Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Andrew Evans

Dr Andrew Evans

Telephone: 0151 231 2145

Biography

Degrees

2003, Liverpool John Moores University, United Kingdom, PhD
1999, University of Liverpool, United Kingdom, Molecular Biology BSc (Hons)

Academic appointments

Senior Lecturer in Pharmacology, School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, 2005 - present

Publications

Journal article

Segun P, Ogbole O, Ismail F, Nahar L, Evans A, Ajaiyeoba E, Sarker S. 2019. Bioassay-Guided Isolation and Structure Elucidation of Cytotoxic Stilbenes and Flavonols from the Leaves of Macaranga barteri Fitoterapia, 134 :151-157 >Public Url

Segun PA, Ogbole OO, Ismail FMD, Nahar L, Evans AR, Ajaiyeoba EO, Sarker SD. 2019. Resveratrol derivatives from Commiphora africana (A. Rich.) Endl. display cytotoxicity and selectivity against several human cancer cell lines Phytotherapy Research, 33 :159-166 >DOI >Public Url

Segun P, Ismail F, Ogbole OO, Nahar L, Evans A, Ajaiyeoba EO, Sarker SD. 2018. Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells Journal of Ethnopharmacology, 227 :131-138 >Public Url

Guetchueng S, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Sarker SD. 2018. Zanthoamides G-I: Three new alkamides from Zanthoxylum zanthoxyloides Phytochemistry Letters, 26 :125-129 >Public Url

Al Groshi A, Evans AR, Ismail F, Nahar L, Sarker S. 2018. Cytotoxicity of Libyan Juniperus phoenicea against Human Cancer Cell Lines A549, EJ138, Hepg2 and MCF7 Pharmcaceutical Sciences, 24 :3-7 >DOI >Public Url

Guetchueng S, Nahar L, Ritchie K, Ismail F, Evans A, Sarker SD. 2018. ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex. Hutch. and Assessment of their Cytotoxicity Against Human Cancer Cell Lines Molecules, :1-9 >Public Url

Khan KM, Nahar L, Mannan A, Arfan M, Khan G, Al Groshi A, Evans A, Dempster NM, Ismail F, Sarker SD. 2018. Liquid chromatography mass spectrometry analysis and cytotoxicity of Asparagus adscendens roots against human cancer cell lines Pharmacognosy Magazine, 13 :890-894 >DOI >Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail, FMD , Wansi JD, Evans AR, Sarker SD. 2017. Kaurane diterpenes from the fruits of Zanthoxylum leprieurii (Rutaceae) Records of Natural Products, 11 :304-309 >Public Url

Tahsin T, Wansi JD, Al-Groshi A, Evans A, Nahar L, Martin C, Sarker SD. 2017. Cytotoxic properties of the stem bark of Citrus reticulata Blanco (Rutaceae) Phytotherapy Research, 31 :1215-1219 >Public Url

Khan KM, Nahar L, Al-Groshi A, Zavoianu AG, Evans A, Dempster NM, Wansi JD, Ismail FMD, Mannan A, Sarker SD. 2016. Cytotoxicity of the Roots of Trillium govanianum Against Breast (MCF7), Liver (HepG2), Lung (A549) and Urinary Bladder (EJ138) Carcinoma Cells Phytotherapy Research, 30 :1716-1720 >DOI >Public Url

Sharma S, Evans A, Hemers E. 2016. Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1. Cell Tissue Res, :357-366 >DOI >Link >Public Url

Bloch KM, Evans AR, Lock EA. 2015. Aristolochic acids - Induced transcriptomic responses in rat renal proximal tubule cells in vitro Genomics Data - Elsevier, 5 :254-256 >DOI >Public Url

Bloch KM, Yaqoob N, Sharma S, Evans A, Aschauer L, Radford R, Jennings P, Ryan MP, van Delft JHM, Lock EA. 2015. Transcriptomic alterations induced by Monuron in rat and human renal proximal tubule cells in vitro and comparison to rat renal-cortex in vivo Toxicological Research, 2 :423-431 >DOI >Public Url

