Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Michael Davies

Dr Michael Davies

Telephone: 0151 231 2024

Biography

I am a United Kingdom registered Pharmacist and hold a PhD in nanoscale materials characterisation from the Laboratory of Biophysics and Surface Analysis (LBSA), The University of Nottingham. At present, I am employed as a Senior Lecturer in Pharmacy Practice and Pharmaceutics at Liverpool John Moores University (LJMU).

Throughout my professional career, I have had a keen interest in the application of pharmaceutical technology to support the scientific knowledge-base and drive forward patient healthcare. To this end, I completed my doctoral studies at The University of Nottingham on the quantitative assessment of the interaction between inhaled drug particulates and simulated internal lung surfaces. The project was sponsored by AstraZeneca. Here, a number of advanced biophysical techniques were exploited including atomic force microscopy (AFM), inverse gas chromatography (IGC), scanning electron microscopy (SEM) and Langmuir monolayer technology. During the work, an opportunity arose for cross-over involvement with the molecular modelling discipline to further develop experimental understanding. The overarching intention was to better understand mechanisms underpinning drug delivery to the body via the inhaled route.

I have substantial experience of teaching at the Higher Education level. In relation to this point, I completed my Post-Graduate Certificate in Higher Education in 2011, with distinction, and am now registered as a Fellow of the Higher Education Academy. Current teaching responsibilities at LJMU are wide ranging and include lecture, workshop and tutorial delivery.

I lead a number of taught sessions covering aspects such as:

1. Interfacial phenomena
2. Advanced biophysical techniques to enable materials characterisation at the nanoscale
3. Dosage form design and routes of drug administration to the body
4. Materials, approaches and tests to ensure suitable package of pharmaceutical dosage forms
5. Modern day dispensing practices and the appropriate handling and storage of medicines
6. Aseptic manufacture and dispensing
7. Extemporaneous dispensing and related patient advice
8. Ophthalmic products and related patient advice
9. How the diet and lifestyle may be tailored to support healthy living

Degrees

2005, The University of Nottingham, United Kingdom, Doctor of Philosophy
2001, The University of Nottingham, United Kingdom, Master of Pharmacy

Publications

Journal Articles

Davies MJ, Leach AG, Fullwood D, Mistry D, Hope A. 2017. The pH dependent interaction between nicotine and simulated pulmonary surfactant monolayers with associated molecular modelling SURFACE AND INTERFACE ANALYSIS, 49 :919-927 >DOI >Link

Davies MJ, Taylor Z, Leach AG, Ren J, Gibbons P. 2017. Crystallisation of aspirin via simulated pulmonary surfactant monolayers and lung-specific additives SURFACE AND INTERFACE ANALYSIS, 49 :864-872 >DOI >Link

Davies MJ, Birkett JW, Kotwa M, Tomlinson L, Woldetinsae R. 2017. The impact of cigarette/e-cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions Surface and Interface Analysis, 49 :654-665 >DOI

Davies M, Costley E, Ren J, Gibbons P, Kondor A, Naderi M. 2016. On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing Journal of 3D Printing in Medicine, 1 :1-17

DAVIES MJ, KOTADIA A, MUGHAL H, HANNAN A, ALQARNI H. 2015. The attitudes of pharmacists, students and the general public on mHealth applications for medication adherence Pharmacy Practice, 13 :644-644 >DOI

Ehtezazi T, Davies MJ, Seton L, Morgan MN, Ross S, Martin GD, Hutchings IM. 2015. Optimizing the primary particle size distributions of pressurized metered dose inhalers by using inkjet spray drying for targeting desired regions of the lungs DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 41 :279-291 >DOI >Link

Davies MJ, Collings M, Fletcher W, Mujtaba H. 2014. Pharmacy apps: A new frontier on the digital landscape? Pharmacy Practice, 12

Davies MJ, Collings M, Fletcher W, Mujtaba H. 2014. Pharmacy Apps: a new frontier on the digital landscape? Pharmacy practice, 12 :453

Davies MJ, Kerry TD, Seton L, Murphy MF, Gibbons P, Khoo J, Naderi M. 2013. The crystal engineering of salbutamol sulphate via simulated pulmonary surfactant monolayers INTERNATIONAL JOURNAL OF PHARMACEUTICS, 446 :34-45 >DOI >Link

Davies MJ, Fleming H, Jones R, Menzie K, Smallwood C, Surendar S. 2013. The inclusion of a business management module within the master of pharmacy degree: A route to asset enrichment? Pharmacy Practice, 11 :109-117

Davies MJ, Fleming H, Jones R, Menzie K, Smallwood C, Surendar S. 2013. The inclusion of a business management module within the master of pharmacy degree: a route to asset enrichment? Pharmacy Practice, 11 :109-117

Davies M, Kerry TD, Seton L, Murphy M, Gibbons P, Khoo J, Naderi M. 2013. The crystal engineering of salbutamol sulphate via simulated pulmonary surfactant monolayers International Journal of Pharmaceutcs, 446 :34-45 >DOI

Davies MJ, Seton L, Tiernan N, Murphy MF, Gibbons P. 2011. Towards crystal engineering via simulated pulmonary surfactant monolayers to optimise inhaled drug delivery INTERNATIONAL JOURNAL OF PHARMACEUTICS, 421 :1-11 >DOI >Link

Davies MJ, Seton L, Tiernan N, Murphy M, Gibbons P. 2011. Towards crystal engineering via simulated pulmonary surfactant monolayers to optimise inhaled drug delivery. International Journal of Pharmaceutics, :1-11

George K, Lovelady C, Connolly D, Parmar S, Davies MJ. 2010. Community pharmacy contribution to weight management: Identifying opportunities International Journal of Pharmacy Practice, 18 :7-12 >DOI

