Monitoring exercise

Dose-response of vitamin C-enriched collagen study

Take part in our study

The dose-response of vitamin C-enriched collagen on markers of collagen synthesis in healthy young men and women following resistance exercise

There is evidence that vitamin C enriched-gelatin supplementation with exercise increases markers of collagen synthesis. However, it is not known what the optimal dose of collagen supplementation is for maximal collagen synthesis. Asfemale athletes are more susceptible to tendon and ligaments injuries (which may be linked to the sex hormone, oestrogen), it is possible that women require a higher dose of collagen to stimulate a similar collagen synthetic response as in men. Therefore, the aim of this study is to investigate an optimal dose of collagen to induce maximal collagen synthesis in young men and women following a single bout of resistance exercise.

I'm looking to recruit participants to take part in a dose response study (resistance exercise and nutrition). This research is investigating the optimal dose of vitamin C-enriched collagen following resistance exercise for tendon health.

You will be eligible to take part in this study if you are a healthy male or female:

  • Age 18-35 years 
  • No history of patellar tendon injuries
  • No history of lower limb musculoskeletal injuries in the past 6 months
  • Currently performing a structured resistance training programme (including the lower limbs) at least 2 days per week
  • Resistance training experienced (barbell back squat and leg press) for at least 6 months prior to study start
  • Nullipara (for young women)
  • Use of oral contraceptive pills and non-users (for young women) for at least 6 months prior to study start
  • Non-smokers (including e-cigarettes)

As collagen is derived from mammals and fish, vegans and vegetarians will not be able to participate in this study.

If you would like to offer your time for this important research project you will be asked to undertake 3 - 5 separate visits to our laboratory over a 4-week or 2-month period.

The first session is a familiarisation session, there will be patellar tendon assessment via ultrasound and you will perform 10-repetition maximum (10 RM) test for the barbell back squat. During the main trials, you will consume different doses of collagens with vitamin C and perform the barbell back squat (4 sets of 10 reps at 10 RM). You will be required to provide 5 ml of blood samples by inserting a cannula, a small plastic tube inserted into the vein from superficial forearm vein to allow for multiple blood sampling and thereby reducing the need for repeated needle insertions.

Full details of the study can be found in the participant information sheet. Please feel free to read this information and should you wish to take part, or if you have any further questions, please contact Joonsung Lee.

This study has been approved by the University Research Ethics Committee (REC) with reference 18/SPS/059.