Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Iain Hargreaves

Dr Iain Hargreaves

Telephone: 0151 231 2711

Publications

Journal article

Ng X, Sadeghian M, Heales S, Hargreaves IP. 2019. Assessment of Mitochondrial Dysfunction in Experimental Autoimmune Encephalomyelitis (EAE) Models of Multiple Sclerosis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20 DOI Author Url Public Url

Hargreaves IP, Mantle D. 2019. Supplementation with selenium and coenzyme Q10 in critically ill patients BRITISH JOURNAL OF HOSPITAL MEDICINE, 80 :589-593 DOI Author Url

Keatley K, Stromei-Cleroux S, Wiltshire T, Rajala N, Burton G, Holt WV, Littlewood DTJ, Briscoe AG, Jung J, Ashkan K, Heales SJ, Pilkington GJ, Meunier B, McGeehan JE, Hargreaves IP, McGeehan RE. 2019. Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma International Journal of Molecular Sciences, 20 DOI Author Url Publisher Url Public Url

Heaton R, Millichap L, Saleem F, Gannon J, Begum G, Hargreaves IP. 2019. Current biochemical treatments of mitochondrial respiratory chain disorders Expert opinion on orphan drugs, 7 :277-285 DOI Author Url Publisher Url Public Url

Thueson E, Leadon DP, Heaton R, Hargreaves IP, Bayly WM. 2019. Effect of daily supplementation with ubiquinol on muscle coenzyme Q10 concentrations in Thoroughbred racehorses Comparative Exercise Physiology, 15 :219-226 DOI

Bugiardini E, Mitchell AL, Rosa ID, Horning-Do H-T, Pitmann AM, Poole OV, Holton JL, Shah S, Woodward C, Hargreaves I, Quinlivan R, Amunts A, Wiesner RJ, Houlden H, Holt IJ, Hanna MG, Pitceathly RDS, Spinazzola A. 2019. MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy Human Molecular Genetics, DOI Publisher Url Public Url

Foti SC, Hargreaves I, Carrington S, Kiely AP, Houlden H, Holton JL. 2019. Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson's disease. Scientific Reports, 9 DOI Author Url Publisher Url Public Url

Hargreaves I, Mantle D, Milford D. 2019. Chronic kidney disease and coenzyme Q10 supplementation Journal of Kidney Care, 4 :82-90 DOI Publisher Url Public Url

Mantle D, Hargreaves I. 2019. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview Antioxidants, 8 DOI Author Url Publisher Url Public Url

Montero R, Yubero D, Salgado MC, Julieta Gonzalez M, Campistol J, del Mar O'Callaghan M, Pineda M, Delgadillo V, Maynou J, Fernandez G, Montoya J, Ruiz-Pesini E, Meavilla S, Neergheen V, Garcia-Cazorla A, Navas P, Hargreaves I, Artuch R. 2019. Plasma coenzyme Q(10) status is impaired in selected genetic conditions SCIENTIFIC REPORTS, 9 DOI Author Url Public Url

Hargreaves IP, Mantle D. 2019. Coenzyme Q10 Supplementation in Fibrosis and Aging 1178 :103-112 DOI Author Url

Hargreaves I, Mantle D. 2018. Vitamin K2 supplementation in haemodialysis patients Journal of Kidney Care, 3 :368-373 DOI Publisher Url Public Url

Mantle D, Hargreaves IP. 2018. Organophosphate poisoning and coenzyme Q10: an overview British Journal of Neuroscience Nursing, 14 :206-214 DOI

Hargreaves IP. 2018. Biochemical Assessment and Monitoring of Mitochondrial Disease JOURNAL OF CLINICAL MEDICINE, 7 DOI Author Url Public Url

Hargreaves I, Mody N, Land J, Heales S. 2018. Blood Mononuclear Cell Mitochondrial Respiratory Chain Complex IV Activity is Decreased in Multiple Sclerosis Patients: Effects of beta-Interferon Treatment Journal of Clinical Medicine, 7 DOI Author Url Publisher Url Public Url

Ahmed ST, Alston CL, Hopton S, He L, Hargreaves IP, Falkous G, Olahova M, McFarland R, Turnbull DM, Rocha MC, Taylor RW. 2017. Using a quantitative quadruple immunofluorescent assay to diagnose isolated mitochondrial Complex I deficiency Scientific Reports, 7 DOI Author Url Publisher Url Public Url

Al Shahrani M, Heales S, Hargreaves I, Orford M. 2017. Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease JOURNAL OF CLINICAL MEDICINE, 6 DOI Author Url Public Url

Manole A, Jaunmuktane Z, Hargreaves IP, Ludtmann MHR, Salpietro V, Bello OD, Pope S, Pandraud A, Horga A, Scalco RS, Li A, Ashokkumar B, Lourenc¸o CM, Heales S, Horvath R, Chinnery PF, Toro C, Singleton AB, Jacques TS, Abramov AY, Muntoni F, Hanna MG, Reilly MM, Revesz T, Kullmann DM, Jepson JEC, Houlden H. 2017. Clinical, pathological and functional characterization of riboflavin-responsive neuropathy Brain, 140 :2820-2837 DOI Publisher Url Public Url