Pujol-Gimenez J, Perez de Heredia F, Idoate MA, Airley R, Lostao MP, Evans AR. 2015. Could GLUT12 be a potential therapeutic target in cancer? A preliminary report Journal of Cancer, 6 :139-143 >DOI >Public Url

Evans AR, yaqoob N, Foster JR, Lock EA. 2014. Trichloroethylene and trichloroethanol-induced formic aciduria and renal injury in male F-344 rats following 12 weeks exposure Toxicology, :70-77 >Public Url

Airley RE, McHugh P, Evans AR, Harris B, Winchester L, Buffa FM, Al-Tameemi W, Leek R, Harris AL. 2014. Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression. Br J Cancer, 110 :715-723 >DOI >Link >Public Url

Yaqoob N, Evans AR, Lock EA. 2013. Trichloroethylene-induced formic aciduria: Effect of dose, sex and strain of rat TOXICOLOGY, 304 :49-56 >DOI >Link

Tawfeek HM, Evans AR, Ifikhar A, Mohammed AR, Shabir A, Somavarapu S, Hutcheon GA, Saleem IY. 2013. Dry powder inhalation of macromolecules using novel PEG-co-polyester microparticle carriers. International Journal of Pharmaceutics, 441 :611-619 >Public Url

Bloch KM, Yaqoob N, Evans A, Radford R, Jennings P, Boei JJWA, McMorrow T, Slattery C, Ryan MP, Gmuender H, van Delft JHM, Lock EA. 2012. Detection of genotoxic and non genotoxic renal carcinogens in vitro in NRK-52E cells using a transcriptomics approach. Toxicology Research, 1 :211-219

Airley R, Evans AR. 2012. How the science of personalized medicines will change the clinical management of patients in the pharmacy Future Medicinal Chemistry, 4 :2023-2026 >Public Url

Airley R, Evans A, Mobasheri A, Hewitt SM. 2010. Glucose transporter Glut-1 is detectable in pen-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 192 :133-138 >DOI >Link >Public Url

Evans A, Bates V, Troy H, Hewitt S, Holbeck S, Chung Y-L, Phillips R, Stubbs M, Griffiths J, Airley R. 2008. Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies. Cancer Chemother Pharmacol, 61 :377-393 >DOI >Link

Airley RE, Phillips RM, Evans AE, Double J, Burger AM, Feibig HH, West CML, Stratford IJ. 2005. Hypoxia-regulated glucose transporter Glut-1 may influence chemosensitivity to some alkylating agents: results of EORTC (First Translational Award) study of the relevance of tumour hypoxia to the outcome of chemotherapy in human tumour-derived xenografts. Int J Oncol, 26 :1477-1484 >Link >Public Url

Conference publication

Bloch K, Evans A, Lock EA. 2019. Developing an in vitro method for assessing the carcinogenic potential of compounds to the kidney. Toxicology, 262 :9-9

Javed S, Ismail FMD, Evans AR, Nahar L, Sarker SD. 2018. Bioassay-guided fractionation through the cytotoxic activity of Sorbaria tomentosa PSE-YSM

Al-Groshi A, Evans AR, Ismail FMD, Dempster NM, Nahar L, Sarker SD. 2018. In vitro cytotoxicity of Ruta chalepensis against human cancer cell lines PSE-YSM

Sarker S, Nahar L, Al Groshi A, Al-Majmaie S, Sharples GP, Evans AR, Ismail FMD. 2018. Evidence-based phytotherapy: Revisiting Ruta chalepensis L Conference abstract,

Bastien M, Downing JD, Evans AR, Henney N. 2017. Identification of new alternatively spliced ghrelin variants in mouse osteoblastic cell line 7F2. 38th World Congress of the International Union of Physiological Sciences (IUPS)conference

Evans AR, Sharma S, Hemers, E . 2016. The role of High-Mobility Group Box 1 protein in mesenchymal-epithelial signalling in the tumour microenvironment. European Journal of Cancer, 61 :S78-S78 >Public Url

