Liverpool Skylilne

PVC Scholarship Research and Knowledge Transfer

Prof Robin Leatherbarrow

Prof Robin Leatherbarrow

Telephone: 0151 231 3503

Publications

Journal article

Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Perez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedan A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EW. 2018. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus NATURE CHEMISTRY, 10 :599-606 >DOI >Link

Cilibrizzi A, Fedorova M, Collins J, Leatherbarrow R, Woscholski R, Vilar R. 2017. A tri-functional vanadium(IV) complex to detect cysteine oxidation DALTON TRANSACTIONS, 46 :6994-7004 >DOI >Link

Goncalves V, Brannigan JA, Laporte A, Bell AS, Roberts SM, Wilkinson AJ, Leatherbarrow RJ, Tate EW. 2017. Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase MedChemComm, 8 :191-197 >DOI

Aronica PGA, Verma C, Popovic B, Leatherbarrow RJ, Gould IR. 2016. The Parasol Protocol for computational mutagenesis Protein Engineering, Design and Selection, 29 :253-261 >DOI

Collins J, Cilibrizzi A, Fedorova M, Whyte G, Mak LH, Guterman I, Leatherbarrow R, Woscholski R, Vilar R. 2016. Vanadyl complexes with dansyl-labelled di-picolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies. Dalton Transactions, 45 :7104-7113 >DOI

Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. 2015. Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase MEDCHEMCOMM, 6 :1767-1772 >DOI >Link

Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. 2015. Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase MedChemComm, 6 :1761-1766 >DOI >Link

Pitchford WH, Kim H-J, Ivanov AP, Kim H-M, Yu J-S, Leatherbarrow RJ, Albrecht T, Kim K-B, Edel JB. 2015. Synchronized Optical and Electronic Detection of Biomolecules Using a Low Noise Nanopore Platform ACS Nano, 9 :1740-1748 >DOI >Link

Paape D, Bell AS, Heal WP, Hutton JA, Leatherbarrow RJ, Tate EW, Smith DF. 2014. Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes PLOS NEGLECTED TROPICAL DISEASES, 8 >DOI >Link

Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. 2014. Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors Journal of Medicinal Chemistry, 57 :8664-8670 >DOI >Link

Olaleye TO, Brannigan JA, Roberts SM, Leatherbarrow RJ, Wilkinson AJ, Tate EW. 2014. Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites Organic and Biomolecular Chemistry, 12 :8132-8137 >DOI >Link

Gray K, Elghadban S, Thongyoo P, Owen KA, Szabo R, Bugge TH, Tate EW, Leatherbarrow RJ, Ellis V. 2014. Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II THROMBOSIS AND HAEMOSTASIS, 112 :402-411 >DOI >Link

Brannigan JA, Roberts SM, Bell AS, Hutton JA, Hodgkinson MR, Tate EW, Leatherbarrow RJ, Smith DF, Wilkinson AJ. 2014. Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors IUCRJ, 1 :250-260 >DOI >Link

Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. 2014. Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP) Journal of Medicinal Chemistry, 57 :2773-2788 >DOI >Link

Roqué Rosell NR, Mokhlesi L, Milton NE, Sweeney TR, Zunszain PA, Curry S, Leatherbarrow RJ. 2014. Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease Bioorganic and Medicinal Chemistry Letters, 24 :490-494 >DOI

Rosell NRR, Mokhlesi L, Milton NE, Sweeney TR, Zunszain PA, Curry S, Leatherbarrow RJ. 2014. Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24 :490-494 >DOI >Link

Wright, M , Clough, B , Rackman, M , Rangachari, K , Brannigan, J , Grainger, M , Moss, D , Bottrill, A , Heal, W , Broncel, M , Serwa, R , Brady, D , Mann, D , Leatherbarrow, R , Tewari, R , Wilkinson, A , Holder, A , Tate, E . 2013. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach Nature Chemistry,

Smith LD, Leatherbarrow RJ, Spivey AC. 2013. Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies. Future Med Chem, 5 :1423-1435 >DOI >Link

