Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Fyaz Ismail

Dr Fyaz Ismail

Telephone: 0151 231 2231

Biography

I began my career in 1983 as a part time lecturer and demonstrator whilst completing a pre-doctoral appointment fro British Petroleum. Concurrently whilst lecturing, I went to complete a part -time PhD in "Inhibition of lipid autoxidation in amphipathic systems". In 1989 I took up a Monsanto research fellowship at Reading University with Dr. Neal Stuart Isaacs at the High pressure research Unit. In 1991 I was appointed as a senior lecturer in Spectroscopy and Medicinal and Organic Chemistry at Hatfield polytechnic which became the University of Hertfordshire shortly thereafter. After a decade I moved to LJMU where I became a Subject leader in medicinal chemistry (until 2005).

Degrees

1989, University of Salford, Salford, United Kingdom, PhD

Publications

Journal Articles

Uddin S, Alnsour L, Segun P, Servi H, Celik S, Gokturk S, Al-Groshi A, Al-Majmaie S, Guetchueng ST, Nahar L, Dempster N, Ismail FMD, Ritchie KJ, Sarker SD. 2017. Flavonoids from two Turkish Centaurea species and their chemotaxonomic implications Trends in Phytochemical Research (TPR), 1 :243-248

Nurunnabi TR, Nahar L, Al-Majmaie S, Rahman SMM, Sohrab MH, Billah MM, Ismail FMD, Rahman MM, Sharples GP, Sarker SD. 2017. Anti-MRSA activity of oxysporone and xylitol from the endophytic fungus Pestalotia sp. growing on the Sundarbans mangrove plant Heritiera fomes. Phytother Res, >DOI >Link

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Wansi JD, Evans A, Sarker SD. 2017. Kaurane Diterpenes from the Fruits of Zanthoxylum leprieurii (Rutaceae) RECORDS OF NATURAL PRODUCTS, 11 :304-309 >Link

Fielding AJ, Lukinovic V, Evans PG, Alizadeh-Shekalgourabi S, Bisby RH, Drew MGB, Male V, Del Casino A, Dunn JF, Randle LE, Dempster NM, Nahar L, Sarker SD, Reinhard FGC, de Visser SP, Dascombe MJ, Ismail FMD. 2017. Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines CHEMISTRY-A EUROPEAN JOURNAL, 23 :6811-6828 >DOI >Link

Khan KM, Nahar L, Al-Groshi A, Zavoianu AG, Evans A, Dempster NM, Wansi JD, Ismail FMD, Mannan A, Sarker SD. 2016. Cytotoxicity of the Roots of Trillium govanianum Against Breast (MCF7), Liver (HepG2), Lung (A549) and Urinary Bladder (EJ138) Carcinoma Cells PHYTOTHERAPY RESEARCH, 30 :1716-1720 >DOI >Link

Javed S, Oise IE, Nahar L, Ismail FMD, Mahmood Z, Sarker SD. 2016. Isolation, Identification and Antiproliferative Activity of Triterpenes from the Genus Monotheca A. DC. RECORDS OF NATURAL PRODUCTS, 10 :782-787 >Link

Lambert DJ, Parikh N, Messham SJ, Edwards G, Hieu VT, Dempster NM, Drew MGB, Nahar L, Sarker SD, Ismail FMD. 2015. One-pot synthesis and negative ion mass spectrometric investigation of a densely functionalized cinnoline TETRAHEDRON LETTERS, 56 :6980-6983 >DOI >Link

Oliveira FM, Barbosa LCA, Ismail FMD. 2014. The diverse pharmacology and medicinal chemistry of phosphoramidates - a review RSC ADVANCES, 4 :18998-19012 >DOI >Link

Ismail FMD, Geocze KC, Barbosa LCA, Fidencio PH, Silverio FO, Lima CF, Barbosa MCA. 2013. Essential oils from pequi fruits from the Brazilian Cerrado ecosystem FOOD RESEARCH INTERNATIONAL, 54 :1-8 >DOI

Geőcze KC, Barbosa LCA, Fidêncio PH, Silvério FO, Lima CF, Barbosa MCA, Ismail FMD. 2013. Essential Volatile oils from pequi fruits from the Brazilian Cerrado ecosystem Food Research International, 54

Green C, Ismail F. 2012. Why you still need to know about micelles Pharmaceutical Journal, 289 :344-345

