I obtained my Doctor of Philosophy (Ph.D.) in nanotoxicology where the evaluation of polymeric nanocarriers for pulmonary drug delivery was carried out using in vitro cell lines, from Liverpool John Moores University, and entitled 'Toxicology and Cellular Interactions of Polymer-based Nanocarriers for Pulmonary Drug Delivery '. Upon completion of my Ph.D., I have joined the FDD group as a Postdoctoral Research Fellow at Liverpool John Moores University, developing vaccines for inhalation delivery using nanocarriers.
My research is involving many interests from formulations of nanocarriers and microcarriers, drug delivery, toxicology, polymeric materials, cell biology, and toxicology. I have published many conference abstracts and presentations, book chapters, and peer-reviewed research articles. These publications contributed to the science pool by reviewing the up-to-date knowledge regarding the generated nanoparticle types so far, the nanotoxicological potentials of pharmaceutical, environmental, and occupational nanoparticles with a focus on the mucosal contact and pulmonary route of delivery. I had presented many talks and poster presentations to present my findings to the scientific community and challenge some of the commonly employed assays with a recommendation to improve the methods to accommodate for the nanoparticles' interference possibilities. I had provided a few pieces of evidence and cases where nanoparticles' interference with the assays has to be suspected and evaluated. Furthermore, formulating nanocarriers for vaccine delivery via inhalation or nasal delivery is a current focus of my postdoctoral research where developing novel vaccines to a variety of human and animal disease to aimed to facilitate non-injectable, self-administered, and cold-chain independent, of lower cost, and inducing higher mucosal protection vaccines.
Languages
Arabic
English
Degrees
2020, Liverpool John Moores University, United Kingdom, PhD
2013, Faculty of Medicine, Sohag University, Egypt, MSc
2008, Faculty of Medicine, Sohag University, Egypt, MBBS
Certifications
2015, Liverpool John Moores University, United Kingdom, 3Is course
2014, Health Education Northwest, NHS, United Kingdom, Advanced Communication Skills
Academic appointments
Postdoctoral Research Fellow, Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 2021 - present
Research Assistant, Formulation, Liverpool John Moores University, 2020 - 2021
Doctoral Researcher, Nanomedicine and FDD, Liverpool John Moores University, 2016 - 2020
Teaching assistant, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 2016 - 2021
Biology Tutor, International Study Centre-LJMU, 2016 - 2022
Research Assistant, Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 2014 - 2015
Assistant Lecturer, Faculty of Medicine, Sohag University, 2008 - 2013
Postgraduate training
Postdoctoral training, United Kingdom, Liverpool John Moores University, 2021 - 2022
Doctoral training, United Kingdom, University of Liverpool, 2019 - 2020
Doctoral training, Ireland, Trinity College Dublin, 2015 - 2016
Predoctoral fellowship, United Kingdom, Liverpool John Moores University, 2014 - 2015
Highlighted publications
Osman N, Sexton D, Saleem I. 2021. CHALLENGING THE CHALLENGES OF NANOPARTICLE TESTING USING IN VITRO METHODS JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 34 :A21-A21 Author Url
Osman NM, Sexton DW, Saleem IY. 2019. Toxicological assessment of nanoparticle interactions with the pulmonary system. Nanotoxicology, DOI Author Url Publisher Url Public Url
Osman N, Kaneko K, Carini V, Saleem I. 2018. Carriers for the Targeted Delivery of Aerosolized Macromolecules for Pulmonary Pathologies. Expert Opinion on Drug Delivery, DOI Author Url Publisher Url Public Url
Osman N, Sexton D, Hutcheon G, Saleem I. 2017. COMPARATIVE NANOTOXICOLOGY OF POLYMERIC NANOCARRIERS WITH DIFFERENT SURFACE CHARGE AGAINST HUMAN LUNG EPITHELIAL CELLS JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 30 :A17-A18 Author Url
Basar N, Oridupa OA, Ritchie KJ, Nahar L, Osman NMM, Sarker SD, Stafford A, Kushiev H, Kan A. 2015. Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells Phytotherapy Research, 29 :944-948 DOI Author Url Publisher Url Public Url
Journal article
Osman N, Curley P, Box H, Liptrott N, Sexton DW, Saleem I. 2024. In vitro evaluation of physicochemical-dependent effects of polymeric nanoparticles on their cellular uptake and co-localization using pulmonary calu-3 cell lines Drug Development and Industrial Pharmacy, :1-11 DOI Author Url Publisher Url Public Url
Osman NM, Sexton DW, Saleem IY. 2019. Toxicological assessment of nanoparticle interactions with the pulmonary system. Nanotoxicology, DOI Author Url Publisher Url Public Url
Osman N, Kaneko K, Carini V, Saleem I. 2018. Carriers for the Targeted Delivery of Aerosolized Macromolecules for Pulmonary Pathologies. Expert Opinion on Drug Delivery, DOI Author Url Publisher Url Public Url
Basar N, Oridupa OA, Ritchie KJ, Nahar L, Osman NMM, Sarker SD, Stafford A, Kushiev H, Kan A. 2015. Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells Phytotherapy Research, 29 :944-948 DOI Author Url Publisher Url Public Url
Internet publication
Osman N, Saleem I. 2023. Biomimetic systems: nanomedicines in disguise to enhance drug delivery and efficacy Publisher Url
Osman N, Saleem I. 2022. Non-invasive, needle-free delivery of nanomedicines Publisher Url
Chapters
Osman N, Saleem I. 2022. Nanotoxicology and Regulatory Aspects of Nanomaterials and Nanomedicines Drug Delivery Using Nanomaterials :381-401 9780367767938 DOI Publisher Url
Kaneko K, Osman NM, Carini V, Scagnetti G, Saleem IY. 2020. Overview of the Advantages and Disadvantages of Different Mucosal Sites for the Delivery of Nanoparticles Muttil P, kunda N. Mucosal Delivery of Drugs and Biologics in Nanoparticles 41 Springer Nature DOI Publisher Url Public Url
Conference publication
Osman N, Sexton D, Saleem I. 2021. CHALLENGING THE CHALLENGES OF NANOPARTICLE TESTING USING IN VITRO METHODS JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 34 :A21-A21 Author Url
Osman N, Sexton D, Hutcheon G, Saleem I. 2017. COMPARATIVE NANOTOXICOLOGY OF POLYMERIC NANOCARRIERS WITH DIFFERENT SURFACE CHARGE AGAINST HUMAN LUNG EPITHELIAL CELLS JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 30 :A17-A18 Author Url
Osman N, Hilal M, Mohamed S, Dawood A, ritchie K, Saleem I, hutcheon G. 2015. In-vitro Stability and Degradation of PLGA and PGA-co-PDL Microparticles for Pulmonary Drug Delivery Drug Delivery to the Lungs
Scagnetti G, Verhook S, Killoran P, Coxon C, Osman N, Gordon S, Chaudary S, Saleem I. Antimicrobial Activity of Peptide Aurein 3.1 Complexed in Chitosan Nanoparticle for Pulmonary Delivery - 11th PBP World Meeting
Thesis/Dissertation
Mostafa Mahmoud Osman N. 2021. Toxicology and Cellular Interactions of Polymer-based Nanocarriers for Pulmonary Drug Delivery Saleem I, Sexton D. Public Url