Sejberg JJP, Smith LD, Leatherbarrow RJ, Beavil AJ, Spivey AC. 2013. Enantioselective synthesis of (+)-aspercyclide A Tetrahedron Letters, 54 :4970-4972 >DOI

Sejberg JJP, Smith LD, Leatherbarrow RJ, Spivey AC, Beavil AJ. 2013. Enantioselective synthesis of (+)-aspercyclide A Tetrahedron Letters, >DOI

Rackham MD, Brannigan JA, Moss DK, Yu Z, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. 2013. Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase. J Med Chem, 56 :371-375 >DOI >Link

Elvira KS, Leatherbarrow R, Edel J, Demello A. 2012. Droplet dispensing in digital microfluidic devices: Assessment of long-term reproducibility. Biomicrofluidics, 6 :22003-2200310 >DOI >Link

Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ, Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF. 2012. Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs. PLoS Negl Trop Dis, 6 :e1625 >DOI >Link

Bradshaw RT, Aronica PGA, Tate EW, Leatherbarrow RJ, Gould IR. 2012. Mutational Locally Enhanced Sampling (MULES) for quantitative prediction of the effects of mutations at protein-protein interfaces Chemical Science, 3 :1503-1511 >DOI

Goncalves V, Brannigan JA, Thinon E, Olaleye TO, Serwa R, Lanzarone S, Wilkinson AJ, Tate EW, Leatherbarrow RJ. 2012. A fluorescence-based assay for N-myristoyltransferase activity. Anal Biochem, 421 :342-344 >DOI >Link

Offermann DA, McKendrick JE, Sejberg JJP, Mo B, Holdom MD, Helm BA, Leatherbarrow RJ, Beavil AJ, Sutton BJ, Spivey AC. 2012. Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE. J Org Chem, 77 :3197-3214 >DOI >Link

Goncalves V, Brannigan JA, Whalley D, Ansell KH, Saxty B, Holder AA, Wilkinson AJ, Tate EW, Leatherbarrow RJ. 2012. Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode. J Med Chem, 55 :3578-3582 >DOI >Link

Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. 2012. Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. J Med Chem, 55 :8879-8890 >DOI >Link

Bradshaw RT, Patel BH, Tate EW, Leatherbarrow RJ, Gould IR. 2011. Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction. Protein Eng Des Sel, 24 :197-207 >DOI >Link

Stuart SF, Leatherbarrow RJ, Willison KR. 2011. A two-step mechanism for the folding of actin by the yeast cytosolic chaperonin. J Biol Chem, 286 :178-184 >DOI >Link

Carr JL, Sejberg JJP, Saab F, Holdom MD, Davies AM, White AJP, Leatherbarrow RJ, Beavil AJ, Sutton BJ, Lindell SD, Spivey AC. 2011. Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution. Org Biomol Chem, 9 :6814-6824 >DOI >Link

So S, Peeva LG, Tate EW, Leatherbarrow RJ, Livingston AG. 2010. Organic solvent nanofiltration: A new paradigm in peptide synthesis Organic Process Research and Development, 14 :1313-1325 >DOI

Zunszain PA, Knox SR, Sweeney TR, Yang J, Roqué-Rosell N, Belsham GJ, Leatherbarrow RJ, Curry S. 2010. Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate. J Mol Biol, 395 :375-389 >DOI >Link

Brannigan JA, Smith BA, Yu Z, Brzozowski AM, Hodgkinson MR, Maroof A, Price HP, Meier F, Leatherbarrow RJ, Tate EW, Smith DF, Wilkinson AJ. 2010. N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis. J Mol Biol, 396 :985-999 >DOI >Link

Carr JL, Offermann DA, Holdom MD, Dusart P, White AJP, Beavil AJ, Leatherbarrow RJ, Lindell SD, Sutton BJ, Spivey AC. 2010. Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether. Chem Commun (Camb), 46 :1824-1826 >DOI >Link