Montanari RM, Barbosa LCA, Demuner AJ, Silva CJ, Andrade NJ, Ismail FMD, Barbosa MCA. 2012. Exposure to Anacardiaceae volatile oils and their constituents induces lipid peroxidation within food-borne bacteria cells. Molecules, 17 :9728-9740 >DOI >Link

Ismail FMD, Dascombe MJ, Drew MGB. 2009. Modulation of drug pharmacokinetics and pharmacodynamics by fluorine substitution Chimica Oggi Chemistry Today, 27 :16-20

Barbosa LCA, Maltha CRA, Cusati RC, Teixeira RR, Rodrigues FF, Silva AA, Drew MGB, Ismail FMD. 2009. Synthesis and Biological Evaluation of New Ozonides with Improved Plant Growth Regulatory Activity JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57 :10107-10115 >DOI >Link

Ismail FMD, Levitsky DO, Dembitsky VM. 2009. Aziridine alkaloids as potential therapeutic agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 44 :3373-3387 >DOI >Link

Silva CJ, Barbosa LCA, Maltha URA, Pinheiro AL, Ismail FMD. 2007. Comparative study of the essential oils of seven Meialeuca (Myrtaceae) species grown in Brazil FLAVOUR AND FRAGRANCE JOURNAL, 22 :474-478 >DOI >Link

Drew MGB, Metcalfe J, Dascombe MJ, Ismail FMD. 2007. De novo identification and stability of the artemisinin pharmacophore: Studies of the reductive decomposition of deoxyartemisinins and deoxyarteethers and the implications for the mode of antimalarial action JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 823 :34-46 >DOI >Link

Almeida Barbosa LC, Demuner AJ, Clemente AD, de Paula VF, Ismail FMD. 2007. Seasonal variation in the composition of volatile oils from Schinus terebinthifolius raddi QUIMICA NOVA, 30 :1959-1965 >Link

Teixeira RR, Barbosa LCA, Santana JO, Veloso DP, Ellena J, Doriguetto AC, Drew MGB, Ismail FMD. 2007. Synthesis and structural characterization of two nostoclide analogues JOURNAL OF MOLECULAR STRUCTURE, 837 :197-205 >DOI >Link

Drew MGB, Metcalfe J, Dascombe MJ, Ismail FMD. 2006. Reactions of artemisinin and arteether with acid: Implications for stability and mode of antimalarial action JOURNAL OF MEDICINAL CHEMISTRY, 49 :6065-6073 >DOI >Link

Denisov E, Denisova T, Ismail F. 2005. Intramolecular reactions of free radicals formed from artemisinin INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, 37 :554-565 >DOI

Drew MGB, Metcalfe J, Ismail FMD. 2005. Antimalarial drugs based on artemisinin: DFT calculations on the principal reactions JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 756 :87-95 >DOI >Link

Dascombe MJ, Drew MGB, Morris H, Wilairat P, Auparakkitanon S, Moule WA, Alizadeh-Shekalgourabi S, Evans PG, Lloyd M, Dyas AM, Carr P, Ismail FMD. 2005. Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: Design, construction, characterization, and pharmacology of metaquine JOURNAL OF MEDICINAL CHEMISTRY, 48 :5423-5436 >DOI >Link

El-Sayed MS, Younesian A, Rahman K, Ismail FM, El-Sayed Ali Z. 2004. The effects of arm cranking exercise and training on platelet aggregation in male spinal cord individuals. Thromb Res, 113 :129-136 >DOI >Link

Drew MGB, Metcalfe J, Ismail FMD. 2004. A DFT study of free radicals formed from artemisinin and related compounds JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 711 :95-105 >DOI >Link

Ismail FMD. 2002. Important fluorinated drugs in experimental and clinical use JOURNAL OF FLUORINE CHEMISTRY, 118 :27-33 >DOI >Link

Manzel L, Strekowski L, FMD I, Smith JC, Macfarlane DE. 1999. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: Mechanistic studies JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 291 :1337-1347

Yusof F, Audley BG, FMD I, Walker JM. 1998. Rapid Assay for the Incorporation of Isopentyl Diphosphate in Rubber Biosynthesis Journal of Rubber Research, 1 :48-66

Yusof F, Audley BG, FMD I, Walker JM. 1998. Rapid Assay for the Incorporation of Isopentyl Diphosphate in Rubber Biosynthesis Journal of Rubber Research, 1 :48-66

