Journal article

Prieto JM, Fielding A, Ismail F, Nakouti I, Ehtezazi T, Rahman P, Fatokun AA, Ritchie KJ, Sarker SD. 2024. RESEARCH ACTIVITIES IN THE CENTRE FOR NATURAL PRODUCTS DISCOVERY IN 2023 Journal of Natural Products Discovery, 2 :1-6 DOI

Al Groshi A, Nahar L, Ismail FMD, Evans AR, Sarker SD. 2022. Dichloromethane Extract of the Leaves of Arbutus pavarii Pamp. Exhibits Cytotoxicity Against the Prostate Cancer Cell Line PC3: A Bioassay-guided Isolation and Identification of Arbutin and Betulinic Acid Methyl Ester Journal of Natural Products Discovery, 1 DOI Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Tchinda AT, Tarkang AP, Nnanga EN, Sarker SD. 2022. Haem Polymerization Inhibitory Activity and Cytotoxicity of Six Medicinal Plants Used in Cameroon for the Management of Malaria Acta Pharmaceutica Sciencia, 60 :235-245 DOI Publisher Url Public Url

Silva JG, de Miranda AS, Ismail FMD, Barbosa LCA. 2022. Synthesis and medicinal chemistry of tetronamides: Promising agrochemicals and antitumoral compounds. Bioorganic & medicinal chemistry, 67 :116815 DOI Author Url Publisher Url

Al Groshi A, Nahar L, Ismail FMD, Evans AR, Sarker SD. 2022. Bioassay-guided Isolation of Ursolic Acid as the Major Cytotoxic Compound Present in the Methanolic Extract of the Leaves of Arbutus pavarii Pamp Sarker SATYAJITD. Dhaka University Journal of Pharmaceutical Sciences, 20 :267-274 DOI Publisher Url Public Url

Kelly-Hunt AE, Mehan A, Brooks S, Leanca MA, McKay JED, Mahamed N, Lambert D, Dempster NM, Allen RJ, Evans AR, Sarker SD, Nahar L, Sharples GP, Drew MGB, Fielding AJ, Ismail FMD. 2021. Synthesis and Analytical Characterization of Purpurogallin: A Pharmacologically Active Constituent of Oak Galls Journal of Chemical Education, DOI Author Url Publisher Url Public Url

Nahar L, Talukdar AD, Nath D, Nath S, Mehan A, Ismail FMD, Sarker SD. 2020. Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential Molecules, 25 DOI Author Url Publisher Url Public Url

Ismail F. 2020. Weapons in the War against Malaria Horizon, :1-1 Publisher Url

Ismail FMD, Nahar L, Sarker SD. 2020. Application of INADEQUATE NMR techniques for directly tracing out the carbon skeleton of a natural product Phytochemical Analysis, 32 :7-23 DOI Author Url Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Dempster NM, Nnanga EN, Sarker SD. 2020. Phenolic compounds from the leaves and stem bark of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) Biochemical Systematics and Ecology, 91 DOI Author Url Publisher Url Public Url

Nurunnabi TR, Al-Majmaie S, Nahar L, Nakouti I, Rahman SMM, Sohrab MH, Billah MM, Ismail FMD, Sharples GP, Sarker SD. 2019. Sonneratinone: A New Antimicrobial Benzofuranone Derivative from the Endophytic Fungus Aspergillus niger Isolated from the Mangrove Plant Sonneratia apetala Buch.-Ham Trends in Phytochemical Research (TPR), 3 :225-230 Publisher Url Public Url

Cerceau C, Barbosa LCA, Alvarenga ES, Maltha CRA, Ismail FMD. 2019. H-1-NMR and GC for detection of adulteration in commercial essential oils of Cymbopogon ssp PHYTOCHEMICAL ANALYSIS, 31 :88-97 DOI Author Url Publisher Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Dempster NM, Evans AR, Sarker SD. 2019. Four new neo-clerodane diterpenes from the stem bark of Croton oligandrus. Natural Product Research, DOI Author Url Publisher Url Public Url

Al Groshi A, Jasim HA, Evans AR, Ismail FMD, Dempster NM, Nahar L, Sarker SD. 2019. Growth inhibitory activity of biflavonoids and diterpenoids from the leaves of the Libyan Juniperus phoenicea against human cancer cells Phytotherapy Research, 33 :2075-2082 DOI Author Url Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Dempster NM, Sarker SD. 2019. Justicialosides A and B, two new flavone glycosides from the leaves of Ruspolia hypocrateriformis (Vahl) Milne-Redh. (Acanthaceae) Phytochemistry Letters, 31 :101-103 DOI Author Url Publisher Url Public Url

Segun P, Ogbole O, Ismail FMD, Nahar L, Evans AR, Ajaiyeoba E, Sarker SD. 2019. Bioassay-Guided Isolation and Structure Elucidation of Cytotoxic Stilbenes and Flavonols from the Leaves of Macaranga barteri Fitoerapia, DOI Author Url Publisher Url Public Url

Segun PA, Ogbole OO, Ismail FMD, Nahar L, Evans AR, Ajaiyeoba EO, Sarker SD. 2018. Resveratrol derivatives from Commiphora africana (A. Rich.) Endl. display cytotoxicity and selectivity against several human cancer cell lines Phytotherapy Research, 33 :159-166 DOI Author Url Publisher Url Public Url

