Liverpool Skylilne

Sport and Exercise Sciences

Dr Sam Shepherd

Dr Sam Shepherd

Telephone: 0151 904 6293

Publications

Journal article

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Mein CA, Sharples AP. 2018. Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining Scientific Data, 5 >DOI >Link

Scott SN, Cocks MS, Andrews RC, Narendran P, Purewal TS, Cuthbertson DJ, Wagenmakers AJM, Shepherd SO. 2018. Hit Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People with Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism, >DOI >Link

Scott SN, Cocks M, Andrews RC, Narendran P, Purewal TS, Cuthbertson DJ, Wagenmakers AJM, Shepherd SO. 2018. Fasted High-Intensity Interval and Moderate-Intensity Exercise do not Lead to Detrimental 24-Hour Blood Glucose Profiles. Journal of Clinical Endocrinology and Metabolism, >DOI >Link

Morris AS, Murphy RC, Shepherd S, Graves LEF. 2018. Multi-stakeholder perspectives of factors that influence contact centre call agent’s workplace physical activity and sedentary behaviour International Journal of Environmental Research and Public Health, 7 >DOI

Impey SG, Hammond KM, Naughton R, Langan-Evans C, Shepherd SO, Sharples AP, Cegielski J, Smith K, Jeromson S, Hamilton DL, Close GL, Morton JP. 2018. Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability International Journal of Sport Nutrition and Exercise Metabolism, 0 :1-26 >DOI

Strauss JA, Willems MET, Shepherd SO. 2018. New Zealand blackcurrant extract enhances fat oxidation during prolonged cycling in endurance-trained females. European Journal of Applied Physiology, >DOI >Link

Kinnafick F-E, Thogersen-Ntoumani C, Shepherd SO, Wilson OJ, Wagenmakers AJM, Shaw CS. 2018. In It Together: A Qualitative Evaluation of Participant Experiences of a 10-Week, Group-Based, Workplace HIIT Program for Insufficiently Active Adults JOURNAL OF SPORT & EXERCISE PSYCHOLOGY, 40 :10-19 >DOI >Link

Whytock KL, Shepherd SO, Wagenmakers AJM, Strauss JA. 2018. Hormone-sensitive lipase preferentially redistributes to lipid droplets associated with perilipin-5 in human skeletal muscle during moderate-intensity exercise JOURNAL OF PHYSIOLOGY-LONDON, 596 :2077-2090 >DOI >Link

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP. 2018. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy Scientific Reports, 8 >DOI

Srisawat K, Shepherd SO, Lisboa PJ, Burniston JG. 2017. A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training. Proteomes, 5 >DOI >Link

Whytock KL, Jevons EFP, Strauss JA, Shepherd SO. 2017. Under the microscope: insights into limb-specific lipid droplet metabolism. J Physiol, >DOI >Link

Shepherd SO, Cocks M, Meikle PJ, Mellett NA, Ranasinghe AM, Barker TA, Wagenmakers AJM, Shaw CS. 2017. Lipid droplet remodelling and reduced muscle ceramides following sprint interval and moderate-intensity continuous exercise training in obese males INTERNATIONAL JOURNAL OF OBESITY, 41 :1745-1754 >DOI >Link

Bartlett DB, Shepherd SO, Wilson OJ, Adlan AM, Wagenmakers AJM, Shaw CS, Lord JM. 2017. Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, >DOI >Link

Shepherd SO, Strauss JA, Wang Q, Dube JJ, Goodpaster B, Mashek DG, Chow LS. 2017. Training alters the distribution of perilipin proteins in muscle following acute free fatty acid exposure JOURNAL OF PHYSIOLOGY-LONDON, 595 :5587-5601 >DOI >Link

Allan R, Sharples AP, Close GL, Drust B, Shepherd SO, Dutton J, Morton JP, Gregson W. 2017. Post-exercise cold-water immersion modulates skeletal muscle PGC-1α mRNA expression in immersed and non-immersed limbs: evidence of systemic regulation Journal of Applied Physiology, 123 :451-459 >DOI >Link

Chow LS, Mashek DG, Wang Q, Shepherd SO, Goodpaster BH, Dube JJ. 2017. Effect of acute physiological free fatty acid elevation in the context of hyperinsulinemia on fiber type specific IMCL accumulation. Journal of applied physiology (Bethesda, Md. : 1985), :jap.00209.2017-jap.00209.2017 >DOI >Link

Bradley WJ, Hannon MP, Benford V, Morehen JC, Twist C, Shepherd S, Cocks M, Impey SG, Cooper RG, Morton JP, Close GL. 2017. Metabolic demands and replenishment of muscle glycogen after a rugby league match simulation protocol. Journal of Science and Medicine in Sport, 20 :878-883 >DOI >Link