FMD I, Dascombe MJ, Carr P, SAM M, Rouault P. 1998. Novel aryl-bis-quinolines with antimalarial activity in-vivo JOURNAL OF PHARMACY AND PHARMACOLOGY, 50 :483-492

Isaacs NS, Ismail F, Hilton MJ, Coulson M. 1998. Mechanism of formation of benzothiazole-2-thiol JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 11 :1-9

Frearson MJ, Bhatt R, Carr P, FMD I. 1997. Electron impact induced elimination of HNO2 from trifluralin-phenylenediamine dimers - An ortho-effect resulting from a pi-pi interaction persisting into the vapour phase RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 11 :201-205

Hilton PJ, White RW, Lord GA, Garner GV, Gordon DB, Hilton MJ, Forni LG, McKinnon W, FMD I, Keenan M, Jones K, Morden WE. 1996. An inhibitor of the sodium pump obtained from human placenta LANCET, 348 :303-305

FMD I, Dascombe MJ, Carr PE, North S. 1996. An exploration of the structure-activity relationships of 4-aminoquinolines: Novel antimalarials with activity in-vivo JOURNAL OF PHARMACY AND PHARMACOLOGY, 48 :841-850

ISMAIL FMD, HILTON MJ, STEFINOVIC M. 1992. VERSATILE SYNTHESIS OF BENZOPYRANS VIA ORTHO-CLAISEN REARRANGEMENT OF ALLYL ETHERS TETRAHEDRON LETTERS, 33 :3795-3796 >DOI >Link

FMD I, MJ H, STEFINOVIC M. 1992. VERSATILE SYNTHESIS OF BENZOPYRANS VIA ORTHO-CLAISEN REARRANGEMENT OF ALLYL ETHERS TETRAHEDRON LETTERS, 33 :3795-3796

Sarker SD, Nahar L, Nurunnabi TR, Rahman SMM, Sohrab MH, Billah MM, Ismail FMD, Sharples GP. A mini-review on oxysporone Trends in Phytochemical Research,

Khan KM, Nahar L, Evans A, Ismail FMD, Dempster N, Al-Groshi A, Zazoianu AG, Wansi JD, Sarker SD. Evaluation of cytotoxicity of Trillium govanianum (Melanthiaceae) Phytotherapy Research,

lambert D, Parikh N, Messham SJ, Edwards G, Truong HV, Dempster NM, Drew MGB, Nahar L, Sarker SD, Ismail FMD. One-pot synthesis and negative ion mass spectrometric investigation of a densely functionalized cinnoline, 3-amino-5,7,8-trichloro-6-hydroxycinnoline-4-carbonitrile tetrahedron Letters,

Conference Publication (journal proceedings)

Ismail FMD, Tawfeek HM, Hutcheon GA, Saleem IY . 2011. Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 :303-334

Ismail FMD, Tawfeek HM, Hutcheon GW, Saleem IY. 2011. Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers DDL conference

Ismail FMD, Cox AH, Dempster NM , Ford JL , Dascombe MJ , Drew MGB . 2010. LC-MS & DFT Investigations of Cryptolepis Sanginolenta Root Extracts JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1489-1490

Ismail FMD, Dempster NM, Ford JL. 2009. Rapid and efficient isolation of cryptolepine from Cryptolepis sanguinolenta using focused microwave extraction methods: a haem-binding antimalarial JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A9-A10 >Link

Ismail FMD, Drew MGB, Navaratnam S, Bisby RH. 2009. A pulse radiolysis study of free radicals formed by one-electron oxidation of the antimalarial drug pyronaridine RESEARCH ON CHEMICAL INTERMEDIATES, 8th International Conference on Pulse Investigations in Chemistry, Biology and Physics 35 :363-377 >DOI >Link

Bhatt R, Carr P, Frearson M, Ismail F. 1998. Electron impact induced losses of HNO2 from trifluralin-phenylenediamine dimers mechanistic studies Advances in Mass Spectrometry, 22nd Annual British Mass Spectrometry Conference 14 :A016930/1-A016930/16

Segun PA, Ismail F, Ogbole OO, Nahar L, Evans AR, Sarker SD. Antiproliferative activities of Citrus aurantium against breast (MCF7), cervix (HeLa) and urinary bladder (EJ138) carcinoma cells >DOI

Ismail FMD, Bisby RH, Truong HV, Drew MGB, Dascombe MJ. Antimalarial Drug Reactions at the Heme Receptor: Vibartional Spectroscopy of Pyronaridine and other antimalarials Lasers for Science Facility User Meeting