Segun P, Ismail FMD, Ogbole OO, Nahar L, Evans AR, Ajaiyeoba EO, Sarker SD. 2018. Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells Journal of Ethnopharmacology, 227 :131-138 DOI Author Url Publisher Url Public Url

Del Casino A, Lukinović V, Bhatt R, Randle LE, Dascombe MJ, Fennell BJ, Drew MGB, Bell A, Fielding AJ, Ismail FMD. 2018. Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials ChemistrySelect, 26 :7572-7580 DOI Author Url Publisher Url Public Url

Guetchueng S, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Sarker SD. 2018. Zanthoamides G-I: Three new alkamides from Zanthoxylum zanthoxyloides Phytochemistry Letters, 26 :125-129 DOI Author Url Publisher Url Public Url

Nurunnabi TR, Al-Majmaie S, Nakouti I, Nahar L, Rahman M, Sohrab H, Billah M, Ismail FMD, Sharples GP, Sarker SD. 2018. Antimicrobial activity of kojic acid from endophytic fungus Colletotrichum gloeosporioides isolated from Sonneratia apetala, a mangrove plant of the Sundarbans Asian Pacific Journal of Tropical Medicine, 11 :350-354 DOI Author Url Publisher Url Public Url

Al Groshi A, Evans AR, Ismail FMD, Nahar L, Sarker SD. 2018. Cytotoxicity of Libyan Juniperus phoenicea against Human Cancer Cell Lines A549, EJ138, Hepg2 and MCF7 Pharmcaceutical Sciences, 24 :3-7 DOI Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Sarker SD. 2018. ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex. Hutch. and Assessment of their Cytotoxicity Against Human Cancer Cell Lines Molecules, 23 DOI Author Url Publisher Url Public Url

Khan KM, Nahar L, Mannan A, Arfan M, Khan G, Al Groshi A, Evans AR, Dempster NM, Ismail FMD, Sarker SD. 2018. Liquid chromatography mass spectrometry analysis and cytotoxicity of Asparagus adscendens roots against human cancer cell lines Pharmacognosy Magazine, 13 :890-894 DOI Author Url Publisher Url Public Url

Uddin S, Alnsour L, Segun P, Servi H, Celik S, Gokturk S, Al-Groshi A, Al-Majmaie S, Guetchueng ST, Nahar L, Dempster NM, Ismail FMD, Ritchie KJ, Sarker SD. 2017. Flavonoids from two Turkish Centaurea species and their chemotaxonomic implications Trends in Phytochemical Research (TPR), 1 :243-248 Publisher Url Public Url

Nurunnabi TR, Nahar L, Al-Majmaie S, Rahman MM, Sohrab MH, Billah MM, Ismail FMD, Rahman MM, Sharples GP, Sarker SD. 2017. Anti-MRSA Activity of Oxysporone and Xylitol from the Endophytic Fungus Pestalotia sp. Growing on the Sundarbans Mangrove Plant Heritiera fomes Phytotherapy Research, DOI Author Url Publisher Url Public Url

Sarker SD, Nahar L, Nurunnabi TR, Rahman SMM, Sohrab MH, Billah MM, Ismail FMD, Sharples GP. 2017. A mini-review on oxysporone Trends in Phytochemical Research, 1 :55-60 Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail, FM, Wansi JD, Evans AR, Sarker SD. 2017. Kaurane diterpenes from the fruits of Zanthoxylum leprieurii (Rutaceae) Records of Natural Products, 11 :304-309 Author Url Publisher Url Public Url

Fielding AJ, Evans PG, Alizadeh S, Bisby R, Drew MGB, Del Casino A, Dunn JF, Randle LE, Dempster NM, Nahar L, Sarker SD, Cantú Reinhard FG, de Visser SP, Dascombe MJ, Ismail FMD. 2017. Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines Chemistry - A European Journal, DOI Author Url Publisher Url Public Url

Javed S, Oise IE, Nahar L, Ismail FMD, Mahmood Z, Sarker SD. 2016. Isolation, identification and antiproliferative activity of triterpenes from the genus Monotheca A. DC. Records of Natural Products, 10 :782-787 Author Url Publisher Url Public Url

Khan KM, Nahar L, Al-Groshi A, Zavoianu AG, Evans AR, Dempster NM, Wansi JD, Ismail FMD, Mannan A, Sarker SD. 2016. Cytotoxicity of the Roots of Trillium govanianum Against Breast (MCF7), Liver (HepG2), Lung (A549) and Urinary Bladder (EJ138) Carcinoma Cells. Phytotherapy Research, 30 :1716-1720 DOI Author Url Publisher Url Public Url

Lambert DJ, Parikh N, Messham SJ, Edwards G, Hieu VT, Dempster NM, Drew MGB, Nahar L, Sarker SD, Ismail FMD. 2015. One-pot synthesis and negative ion mass spectrometric investigation of a densely functionalized cinnoline TETRAHEDRON LETTERS, 56 :6980-6983 DOI Author Url Publisher Url

Lambert DJ, Parikh N, Messham SJ, Edwards G, Truong HV, Dempster NM, Drew MGB, Nahar L, Sarker SD, Ismail FMD. 2015. One-pot synthesis and negative ion mass spectrometric investigation of a densely functionalized cinnoline, 3-amino-5,7,8-trichloro-6-hydroxycinnoline-4-carbonitrile Tetrahedron Letters, 56 :6980-6983 Publisher Url Public Url

