Dr Iftikhar Khan

Pharmacy and Biomolecular Sciences

Biosketch
I am currently a Lecturer/Senior Lecturer in Pharmaceutics within the School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, UK. I attained my Pharmacy degree from the University of Peshawar, Pakistan. Upon completing my BPharm, I worked extensively in industry involved in quality control for manufacture of solid dosage forms. I subsequently completed my MSc in Pharmaceutical Analysis from Sheffield Hallam University; focusing upon antibiotic synthesis. Following MSc, I was fortunate to go onto complete my PhD at the University of Central Lancashire on scholarship; thesis entitled “Compressible Proliposome Formulations For Nebulization”.

Research Interests;
• Micro and Nano-scale Drug Delivery
• Nano-formulations
• Pulmonary and Oral Drug Delivery
• Lipid-based formulations and their effect in in-vivo and in-vitro studies
• Combination and outcomes of lipid-based with vaccine formulations
• Member of Formulation and Drug Delivery group
• Polymeric Drug Delivery Systems
• Scale up of Advanced Drug Delivery systems

Highlighted publications

Khan I, Hussein S, Houacine C, Khan Sadozai S, Islam Y, Bnyan R, Elhissi A, Yousaf S. 2021. Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers International Journal of Pharmaceutics, 598 :120376-120376 DOI Author Url Publisher Url Public Url

Khan I, Apostolou M, Bnyan R, Houacine C, Elhissi A, Yousaf SS. 2019. Paclitaxel-loaded Micro or Nano Transfersome Formulation into Novel Tablets for Pulmonary Drug Delivery via Nebulization. International Journal of Pharmaceutics, :118919-118919 DOI Author Url Publisher Url Public Url

Khan I, Yousaf S, Subramanian S, Korale O, Alhnan M, Ahmed W, Taylor K, Elhissi A. 2015. Proliposome powders prepared using a slurry method for the generation of beclometasone dipropionate liposomes International Journal of Pharmaceutics, 496 :342-350 DOI Author Url Publisher Url

Journal article

Charitakis A, Assi S, Yousaf S, Khan I. 2022. Overcoming Skin Damage from Pollution via Novel Skincare Strategies. Current pharmaceutical design, 28 DOI Author Url Publisher Url Public Url

Bakhtiar C, Khan I. 2021. Vitamin C in Skin Care Applications: An Overview Global Personal Care, 22 Author Url Publisher Url

Khan I, Needham R, Yousaf S, Houacine C, Islam Y, Bnyan R, Sadozai SK, Elrayess MA, Elhissi A. 2021. Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery Journal of Drug Delivery Science and Technology, 66 DOI Author Url Publisher Url Public Url

Noun M, Nasr L, Khan I, Arafat B, Assi S. 2021. Knowledge and perspectives of the public towards the prevalence and harm associated with counterfeit medicines in Lebanon Emerging Trends in Drugs, Addictions, and Health, 1 :100019-100019 DOI Publisher Url Public Url

Yousaf SS, Isreb A, Khan I, Mewsiga E, Elhissi A, Ahmed W, Alhnan MA. 2021. Impact of Nanosizing on the Formation and Characteristics of Polymethacrylate Films: Micro- versus Nano- suspensions. Pharmaceutical development and technology, :1-29 DOI Author Url Publisher Url Public Url

Apostolou M, Assi S, Fatokun AA, Khan I. 2021. The Effects of Solid and Liquid Lipids on the Physicochemical Properties of Nanostructured Lipid Carriers Journal of Pharmaceutical Sciences, DOI Author Url Publisher Url Public Url

Khan I, Hussein S, Houacine C, Khan Sadozai S, Islam Y, Bnyan R, Elhissi A, Yousaf S. 2021. Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers International Journal of Pharmaceutics, 598 :120376-120376 DOI Author Url Publisher Url Public Url

Houacine C, Ibrahim G, Alnasif H, Suliman H, Khan I, Himoudy I, Nasr N, Mohamedkhair R, Ballal R, Yousaf S, Elbashir S. 2021. A Current Review from Recent Literature on Novel Sars-cov-2 Outbreak International Journal of Pharmaceutical Sciences and Research, 12 :692-713 DOI Author Url Publisher Url Public Url

Houacine C, Khan I, Yousaf SS. 2021. Potential Cardio-Protective Agents: A Resveratrol Review (2000-2019) CURRENT PHARMACEUTICAL DESIGN, 27 :2943-2955 DOI Author Url