Ismail FMD, Umar Z, Drew MGB. dentification of Novel intermolecular Interactions in self associating bis-quinolines The Science of Medicines, Pharm. Sci. 2001,

Ismail FMD, Abdullah A, Dempster NM, Saleem IY, Kasaija F, Alizadeh-Shekalgourabi S, Evans PG, Dascombe MGB, Drew MGB. Persistence of Solid Phase Interactions into the Gas Phase: Edge on Hydrogen Bonded Adducts of 1,5-napthyridine-4-ol with the Haem Cation The Science of Medicines, Pharm. Sci. 2001,

Ismail FMD. Observations of Asymmetry in the Solid and Solution State: Novel Applications of Newman's Rule of Six in Understanding Antimalarial Heterocycle Formation The Science of Medicines, Pharm. Sci. 2001, 1st September, 2011

Ismail FMD. Microwave Accelerated SNAr & Mannich Reactions: Atom Efficient Green Syntheses of 4-Aminoquinolines with Potent Antimalarial Activity in vivo The Science of Medicines, Pharm. Sci. 2011

Ismail FMD. Microwave Accelerated SNAr & Mannich Reactions: Atom Efficient Green Syntheses of 4-Aminoquinolines with Potent Antimalarial Activity in vivo The Science of Medicines, Pharm. Sci. 2011

Ismail FMD, Morris H, Dempster NM, Saleem IY, Kasaija IY, Truong HV, Randle LE, Alizadeh-Shekalgourabi S, Edwards G, Williams JP, Dascombe MJ, Drew MGB. Deducing the definitive geometry of chloroquine-haematin interactions using mass spectrometry and DFT investigations From Atoms to Biomolecules: Celebrating the technological innovations in mass spectrometry on the 30th Anniversary of Fast Atom Bombardment (FAB)

Ismail FMD, Abduallah , Dempster, NM, Saleem IY. Definitive Geometry of Chloroquine-Haematin Interactions: Spectroscopic, Spectrometric and DFT Investigations The Science of Medicines, Pharm. Sci. 2001, 1st September, 2011, D

Ismail FMD, Morris H, Dempster NM, Saleem IY, Kasaija F, Alizadeh-Shekalgourabi S, Edwards G, Ford JL, Dascombe MJ, Drew MGB. Defining Antimalarial Action of 4-Aminoquinolines using Spectroscopy, Spectrometry and DFT Theory The Many Paths to Patient Benefit" IHR Annual Conference

Ismail FMD. Xenobiotic Metabolism: Chemical Characterisation, Microsomal Incubations and HPLC-Electrospray Mass Spectrometry Analysis of Various Antimalarials Including Artemisinin, Pyronaridine and Novel Bisquinolines Especially Metaquine http://bmss.org.uk/Docs/BMSS%20Annual%20Meeting%202012%20-%20Poster%20Presentations.pdf, BMSS Annual Meeting 2012

Ismail FMD. DFT guided Ion-Mobility Studies Offer a Powerful Strategy for Understanding Pharmacodynamic Interactions within Antimalarial Haem Complexes http://bmss.org.uk/Docs/BMSS%20Annual%20Meeting%202012%20-%20Poster%20Presentations.pdf, BMSS Annual Meeting 2012

Ismail FMD, Cox AH, Dempster NM, Ford JL, Dascombe JL, Drew MGB. LC-MS & DFT Investigations of Cryptolepis Sanginolenta Root Extracts Journal of Pharmacy and Pharmacology, UK-PharmSci 2010, The Science of Medicines 62 :1489-1490

FMD I, Mahmood R, Evans PG, Conway E. Invited lecture: ISMAIL F.M.D.*, Mahmood, R; Evans, P. G.; Conway, E. : A Versatile Synthesis of benzofurans and benzopyrans via an ortho-Claisen rearrangement of aryl-allyl ethers: Reaction Mechanisms: The Royal Society of Chemsitry, , 9-12 July, 1996. Yes, Reaction Mechanisms: The Royal Society of Chemsitry, 6th International Meeting

FMD I. Invited Lecture: A Deductive Approach to the Elucidation of Pharmaceutical Structures using Multi-dimensional NMR spectroscopy. No, One day meeting on Applications of NMR Spectroscopy to Food and Pharmaceutical Analysis"Royal Society of Chemistry: Anaytical Divison-East Anglia Region

