doughty SW, Marlow M, Roberts CJ. 2009. A quantitative assessment of inhaled drug particle-pulmonary surfactant interaction by atomic force microscopy COLLOIDS AND SURFACES B-BIOINTERFACES, 73 :97-102 >DOI >Link
Davies MJ, Krska J, Lovelady C, Connolly D, Parmar S. 2009. Community pharmacy contribution to weight management: Identifying opportunities. International Journal of Pharmacy Practice, 18 :1-6
Davies MJ, Brindley A, Chen X , Doughty SW , Marlow M , Roberts CJ. 2009. A quantitative assessment of inhaled drug particle – pulmonary surfactant interaction by atomic force microscopy. Colloids and Surfaces B: Biointerfaces, 73 :97-102
Davies M, Brindley A, Chen X, Marlow M, Doughty SW, Shrubb I, Roberts CJ. 2005. Characterization of drug particle surface energetics and young's modulus by atomic force microscopy and inverse gas chromatography Pharmaceutical Research, 22 :1158-1166 >DOI
Davies M, Taylor Z, Ren J, Leach A, Gibbons P. Crystallisation of Aspirin via Simulated Pulmonary Surfactant Monolayers and Lung-Specific Additives Surface and Interface Analysis, >DOI
Davies MJ, Seton L, Tiernan N, Murphy MF, Gibbons P. Towards Crystal Engineering in a Simulated Pulmonary Environment to Optimise Inhaled Drug Delivery International Journal of Pharmaceutics,
Davies MJ, Birkett JW, ren J. 2017. Development of the Lung Biosimulator for Orally Inhaled Product (OIP) Dissolution: MRC Bid: MR/R015619/1 MRC Biomedical Catalyst,
Davies MJ. 2014. Device and method for simulating pulmonary environments
Davies MJ, Bradbury S, Mistry K, Nolan E. Improvements in and relating to assessment of drug dissolution.
Iram S, Al-Jumeily D, Fergus P, Randles M, Davies M. 2011. E-health: The potential of linked data and stream reasoning for personalised healthcare Proceedings - 4th International Conference on Developments in eSystems Engineering, DeSE 2011, :46-49 >DOI
Davies MJ, Seton L, Tiernan N. 2010. Towards the Rational Design of Crystalline Material for Pulmonary Delivery JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1358-1359 >Link
Davies MJ, Seton L, Tiernan N. 2010. Towards the rational design of crystalline material for pulmonary delivery. Journal of Pharmacy and Pharmacology, 62 :1358-1358
Davies M, Krska J, Mackridge A, Khela A, Brown K, Museredza F. 2009. The general public’s attitudes towards medicinal products. International Journal of Pharmacy Practice, 17 :A23
Davies M, Seton L, Ali M. 2009. The crystallisation of theophylline via a Langmuir-Blodgett approach JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A84-A84 >Link
Davies M, Mackridge AJ, Singh R, Day J. 2008. An investigation of the attitudes of medical and nursing staff to monitoring adverse events associated with antipsychotic medication International Journal of Pharmacy Practice, S1 :A22
Darwood MW, Davies M, Godden D, Jackson P, James K, Stitt EH. 2003. Development and implementation of gamma-ray tomography for field applications 3rd World Congress on Industrial Process Tomography, :207-212
Davies MJ. BPSA Science to Practice Conference BPSA Science to Practice Conference
Engagement & Impact
Runner Up, Bionow Start-up of the Year Award 2014, http://www.bionow.co.uk/events/2014bionowannualawardsdinner.aspx
Runner up, Merseyside Innovation Awards 2014, http://www.merseysideinnovationawards.co.uk/news/supercar-developer-crowned-merseyside-innovation-awards-winner/
The University of Nottingham, Prof Clive Roberts Clive and I have worked on two research papers that have been published in high impact journals. Should I wish to analyse the surface features / chemistries of drug particulates in the future Clive would be willing to support me in my efforts.
Surface Measurement Systems and GlaxoSmithKline., Majid Naderi and Jiyi Khoo. Both organisations are postive in terms of collaboration, respectively. Should I have samples requiring Inverse Gas Chromatography assessment I can send these to SMS. Alternative analysis via other approaches is available upon request. In addition, my contact at GSK has shown interest in the surface profiling of drug particulates and would be willing to collaborate on any PhD project I supervise.
Fellow of the Higher Education Academy (#37138), Higher Education Academy
3M, Research Agreement with Pulmorphix Ltd.
Incorporation of the contract research organisation 'Pulmorphix Ltd'., I hold the position of Scientific Director within Pulmorphix Ltd. I am also a board member within this CRO. The company aims to provide Pharma with an in depth understanding of how inhaled formulations release their drug substance(s) with respect to time in an environment that reflects the deep lung. The crystallisation propensity of active pharmaceutical ingredients may also be probed via our technology platform(s).
Membership of professional bodies:
MRPharmS, The General Pharmaceutical Council
Other invited event:
Enterprising Birmingham Innovation Competition: Key Note Speaker, Birmingham University, I was invited to attend the Enterprising Birmingham Showcase event as a Key Note Speaker to detail how Pulmorphix Ltd developed from an idea to a spin-out company.
Research Grants Awarded:
CrowdCube, Pulmorphix Ltd, Mr Kish Mistry and Ms Emma Nolan, Grant value (£): 125,000.00, Duration of research project: Ongoing - Pulmorphix Ltd
The Technology Strategy Board, The Development of the World's First Lung Biosimulator Device, Emma Nolan (BDC) and Kish Mistry (External), Grant value (£): 82,500.00, Duration of research project: Start-up SME - Ongoing
Liverpool John Moores University, The Methadone Jet Pipette - A Feasibility Study, Dr Touraj Ehtezazi, Grant value (£): 500, Duration of research project: Ongoing
Liverpool John Moores University, Drug Crystal Engineering Strategies for Chronic Pain Management via the Lung, Linda Seton and Mark Murphy, Grant value (£): 15K + Bench Fees + 1.5K for consumables, Duration of research project: 3 years
The Technology Strategy Board, The development of an innovative technology platform to probe the dissolution behaviour and crystallisation propensity of orally inhaled products within a simulated pulmonary environment., Kish Mistry and Emma Nolan, Grant value (£): 100K, Duration of research project: Ongoing