So S, Peeva LG, Tate EW, Leatherbarrow RJ, Livingston AG. 2010. Membrane enhanced peptide synthesis. Chem Commun (Camb), 46 :2808-2810 >DOI >Link

Srisa-Art M, Kang D-K, Hong J, Park H, Leatherbarrow RJ, Edel JB, Chang S-I, deMello AJ. 2009. Analysis of protein-protein interactions by using droplet-based microfluidics. Chembiochem, 10 :1605-1611 >DOI >Link

Thongyoo P, Bonomelli C, Leatherbarrow RJ, Tate EW. 2009. Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold. J Med Chem, 52 :6197-6200 >DOI >Link

Heal WP, Wickramasinghe SR, Bowyer PW, Holder AA, Smith DF, Leatherbarrow RJ, Tate EW. 2008. Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry. Chem Commun (Camb), :480-482 >DOI >Link

Bowyer PW, Tate EW, Leatherbarrow RJ, Holder AA, Smith DF, Brown KA. 2008. N-myristoyltransferase: a prospective drug target for protozoan parasites. ChemMedChem, 3 :402-408 >DOI >Link

Thongyoo P, Roqué-Rosell N, Leatherbarrow RJ, Tate EW. 2008. Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides. Org Biomol Chem, 6 :1462-1470 >DOI >Link

Heal WP, Wickramasinghe SR, Leatherbarrow RJ, Tate EW. 2008. N-Myristoyl transferase-mediated protein labelling in vivo. Org Biomol Chem, 6 :2308-2315 >DOI >Link

Busch GK, Tate EW, Gaffney PRJ, Rosivatz E, Woscholski R, Leatherbarrow RJ. 2008. Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation. Chem Commun (Camb), :3369-3371 >DOI >Link

Roque-Rosell N, Curry S, Leatherbarrow RJ. 2007. Studies toward a new foot-and-mouth disease antiviral agent ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 233 :515-515 >Link

Sweeney TR, Roqué-Rosell N, Birtley JR, Leatherbarrow RJ, Curry S. 2007. Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis. J Virol, 81 :115-124 >DOI >Link

Curry S, Roqué-Rosell N, Sweeney TR, Zunszain PA, Leatherbarrow RJ. 2007. Structural analysis of foot-and-mouth disease virus 3C protease: A viable target for antiviral drugs? Biochemical Society Transactions, 35 :594-598 >DOI

Curry S, Roqué-Rosell N, Zunszain PA, Leatherbarrow RJ. 2007. Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target. Int J Biochem Cell Biol, 39 :1-6 >DOI >Link

Curry S, Roqué-Rosell N, Sweeney TR, Zunszain PA, Leatherbarrow RJ. 2007. Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs? Biochem Soc Trans, 35 :594-598 >DOI >Link

Brauer ABE, McBride JD, Kelly G, Matthews SJ, Leatherbarrow RJ. 2007. Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds. Bioorg Med Chem, 15 :4618-4628 >DOI >Link

Thongyoo P, Jaulent AM, Tate EW, Leatherbarrow RJ. 2007. Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins. Chembiochem, 8 :1107-1109 >DOI >Link

Jaulent AM, Fahy AS, Knox SR, Birtley JR, Roqué-Rosell N, Curry S, Leatherbarrow RJ. 2007. A continuous assay for foot-and-mouth disease virus 3C protease activity. Anal Biochem, 368 :130-137 >DOI >Link

Bowyer PW, Gunaratne RS, Grainger M, Withers-Martinez C, Wickramsinghe SR, Tate EW, Leatherbarrow RJ, Brown KA, Holder AA, Smith DF. 2007. Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum. Biochem J, 408 :173-180 >DOI >Link

Tate EW, Bowyer PW, Brown KA, Smith DF, Holder AA, Leatherbarrow RJ. 2006. Peptide-based inhibitors of N-myristoyl transferase generated from a lipid/combinatorial peptide chimera library Signal Transduction, 6 :160-166 >DOI