Oliveira FM, Barbosa LCA, Ismail FMD. 2014. The diverse pharmacology and medicinal chemistry of phosphoramidates - a review RSC Advances, 4 :18998-19012 DOI Author Url Publisher Url

Ismail FMD, Geocze KC, Barbosa LCA, Fidencio PH, Silverio FO, Lima CF, Barbosa MCA. 2013. Essential oils from pequi fruits from the Brazilian Cerrado ecosystem FOOD RESEARCH INTERNATIONAL, 54 :1-8 DOI

Geőcze KC, Barbosa LCA, Fidêncio PH, Silvério FO, Lima CF, Barbosa MCA, Ismail FMD. 2013. Essential Volatile oils from pequi fruits from the Brazilian Cerrado ecosystem Food Research International, 54 DOI Author Url Publisher Url

Montanari RM, Barbosa LCA, Demuner AJ, Silva CJ, Andrade NJ, Ismail FMD, Barbosa MCA. 2012. Exposure to Anacardiaceae volatile oils and their constituents induces lipid peroxidation within food-borne bacteria cells. Molecules, 17 :9728-9740 DOI Author Url Publisher Url

Green C, Ismail F. 2012. Why you still need to know about micelles Pharmaceutical Journal, 289 :344-345

Barbosa LCA, Maltha CRA, Cusati RC, Teixeira RR, Rodrigues FF, Silva AA, Drew MGB, Ismail FMD. 2009. Synthesis and Biological Evaluation of New Ozonides with Improved Plant Growth Regulatory Activity JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57 :10107-10115 DOI Author Url Publisher Url

Ismail FMD, Levitsky DO, Dembitsky VM. 2009. Aziridine alkaloids as potential therapeutic agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 44 :3373-3387 DOI Author Url Publisher Url

Ismail FMD, Dascombe MJ, Drew MGB. 2009. Modulation of drug pharmacokinetics and pharmacodynamics by fluorine substitution Chimica Oggi Chemistry Today, 27 :16-20

Drew MGB, Metcalfe J, Dascombe MJ, Ismail FMD. 2007. De novo identification and stability of the artemisinin pharmacophore: Studies of the reductive decomposition of deoxyartemisinins and deoxyarteethers and the implications for the mode of antimalarial action JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 823 :34-46 DOI Author Url Publisher Url

Silva CJ, Barbosa LCA, Maltha URA, Pinheiro AL, Ismail FMD. 2007. Comparative study of the essential oils of seven Meialeuca (Myrtaceae) species grown in Brazil FLAVOUR AND FRAGRANCE JOURNAL, 22 :474-478 DOI Author Url Publisher Url

Teixeira RR, Barbosa LCA, Santana JO, Veloso DP, Ellena J, Doriguetto AC, Drew MGB, Ismail FMD. 2007. Synthesis and structural characterization of two nostoclide analogues JOURNAL OF MOLECULAR STRUCTURE, 837 :197-205 DOI Author Url Publisher Url

Almeida Barbosa LC, Demuner AJ, Clemente AD, de Paula VF, Ismail FMD. 2007. Seasonal variation in the composition of volatile oils from Schinus terebinthifolius raddi QUIMICA NOVA, 30 :1959-1965 DOI Author Url Publisher Url

Drew MGB, Metcalfe J, Dascombe MJ, Ismail FMD. 2006. Reactions of artemisinin and arteether with acid: Implications for stability and mode of antimalarial action JOURNAL OF MEDICINAL CHEMISTRY, 49 :6065-6073 DOI Author Url Publisher Url

Drew MGB, Metcalfe J, Ismail FMD. 2005. Antimalarial drugs based on artemisinin: DFT calculations on the principal reactions JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 756 :87-95 DOI Author Url Publisher Url

Denisov E, Denisova T, Ismail F. 2005. Intramolecular reactions of free radicals formed from artemisinin INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, 37 :554-565 DOI Author Url Publisher Url

Dascombe MJ, Drew MGB, Morris H, Wilairat P, Auparakkitanon S, Moule WA, Alizadeh-Shekalgourabi S, Evans PG, Lloyd M, Dyas AM, Carr P, Ismail FMD. 2005. Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: Design, construction, characterization, and pharmacology of metaquine JOURNAL OF MEDICINAL CHEMISTRY, 48 :5423-5436 DOI Author Url Publisher Url

Drew MGB, Metcalfe J, Ismail FMD. 2004. A DFT study of free radicals formed from artemisinin and related compounds JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 711 :95-105 DOI Author Url Publisher Url

El-Sayed MS, Younesian A, Rahman K, Ismail FM, El-Sayed Ali Z. 2004. The effects of arm cranking exercise and training on platelet aggregation in male spinal cord individuals. Thromb Res, 113 :129-136 DOI Author Url Publisher Url

Ismail FMD. 2002. Important fluorinated drugs in experimental and clinical use JOURNAL OF FLUORINE CHEMISTRY, 118 :27-33 DOI Author Url Publisher Url

Manzel L, Strekowski L, FMD I, Smith JC, Macfarlane DE. 1999. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: Mechanistic studies JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 291 :1337-1347 Author Url

FMD I, Dascombe MJ, Carr P, SAM M, Rouault P. 1998. Novel aryl-bis-quinolines with antimalarial activity in-vivo JOURNAL OF PHARMACY AND PHARMACOLOGY, 50 :483-492 DOI Author Url Publisher Url

