Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Iain Hargreaves

Dr Iain Hargreaves

Telephone: 0151 231 2711


Journal article

Hargreaves I, Mantle D, Milford D. 2019. Chronic kidney disease and coenzyme Q10 supplementation Journal of Kidney Care, 4 :82-90 >DOI >Public Url

Mantle D, Hargreaves I. 2019. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview Antioxidants, 8 >DOI >Link >Public Url

Montero R, Yubero D, Salgado MC, Julieta Gonzalez M, Campistol J, del Mar O'Callaghan M, Pineda M, Delgadillo V, Maynou J, Fernandez G, Montoya J, Ruiz-Pesini E, Meavilla S, Neergheen V, Garcia-Cazorla A, Navas P, Hargreaves I, Artuch R. 2019. Plasma coenzyme Q(10) status is impaired in selected genetic conditions SCIENTIFIC REPORTS, 9 >DOI >Link >Public Url

Hargreaves I, Mantle D. 2018. Vitamin K2 supplementation in haemodialysis patients Journal of Kidney Care, 3 :368-373 >DOI >Public Url

Hargreaves I, Mody N, Land J, Heales S. 2018. Blood Mononuclear Cell Mitochondrial Respiratory Chain Complex IV Activity is Decreased in Multiple Sclerosis Patients: Effects of beta-Interferon Treatment Journal of Clinical Medicine, 7 >DOI >Link >Public Url

Mantle D, Hargreaves IP. 2018. Organophosphate poisoning and coenzyme Q10: an overview British Journal of Neuroscience Nursing, 14 :206-214 >DOI

Hargreaves IP. 2018. Biochemical Assessment and Monitoring of Mitochondrial Disease JOURNAL OF CLINICAL MEDICINE, 7 >DOI >Link >Public Url

Neergheen V, Chalasani A, Wainwright L, Yubero D, Montero R, Artuch R, Hargreaves IP. 2017. Coenzyme Q10 in the treatment of mitochondrial disease Journal of Inborn Errors of Metabolism and Screening, >DOI >Public Url

Ghose A, Taylor C, Howie A, Chalasani A, Hargreaves I, Milford D. 2017. Measurement of Respiratory Chain Enzyme Activity in Human Renal Biopsy Specimens Journal of Clinical Medicine, 6 :90-90 >DOI >Public Url

Stepien KM, Heaton R, Rankin S, Murphy A, Bentley J, Sexton D, Hargreaves I. 2017. Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders Journal of Clinical Medicine, 6 >DOI >Public Url

Bugiardini E, Poole OV, Manole A, Pittman AM, Horga A, Hargreaves I, Woodward CE, Sweeney MG, Holton JL, Taanman J-W, Plant GT, Poulton J, Zeviani M, Ghezzi D, Taylor J, Smith C, Fratter C, Kanikannan MA, Paramasivam A, Thangaraj K, Spinazzola A, Holt IJ, Houlden H, Hanna MG, Pitceathly RDS. 2017. Clinicopathologic and molecular spectrum of RNASEH1 -related mitochondrial disease Neurology Genetics, 3 :e149-e149 >DOI >Public Url

Cornelius N, Wardman JH, Hargreaves IP, Neergheen V, Bie AS, Tümer Z, Nielsen JE, Nielsen TT. 2017. Evidence of oxidative stress and mitochondrial dysfunction in spinocerebellar ataxia type 2 (SCA2) patient fibroblasts: Effect of coenzyme Q10 supplementation on these parameters Mitochondrion, 34 :103-114 >DOI >Public Url

Dyson A, Dal-Pizzol F, Sabbatini G, Lach AB, Galfo F, dos Santos Cardoso J, Pescador Mendonça B, Hargreaves I, Bollen Pinto B, Bromage DI, Martin JF, Moore KP, Feelisch M, Singer M. 2017. Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models Brohi K. PLoS Medicine, 14 :e1002310-e1002310 >DOI >Public Url

Manole A, Jaunmuktane Z, Hargreaves IP, Ludtmann MHR, Salpietro V, Bello OD, Pope S, Pandraud A, Horga A, Scalco RS, Li A, Ashokkumar B, Lourenc¸o CM, Heales S, Horvath R, Chinnery PF, Toro C, Singleton AB, Jacques TS, Abramov AY, Muntoni F, Hanna MG, Reilly MM, Revesz T, Kullmann DM, Jepson JEC, Houlden H. 2017. Clinical, pathological and functional characterization of riboflavin-responsive neuropathy Brain, 140 :2820-2837 >DOI >Public Url

Ahmed ST, Alston CL, Hopton S, He L, Hargreaves IP, Falkous G, Olahova M, McFarland R, Turnbull DM, Rocha MC, Taylor RW. 2017. Using a quantitative quadruple immunofluorescent assay to diagnose isolated mitochondrial Complex I deficiency Scientific Reports, 7 >DOI >Link >Public Url

Al Shahrani M, Heales S, Hargreaves I, Orford M. 2017. Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease JOURNAL OF CLINICAL MEDICINE, 6 >DOI >Link >Public Url

Sadeghian M, Mastrolia V, Rezaei Haddad A, Mosley A, Mullali G, Schiza D, Sajic M, Hargreaves I, Heales S, Duchen MR, Smith KJ. 2016. Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis Scientific Reports, 6 >DOI >Public Url

McKiernan P, Ball S, Santra S, Foster K, Fratter C, Poulton J, Craig K, McFarland R, Rahman S, Hargreaves I, Gupte G, Sharif K, Taylor RW. 2016. Incidence of Primary Mitochondrial Disease in Children Younger Than 2 Years Presenting With Acute Liver Failure Journal of Pediatric Gastroenterology and Nutrition, 63 :592-597 >DOI >Public Url

Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Neergheen V, Aiken CE, Ozanne SE. 2016. Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats. Disease Models and Mechanisms, 9 :1221-1229 >DOI >Public Url

Hargreaves IP. Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders. Mitochondrion,

Hargreaves IP. Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis. Clinical science (London, England : 1979),

Conference publication

Chambers D, Kumar A, Feng L, Hargreaves I, Lam A, Heales S, Manzur A, Muntoni F, Sewry C, Poulton J, Phadke R. 2019. A novel multiplex chromogenic immunoassay for evaluating mitochondrial respiratory chain complex I and complex IV defects in diagnostic muscle biopsies NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium 45 :27-28 >Link

Chambers D, Kumar A, Feng L, Hargreaves I, Lam A, Manzur A, Muntoni F, Sewry C, Poulton J, Phadke R. 2018. A novel multiplex chromogenic immunoassay for evaluating mitochondrial respiratory chain complex I and complex IV defects in diagnostic muscle biopsies NEUROMUSCULAR DISORDERS, 23rd International Annual Congress of the World-Muscle-Society (WMS) 28 :S86-S86 >DOI >Link

Lam A, Neergheen V, Chalasani A, Salih K, Pope S, Hargreaves I, Prunty H, Heales S. 2018. Biochemical markers of primary mitochondrial respiratory chain enzyme disorders NEUROMUSCULAR DISORDERS, 11th UK Neuromuscular Translational Research Conference 28 :S31-S31 >DOI >Link


Neergheen V, Dyson A, Wainwright L, Hargreaves IP. 2018. Statin and Fibrate-Induced Dichotomy of Mitochondrial Function Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 2-2 :457-473 9781119329701 >DOI

Neergheen V, Hargreaves IP. 2018. Secondary coenzyme Q10 deficiency: Causes and consequence Coenzyme Q10: Uses, Health Effects and Role in Disease :89-110 9781536132847