Hammond KM, Impey SG, Currell K, Mitchell N, Shepherd SO, Jeromson S, Hawley JA, Close GL, Hamilton DL, Sharples AP, Morton JP. 2016. Post exercise high-fat feeding supresses p70S6K1 activity in human skeletal muscle Medicine and Science in Sports and Exercise, 48 :2108-2117 >DOI >Link

Bradley WJ, Morehen JC, Haigh J, Clarke J, Donovan TF, Twist C, Cotton C, Shepherd S, Cocks M, Sharma A, Impey SG, Cooper RG, Maclaren DPM, Morton JP, Close GL. 2016. Muscle glycogen utilisation during Rugby match play: Effects of pre-game carbohydrate Journal of Science and Medicine in Sport, 19 :1033-1038 >DOI

Impey S, Hammond K, Shepherd S, Sharples AP, Stewart CE, Limb M, Smith K, Philp A, Jeromson S, Hamilton DL, Close GL, Morton JP. 2016. Fuel for the work required: a practical approach to amalgamating train-low paradigms for endurance athletes Physiological Reports, 4 :e12803-e12803 >DOI >Link

Thøgersen-Ntoumani C, Shepherd SO, Ntoumanis N, Wagenmakers AJ, Shaw CS. 2016. Intrinsic motivation in two exercise interventions: Associations with fitness and body composition. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 35 :195-198 >DOI

Cocks M, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe A, Barker TA, Wagenmakers AJM. 2016. Sprint interval and moderate-intensity continuous training have equal benefits on aerobic capacity, insulin sensitivity, muscle capillarisation and endothelial eNOS/NAD(P)Hoxidase protein ratio in obese men JOURNAL OF PHYSIOLOGY-LONDON, 594 :2307-2321 >DOI >Link

Wagenmakers AJM, Strauss JA, Shepherd SO, Keske MA, Cocks M. 2016. Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing JOURNAL OF PHYSIOLOGY-LONDON, 594 :2207-2222 >DOI >Link

Graves LEF, Murphy RC, Shepherd SO, Cabot J, Hopkins ND. 2015. Evaluation of sit-stand workstations in an office setting: A randomised controlled trial BMC Public Health, 15 >DOI

Shepherd SO, Wilson OJ, Taylor AS, Thogersen-Ntoumani C, Adlan AM, Wagenmakers AJM, Shaw CS. 2015. Low-Volume High-Intensity Interval Training in a Gym Setting Improves Cardio-Metabolic and Psychological Health PLOS ONE, 10 >DOI >Link

Bradley H, Shaw CS, Worthington PL, Shepherd SO, Cocks M, Wagenmakers AJM. 2014. Quantitative immunofluorescence microscopy of subcellular GLUT4 distribution in human skeletal muscle: Effects of endurance and sprint interval training Physiological Reports, 2 >DOI

Shepherd SO, Cocks M, Tipton KD, Witard OC, Ranasinghe AM, Barker TA, Wagenmakers AJM, Shaw CS. 2014. Resistance training increases skeletal muscle oxidative capacity and net intramuscular triglyceride breakdown in type I and II fibres of sedentary males EXPERIMENTAL PHYSIOLOGY, 99 :894-908 >DOI >Link

Shepherd S, Cocks M, Ranasinghe A, Barker T, McClean A, Wagenmakers AJM, Shaw CS. 2014. High intensity interval and traditional endurance training both increase insulin sensitivity, V̇O2peakand skeletal muscle perilipin 2 and perilipin 5 content in sedentary obese males Japanese Journal of Physical Fitness and Sports Medicine, 63 :163 >DOI

Shaw CS, Clark JA, Shepherd SO. 2013. HSL and ATGL: The movers and shakers of muscle lipolysis Journal of Physiology, 591 :6137-6138 >DOI

Cocks M, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe AM, Barker TA, Tipton KD, Wagenmakers AJM. 2013. Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males. J Physiol, 591 :641-656 >DOI >Link

Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJM, Shaw CS. 2013. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5. J Physiol, 591 :657-675 >DOI >Link

Cocks M, Shepherd SO, Shaw CS, Achten J, Costa ML, Wagenmakers AJM. 2012. Immunofluorescence microscopy to assess enzymes controlling nitric oxide availability and microvascular blood flow in muscle. Microcirculation, 19 :642-651 >DOI >Link