Isaacs NS, Ismail F, Hilton MJ, Coulson M. 1998. Mechanism of formation of benzothiazole-2-thiol JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 11 :1-9 DOI Author Url Publisher Url

Yusof F, Audley BG, FMD I, Walker JM. 1998. Rapid Assay for the Incorporation of Isopentyl Diphosphate in Rubber Biosynthesis Journal of Rubber Research, 1 :48-66

Yusof F, Audley BG, FMD I, Walker JM. 1998. Rapid Assay for the Incorporation of Isopentyl Diphosphate in Rubber Biosynthesis Journal of Rubber Research, 1 :48-66

Frearson MJ, Bhatt R, Carr P, FMD I. 1997. Electron impact induced elimination of HNO2 from trifluralin-phenylenediamine dimers - An ortho-effect resulting from a pi-pi interaction persisting into the vapour phase RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 11 :201-205 DOI Author Url Publisher Url

FMD I, Dascombe MJ, Carr PE, North S. 1996. An exploration of the structure-activity relationships of 4-aminoquinolines: Novel antimalarials with activity in-vivo JOURNAL OF PHARMACY AND PHARMACOLOGY, 48 :841-850 DOI Author Url Publisher Url

Hilton PJ, White RW, Lord GA, Garner GV, Gordon DB, Hilton MJ, Forni LG, McKinnon W, FMD I, Keenan M, Jones K, Morden WE. 1996. An inhibitor of the sodium pump obtained from human placenta LANCET, 348 :303-305 DOI Author Url Publisher Url

ISMAIL FMD, HILTON MJ, STEFINOVIC M. 1992. VERSATILE SYNTHESIS OF BENZOPYRANS VIA ORTHO-CLAISEN REARRANGEMENT OF ALLYL ETHERS TETRAHEDRON LETTERS, 33 :3795-3796 DOI Author Url Publisher Url

FMD I, MJ H, STEFINOVIC M. 1992. VERSATILE SYNTHESIS OF BENZOPYRANS VIA ORTHO-CLAISEN REARRANGEMENT OF ALLYL ETHERS TETRAHEDRON LETTERS, 33 :3795-3796 DOI Publisher Url

Khan KM, Nahar L, Evans AR, Ismail FMD, Dempster NM, Al-Groshi A, Zazoianu AG, Wansi JD, Sarker SD. Evaluation of cytotoxicity of Trillium govanianum (Melanthiaceae) Phytotherapy Research,

Conference publication

Sarker SD, Al Groshi A, Nahar L, Evans AR, Ismail FMD. 2023. Can Ruta chalepensis from Libya treat cancer. International Conference on Biotechnology in Sustainable Development

Benson SO, Ismail FMD, Fatokun A. 2020. PARPi-FL, a fluorescent version of the PARP inhibitor olaparib, exhibits decreased potency but similar efficacy compared to olaparib in a cell-based assay. Yes, British Pharmacological Society's Pharmacy 2019 2020 :47-48 DOI Publisher Url

Al Groshi A, Evans A, Jasim H, Ismail F, Dempster N, Nahar L, Sarker S. 2020. In vitro cytotoxicity of Arbutus pavarii against human cancer cell lines T20 PSE Conference :53-53

Al Groshi A, Evans A, Jasim HA, Ismail FMD, Dempster NM, Nahar L, Sarker SD. 2019. In vitro cytotoxicity of Asphodelus aestivus against human cancer cell lines PSE-YSM

Al Groshi A, Nahar L, Evans A, Ismail FMD, Sarker SD. 2019. Libyan medicinal plants and their cytotoxic compounds PSE-YSM

Sarker S, Nahar L, Al Groshi A, Al-Majmaie S, Sharples GP, Evans AR, Ismail FMD. 2018. Evidence-based phytotherapy: Revisiting Ruta chalepensis L Conference abstract,

Al Groshi A, Evans AR, Ismail FMD, Dempster NM, Nahar L, Sarker SD. 2018. In vitro cytotoxicity of Ruta chalepensis against human cancer cell lines PSE-YSM2018 Liverpool Conference abstract,

Javed SA, Ismail FMD, Evans AR, Nahar L, Sarker SD. 2018. Bioassay-guided fractionation through the cytotoxic activity of Sorbaria tomentosa PSE-YSM2018 Liverpool Conference Abstract,

Al-Groshi A, Evans AR, Ismail FMD, Dempster NM, Nahar L, Sarker SD. 2018. In vitro cytotoxicity of Ruta chalepensis against human cancer cell lines PSE-YSM

Javed S, Ismail FMD, Evans AR, Nahar L, Sarker SD. 2018. Bioassay-guided fractionation through the cytotoxic activity of Sorbaria tomentosa PSE-YSM

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Sarker SD. 2018. New alkaloids and other constituents from the fruits of Zanthoxylum zanthoxyloides and evaluation of their cytotoxicity International Journal of Clinical Pharmacology and drug therapy, 22nd International Congress 16 :34-34

Al-Groshi A, Evans AR, Ismail F, Jasim HA, Dempster N, Nahar L, Sarker S. 2018. Bioassay-guided isolation of cytotoxic compounds from the Libyan plant Juniperus Phoenicea Phytopharm 22nd International Congress

Al-Groshi A, Evans AR, Ismail FMD, Nahar L, Sarker SD. 2017. . Cytotoxicity of Ruta chalepensis Against Human Cancer Cell Lines JPAG symposium