Panethymitaki C, Bowyer PW, Price HP, Leatherbarrow RJ, Brown KA, Smith DF. 2006. Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major. Biochem J, 396 :277-285 >DOI >Link

Thongyoo P, Tate EW, Leatherbarrow RJ. 2006. Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II. Chem Commun (Camb), :2848-2850 >Link

Birtley JR, Knox SR, Jaulent AM, Brick P, Leatherbarrow RJ, Curry S. 2005. Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity. J Biol Chem, 280 :11520-11527 >DOI >Link

Karp NA, Edwards PR, Leatherbarrow RJ. 2005. Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors. Biosens Bioelectron, 21 :128-134 >DOI >Link

Jaulent AM, Brauer ABE, Matthews SJ, Leatherbarrow RJ. 2005. Solution structure of a novel C2-symmetrical bifunctional bicyclic inhibitor based on SFTI-1. J Biomol NMR, 33 :57-62 >DOI >Link

Knox SK, Leatherbarrow RJ. 2004. STUDIES TOWARDS A NEW FOOT AND MOUTH DISEASE ANTIVIRAL AGENT JOURNAL OF PEPTIDE SCIENCE, 10 :209-209 >Link

Miles SM, Leatherbarrow RJ, Marsden SP, Coates WJ. 2004. Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues. Org Biomol Chem, 2 :281-283 >DOI >Link

Jaulent AM, Leatherbarrow RJ. 2004. Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors. Protein Eng Des Sel, 17 :681-687 >DOI >Link

Miles SM, Marsden SP, Leatherbarrow RJ, Coates WJ. 2004. Reagent-controlled stereoselective synthesis of lignan-related tetrahydrofurans. J Org Chem, 69 :6874-6882 >DOI >Link

Miles SM, Marsden SP, Leatherbarrow RJ, Coates WJ. 2004. A novel, stereoselective and convergent synthesis of aryltetralins. Chem Commun (Camb), :2292-2293 >DOI >Link

Scarpi D, McBride JD, Leatherbarrow RJ. 2004. Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor. Bioorg Med Chem, 12 :6045-6052 >DOI >Link

Brauer ABE, Nievo M, McBride JD, Leatherbarrow RJ. 2003. The structural basis of a conserved P2 threonine in canonical serine proteinase inhibitors. J Biomol Struct Dyn, 20 :645-656 >DOI >Link

Brauer ABE, Leatherbarrow RJ. 2003. The conserved P1' Ser of Bowman-Birk-type proteinase inhibitors is not essential for the integrity of the reactive site loop. Biochem Biophys Res Commun, 308 :300-305 >Link

Brauer ABE, Kelly G, Matthews SJ, Leatherbarrow RJ. 2002. The H-1-NMR solution structure of the antitryptic core peptide of Bowman-Birk inhibitor proteins: A minimal 'canonical loop' JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 20 :59-70 >DOI >Link

McBride JD, Watson EM, Brauer ABE, Jaulent AM, Leatherbarrow RJ. 2002. Peptide mimics of the Bowman-Birk inhibitor reactive site loop. Biopolymers, 66 :79-92 >DOI >Link

Scarpi D, McBride JD, Leatherbarrow RJ. 2002. Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides. J Pept Res, 59 :90-93 >Link

Brauer ABE, Kelly G, Matthews SJ, Leatherbarrow RJ. 2002. The (1)H-NMR solution structure of the antitryptic core peptide of Bowman-Birk inhibitor proteins: a minimal canonical loop. J Biomol Struct Dyn, 20 :59-70 >DOI >Link

Brauer ABE, Domingo GJ, Cooke RM, Matthews SJ, Leatherbarrow RJ. 2002. A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein. Biochemistry, 41 :10608-10615 >Link

Brauer ABE, Kelly G, McBride JD, Cooke RM, Matthews SJ, Leatherbarrow RJ. 2001. Erratum: The bowman-birk inhibitor reactive site loop sequence represents an independent structural β-hairpin motif (Journal of Molecular Biology (2001) 306 (799-807)) Journal of Molecular Biology, 308 :565-566 >DOI