Shaw CS, Shepherd SO, Wagenmakers AJM, Hansen D, Dendale P, van Loon LJC. 2012. Prolonged exercise training increases intramuscular lipid content and perilipin 2 expression in type I muscle fibers of patients with type 2 diabetes. Am J Physiol Endocrinol Metab, 303 :E1158-E1165 >DOI >Link

Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJM, Shaw CS. 2012. Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise. Exp Physiol, 97 :970-980 >DOI >Link

Cocks MS, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe A, baker TA, Wagenmakers AJM. Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males. The Journal of Physiology,

Cocks M, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe AM, Barker TA, Tipton KD, Wagenmakers AJM. Effect of Resistance Training on Microvascular Density and eNOS Content in Skeletal Muscle of Sedentary Men MICROCIRCULATION, 21 :738-746 >DOI >Link

Conference publication

Morris A, Murphy R, Shepherd S, Healy G, Edwardson C, Graves L. 2018. Move More, Sit Less: Using the MRC framework to develop a multi-level workplace intervention within a contact centre setting JOURNAL OF PHYSICAL ACTIVITY & HEALTH, 15 :S155-S155 >Link

Gavin D, Millard A, Cochrane M, Hopkins N, Low D, Murphy R, Shepherd S, Watson P, Timpson H, Jones L, Haycox A, Collins B, Healy G, Edwardson C, Dunstan D, Graves L. 2018. Multi-level workplace intervention to improve cardiovascular outcomes in contact centre call agents: Study protocol JOURNAL OF PHYSICAL ACTIVITY & HEALTH, 15 :S155-S155 >Link

Shepherd S, Wilson O, Bradley H, Clark J, Cocks M, Thogersen-Ntoumani C, Taylor A, Anton W, Shaw C. 2013. Group-based High Intensity Interval Training Improves Adherence and Reduces Cardio-metabolic Risk Factors in Sedentary Individuals MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 60th Annual Meeting of the American-College-of-Sports-Medicine 45 :509-509 >Link

Engagement & Impact

Award:

Preferential utilisation of perilipin 2 associated intramuscular triglycerides during one hour of moderate intensity endurance-type exercise, Physiological Society, Poster Communication (1st place)

Preferential utilisation of perilipin 2 associated intramuscular triglycerides during one hour of moderate intensity endurance-type exercise, Physiological Society - Poster Prize (1st place)

Resistance training increases skeletal muscle oxidative capacity and net intramuscular triglyceride breakdown in type I and II fibres of sedentary males, European College of Sport Science (ECSS) Young Investigator Award

High intensity interval and traditional endurance training both increase insulin sensitivity, VO2peak and skeletal muscle perilipin 2 and perilipin 5 content in sedentary obese males, European College of Sport Science (ECSS) Young Investigator Award

Research Grants Awarded:

Dunhill Medical Trust, Understanding the role of obesity in the deterioration of skeletal muscle mass and quality in old age: New mechanistic insights, PI: Dr Leigh Breen (University of Birmingham), Prof Jamie McPhee (MMU), Prof Janice Thompson (University of Birmingham), Prof Jan Boren (University of Gothenburg), Dr Joachim Nielsen (University of Southern Denmark), Grant value (£): 228,342, Duration of research project: 3 years

Diabetes UK, Inhibition of adipose tissue lipolysis to enhance the effectiveness of a walking programme to improve insulin sensitivity in people with prediabetes, Professor Anton Wagenmakers (LJMU), Grant value (£): 97,888, Duration of research project: 3 years

Liverpool John Moores University - PhD Scholarship, High intensity interval training to improve glucose control in diabetes, Dr Matthew Cocks (Liverpool John Moores University), Prof Anton Wagenmakers (Liverpool John Moores University), Grant value (£): 57285, Duration of research project: 3 years

Physiological Society, Summer studentship: Visualisation of SNAP23 translocation in skeletal muscle in response to glucose feeding using immunofluorescence microscopy, Grant value (£): 1,200, Duration of research project: 10 weeks

Diabetes Research & Wellness Foundation, Is high intensity interval training an efficient and effective form of exercise for people with type 1 diabetes?, Dr Matthew Cocks (LJMU), Prof Anton Wagenmakers (LJMU), Dr Parth Narendran (Uni of Birmingham), Dr Rob Andrews (Uni of Bristol), Dr Cecilie Thogersen-Ntoumani (Curtin Uni, Aus), Dr Ian Gallen (Royal Berkshire Hospital), Grant value (£): 19,811, Duration of research project: 12 months

Society for Endocrinology, Use of high-fat overfeeding to determine the early molecular changes in skeletal muscle that contribute to insulin resistance, Grant value (£): 9960, Duration of research project: 12 monrhs

Teaching qualification:

Postgraduate Certificate in Learning & Teaching in HE