Ghose A, Taylor C, Howie A, Chalasani A, Hargreaves I, Milford D. 2017. Measurement of Respiratory Chain Enzyme Activity in Human Renal Biopsy Specimens Journal of Clinical Medicine, 6 :90-90 DOI Public Url

Stepien KM, Heaton R, Rankin S, Murphy A, Bentley J, Sexton D, Hargreaves I. 2017. Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders Journal of Clinical Medicine, 6 DOI Publisher Url Public Url

Dyson A, Dal-Pizzol F, Sabbatini G, Lach AB, Galfo F, dos Santos Cardoso J, Pescador Mendonça B, Hargreaves I, Bollen Pinto B, Bromage DI, Martin JF, Moore KP, Feelisch M, Singer M. 2017. Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models Brohi K. PLoS Medicine, 14 :e1002310-e1002310 DOI Publisher Url Public Url

Bugiardini E, Poole OV, Manole A, Pittman AM, Horga A, Hargreaves I, Woodward CE, Sweeney MG, Holton JL, Taanman J-W, Plant GT, Poulton J, Zeviani M, Ghezzi D, Taylor J, Smith C, Fratter C, Kanikannan MA, Paramasivam A, Thangaraj K, Spinazzola A, Holt IJ, Houlden H, Hanna MG, Pitceathly RDS. 2017. Clinicopathologic and molecular spectrum of RNASEH1 -related mitochondrial disease Neurology Genetics, 3 :e149-e149 DOI Publisher Url Public Url

Neergheen V, Chalasani A, Wainwright L, Yubero D, Montero R, Artuch R, Hargreaves IP. 2017. Coenzyme Q10 in the treatment of mitochondrial disease Journal of Inborn Errors of Metabolism and Screening, DOI Publisher Url Public Url

Cornelius N, Wardman JH, Hargreaves IP, Neergheen V, Bie AS, Tümer Z, Nielsen JE, Nielsen TT. 2017. Evidence of oxidative stress and mitochondrial dysfunction in spinocerebellar ataxia type 2 (SCA2) patient fibroblasts: Effect of coenzyme Q10 supplementation on these parameters Mitochondrion, 34 :103-114 DOI Publisher Url Public Url

McKiernan P, Ball S, Santra S, Foster K, Fratter C, Poulton J, Craig K, McFarland R, Rahman S, Hargreaves I, Gupte G, Sharif K, Taylor RW. 2016. Incidence of Primary Mitochondrial Disease in Children Younger Than 2 Years Presenting With Acute Liver Failure Journal of Pediatric Gastroenterology and Nutrition, 63 :592-597 DOI Publisher Url Public Url

Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Neergheen V, Aiken CE, Ozanne SE. 2016. Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats. Disease Models and Mechanisms, 9 :1221-1229 DOI Publisher Url Public Url

Sadeghian M, Mastrolia V, Rezaei Haddad A, Mosley A, Mullali G, Schiza D, Sajic M, Hargreaves I, Heales S, Duchen MR, Smith KJ. 2016. Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis Scientific Reports, 6 DOI Publisher Url Public Url

Hargreaves IP. Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis. Clinical science (London, England : 1979),

Hargreaves IP. Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders. Mitochondrion,

Horga A, Bugiardini E, Manole A, Bremner F, Jaunmuktane Z, Dankwa L, Rebelo AP, Woodward CE, Hargreaves IP, Cortese A, Pittman AM, Brandner S, Polke JM, Pitceathly RDS, Züchner S, Hanna MG, Scherer SS, Houlden H, Reilly MM. Autosomal dominant optic atrophy and cataract “plus” phenotype including axonal neuropathy Neurology Genetics, 5 :e322-e322 DOI

Book

Hargreaves IP. 2019. Mitochondrial Respiratory Chain Disorders From Clinical Presentation to Diagnosis and Treatment 9781536150537

Conference publication

Chambers D, Kumar A, Feng L, Hargreaves I, Lam A, Heales S, Manzur A, Muntoni F, Sewry C, Poulton J, Phadke R. 2019. A novel multiplex chromogenic immunoassay for evaluating mitochondrial respiratory chain complex I and complex IV defects in diagnostic muscle biopsies NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium 45 :27-28 Author Url

Chambers D, Kumar A, Feng L, Hargreaves I, Lam A, Manzur A, Muntoni F, Sewry C, Poulton J, Phadke R. 2018. A novel multiplex chromogenic immunoassay for evaluating mitochondrial respiratory chain complex I and complex IV defects in diagnostic muscle biopsies NEUROMUSCULAR DISORDERS, 23rd International Annual Congress of the World-Muscle-Society (WMS) 28 :S86-S86 DOI Author Url

Lam A, Neergheen V, Chalasani A, Salih K, Pope S, Hargreaves I, Prunty H, Heales S. 2018. Biochemical markers of primary mitochondrial respiratory chain enzyme disorders NEUROMUSCULAR DISORDERS, 11th UK Neuromuscular Translational Research Conference 28 :S31-S31 DOI Author Url

Chapters

Neergheen V, Dyson A, Wainwright L, Hargreaves IP. 2018. Statin and Fibrate-Induced Dichotomy of Mitochondrial Function Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 2-2 :457-473 9781119329701 DOI

Neergheen V, Hargreaves IP. 2018. Secondary coenzyme Q10 deficiency: Causes and consequence Coenzyme Q10: Uses, Health Effects and Role in Disease :89-110 9781536132847