Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Alistair Fielding

Dr Alistair Fielding

Telephone: 0151 231 2576

Biography

Bruker Applications Scientist/Senior Lecturer (2012-2017), University of Manchester, UK
DFG Fellowship (2008-2012), Max-Planck for Biophysical Chemistry, Goettingen, Germany
CEA Fellowship (2006-2008) at CEA-Saclay, France
Postdoctoral research Associate (2003-2006), University of Denver, USA

RESEARCH INTERESTS
I am Senior Lecturer in Analytical Chemistry within the School of Pharmacy and Biomolecular Sciences. I have an established record in electron paramagnetic resonance (EPR) spectroscopy. On the recent move to LJMU my research will include further analytical techniques such as nuclear magnetic resonance (NMR) and mass spectroscopy as well as keeping strong links to the National EPR service. The Fielding group’s research is wide-ranging and problem driven.

Drug Interactions
A prime focus is using EPR and other spectroscopic techniques to measure drug interactions. A recent example can be found here: DOI: 10.1002/chem.201605099

Surface Interactions
Excitingly, we have developed a new synthetic strategy that uses spin labels to link biofunctional groups to surfaces: http://dx.doi.org/10.1002/anie.201703929

Structural Biology
We apply the latest EPR techniques to structural, mechanistic and kinetic questions concerning flavins, cytochromes, kinases and phosphatases. A good example of our work using double electron electron resonance (DEER) can be found here: http://dx.doi.org/10.1016/j.str.2016.10.006
Other expertise includes UV-vis stopped flow and rapid freeze-quench.

Materials Science
We have a number of collaborations concerning novel materials. We have recently worked on the surface chemistry of MoS2: http://dx.doi.org/10.1021/acs.chemmater.7b01245

In all endeavours, we welcome collaborative partners both nationally and abroad. Phone calls always welcome.

Industrial consulting in EPR spectroscopy, possible.

We work with several industrial companies concerning challenging analytical problems. We welcome enquiries.

Publications

Highlighted publications

Gonzalez JR, Alcantara R, Tirado JL, Fielding AJ, Dryfe RAW. 2017. Electrochemical Interaction of Few-Layer Molybdenum Disulfide Composites vs Sodium: New Insights on the Reaction Mechanism CHEMISTRY OF MATERIALS, 29 :5886-5895 >DOI >Link

Hollas MA, Webb SJ, Flitsch SL, Fielding AJ. 2017. A Bifunctional Spin Label for Ligand Recognition on Surfaces Angewandte Chemie - International Edition, 56 :9449-9453 >DOI

Fielding AJ, Lukinovic V, Evans PG, Alizadeh-Shekalgourabi S, Bisby RH, Drew MGB, Male V, Del Casino A, Dunn JF, Randle LE, Dempster NM, Nahar L, Sarker SD, Reinhard FGC, de Visser SP, Dascombe MJ, Ismail FMD. 2017. Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines CHEMISTRY-A EUROPEAN JOURNAL, 23 :6811-6828 >DOI >Link

Journal Articles

Boulon ME, Fernandez A, Moreno Pineda E, Chilton NF, Timco G, Fielding AJ, Winpenny REP. 2017. Measuring Spin⋅⋅⋅Spin Interactions between Heterospins in a Hybrid [2]Rotaxane Angewandte Chemie - International Edition, 56 :3876-3879 >DOI

Park SS, Hendon CH, Fielding AJ, Walsh A, O'Keeffe M, Dinca M. 2017. The Organic Secondary Building Unit: Strong Intermolecular pi Interactions Define Topology in MIT-25, a Mesoporous MOF with Proton-Replete Channels JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 139 :3619-3622 >DOI >Link

Gonzalez JR, Alcantara R, Tirado JL, Fielding AJ, Dryfe RAW. 2017. Electrochemical Interaction of Few-Layer Molybdenum Disulfide Composites vs Sodium: New Insights on the Reaction Mechanism CHEMISTRY OF MATERIALS, 29 :5886-5895 >DOI >Link

Brandariz-de-Pedro G, Heyes DJ, Hardman SJO, Shanmugam M, Jones AR, Weber S, Nohr D, Scrutton NS, Fielding AJ. 2017. Direct Evidence of an Excited-State Triplet Species upon Photoactivation of the Chlorophyll Precursor Protochlorophyllide JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 8 :1219-1223 >DOI >Link

Hollas MA, Webb SJ, Flitsch SL, Fielding AJ. 2017. A Bifunctional Spin Label for Ligand Recognition on Surfaces Angewandte Chemie - International Edition, 56 :9449-9453 >DOI

Fielding AJ, Lukinovic V, Evans PG, Alizadeh-Shekalgourabi S, Bisby RH, Drew MGB, Male V, Del Casino A, Dunn JF, Randle LE, Dempster NM, Nahar L, Sarker SD, Reinhard FGC, de Visser SP, Dascombe MJ, Ismail FMD. 2017. Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines CHEMISTRY-A EUROPEAN JOURNAL, 23 :6811-6828 >DOI >Link

Burgess SG, Grazia Concilio M, Bayliss R, Fielding AJ. 2016. Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR Spectroscopy ChemistryOpen, 5 :531-534 >DOI

Engagement & Impact

Industrial connections:

Company: AstraZeneca, Alderley Park (15/09/16), Position or project: Bespoke talk titled: Electron Paramagnetic Resonance Spectroscopy in Pharmaceutical Research, Development and Analysis

Membership of professional bodies:

Member of the International EPR Society, International EPR Society

Member of the Royal Society of Chemistry, Royal Society of Chemistry

Other Professional Activity:

Describe the Professional Activities: Honorary Lecturer, The University of Manchester

Teaching qualification:

Title of qualification gained: HEA Fellowship