Core Methods and Applications of Artificial Intelligence (CORE-AI)

CORE-AI advances foundational and translational Artificial Intelligence methods that enable understanding, simulation, and intervention in complex real-world systems. The group develops and integrates:

  • explainable and causal AI
  • hybrid AI-driven modelling
  • structured and graph-based machine learning
  • transformer-based and foundation model architectures
  • large language models
  • federated and distributed learning frameworks

Our work moves beyond purely predictive paradigms towards AI systems that support causality, explainability, counterfactual analysis, and decision-making under uncertainty. We are particularly interested in methodological frameworks that combine theoretical robustness, computational scalability, and federated and distributed learning paradigms to enable AI systems that learn effectively across heterogeneous data sources and dynamic environments while remaining deployable in real-world settings.

A central objective of CORE-AI is to translate methodological advances into system-level tools, including:

  • digital twins
  • AI virtual assistants
  • decision-support systems

These tools are designed for domains characterised by complexity, temporal dynamics, partial observability, and heterogeneous or data-constrained environments.

Research focus

CORE-AI operates at the interface of theory and application. Our research addresses:

  • causal reasoning, structural modelling, and counterfactual inference
  • explainable and interpretable AI systems
  • robust and uncertainty-aware machine learning
  • hybrid AI integrating multimodal data‑driven methods with other modelling approaches
  • structured, graph-based, and relational learning
  • scalable transformer and foundation model architectures
  • federated and distributed model training across heterogeneous data regimes

We aim to develop AI systems that are not only accurate, but also transparent, adaptable, and capable of supporting informed intervention and system-level reasoning.

Collaboration and community

CORE-AI is an inclusive and interdisciplinary research group. We welcome collaboration across methodological, theoretical, and applied domains where core AI innovation is required.

The group supports:

  • interdisciplinary research development
  • joint funding applications
  • doctoral and MSc project supervision
  • early-career mentorship and methodological development

Through collective expertise and collaboration, CORE-AI seeks to strengthen research excellence and contribute deployable, explainable, and robust AI systems across complex domains.

Active research projects

  • EU project TARGET (Grant Agreement No. 101136244). 2024-2028, €10M. TARGET is a multidisciplinary Horizon Europe research project developing personalised, multi-scale AI-driven virtual twin models and decision-support tools to improve the prevention, acute management, and rehabilitation of atrial fibrillation and stroke, ultimately aiming to enhance patient outcomes and reduce healthcare costs.
  • EU project ARISTOTELES (Grant Agreement No. 101080189). 2023-2028, €6M. ARISTOTELES is a multidisciplinary Horizon Europe research project applying advanced AI to define clinical trajectories and enable personalised prediction and early detection of comorbidity and multimorbidity patterns, initially focusing on atrial fibrillation, with the aim of supporting earlier risk stratification and more precise, proactive care across Europe.

Members

Prof Sandra Ortega-Martorell, Research Group Leader

Prof Ivan Olier, Head of the AIDTRI

Dr Ryan Bellfield, Senior Lecturer

Dharmesh Mistry, Research Associate

Hector Hortua Orjuela, Research Associate

George Margereson, Research Associate

Yan Gou, Research Associate

Bradley Walters, PhD student

Andrea Sante, PhD student

Akhil Naik, PhD student

Joseph Mahon, PhD student

Nosa Aikodon, PhD student

Salma Louhaichy, PhD student

Zainab Mahmood, PhD student