Brauer AB, Kelly G, McBride JD, Cooke RM, Matthews SJ, Leatherbarrow RJ. 2001. The Bowman-Birk inhibitor reactive site loop sequence represents an independent structural beta-hairpin motif. J Mol Biol, 306 :799-807 >DOI >Link

Scarpi D, Occhiato EG, Trabocchi A, Leatherbarrow RJ, Brauer AB, Nievo M, Guarna A. 2001. Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: synthesis and conformational analysis. Bioorg Med Chem, 9 :1625-1632 >Link

McBride JD, Leatherbarrow RJ. 2001. Synthetic peptide mimics of the Bowman-Birk inhibitor protein. Curr Med Chem, 8 :909-917 >Link

McBride JD, Freeman HN, Leatherbarrow RJ. 2000. Identification of chymotrypsin inhibitors from a second-generation template assisted combinatorial peptide library. J Pept Sci, 6 :446-452 >DOI >Link

McNee JJ, Wang F, Leatherbarrow RJ. 1999. Expression and Secretion of Biologically Active CMTI I in Saccharomyces cerevisiae Protein and Peptide Letters, 6 :351-358

Gariani T, McBride JD, Leatherbarrow RJ. 1999. The role of the P2' position of Bowman-Birk proteinase inhibitor in the inhibition of trypsin. Studies on P2' variation in cyclic peptides encompassing the reactive site loop. Biochim Biophys Acta, 1431 :232-237 >Link

Leatherbarrow RJ, Edwards PR. 1999. Analysis of molecular recognition using optical biosensors. Curr Opin Chem Biol, 3 :544-547 >Link

McBride JD, Freeman HN, Leatherbarrow RJ. 1999. Selection of human elastase inhibitors from a conformationally constrained combinatorial peptide library. Eur J Biochem, 266 :403-412 >Link

Foord RL, Leatherbarrow RJ. 1998. Effect of osmolytes on the exchange rates of backbone amide protons in proteins. Biochemistry, 37 :2969-2978 >DOI >Link

Hasan Z, Leatherbarrow RJ. 1998. A study of the specificity of barley chymotrypsin inhibitor 2 by cysteine engineering of the P1 residue. Biochim Biophys Acta, 1384 :325-334 >Link

McBride JD, Brauer AB, Nievo M, Leatherbarrow RJ. 1998. The role of threonine in the P2 position of Bowman-Birk proteinase inhibitors: studies on P2 variation in cyclic peptides encompassing the reactive site loop. J Mol Biol, 282 :447-458 >DOI >Link

Edwards PR, Maule CH, Leatherbarrow RJ, Winzor DJ. 1998. Second-order kinetic analysis of IAsys biosensor data: its use and applicability. Anal Biochem, 263 :1-12 >DOI >Link

Hasan Z, Leatherbarrow RJ. 1997. Introduction of trypsin specificity into chymotrypsin inhibitor II Protein and Peptide Letters, 4 :335-342

Edwards PR, Leatherbarrow RJ. 1997. Determination of association rate constants by an optical biosensor using initial rate analysis. Anal Biochem, 246 :1-6 >DOI >Link

Edwards PR, Lowe PA, Leatherbarrow RJ. 1997. Ligand loading at the surface of an optical biosensor and its effect upon the kinetics of protein-protein interactions. J Mol Recognit, 10 :128-134 >DOI >Link

Gariani T, Leatherbarrow RJ. 1997. Stability of protease inhibitors based on the Bowman-Birk reactive site loop to hydrolysis by proteases. J Pept Res, 49 :467-475 >Link

McBride JD, Harbeck B, Leatherbarrow RJ. 1996. Resin-coupled cyclic peptides as proteinase inhibitors Protein and Peptide Letters, 3 :193-198

Holmes DIR, Mantafounis D, Ward WHJ, Leatherbarrow RJ. 1996. Bacteriophage display of chymotrypsin inhibitor 2 Protein and Peptide Letters, 3 :415-422

