Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Iain Dykes

Dr Iain Dykes

Telephone: 0151 231 8100

Biography

I am interested in embryonic development and genetics. I study the genetic basis of congenital heart disease. Much of my previous work has been concerned with how transcription factors regulate developmental processes and lineage commitment within the embryo. I'm also interested in post-transcriptional mechanisms of gene regulation such as non-coding RNA as well as exosome-based intercellular communication.

Degrees

2002, Sussex University, United Kingdom, Ph.D. Molecular biology
1997, University of Bristol, United Kingdom, B.Sc.Zoology

Academic appointments

Senior Lecturer in Molecular Biology, Liverpool John Moores University, 2018 - present
Lecturer in Cardiovascular basic science, University of Bristol, 2016 - 2018
Postdoctoral research in Congenital heart disease, University of Oxford, 2013 - 2016
Postdoctoral research in Congenital heart disease, University College London (Institute of Child Health), 2010 - 2013
Postdoctoral research in Neuroscience, University of California San Diego, 2002 - 2008

Publications

Highlighted publications

Turton N, Swan R, Mahenthiralingam T, Pitts D, Dykes IM. 2019. The Functions of Long Non-Coding RNA during Embryonic Cardiovascular Development and Its Potential for Diagnosis and Treatment of Congenital Heart Disease Journal of Cardiovascular Development and Disease, 6 >DOI >Public Url

Journal article

Turton N, Swan R, Mahenthiralingam T, Pitts D, Dykes IM. 2019. The Functions of Long Non-Coding RNA during Embryonic Cardiovascular Development and Its Potential for Diagnosis and Treatment of Congenital Heart Disease Journal of Cardiovascular Development and Disease, 6 >DOI >Public Url

Dykes IM, van Bueren KL, Scambler PJ. 2018. HIC2 regulates isoform switching during maturation of the cardiovascular system. Journal of Molecular and Cellular Cardiology, 114 :29-37 >DOI >Link >Public Url

Dykes IM, Szumska D, Kuncheria L, Puliyadi R, Chen C, Papanayotou C, Lockstone H, Dubourg C, David V, Schneider JE, Keane TM, Adams DJ, Brown SDM, Mercier S, Odent S, Collignon J, Bhattacharya S. 2018. A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity Scientific Reports, 8 >DOI >Public Url

Dykes IM, Emanueli C. 2017. Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. Genomics, Proteomics and Bioinformatics, 15 :177-186 >DOI >Link >Public Url

Dykes IM. 2017. Exosomes in Cardiovascular Medicine Cardiology and Therapy, 6 :225-237 >DOI >Public Url

Dykes IM, van Bueren KL, Ashmore RJ, Floss T, Wurst W, Szumska D, Bhattacharya S, Scambler PJ. 2014. HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circulation research, 115 :23-31 >DOI

Dykes IM. 2014. Left Right Patterning, Evolution and Cardiac Development. Journal of cardiovascular development and disease, 1 :52-72 >DOI

Dykes IM, Tempest L, Lee S-I, Turner EE. 2011. Brn3a and Islet1 Act Epistatically to Regulate the Gene Expression Program of Sensory Differentiation JOURNAL OF NEUROSCIENCE, 31 :9789-9799 >DOI >Link

Dykes IM, Lanier J, Eng SR, Turner EE. 2010. Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation NEURAL DEVELOPMENT, 5 >DOI >Link

Dykes IM. 2010. A molecular study of regeneration in the CNS of the leech, Hirudo medicinalis.

Lanier J, Dykes IM, Nissen S, Eng SR, Turner EE. 2009. Brn3a Regulates the Transition from Neurogenesis to Terminal Differentiation and Represses Non-Neural Gene Expression in the Trigeminal Ganglion DEVELOPMENTAL DYNAMICS, 238 :3065-3079 >DOI >Link

Sun Y, Dykes IM, Liang X, Eng SR, Evans SM, Turner EE. 2008. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs NATURE NEUROSCIENCE, 11 :1283-1293 >DOI >Link

Eng SR, Dykes IM, Lanier J, Fedtsova N, Turner EE. 2007. POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia NEURAL DEVELOPMENT, 2 >DOI >Link

Dykes IM, Macagno ER. 2006. Molecular characterization and embryonic expression of innexins in the leech Hirudo medicinalis DEVELOPMENT GENES AND EVOLUTION, 216 :185-197 >DOI >Link

Dykes IM, Freeman FM, Bacon JP, Davies JA. 2004. Molecular basis of gap junctional communication in the CNS of the leech Hirudo medicinalis JOURNAL OF NEUROSCIENCE, 24 :886-894 >DOI >Link

Dykes IM, Davies JA. 2004. Cloning and expression of a leech complexin GENE EXPRESSION PATTERNS, 4 :93-97 >DOI >Link

Engagement & Impact

Research Grants Awarded:

Newlife Foundation for sick children, Exosome based signalling in the embryo and congenital heart disease, Grant value (£): £13,230

Teaching qualification:

Fellow of The Higher Education Academy

Associate Fellow of The Higher Education Academy