Davies MJ, Brindley A, Chen X, Doughty SW, Marlow M, Roberts CJ. 2009. A quantitative assessment of inhaled drug particle-pulmonary surfactant interaction by atomic force microscopy COLLOIDS AND SURFACES B-BIOINTERFACES, 73 :97-102 >DOI >Link

Davies MJ, Krska J, Lovelady C, Connolly D, Parmar S. 2009. Community pharmacy contribution to weight management: Identifying opportunities. International Journal of Pharmacy Practice, 18 :1-6

Davies MJ, Brindley A, Chen X , Doughty SW , Marlow M , Roberts CJ. 2009. A quantitative assessment of inhaled drug particle – pulmonary surfactant interaction by atomic force microscopy. Colloids and Surfaces B: Biointerfaces, 73 :97-102

Patents

Davies MJ. 2014. Device and method for simulating pulmonary environments

Davies MJ, Bradbury S, Mistry K, Nolan E. Improvements in and relating to assessment of drug dissolution.

Conference Publication (journal proceedings)

Iram S, Al-Jumeily D, Fergus P, Randles M, Davies M. 2011. E-health: The potential of linked data and stream reasoning for personalised healthcare Proceedings - 4th International Conference on Developments in eSystems Engineering, DeSE 2011, :46-49 >DOI

Davies MJ, Seton L, Tiernan N. 2010. Towards the Rational Design of Crystalline Material for Pulmonary Delivery JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1358-1359 >Link

Davies MJ, Seton L, Tiernan N. 2010. Towards the rational design of crystalline material for pulmonary delivery. Journal of Pharmacy and Pharmacology, 62 :1358-1358

Davies M, Krska J, Mackridge A, Khela A, Brown K, Museredza F. 2009. The general public’s attitudes towards medicinal products. International Journal of Pharmacy Practice, 17 :A23

Davies M, Seton L, Ali M. 2009. The crystallisation of theophylline via a Langmuir-Blodgett approach JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A84-A84 >Link

Davies M, Mackridge AJ, Singh R, Day J. 2008. An investigation of the attitudes of medical and nursing staff to monitoring adverse events associated with antipsychotic medication International Journal of Pharmacy Practice, S1 :A22

Davies MJ. BPSA Science to Practice Conference BPSA Science to Practice Conference

Engagement & Impact

Award:

Award title: Runner Up, Awarding body: Bionow Start-up of the Year Award 2014, URL: http://www.bionow.co.uk/events/2014bionowannualawardsdinner.aspx

Award title: Runner up, Awarding body: Merseyside Innovation Awards 2014, URL: http://www.merseysideinnovationawards.co.uk/news/supercar-developer-crowned-merseyside-innovation-awards-winner/

External collaboration:

Institution: The University of Nottingham, Collaborator: Prof Clive Roberts Clive and I have worked on two research papers that have been published in high impact journals. Should I wish to analyse the surface features / chemistries of drug particulates in the future Clive would be willing to support me in my efforts.

Institution: Surface Measurement Systems and GlaxoSmithKline., Collaborator: Majid Naderi and Jiyi Khoo. Both organisations are postive in terms of collaboration, respectively. Should I have samples requiring Inverse Gas Chromatography assessment I can send these to SMS. Alternative analysis via other approaches is available upon request. In addition, my contact at GSK has shown interest in the surface profiling of drug particulates and would be willing to collaborate on any PhD project I supervise.

Fellowships:

Fellowship title: Fellow of the Higher Education Academy (#37138), Organisation: Higher Education Academy

Industrial connections:

Company: 3M, Position or project: Research Agreement with Pulmorphix Ltd.

Company: Incorporation of the contract research organisation 'Pulmorphix Ltd'., Position or project: I hold the position of Scientific Director within Pulmorphix Ltd. I am also a board member within this CRO. The company aims to provide Pharma with an in depth understanding of how inhaled formulations release their drug substance(s) with respect to time in an environment that reflects the deep lung. The crystallisation propensity of active pharmaceutical ingredients may also be probed via our technology platform(s).

Membership of professional bodies:

MRPharmS, The General Pharmaceutical Council

Other invited event:

Title of event: Enterprising Birmingham Innovation Competition: Key Note Speaker, Location: Birmingham University, Description: I was invited to attend the Enterprising Birmingham Showcase event as a Key Note Speaker to detail how Pulmorphix Ltd developed from an idea to a spin-out company.

Research Grants Awarded:

CrowdCube, Pulmorphix Ltd, Mr Kish Mistry and Ms Emma Nolan, Grant value (£): 125,000.00, Duration of research project: Ongoing - Pulmorphix Ltd

The Technology Strategy Board, The Development of the World's First Lung Biosimulator Device, Emma Nolan (BDC) and Kish Mistry (External), Grant value (£): 82,500.00, Duration of research project: Start-up SME - Ongoing

Liverpool John Moores University, The Methadone Jet Pipette - A Feasibility Study, Dr Touraj Ehtezazi, Grant value (£): 500, Duration of research project: Ongoing

Liverpool John Moores University, Drug Crystal Engineering Strategies for Chronic Pain Management via the Lung, Linda Seton and Mark Murphy, Grant value (£): 15K + Bench Fees + 1.5K for consumables, Duration of research project: 3 years

The Technology Strategy Board, The development of an innovative technology platform to probe the dissolution behaviour and crystallisation propensity of orally inhaled products within a simulated pulmonary environment., Kish Mistry and Emma Nolan, Grant value (£): 100K, Duration of research project: Ongoing

Teaching qualification:

Title of qualification gained: FHEA

Title of qualification gained: PGCert HE