Sagun PA, Ismail F, Ogbole OO, Nahar L, Evans A, Sarker S. 2017. Antiproliferative activities of Citrus aurantium against breast (MCF7), cervix (HeLa) and urinary bladder (EJ138) carcinoma cells DOI

Segun PA, Ismail F, Ogbole OO, Nahar L, Evans AR, Sarker SD. 2017. Antiproliferative activities of Citrus aurantium against breast (MCF7), cervix (HeLa) and urinary bladder (EJ138) carcinoma cells DOI Publisher Url

Segun PA, Ismail F, Ogbole OO, Nahar L, Evans AR, Sarker S. 2017. Resveratrol derivatives from Commiphora africana display cytotoxicity against MCF-7 carcinoma cells. Trends Nat. Prod. Res., PSE Young Scientists’ Meeting

Mehan A, Migaz N, Parikh N, Truong HV, Lambert DJ, Messham SJ, McKay J, Mahamed N, Brooks SJ, Lloyd M, Morris H, Dempster NM, Randle LE, Burrell HE, Sarker SD, Nahar L, Evans PG, Dascombe MJ, Strashnov N, Edwards G, Drew MGB, Barran P, Ismail FMD. 2015. Purpurogallin-A heme binding component of oak galls BMSS Annual Meeting: Birmingham Publisher Url Public Url

Al-Groshi A, Evans AR, Ismail FMD, Nahar L, Sarker SD. 2015. phytochemical and cytotoxicity studies on Juniperus phoenicea grown in Libya APS conference,

Ismail FMD, Tawfeek HM, Hutcheon GA, Saleem IY . 2011. Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 :303-334

Ismail FMD, Tawfeek HM, Hutcheon GW, Saleem IY. 2011. Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers DDL conference

Ismail FMD, Cox AH, Dempster NM , Ford JL , Dascombe MJ , Drew MGB . 2010. LC-MS & DFT Investigations of Cryptolepis Sanginolenta Root Extracts JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1489-1490

Ismail FMD, Drew MGB, Navaratnam S, Bisby RH. 2009. A pulse radiolysis study of free radicals formed by one-electron oxidation of the antimalarial drug pyronaridine RESEARCH ON CHEMICAL INTERMEDIATES, 8th International Conference on Pulse Investigations in Chemistry, Biology and Physics 35 :363-377 DOI Author Url Publisher Url

Ismail FMD, Dempster NM, Ford JL. 2009. Rapid and efficient isolation of cryptolepine from Cryptolepis sanguinolenta using focused microwave extraction methods: a haem-binding antimalarial JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A9-A10 Author Url

Bhatt R, Carr P, Frearson M, Ismail F. 1998. Electron impact induced losses of HNO2 from trifluralin-phenylenediamine dimers mechanistic studies Advances in Mass Spectrometry, 22nd Annual British Mass Spectrometry Conference 14 :A016930/1-A016930/16

FMD I, Dempster NM, Ford JL. Rapid and efficient isolation of cryptolepine from Cryptolepis sanguinolenta using focused microwave extraction methods: a haem-binding antimalarial yes, BPC Conference 2009 Science Publisher Url

Bisby RH, FMD I, Navaratnam S, MGB D. Pulse radiolysis and Density functional Theory studies of the benznaphthyridine antimalarial drug pyronaridine No, UK Synchrotron Radiation User Meeting 2008

FMD I, Dascombe MJ, Drew MGBM, Morris H, Wilairat P, Auparakkitanon S, Moule WA, Alizadeh-Shekalgourabi S, Evans PG, Lloyd M, Dyas AM, Carr P, Suttcliffe L. Mapping Functional Antimalarial Pharmacophores as a Useful Tool for the Rapid Discovery of Drugs Effective In Vivo: Design, Construction, Characterization, and Pharmacology of Weakly Basic Azacycles No, Gordon Conference: Malaria Author Url

FMD I. Accelerating Antimalarial Drug Discovery Using focused Microwaves: Discovery and Synthesis of Metaquine: invited lecture No, "The applications of microwaves in synthetic and analytical chemistry" One day Joint Symposium by The Royal Society of Chemistry Liverpool section & Northwest Analytical Division

Brooke R, Bisby RH, FMD I. Characterisation and quantification of phenolic antioxidants using the “Oxygen Radical Absorbance Capacity” (ORAC) assay for antioxidants: Invited Lecture Yes, Free Radicals and Excited States in Aqueous and Non-Aqueous Solutions: A meeting of the Free Radical Research Facility @ Daresbury (http://www.frrf.dl.ac.uk/) sponsored by the European Commission’s “Transnational Access to Major Research Infrastructures – Enhancing Access to Research Infrastructures – Human Potential Programme” :1-37 Publisher Url

FMD I. Synthesis of Putatative Antimalarials 2,3-dioxa-bicyclo[3.3.1]nonan-7-one using thiol mediated radical cascades. Yes, Free Radicals and Excited States in Chemistry and Biochemistry;19th -21st May 2003 CCLRC Daresbury Laboratory. A meeting of the Free Radical Research Facility @ Daresbury (http://www.frrf.dl.ac.uk/) sponsored by the European Commission’s “Transnational Access to Major Research Infrastructures – Enhancing Access to Research Infrastructures – Human Potential Programme” :1-25 Author Url Publisher Url

FMD I. Invited Lecture: "Fluoropharma: Important fluorinated Drugs in Experimental and Clinical Use" No, Fluorine Technology Bureau meeting

