Educational resources
Here we identify several educational resources available to PBK model developers. Those new to the area may find these particularly helpful as they provide background information on what PBK models are and their potential applications.
Online tutorials are a good place to start for those wishing to begin building their own PBK models.
Online tutorials
esq-Labs provide a range of online training courses introducing PBK modelling and the OSP (Open Systems Pharmacology) Suite - PK-Sim and MoBi software. Freely available and commercially available resources are provided.
Discover online videos regarding PBPK Modeling
Textbooks
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment (2020)
Jeffrey W. Fisher, Jeffery M Gearhart and Zhoumeng Lin, Academic Press, Elsevier Inc, London UK
This book provides an excellent introduction to the basics of PBK modelling aimed at students and professionals. It begins with an overview of classical pharmacokinetics and progresses into an explanation of fundamental principles and uses of PBK models. The text is informative and accessible for novices and chapters are supplemented with hands-on exercises for readers to try for themselves.
Physiologically Based Pharmacokinetic Modeling and Simulations: Principles, Methods and Applications in the Pharmaceutical Industry (2022)
Sheila Annie Peters, John Wiley & Sons Inc, Hoboken NJ
This book explains the principles of PBK (PBPK) modelling, focussing on applications in, and case studies from, the drug development industry.
The Art and Science of Physiologically-Based Pharmacokinetics Modeling (2025)
Rodrigo Cristofoletti and Amin Rostami-Hodjegan (Eds), CRC Press, Boca Raton, Florida
This book provides an introduction to PBK models and the underpinning science. Focussing on drug development, it includes chapters on drug-drug interactions, bioequivalence, biopharmaceutics and applications in regulatory decision-making.
View The Art and Science of Physiologically-Based Pharmacokinetics Modeling textbook
Articles
- Deepika, D and Kumar, V. The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment (2023) Int. J. Environ. Res. Public Health 20, 3473.
- Jones, HM and Rowland-Yeo, K. Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development. (2013) CPT Pharmacometrics Syst Pharmacol. 14;2(8):e63. doi:10.1038/psp.2013.41.
- Zhuang, X and Lu, C. PBPK modeling and simulation in drug research and development (2016) Acta Pharmaceutica Sinica B, 6(5):430–440.
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Kuepfer et al, Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model (2016) CPT Pharmacometrics Syst Pharmacol 5(10):516-531. doi: 10.1002/psp4.12134.