Khan KM, Nahar L, Evans A, Ismail FMD, Dempster N, Al-Groshi A, Zazoianu AG, Wansi JD, Sarker SD. 2016. Evaluation of cytotoxicity of Trillium govanianum (Melanthiaceae) Phytotherapy Research, >Public Url

Sheperd S, Chapman L, Day S, McHugh P, Evans AR, Airley R. 2014. The development of drug sensitivity biomarkers for personalized cancer chemotherapy

Bloch KM, Evans A, Lock EA. 2012. Detection of renal genotoxic carcinogens using NRK52E cells - a normal rat renal proximal tubule cell line with an external metabolising system British Toxicological Society Meeting

Bloch KM, Evans A, van Delft J, Lock EA. 2012. Genome-wide expression profiling in rat kidney and a rat kidney cell line NRK-52E following short-term exposure to Monuron British Toxicological Society Meeting

Airley R, Evans A, Harris B, Winchester L, Leek R, Harris A. 2012. Carbohydrate responce element binding protein (ChREBP) - a new metabolic biomarker in breast cancer? European Journal of Cancer, 48 :s80-s80

Bloch K, Evans A, Lock EA. 2011. The addition of liver rat external metabolising system (S9) to cell cultures to help predict carcinogenic potential of genotoxic chemicals in vitro using transcriptomics analysis National Cancer Research Institute (NCRI) Conference :145-145

Sharma S, Hemers E, Evans AR. 2011. Investigation into the role of HMGb1 in relation to myofibroblasts and cancer cells exposed to various conditions Institute for Health Research Conference (IHR)

Bloch KM, Evans A, van Delft J, Lock EA. 2011. The effect of four non-genotoxic carcinogens and four non-carcinogens on NRK-52E cells using a transcriptomics approach. Toxicology, :110-110

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Evans A, Gaskell EE, Hutcheon GA. 2010. Encapsulation, release, bioactivity and cytotoxicity of lysozyme loaded poly(glycerol adipte-co-omega-pentadecalactone) microparticles JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1431-1432 >Link

McAllister L, Evans A, Hutcheon G, Gaskell E. 2009. Encapsulation of epirubicin for the treatment of cancer JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A82-A82 >Link

Olidimeji B, Lerston S, Evans A, Estlin E, Airley R. 2005. Bone marrow hypoxia as a target in acute lymphoblastic leukaemia: toxicity assays using the bioreductive cytotoxic agent tirapazamine JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S77-S77 >Link

Lonergan S, Haddad N, Evans A, Airley R. 2005. Ascorbic acid toxicity in tumours: role of facilitative glucose transporter Glut-1 and hypoxia JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S77-S77 >Link

Hodgson G, Evans A, Airley R. 2005. Deregulated glucose transport as a target for anticancer drug development: use of a Glut-1 over-expressing colon carcinoma cell line to screen tyrosine kinase inhibitors for Glut-1-dependent toxicity JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S76-S76 >Link

Hermitage N, Evans A, Houghton P, Stratford I, Estlin E, Airley R. 2004. Hypoxia-regulated gene expression in rhabdomyosarcoma cell lines BRITISH JOURNAL OF CANCER, British Cancer Research Meeting 2004 91 :S68-S68 >Link

Santos K, Evans A, Kelsey A, Wynn R, Estlin E, Airley R. 2004. Is hypoxia a therapeutic target in haematological malignancies? GLUT-1 and LDH expression in acute lymphoblastic leukaemia BRITISH JOURNAL OF CANCER, British Cancer Research Meeting 2004 91 :S49-S49 >Link

Lunt A, Evans A, Houghton P, Stratford I, Estlin E, Airley R. 2004. The role of MYCN amplification and hypoxia in the expression of facilitative glucose transporters in neuroblastoma cell lines lililinesroblastoma cell lines BRITISH JOURNAL OF CANCER, British Cancer Research Meeting 2004 91 :S48-S48 >Link

