Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Darren Sexton

Dr Darren Sexton

Publications

Journal article

Dubourg A, Xia D, Winpenny JP, Naimi SA, Bouzid M, Sexton DW, Wastling JM, Hunter PR, Tyler KM. 2018. Giardia Secretome Highlights Secreted Tenascins as a Key Component of Pathogenesis. Gigascience, >DOI >Link

Hanson K, Robinson SR, Al-Yousuf K, Hendry AE, Sexton DW, Sherwood V, Wheeler GN. 2018. The anti-rheumatic drug, leflunomide, synergizes with MEK inhibition to suppress melanoma growth ONCOTARGET, 9 :3815-3829 >DOI >Link

Richardson A, Muir L, Mousdell S, Sexton D, Jones S, Howl J, Ross K. 2018. Modulation of mitochondrial activity in HaCaT keratinocytes by the cell penetrating peptide Z-Gly-RGD(DPhe)-mitoparan BMC Research Notes, 11 :82-82 >DOI

Kotecha J, Shulgina L, Sexton D, Atkins C, Wilson A. 2016. Plasma Vascular Endothelial Growth Factor Concentration and Alveolar Nitric Oxide as Potential Predictors of Disease Progression and Mortality in Idiopathic Pulmonary Fibrosis Journal of Clinical Medicine, 5 :80-80 >DOI

Steverding D, Tyler KM, Sexton DW. 2016. Evaluation of marking of peer marking in oral presentation. Perspectives on medical education, 5 :103-107

Bidula S, Sexton DW, Schelenz S. 2016. Serum opsonin ficolin-A enhances host-fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 205 :133-142 >DOI >Link

Wang W, Yu G, Sexton DW, Wileman T, Bao Y, He Y, Li B, Roberts AA, Hamilton CJ, Liu R, Chao Y, Shan Y. 2015. Sulforaphane protects the liver against CdSe quantum dot-induced cytotoxicity PLoS ONE, 10 >DOI

Jacques RO, Mills SC, Zerwes PC, Fagade FO, Green JE, Downham S, Sexton DW, Mueller A. 2015. Dynamin function is important for chemokine receptor-induced cell migration CELL BIOCHEMISTRY AND FUNCTION, 33 :407-414 >DOI >Link

Bidula S, Sexton DW, Yates M, Abdolrasouli A, Shah A, Wallis R, Reed A, Armstrong-James D, Schelenz S. 2015. H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses IMMUNOLOGY, 146 :281-291 >DOI >Link

Bidula S, Sexton DW, Abdolrasouli A, Shah A, Reed A, Armstrong-James D, Schelenz S. 2015. The serum opsonin L-ficolin is detected in lungs of human transplant recipients following fungal infections and modulates inflammation and killing of aspergillus fumigatus Journal of Infectious Diseases, 212 :234-246 >DOI

Ellis S, Sexton DW, Steverding D. 2015. Trypanotoxic activity of thiosemicarbazone iron chelators Experimental Parasitology, 150 :7-12 >DOI

Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. 2014. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 9 :715-721 >DOI >Link

Campwala H, Sexton DW, Crossman DC, Fountain SJ. 2014. P2Y6receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells Journal of Cell Science, 127 :4964-4973 >DOI

Steverding D, Sexton DW. 2013. Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling Parasites and Vectors, 6 >DOI

Livak KJ, Wills QF, Tipping AJ, Datta K, Mittal R, Goldson AJ, Sexton DW, Holmes CC. 2013. Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells Methods, 59 :71-79 >DOI

Prussin C, Scott GD, Fryer AD, Schroeder S, Masterson JC, Fillon S, Furuta GT, Akuthota P, Xenakis JJ, Wang H, Weller PF, Jacobsen EA, Teplinsky A, Elishmereni M, Katz HR, Levi-Schaffer F, Chu VT, Berek C, Sexton DW, Walsh GM, Wole Odemuyiwa SO, Tulic MK, Cravetchi VO, Lee JJ, Moqbel R. 2013. Eosinophil Cell-Cell Communication :329-390 >DOI

