Core Methods and Applications of Artificial Intelligence (CORE-AI)
CORE-AI advances foundational and translational Artificial Intelligence methods that enable understanding, simulation, and intervention in complex real-world systems.
The group develops and integrates:
- explainable and causal AI
- hybrid AI-driven modelling
- structured and graph-based machine learning
- transformer-based and foundation model architectures
- large language models
- federated and distributed learning frameworks
Our work moves beyond purely predictive paradigms towards AI systems that support causality, explainability, counterfactual analysis, and decision-making under uncertainty. We are particularly interested in methodological frameworks that combine theoretical robustness, computational scalability, and federated and distributed learning paradigms to enable AI systems that learn effectively across heterogeneous data sources and dynamic environments while remaining deployable in real-world settings.
A central objective of CORE-AI is to translate methodological advances into system-level tools, including:
- digital twins
- AI virtual assistants
- decision-support systems
These tools are designed for domains characterised by complexity, temporal dynamics, partial observability, and heterogeneous or data-constrained environments.
Research focus
CORE-AI operates at the interface of theory and application. Our research addresses:
- causal reasoning, structural modelling, and counterfactual inference
- explainable and interpretable AI systems
- robust and uncertainty-aware machine learning
- hybrid AI integrating multimodal data‑driven methods with other modelling approaches
- structured, graph-based, and relational learning
- scalable transformer and foundation model architectures
- federated and distributed model training across heterogeneous data regimes
We aim to develop AI systems that are not only accurate, but also transparent, adaptable, and capable of supporting informed intervention and system-level reasoning.
Collaboration and community
CORE-AI is an inclusive and interdisciplinary research group. We welcome collaboration across methodological, theoretical, and applied domains where core AI innovation is required.
The group supports:
- interdisciplinary research development
- joint funding applications
- doctoral and MSc project supervision
- early-career mentorship and methodological development
Through collective expertise and collaboration, CORE-AI seeks to strengthen research excellence and contribute deployable, explainable, and robust AI systems across complex domains.
Active research projects
- EU project TARGET (Grant Agreement No. 101136244). 2024-2028, €10M. TARGET is a multidisciplinary Horizon Europe research project developing personalised, multi-scale AI-driven virtual twin models and decision-support tools to improve the prevention, acute management, and rehabilitation of atrial fibrillation and stroke, ultimately aiming to enhance patient outcomes and reduce healthcare costs.
- EU project ARISTOTELES (Grant Agreement No. 101080189). 2023-2028, €6M. ARISTOTELES is a multidisciplinary Horizon Europe research project applying advanced AI to define clinical trajectories and enable personalised prediction and early detection of comorbidity and multimorbidity patterns, initially focusing on atrial fibrillation, with the aim of supporting earlier risk stratification and more precise, proactive care across Europe.
Members
Prof Sandra Ortega-Martorell, Research Group Leader
Prof Ivan Olier, Head of the AIDTRI
Dr Ryan Bellfield, Senior Lecturer
Dharmesh Mistry, Research Associate
Hector Hortua Orjuela, Research Associate
George Margereson, Research Associate
Yan Gou, Research Associate
Bradley Walters, PhD student
Andrea Sante, PhD student
Akhil Naik, PhD student
Joseph Mahon, PhD student
Nosa Aikodon, PhD student
Salma Louhaichy, PhD student
Zainab Mahmood, PhD student