Evans A, Hewitt S, Stratford IJ, Airley RE. 2003. Glut-1 as a novel target for anticancer therapy: A compare analysis using the NCI panel of 60 cell lines BRITISH JOURNAL OF CANCER, British Cancer Research Meeting 2003 88 :S12-S12

Evans AR. Assessment of cytotoxicity of phytochemicals: issues to consider Advances in Phytochemical Research (Trends in Natural Products Research) Keynote Lecture, Phytochemical Society of Europe -Young Scientists (PSE YSM) :116-116

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Sarker SD. New alkaloids and other constituents from the fruits of Zanthoxylum zanthoxyloides and evaluation of their cytotoxicity International Journal of Phytopharmacy, 22nd International Congress

Lilley L, Downing J, Evans AR. Treatment with components of grapefruit juice can reverse drug resistance in bladder cancer cells resistant to chemotherapeutic agent epirubicin in vitro LJMU Institute for Health Research Conference (IHR)

Al-Groshi A, Evans AR, Ismail FMD, Nahar L, Sarker SD. . Cytotoxicity of Ruta chalepensis Against Human Cancer Cell Lines JPAG symposium

Segun PA, Ismail F, Ogbole OO, Nahar L, Evans AR, Sarker S. Resveratrol derivatives from Commiphora africana display cytotoxicity against MCF-7 carcinoma cells. Trends Nat. Prod. Res., PSE Young Scientists’ Meeting

Al-Groshi A, Evans AR, Ismail FMD, Nahar L, Sarker SD. phytochemical and cytotoxicity studies on Juniperus phoenicea grown in Libya APS conference,

Evans A, Brittain-Dissont S, Williams KJ, Stratford IJ, Airley RE. The facilitative glucose transporter GLUT-1 as a target for novel anti-cancer agents. Eur. J. Cancer, Suppl. :2004.

Segun PA, Ismail F, Ogbole OO, Nahar L, Evans AR, Sarker SD. Antiproliferative activities of Citrus aurantium against breast (MCF7), cervix (HeLa) and urinary bladder (EJ138) carcinoma cells >DOI

Sharma S, Hemers E, Evans A. Investigation into the role of HMGb1 in relation to myofibroblasts and cancer cells exposed to various conditions NCRI Poster Abstracts, National Cancer Research Institute (NCRI) :283-283

Evans AR, Alexander D, Burke P, Reed CJ. Toxicity and transfection efficiency: comparison between four commercially available non-viral transfection reagents in a human bronchial epithelial cell line. British Pharmaceutical Conference Abstract Book, :2001

Brittain-Dissont SJ, Williams KJ, Sheppard F, Evans A, Carruthers A, Stratford I, Airley R. Role of glucose transporter Glut-1 in tumour growth and response to therapy. Br. J. Cancer, Suppl 1 :2004

Chapters

Evans AR. 2013. Molecular Cell Biology Gaskell E, Rostron C. Therapeutics and Human Physiology: How drugs work (Intergrated Foundations Of Pharmacy) OUP Oxford 978-0199655298

Engagement & Impact

External collaboration:

Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain, Dr Jonai Pujol Gimenez & Prof. Maria Lostao

Department of Pharmacy, Huddersfield University, UK, Dr Rachel Airley

Tom Connors Cancer Research Unit, University of Bradford, UK., Dr Roger Phillips

Industrial connections:

Quality Control North West (QCNW) associated with the NHS, Lead supervisor for 1 MSc students funded by Quality Control North West (QCNW) as part of a larger National study (VEGF in Age-related choroidal Neovascularisation study (IVAN)). 2nd supervisor for 1 MSc student funded by Quality Control North West (QCNW) and the Marie Curie Palliative Care Institute, Liverpool)

Membership of professional bodies:

British Association of Cancer Research (BACR), British Association of Cancer Research (BACR)

Research Grants Awarded:

The School of Pharmacy and Bimolecular Science, The role of HMGb1 in relation to myofibroblasts and cancer cells exposed to various microenvironmental stress conditions, Grant value (£): Approx Value £40,000, Duration of research project: 3 years