Sexton DW. 2013. Eosinophil apoptosis and fate :257-284

Phillips EA, Sexton DW, Steverding D. 2013. Bitter melon extract inhibits proliferation of Trypanosoma brucei bloodstream forms in vitro Experimental Parasitology, 133 :353-356 >DOI

Kerr JS, Jacques RO, Moyano Cardaba C, Tse T, Sexton D, Mueller A. 2013. Differential regulation of chemotaxis: Role of Gβγ in chemokine receptor-induced cell migration Cellular Signalling, 25 :729-735 >DOI

Bidula S, Kenawy H, Ali YM, Sexton D, Schwaeble WJ, Schelenz S. 2013. Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic aspergillus species Infection and Immunity, 81 :1730-1740 >DOI

Wills QF, Livak KJ, Tipping AJ, Enver T, Goldson AJ, Sexton DW, Holmes C. 2013. Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments Nature Biotechnology, 31 :748-752 >DOI

Schelenz S, Kirchhof N, Bidula S, Wallis R, Sexton DW. 2013. Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans. Immunobiology, 218 :477-483 >DOI >Link

Steverding D, Sexton DW, Wang X, Gehrke SS, Wagner GK, Caffrey CR. 2012. Trypanosoma brucei: Chemical evidence that cathepsin L is essential for survival and a relevant drug target International Journal for Parasitology, 42 :481-488 >DOI

Steverding D, Sexton DW, Chrysochoidi N, Cao F. 2012. Trypanosoma brucei transferrin receptor can bind C-lobe and N-lobe fragments of transferrin Molecular and Biochemical Parasitology, 185 :99-105 >DOI

Greatorex JS, Page RF, Curran MD, Digard P, Enstone JE, Wreghitt T, Powell PP, Sexton DW, Vivancos R, Nguyen-Van-Tam JS. 2010. Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1 PLoS ONE, 5 >DOI

Steverding D, Wang X, Sexton DW. 2009. The trypanocidal effect of NO-releasing agents is not due to inhibition of the major cysteine proteinase in Trypanosoma brucei Parasitology Research, 105 :1333-1338 >DOI

Winpenny JP, Marsey LL, Sexton DW. 2009. The CLCA gene family: Putative therapeutic target for respiratory diseases Inflammation and Allergy - Drug Targets, 8 :146-160 >DOI

Sexton DW. 2008. Targeting airway inflammation: PMX464 and the epithelial bulls eye British Journal of Pharmacology, 155 :620-622 >DOI

Walsh GM, Al-Rabia M, Blaylock MG, Sexton DW, Duncan CJA, Lawrie A. 2005. Control of eosinophil toxicity in the lung Current Drug Targets: Inflammation and Allergy, 4 :481-486 >DOI

Sexton DW, Walsh GM. 2005. Airway inflammation resolution CLINICAL AND EXPERIMENTAL ALLERGY, 35 :838-840 >DOI >Link

Al-Rabia MW, Blaylock MG, Sexton DW, Walsh GM. 2004. Membrane receptor-mediated apoptosis and caspase activation in the differentiated EoL-1 eosinophilic cell line JOURNAL OF LEUKOCYTE BIOLOGY, 75 :1045-1055 >DOI >Link

Sexton DW, Al-Rabia M, Blaylock MG, Walsh GM. 2004. Phagocytosis of apoptotic eosinophils but not neutrophils by bronchial epithelial cells CLINICAL AND EXPERIMENTAL ALLERGY, 34 :1514-1524 >DOI >Link

Al-Rabia MW, Blaylock MG, Sexton DW, Thomson L, Walsh GM. 2003. Granule protein changes and membrane receptor phenotype in maturing human eosinophils cultured from CD34(+) progenitors CLINICAL AND EXPERIMENTAL ALLERGY, 33 :640-648 >DOI >Link