Alizadeh-Shekalgourabi S, Dascombe MJ, MGB D, Blackaby AJ, Moule WA, Evans PG, FMD I. Pharmacology, Spectroscopy and Molecular Modelling of Ro-47-7737 Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry (RSC), 11th Symposium of Medicinal Chemistry in Eastern England

FMD I, Dascombe MJ, Wilairat P, Auparakkitanon S, Moule WA, Evans PG, Blackaby AJ, Carr P, Alizadeh-Shekalgourabi S. Structural, Spectroscopic, Spectrometric and Biological properties of Synthetic 2,6-bispyrrolidin-yl methyl-phenol-9-amino-acridine Antimalarials: Pyronaridine and Pyracrine. No, Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry (RSC)11th Symposium of Medicinal Chemistry in Eastern England,2000

FMD I, Dascombe MJ, Carr P, Sutcliffe LJ, Wilairat P, Auparakkitanon S, Alizadeh-Shekalgourabi S, Moule WA, Evans PG. Poster Presentation: M.J. Dascombe, Fyaz M. D. Ismail, P. Wilairat, P. Carr, L. J. Sutcliffe, S. Auparakkitanon,S. Alizadeh-Shekalgourabi, W. A. Moule, P. G. Evans, Exploration of Structure-Activity Relationships beteeen monomeric and dimeric 4-aminoquinolines: Synthesis, Pharmacology & Molecular Modelling of Novel Antimalarials with activity in vivo. no, Gordon Conference: Malaria

FMD I, Banin M, Khan P, Li C, Tuladhar R, Winter B. WR238605 No, Gordon Conference: Malaria

FMD I. Invited Lecture: "Fluoropharma: Important fluorinated Drugs in Experimental and Clinical Use" No, Fluorine Technology Bureau meeting

FMD I. Synthesis of Putatative Antimalarials 2,3-dioxa-bicyclo[3.3.1]nonan-7-one using thiol mediated radical cascades. Yes, Free Radicals and Excited States in Chemistry and Biochemistry;19th -21st May 2003 CCLRC Daresbury Laboratory. A meeting of the Free Radical Research Facility @ Daresbury (http://www.frrf.dl.ac.uk/) sponsored by the European Commission’s “Transnational Access to Major Research Infrastructures – Enhancing Access to Research Infrastructures – Human Potential Programme” :1-25 >Link

Brooke R, Bisby RH, FMD I. Characterisation and quantification of phenolic antioxidants using the “Oxygen Radical Absorbance Capacity” (ORAC) assay for antioxidants: Invited Lecture Yes, Free Radicals and Excited States in Aqueous and Non-Aqueous Solutions: A meeting of the Free Radical Research Facility @ Daresbury (http://www.frrf.dl.ac.uk/) sponsored by the European Commission’s “Transnational Access to Major Research Infrastructures – Enhancing Access to Research Infrastructures – Human Potential Programme” :1-37

FMD I. Accelerating Antimalarial Drug Discovery Using focused Microwaves: Discovery and Synthesis of Metaquine: invited lecture No, "The applications of microwaves in synthetic and analytical chemistry" One day Joint Symposium by The Royal Society of Chemistry Liverpool section & Northwest Analytical Division

FMD I, Dascombe MJ, Drew MGBM, Morris H, Wilairat P, Auparakkitanon S, Moule WA, Alizadeh-Shekalgourabi S, Evans PG, Lloyd M, Dyas AM, Carr P, Suttcliffe L. Mapping Functional Antimalarial Pharmacophores as a Useful Tool for the Rapid Discovery of Drugs Effective In Vivo: Design, Construction, Characterization, and Pharmacology of Weakly Basic Azacycles No, Gordon Conference: Malaria >Link

Bisby RH, FMD I, Navaratnam S, MGB D. Pulse radiolysis and Density functional Theory studies of the benznaphthyridine antimalarial drug pyronaridine No, UK Synchrotron Radiation User Meeting 2008

FMD I, Dempster NM, Ford JL. Rapid and efficient isolation of cryptolepine from Cryptolepis sanguinolenta using focused microwave extraction methods: a haem-binding antimalarial yes, BPC Conference 2009 Science

Posters

Ismail FMD, Ford JL, Dempster NM, Edwards G, Morris H, Saleem I, Alrawahi A, Azam M, Dascombe MJ, Smith M, Parker AW, Clark IP, Alizadeh-Shekalgourabi S, Drew MGB. 2010. Quantification of Haem:Antimalarial Drug Receptor Geometry by Crystallography, DFT, Spectroscopic and Spectrometric Methods in vitro and in silico BMSS2010: Mass Spectrometry in a Changing World

FMD I, Dascombe MJ. 1996. Correlation of Biological Activity with NMR Spectral Parameters for Various Antimalarials. Division of Neursoscience, School of Biological Sciences, Stopford Building 1.124, University of Manchester M13 9PT, United Kingdom.