McBride JD, Freeman N, Domingo GJ, Leatherbarrow RJ. 1996. Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library. J Mol Biol, 259 :819-827 >DOI >Link

Gill A, Leatherbarrow RJ, Hoare M, Pollard-Knight DV, Lowe PA, Fortune DH. 1996. Analysis of kinetic data of antibody-antigen interaction from an optical biosensor by exponential curve fitting. J Biotechnol, 48 :117-127 >Link

Domingo GJ, Leatherbarrow RJ, Freeman N, Patel S, Weir M. 1995. Synthesis of a mixture of cyclic peptides based on the Bowman-Birk reactive site loop to screen for serine protease inhibitors. Int J Pept Protein Res, 46 :79-87 >Link

Edwards PR, Gill A, Pollard-Knight DV, Hoare M, Buckle PE, Lowe PA, Leatherbarrow RJ. 1995. Kinetics of protein-protein interactions at the surface of an optical biosensor. Anal Biochem, 231 :210-217 >Link

DOMINGO GJ, LEATHERBARROW RJ. 1994. USE OF SYNTHETIC PEPTIDE LIBRARIES TO SCREEN FOR PROTEINASE-INHIBITORS JOURNAL OF CELLULAR BIOCHEMISTRY, :154-154 >Link

GARIANI T, LEATHERBARROW RJ. 1994. STUDY OF DIFFERENT BASED BOWMAN AND BIRK PEPTIDES INHIBITORS JOURNAL OF CELLULAR BIOCHEMISTRY, :155-155 >Link

MANTAFOUNIS D, HOLMES DIR, LEATHERBARROW RJ. 1994. CHYMOTRYPSIN INHIBITOR-2 (C-12) DISPLAY ON THE SURFACE OF BACTERIOPHAGE JOURNAL OF CELLULAR BIOCHEMISTRY, :157-157 >Link

Greagg MA, Brauer AB, Leatherbarrow RJ. 1994. Expression and kinetic characterization of barley chymotrypsin inhibitors 1a and 1b. Biochim Biophys Acta, 1222 :179-186 >Link

MATTHEWS SJ, JANDU SK, LEATHERBARROW RJ. 1993. C-13 NMR-STUDY OF THE EFFECTS OF MUTATION ON THE TRYPTOPHAN DYNAMICS IN CHYMOTRYPSIN INHIBITOR-2 - CORRELATIONS WITH STRUCTURE AND STABILITY BIOCHEMISTRY, 32 :657-662 >DOI >Link

Matthews SJ, Leatherbarrow RJ. 1993. The use of osmolytes to facilitate protein NMR spectroscopy Journal of Biomolecular NMR, 3 :597-600 >DOI

Matthews SJ, Jandu SK, Leatherbarrow RJ. 1993. Corrections: 13C NMR Study of the Effects of Mutation on the Tryptophan Dynamics in Chymotrypsin Inhibitor 2: Correlations with Structure and Stability. (Biochemistry (1993) 32(2) (657–662) (10.1021/bi00053a034)) Biochemistry, 32 :4474 >DOI

Matthews SJ, Jandu SK, Leatherbarrow RJ. 1993. 13C NMR study of the effects of mutation on the tryptophan dynamics in chymotrypsin inhibitor 2: correlations with structure and stability. Biochemistry, 32 :657-662 >Link

LEATHERBARROW RJ, MATTHEWS SJ. 1992. C-13 NUCLEAR-MAGNETIC-RESONANCE RELAXATION STUDY OF CHYMOTRYPSIN INHIBITOR-2 (CI-2) MAGNETIC RESONANCE IN CHEMISTRY, 30 :1255-1260 >DOI >Link

Wells TN, Stedman M, Leatherbarrow RJ. 1992. Imaging of proteins by scanning tunnelling microscopy. Ultramicroscopy, 42-44 ( Pt B) :1200-1203 >Link