FMD I, Banin M, Khan P, Li C, Tuladhar R, Winter B. WR238605 No, Gordon Conference: Malaria

FMD I, Dascombe MJ, Carr P, Sutcliffe LJ, Wilairat P, Auparakkitanon S, Alizadeh-Shekalgourabi S, Moule WA, Evans PG. Poster Presentation: M.J. Dascombe, Fyaz M. D. Ismail, P. Wilairat, P. Carr, L. J. Sutcliffe, S. Auparakkitanon,S. Alizadeh-Shekalgourabi, W. A. Moule, P. G. Evans, Exploration of Structure-Activity Relationships beteeen monomeric and dimeric 4-aminoquinolines: Synthesis, Pharmacology & Molecular Modelling of Novel Antimalarials with activity in vivo. no, Gordon Conference: Malaria

FMD I, Dascombe MJ, Wilairat P, Auparakkitanon S, Moule WA, Evans PG, Blackaby AJ, Carr P, Alizadeh-Shekalgourabi S. Structural, Spectroscopic, Spectrometric and Biological properties of Synthetic 2,6-bispyrrolidin-yl methyl-phenol-9-amino-acridine Antimalarials: Pyronaridine and Pyracrine. No, Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry (RSC)11th Symposium of Medicinal Chemistry in Eastern England,2000

Alizadeh-Shekalgourabi S, Dascombe MJ, MGB D, Blackaby AJ, Moule WA, Evans PG, FMD I. Pharmacology, Spectroscopy and Molecular Modelling of Ro-47-7737 Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry (RSC), 11th Symposium of Medicinal Chemistry in Eastern England

FMD I. Invited Lecture: A Deductive Approach to the Elucidation of Pharmaceutical Structures using Multi-dimensional NMR spectroscopy. No, One day meeting on Applications of NMR Spectroscopy to Food and Pharmaceutical Analysis"Royal Society of Chemistry: Anaytical Divison-East Anglia Region

FMD I, Mahmood R, Evans PG, Conway E. Invited lecture: ISMAIL F.M.D.*, Mahmood, R; Evans, P. G.; Conway, E. : A Versatile Synthesis of benzofurans and benzopyrans via an ortho-Claisen rearrangement of aryl-allyl ethers: Reaction Mechanisms: The Royal Society of Chemsitry, , 9-12 July, 1996. Yes, Reaction Mechanisms: The Royal Society of Chemsitry, 6th International Meeting

Ismail FMD, Cox AH, Dempster NM, Ford JL, Dascombe JL, Drew MGB. LC-MS & DFT Investigations of Cryptolepis Sanginolenta Root Extracts Journal of Pharmacy and Pharmacology, UK-PharmSci 2010, The Science of Medicines 62 :1489-1490 Author Url Publisher Url

Ismail FMD. DFT guided Ion-Mobility Studies Offer a Powerful Strategy for Understanding Pharmacodynamic Interactions within Antimalarial Haem Complexes http://bmss.org.uk/Docs/BMSS%20Annual%20Meeting%202012%20-%20Poster%20Presentations.pdf, BMSS Annual Meeting 2012

Ismail FMD. Xenobiotic Metabolism: Chemical Characterisation, Microsomal Incubations and HPLC-Electrospray Mass Spectrometry Analysis of Various Antimalarials Including Artemisinin, Pyronaridine and Novel Bisquinolines Especially Metaquine http://bmss.org.uk/Docs/BMSS%20Annual%20Meeting%202012%20-%20Poster%20Presentations.pdf, BMSS Annual Meeting 2012

Ismail FMD, Morris H, Dempster NM, Saleem IY, Kasaija F, Alizadeh-Shekalgourabi S, Edwards G, Ford JL, Dascombe MJ, Drew MGB. Defining Antimalarial Action of 4-Aminoquinolines using Spectroscopy, Spectrometry and DFT Theory The Many Paths to Patient Benefit" IHR Annual Conference

Ismail FMD, Abduallah , Dempster, NM, Saleem IY. Definitive Geometry of Chloroquine-Haematin Interactions: Spectroscopic, Spectrometric and DFT Investigations The Science of Medicines, Pharm. Sci. 2001, 1st September, 2011, D

Ismail FMD, Morris H, Dempster NM, Saleem IY, Kasaija IY, Truong HV, Randle LE, Alizadeh-Shekalgourabi S, Edwards G, Williams JP, Dascombe MJ, Drew MGB. Deducing the definitive geometry of chloroquine-haematin interactions using mass spectrometry and DFT investigations From Atoms to Biomolecules: Celebrating the technological innovations in mass spectrometry on the 30th Anniversary of Fast Atom Bombardment (FAB)

Ismail FMD. Microwave Accelerated SNAr & Mannich Reactions: Atom Efficient Green Syntheses of 4-Aminoquinolines with Potent Antimalarial Activity in vivo The Science of Medicines, Pharm. Sci. 2011

Ismail FMD. Microwave Accelerated SNAr & Mannich Reactions: Atom Efficient Green Syntheses of 4-Aminoquinolines with Potent Antimalarial Activity in vivo The Science of Medicines, Pharm. Sci. 2011

Ismail FMD. Observations of Asymmetry in the Solid and Solution State: Novel Applications of Newman's Rule of Six in Understanding Antimalarial Heterocycle Formation The Science of Medicines, Pharm. Sci. 2001, 1st September, 2011