FMD I, Forristal A, Alizadeh-shekalghorabi S. 1996. Poster presentation. Correlation of NMR Spectral parameters with biological activity of 1,2,4-trioxanes. RSC/SCI Medicinal Chemistry Symposium September 4-7, Churchill College, Cambridge, UK RSC/SCI Medicinal Chemistry Symposium

Chapters

Dascombe MJ, MGB D, Evans PG, FMD I. 2007. Rational Design Strategies for the Development of Synthetic Quinoline and Acridine Based Antimalarials Caldwell GW, Atta-ur-Rahman , Player MR, Choudhary MI. Frontiers in Drug Design & Discovery: Structure-Based Drug Design in the 21st Century 3 :559-609 Bentham Science Publishers Ltd.

Internet Publications

FMD I. 2004. Nature of the TBA Chromogen

FMD I. 2003. Sources of Helpful Hints for Growing X-ray Quality Crystals

FMD I. 2003. di-tert-butylamine

FMD I. 2003. Web-dictionary of Organic abbreviations?

FMD I. 2002. Mifepristone (RU-486) The 'morning after' pill

FMD I. 2002. What is the Abramov Reaction???

FMD I. 2002. Overpressure Valves

FMD I. Patent Searches

Patents

MACFARLANE DE, STREKOWSKI L, MANZEL L, ISMAIL F, BARLIN GB. 2000. ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES

Atterwill CK, Purcell WM, FMD I. 1998. Targeted Antioxidants

Atterwill CK, Purcell WM, FMD I. 1998. Targeted Antioxidants

FMD I, Dascombe MJ. Novel bis-1,6-naphthyridines.

FMD I, Dascombe MJ. Novel bis-1,5-naphthyridines.

Theses / Dissertations

FMD I. 1989. Inhibition of Autoxidation in Amphipathic Systems Bisby RH. University of Salford, Lancashire, U.K

Other

FMD I, Dascombe MJ. Research into New Medicines for Malaria: Annual Review:Gateway to the new Era. University of Hertfordshire's Annual Review. 1999,

Engagement & Impact

Editorial boards:

Publication: Journal of Medicinal Chemsitry, Position: Reviewer

External collaboration:

Institution: Dr. Andrew Peters, Collaborator: Waters Corporation, Floats Rd, Manchester M23 9LZ

Institution: Waters Corporation, Floats Rd, Manchester M23 9LZ, Collaborator: Dr. John P Williams

Institution: SAFC Member of the Sigma-Aldrich Group 250 Cambridge Science Park, Milton Road Cambridge, Cambridgeshire, CB4 0WE, UK, Collaborator: Matt Tandy PhD CSci CChem MRSC Scientist

Institution: Pfizer Oncology Medicinal Chemistry 10777 Science Centre Drive La Jolla, CA 92130, USA, Collaborator: Dr. Neal Sach Senior Principal Scientist

External committees:

Committee name: New Medicines for Malaria Venture Expert Advisory Committee Meeting, Invited Presentation 1999, Organisation: MMV/WHO, Position: Special Advisor

External PGR examinations performed:

Name of University: University of Manchester, Award student examined for: PhD

Name of University: University of Manchester, Award student examined for: PhD

Industrial connections:

Company: Medicines for Malaria Venture (MMV) Consortium., Position or project: WHO special advisor

Membership of professional bodies:

APS, The Academy of Pharmaceutical Sciences, http://www.apsgb.co.uk/Default.asp

British Mass Spectrometry Society, British Mass Spectrometry Society

manager, Association of Managers in Magnetic Resonance Laboratories

member, Interwar Health Group

member, American Association for the Advancement of Science

member, Society for The History of Chemistry

member, Society for Chemistry and Industry

member, American Chemical Society

Research Grants Awarded:

Grand Challenges Explorations Bill & Melinda Gates Foundation, New Approaches for the Interrogation of Anti-malarial Compounds, Manchester University Reading University, University of Mahidol, Waters Corporation, Grant value (£): US $100,000 each, Duration of research project: 1 year