Leatherbarrow RJ, Stedman M, Wells TN. 1991. Structure of immunoglobulin G by scanning tunnelling microscopy. J Mol Biol, 221 :361-365 >Link

Leatherbarrow RJ, Salacinski HJ. 1991. Design of a small peptide-based proteinase inhibitor by modeling the active-site region of barley chymotrypsin inhibitor 2. Biochemistry, 30 :10717-10721 >Link

Rudd PM, Leatherbarrow RJ, Rademacher TW, Dwek RA. 1991. Diversification of the IgG molecule by oligosaccharides. Mol Immunol, 28 :1369-1378 >Link

LEATHERBARROW RJ. 1990. EXAMINATION OF THE STRUCTURE AND STABILITY OF ENGINEERED PROTEINS BY NMR ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 200 :53-BIOT >Link

Leatherbarrow RJ. 1990. On to the second generation Nature, 348 :482 >DOI

Self SJ, Hunter CN, Leatherbarrow RJ. 1990. Molecular cloning, sequencing and expression of cytochrome c2 from Rhodospirillum rubrum. Biochem J, 265 :599-604 >Link

Leatherbarrow RJ. 1990. Use of nonlinear regression to analyze enzyme kinetic data: application to situations of substrate contamination and background subtraction. Anal Biochem, 184 :274-278 >Link

Garcia GA, Leatherbarrow RJ, Eckstein F, Fersht AR. 1990. Metal ion dependence of phosphorothioate ATP analogues in the Bacillus stearothermophilus tyrosyl-tRNA synthetase reaction. Biochemistry, 29 :1643-1648 >Link

Jandu SK, Ray S, Brooks L, Leatherbarrow RJ. 1990. Role of arginine 67 in the stabilization of chymotrypsin inhibitor 2: examination of amide proton exchange rates and denaturation thermodynamics of an engineered protein. Biochemistry, 29 :6264-6269 >Link

Wang N, Southan C, DeWolf WE, Wells TN, Kruse LI, Leatherbarrow RJ. 1990. Bovine dopamine beta-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing. Biochemistry, 29 :6466-6474 >Link

Leatherbarrow RJ. 1990. Using linear and non-linear regression to fit biochemical data. Trends Biochem Sci, 15 :455-458 >Link

Leatherbarrow RJ. 1990. Catalytic antibodies. On to the second generation. Nature, 348 :482 >DOI >Link

Leatherbarrow RJ. 1989. Designer catalytic antibodies. Nature, 338 :206-207 >DOI >Link

Leatherbarrow RJ. 1988. Mouse + micro = molecular model. AlchemyMolecular modelling software for... Trends in Biochemical Sciences, 13 :188-189 >DOI

Fersht AR, Leatherbarrow RJ, Wells TN. 1987. Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships. Biochemistry, 26 :6030-6038 >Link

Leatherbarrow RJ, Fersht AR. 1987. Investigation of transition-state stabilization by residues histidine-45 and threonine-40 in the tyrosyl-tRNA synthetase. Biochemistry, 26 :8524-8528 >Link

FERSHT AR, LEATHERBARROW RJ, WELLS TNC. 1986. STRUCTURE AND ACTIVITY OF THE TYROSYL-TRANSFER RNA-SYNTHETASE - THE HYDROGEN-BOND IN CATALYSIS AND SPECIFICITY PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 317 :305-320 >DOI >Link

Fersht AR, Leatherbarrow RJ, Wells TNC. 1986. Quantitative analysis of structure-activity relationships in engineered proteins by linear free-energy relationships Nature, 322 :284-286 >DOI

Fersht AR, Leatherbarrow RJ, Wells TNC. 1986. Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase Trends in Biochemical Sciences, 11 :321-325 >DOI

Leatherbarrow RJ, Fersht AR. 1986. Protein engineering. Protein Eng, 1 :7-16 >Link

Leatherbarrow RJ, Rademacher TW, Dwek RA, Woof JM, Clark A, Burton DR, Richardson N, Feinstein A. 1985. Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor. Mol Immunol, 22 :407-415 >Link