Ismail FMD, Abdullah A, Dempster NM, Saleem IY, Kasaija F, Alizadeh-Shekalgourabi S, Evans PG, Dascombe MGB, Drew MGB. Persistence of Solid Phase Interactions into the Gas Phase: Edge on Hydrogen Bonded Adducts of 1,5-napthyridine-4-ol with the Haem Cation The Science of Medicines, Pharm. Sci. 2001,

Ismail FMD, Umar Z, Drew MGB. dentification of Novel intermolecular Interactions in self associating bis-quinolines The Science of Medicines, Pharm. Sci. 2001,

Ismail FMD, Bisby RH, Truong HV, Drew MGB, Dascombe MJ. Antimalarial Drug Reactions at the Heme Receptor: Vibartional Spectroscopy of Pyronaridine and other antimalarials Lasers for Science Facility User Meeting

Al Groshi A, Nahar L, Evans A, Auzi A, Ismail F, Sarker S. Cytotoxicity of Asphodelus aestivus against two human cancer cell lines

Poster

Benson SO, Ismail FMD, Fatokun AA. 2021. A cell-based neuroprotection assay targeting poly (ADP-ribose) polymerase (PARP) reveals oncology-based potency ranking of clinically used PARP inhibitors (PARPi) ELRIG's Annual Drug Discovery Meeting (Drug Discovery 2021), The Exhibition Centre, ACC, Liverpool. 19-20 October, 2021.

Benson SO, Ismail FMD, Fatokun AA. 2021. 4′-methoxyflavone (4MF) and 3′,4′-dimethoxyflavone (DMF) directly bind to the poly (ADP-ribose) polymerase (PARP) enzyme to inhibit parthanatos British Pharmacological Society (BPS) Conference (Pharmacology 2021). 7-9 September, 2021. Online. Author Url

Benson SO, Ismail FMD, Fatokun AA. 2019. PARPi-FL, a fluorescent version of the PARP inhibitor olaparib, exhibits decreased potency but similar efficacy compared to olaparib in a cell-based assay British Pharmacological Society's Annual Meeting, Pharmacology 2019, 15-17 December 2019, Edinburgh International Conference Centre, Edinburgh, UK (poster was additionally competitively invited for a flash presentation (British Journal of Pharmacology 2020: 47-48)). DOI: 10.1111/bph.15035 Author Url

Benson SO, Ismail FMD, Fatokun AA. 2019. PARP inhibitors elicit concentration-dependent protection against PARP-mediated cell death even with a delayed addition of up to 12 hours post-insult ELRIG Drug Discovery Conference 2019, 5-6 November, 2019, Liverpool, UK

Ismail FMD, Ford JL, Dempster NM, Edwards G, Morris H, Saleem I, Alrawahi A, Azam M, Dascombe MJ, Smith M, Parker AW, Clark IP, Alizadeh-Shekalgourabi S, Drew MGB. 2010. Quantification of Haem:Antimalarial Drug Receptor Geometry by Crystallography, DFT, Spectroscopic and Spectrometric Methods in vitro and in silico BMSS2010: Mass Spectrometry in a Changing World

FMD I, Dascombe MJ. 1996. Correlation of Biological Activity with NMR Spectral Parameters for Various Antimalarials. Division of Neursoscience, School of Biological Sciences, Stopford Building 1.124, University of Manchester M13 9PT, United Kingdom.

FMD I, Forristal A, Alizadeh-shekalghorabi S. 1996. Poster presentation. Correlation of NMR Spectral parameters with biological activity of 1,2,4-trioxanes. RSC/SCI Medicinal Chemistry Symposium September 4-7, Churchill College, Cambridge, UK RSC/SCI Medicinal Chemistry Symposium

Chapters

Ismail FMD, Nahar L, Zhang KY, Sarker SD. 2020. Antiparasitic natural products Sarker SD, Nahar L. MEDICINAL NATURAL PRODUCTS: A DISEASE-FOCUSED APPROACH 55 :115-151 ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD DOI Author Url Publisher Url

Ismail FMD. 2019. Nature's Armamentarium against Malaria: Antimalarials and Their Semisynthetic Derivatives :333-373 Wiley DOI Publisher Url

Ismail FMD, Nahar L, Sarker S. 2018. Prediction of structure based on spectral data using computational techniques Sarker S, Nahar L. Computational Phytochemistry :193-230 Elsevier 978-0128-12364-5 DOI Publisher Url

Ismail FMD, Nahar L, Sarker S. 2018. High-throughput screening of phytochemicals: Application of computational methods Sarker S, Nahar L. Computational Phytochemistry :165-192 Elsevier 978-0128-12364-5 DOI Publisher Url

Adhikari N, Amin SA, Ardura DA, Atteya WA, Beck JJ, Chetia P, Choudhury MD, Choudhury KD, Dahal K, Das AK, Dewanjee S, Ismail FMD, Jha T, Nahar L, Ningthoujam SS, Paradkar A, Rahman M, Rering CC, Saha A, Sarker SD, Talukdar AD, Trifan A, Willett DS, Wolfram E. 2018. Contributors Computational Phytochemistry :xiii-xiii Elsevier DOI Publisher Url

Dascombe MJ, MGB D, Evans PG, FMD I. 2007. Rational Design Strategies for the Development of Synthetic Quinoline and Acridine Based Antimalarials Caldwell GW, Atta-ur-Rahman , Player MR, Choudhary MI. Frontiers in Drug Design & Discovery: Structure-Based Drug Design in the 21st Century 3 :559-609 Bentham Science Publishers Ltd. DOI Publisher Url