Walsh GM, Sexton DW, Blaylock MG. 2003. Corticosteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma JOURNAL OF ENDOCRINOLOGY, 178 :37-43 >DOI >Link

Thomson L, Blaylock MG, Sexton DW, Campbell A, Walsh GM. 2002. Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells CLINICAL AND EXPERIMENTAL ALLERGY, 32 :1187-1192 >DOI >Link

Sexton DW, Walsh GM. 2002. Eosinophil-epithelial cell interactions: an important facet of asthmatic inflammation CLINICAL AND EXPERIMENTAL ALLERGY, 32 :811-813 >DOI >Link

Sexton DW, Blaylock MG, Walsh GM. 2001. Human alveolar epithelial cells engulf apoptotic eosinophils by means of integrin- and phosphatidylserine receptor-dependent mechanisms: A process upregulated by dexamethasone JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 108 :962-969 >DOI >Link

Walsh GM, Sexton D, Blaylock M. 1999. Ligation of CD45 and CD45RA & RB induces apoptosis in human eosinophils. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 :A33-A33 >Link

Blaylock MG, Sexton DW, Walsh GM. 1999. Ligation of CD45 and the isoforms CD45RA and CD45RB accelerates the rate of constitutive apoptosis in human eosinophils JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 104 :1244-1250 >DOI >Link

Walsh GM, Sexton DW, Blaylock MG, Convery CM. 1999. Resting and cytokine-stimulated human small airway epithelial cells recognize and engulf apoptotic eosinophils BLOOD, 94 :2827-2835 >Link

Conference publication

Osman N, Sexton D, Hutcheon G, Saleem I. 2017. COMPARATIVE NANOTOXICOLOGY OF POLYMERIC NANOCARRIERS WITH DIFFERENT SURFACE CHARGE AGAINST HUMAN LUNG EPITHELIAL CELLS JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 30 :A17-A18 >Link

Poster

Richardson A, Sexton D, Powell AK, Ross K. 2017. A store-operated calcium entry-dependent regulatory loop between nuclear factor of activated T-cells 1 and miR-184 in keratinocytes Non-Coding RNA: Recent Insights into the Mechanism of Action, Biochemical Society Conference, Edinburgh, UK

Richardson A, Sexton D, Powell AK, Ross K. 2017. Defining the Role of Argonautes in Human Epidermal Keratinocytes British Society for Investigative Dermatology Annual Meeting, Manchester, UK

Richardson A, Sexton D, Powell AK, Ross K. 2016. Argonaute Expression in Psoriasis and Epidermal Keratinocytes. Inflammatory diseases - mechanisms and clinical perspectives, Maynooth University, Ireland. A Biochemical Society Focused Meeting.

Chapters

Sexton DW. 2012. Eosinophil apoptosis and fate Eosinophils: Structure, Biological Properties and Role in Disease :257-284 9781611222708

Engagement & Impact

Editorial boards:

Recent Patents on Inflammation & Allergy Drug Discovery, Editorial Board, http://test.benthamscience.com/journal/editorial-board.php?journalID=rpiad

Journal of Cell Death, Editorial Board, http://www.la-press.com/journal.php?pa=editorial_board&journal_id=124

External PGR examinations performed:

University of Messina, Italy, PhD, Chemopreventive effect of Sulforaphane on a bladder cancer cell line

University of East Anglia, PhD, Immune System Involvement in Metal Hip Implant Failure

University of East Anglia, PhD, The vascular and anti-inflammatory activity of cyanidin-3-glucoside and its metabolites in human vascular endothelial cells

University of Cambridge, PhD, Cellular Responses to synthetic intestinal calcium phosphate nanoparticles containing bacterial cargo

Membership of professional bodies:

Member of the British Society for Immunology, British Society for Immunology, https://www.immunology.org/

Member of International Eosinophil Society, International Eosinophil Society, http://www.eosinophil-society.org/about-ies/mission-statement

Member of European Respiratory Society, European Respiratory Society, http://www.ersnet.org/