Leatherbarrow RJ, Fersht AR, Winter G. 1985. Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering. Proc Natl Acad Sci U S A, 82 :7840-7844 >Link

Leatherbarrow RJ, Dwek RA. 1984. Binding of complement subcomponent C1q to mouse IgG1, IgG2a and IgG2b: a novel C1q binding assay. Mol Immunol, 21 :321-327 >Link

DWEK RA, LEATHERBARROW RJ. 1983. MAGNETIC-RESONANCE STUDIES ON ANTIBODY COMBINING SITES PERIODICUM BIOLOGORUM, 85 :21-29 >Link

Leatherbarrow RJ, Dwek RA. 1983. The effect of aglycosylation on the binding of mouse IgG to staphylococcal protein A. FEBS Lett, 164 :227-230 >Link

Gettins P, Pótter M, Leatherbarrow RJ, Dwek RA. 1982. A combined proton and phosphorus-31 nuclear magnetic resonance investigation of the combining site of M603, a phosphocholine-binding myeloma protein. Biochemistry, 21 :4927-4931 >Link

Leatherbarrow RJ, Jackson WR, Dwek RA. 1982. Role of tyrosines in the combining site of the dinitrophenyl-binding IgA myeloma M315: specific nitration and high-resolution hydrogen-1 nuclear magnetic resonance studies. Biochemistry, 21 :5124-5129 >Link

Jackson WR, Leatherbarrow RJ, Gavish M, Givol D, Dwek RA. 1981. Antibody specificity: a 270-MHz hydrogen-1 nuclear magnetic resonance study of the binding of dinitrophenyl compounds to the VL dimer of protein 315. Biochemistry, 20 :2339-2345 >Link

Leatherbarrow RJ, Dean PD. 1980. Studies on the mechanism of binding of serum albumins to immobilized cibacron blue F3G A. Biochem J, 189 :27-34 >Link

Conference publication

Aronica PGA, Gould IR, Leatherbarrow RJ. 2014. Development of a new protocol for computational site-directed mutagenesis ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248th National Meeting of the American-Chemical-Society (ACS) 248 >Link

Bell AS, Goncalves V, Hutton JA, Waugh TM, Wright MH, Yu Z, Brannigan JA, Paape D, Leatherbarrow RJ, Tate EW, Wilkinson AJ, Smith DF. 2014. N-Myristoyltransferase inhibitors as anti-leishmanial agents ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 247th National Spring Meeting of the American-Chemical-Society (ACS) 247 >Link

Cilibrizzi A, Collins J, Woscholski R, Leatherbarrow R, Vilar R. 2014. New vanadium complexes as optical probes to detect Cys sulfenic modifications in PTEN JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 12th European Biological Inorganic Chemistry Conference (EuroBIC) 19 :S873-S873 >Link

Maskuniitty M, Leatherbarrow R, Ying L. 2012. Fluorescence measurements of catalysis by foot-and-mouth disease virus 3C protease ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) 243 >Link

Bradshaw RT, Aronica PGA, Tate EW, Leatherbarrow RJ, Gould IR. 2012. Developing mutational locally enhanced sampling (MULES) for predicting relative binding free energies at protein-protein interfaces ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) 243 >Link

Jaulent AM, Leatherbarrow RJ. 2004. Synthetic bivalent inhibitors based on the Bowman Birk Inhibitors: The BiKK Inhibitor Chorev M, Sawyer TK. Peptide Revolution: Genomics, Proteomics & Therapeutics, 18th American Peptide Symposium :390-391 >Link

Jaulet AM, Leatherbarrow RJ. 2003. Synthetic bivalent inhibitors based on Bowman Birk Inhibitors BIOPOLYMERS, 18th American Peptide Symposium 71 :311-311 >Link

Jaulent AM, Leatherbarrow RJ. 2003. Synthetic bivalent inhibitors based on Bowman birk inhibitors BIOPOLYMERS, 18th American Peptide Symposium 71 :278-278 >Link