Other

Horgan MJ, Leanca MA, Hill CE, Guetchueng ST, Drew MGB, Dempster NM, Nahar L, Sarker SD, Reinhard FGC, de Visser SP, Dascombe MJ, Fielding AJ, Ismail FMD. 2018. Black pepper as a source for new antimalarials

Al-Majmaie S, Nahar L, Sharples GP, Ismail FMD, Dempster NM, Sarker SD. 2018. In vitro antimicrobial activity of Ruta chalepensis growing in Iraq PSE-YSM2018 Liverpool Conference Abstract,

FMD I, Dascombe MJ. Research into New Medicines for Malaria: Annual Review:Gateway to the new Era. University of Hertfordshire's Annual Review. 1999,

Internet publication

FMD I. 2004. Nature of the TBA Chromogen Publisher Url

FMD I. 2003. Sources of Helpful Hints for Growing X-ray Quality Crystals Publisher Url

FMD I. 2003. di-tert-butylamine Publisher Url

FMD I. 2003. Web-dictionary of Organic abbreviations? Publisher Url

FMD I. 2002. What is the Abramov Reaction??? Publisher Url

FMD I. 2002. Mifepristone (RU-486) The 'morning after' pill Publisher Url

FMD I. 2002. Overpressure Valves Publisher Url

FMD I. Patent Searches Publisher Url

Report

FMD I, MGB D, Dascombe MJ, Clark IP, Parker AW. 2004. Unraveling the mechanism of 4-aminoquinoline antimalarial action. CCLRC Annual Report 2004 Author Url

FMD I, Dascombe MJ. 1999. The rational Design and Synthesis& pharmacological evaluation of novel Metazaquines :1-50 Author Url

FMD I. 1999. Establishing the site of protonation in alkyl and aryl bridged bisquinoline drugs using crystallography

FMD I. 1997. Global Networks, UH World of Natural Sciences; Special Issue Toad venom may find uses in medicine :6-6

FMD I, Parker A. 1997. Improvements in the Industrial production of Paclitaxel: A shorter ozonolytic route. Improvements in the Industrial production of Paclitaxel: A shorter ozonolytic route :1-50

FMD I, Richards JT, Cundall RB, Bisby RH. ISMAIL F.M.D., Richards,D. T.; Cundall, R. B. (1985) SERC Marine Technology Directorate/Shell U.K. Ltd Pharmacotherapeutic and Dietary Approaches for Preventing Oxygen Toxicity in the Diving Mammal.

Patent

MACFARLANE DE, STREKOWSKI L, MANZEL L, ISMAIL F, BARLIN GB. 2000. ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES Publisher Url

Atterwill CK, Purcell WM, FMD I. 1998. Targeted Antioxidants Publisher Url

Atterwill CK, Purcell WM, FMD I. 1998. Targeted Antioxidants Publisher Url

FMD I, Dascombe MJ. Novel bis-1,5-naphthyridines.

FMD I, Dascombe MJ. Novel bis-1,6-naphthyridines.

Thesis/Dissertation

FMD I. 1989. Inhibition of Autoxidation in Amphipathic Systems Bisby RH. University of Salford, Lancashire, U.K

Research Grants Awarded:

Faculty of Science, LJMU (PhD studentship), Identification and characterisation of novel poly (ADP-ribose) polymerase (PARP) inhibitors, Dr Amos Fatokun (lead supervisor), Dr Fyaz Ismail (co-supervisor), Grant value (£): 62,000, Duration of research project: 3 years. 2019

Grand Challenges Explorations Bill & Melinda Gates Foundation, New Approaches for the Interrogation of Anti-malarial Compounds, Manchester University Reading University, University of Mahidol, Waters Corporation, Grant value (£): US $100,000 each, Duration of research project: 1 year. 2012

External collaboration:

Dr. Andrew Peters, Waters Corporation, Floats Rd, Manchester M23 9LZ. 2011

Waters Corporation, Floats Rd, Manchester M23 9LZ, Dr. John P Williams. 2011

SAFC Member of the Sigma-Aldrich Group 250 Cambridge Science Park, Milton Road Cambridge, Cambridgeshire, CB4 0WE, UK, Matt Tandy PhD CSci CChem MRSC Scientist. 2011

Pfizer Oncology Medicinal Chemistry 10777 Science Centre Drive La Jolla, CA 92130, USA, Dr. Neal Sach Senior Principal Scientist. 1999

External PGR examinations performed:

University of Manchester, PhD. 2011

University of Manchester, PhD. 2010

Membership of professional bodies:

APS, The Academy of Pharmaceutical Sciences, http://www.apsgb.co.uk/Default.asp. 2010

British Mass Spectrometry Society, British Mass Spectrometry Society. 2010

manager, Association of Managers in Magnetic Resonance Laboratories.

member, American Association for the Advancement of Science.

member, American Chemical Society.

member, Interwar Health Group.

member, Society for Chemistry and Industry.

member, Society for The History of Chemistry.

Industrial connections:

Medicines for Malaria Venture (MMV) Consortium., WHO special advisor. 1998

External committees:

New Medicines for Malaria Venture Expert Advisory Committee Meeting, Invited Presentation 1999, MMV/WHO, Special Advisor. 1998

Editorial boards:

Journal of Medicinal Chemsitry, Reviewer. 1991