Islam Y, Ehtezazi P, Cashmore A, Marinsalda E, Leach AG, Coxon CR, Fatokun AA, Sexton DW, Khan I, Zouganelis GD, Downing J, Pluchino S, Sivakumaran M, Teixido M, Ehtezazi T. 2020. The Inclusion of a Matrix Metalloproteinase-9 Responsive Sequence in Self-assembled Peptide-based Brain-Targeting Nanoparticles Improves the Efficiency of Nanoparticles Crossing the Blood-Brain Barrier at Elevated MMP-9 Levels Journal of Pharmaceutical Sciences, 110 :1349-1364 DOI Author Url Publisher Url Public Url

Khan I, Yousaf S, Najlah M, Ahmed W, Elhissi A. 2020. Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer JOURNAL OF PHARMACEUTICAL INVESTIGATION, 51 :61-73 DOI Author Url

Assi S, Khan I, Edwards A, Osselton D, Al-Obaidi H. 2020. On-spot quantification of modafinil in generic medicines purchased from the Internet using handheld Fourier transform-infrared, near-infrared and Raman spectroscopy Journal of Analytical Science and Technology, 11 DOI Author Url Publisher Url Public Url

Khan I, Lau K, Bnyan R, Houacine C, Roberts M, Isreb A, Elhissi A, Yousaf S. 2020. A Facile and Novel Approach to Manufacture Paclitaxel-Loaded Proliposome Tablet Formulations of Micro or Nano Vesicles for Nebulization. Pharmaceutical Research, 37 DOI Author Url Publisher Url Public Url

Yousaf S, Houacine C, Khan I, Ahmed W, Jackson M. 2020. Importance of biomaterials in biomedical engineering Advances in Medical and Surgical Engineering, :149-176 DOI Author Url

Khan I, Apostolou M, Bnyan R, Houacine C, Elhissi A, Yousaf SS. 2019. Paclitaxel-loaded Micro or Nano Transfersome Formulation into Novel Tablets for Pulmonary Drug Delivery via Nebulization. International Journal of Pharmaceutics, :118919-118919 DOI Author Url Publisher Url Public Url

Bnyan R, Khan I, Ehtezazi T, Saleem IY, Gordon S, O'Neill F, Roberts M. 2019. Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic Journal of Pharmacy and Pharmacology, DOI Author Url Publisher Url Public Url

Khan I, Yousaf S, Subramanian S, Alhnan MA, Ahmed W, Elhissi A. 2018. Proliposome tablets manufactured using a slurry-driven lipid-enriched powders: Development, characterization and stability evaluation INTERNATIONAL JOURNAL OF PHARMACEUTICS, 538 :250-262 DOI Author Url

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, Neill FO, Roberts M. 2018. Surfactant effects on lipid-based vesicles properties. Journal of Pharmaceutical Sciences, DOI Author Url Publisher Url Public Url

Khan I. 2018. Anti-Aging Liposomal formulation: A Mini Review Novel Approaches in Drug Designing & Development, 3 DOI Publisher Url Public Url

Khan I. 2018. Isoflavones-Based Liposome Formulations as Anti-Aging for Skincare Novel Approaches in Drug Designing & Development, 3 DOI Publisher Url Public Url

Khan I, Yousaf S, Subramanian S, Alhnan MA, Ahmed W, Elhissi A. 2018. Proliposome Powders for the Generation of Liposomes: the Influence of Carbohydrate Carrier and Separation Conditions on Crystallinity and Entrapment of a Model Antiasthma Steroid AAPS PHARMSCITECH, 19 :262-274 DOI Author Url

Houacine C, Yousaf SS, Khan I, Khurana RK, Singh KK. 2018. Potential of Natural Biomaterials in Nano-scale Drug Delivery CURRENT PHARMACEUTICAL DESIGN, 24 :5188-5206 DOI Author Url

Subramanian S, Khan I, Korale O, Alhnan MA, Ahmed W, Najlah M, Taylor KMG, Elhissi A. 2016. A simple approach to predict the stability of phospholipid vesicles to nebulization without performing aerosolization studies International Journal of Pharmaceutics, 502 :18-27 DOI Author Url

Houacine S, Khan I, Yousaf S, Pawar S, Houacine N, Elkhawad A. 2015. Investigation of the Rational Medicines use among Pregnant Women in Sudan Hospital WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 4 :350-360 Author Url

Khan I, Yousaf S, Subramanian S, Korale O, Alhnan M, Ahmed W, Taylor K, Elhissi A. 2015. Proliposome powders prepared using a slurry method for the generation of beclometasone dipropionate liposomes International Journal of Pharmaceutics, 496 :342-350 DOI Author Url Publisher Url

Gala RP, Khan I, Elhissi AMA, Alhnan MA. 2015. A comprehensive production method of self-cryoprotected nano-liposome powders International Journal of Pharmaceutics, 486 :153-158 DOI Author Url

Bnyan R, Cesarini L, Khan I, Roberts M, Ehtezazi T. The Effect of Ethanol Evaporation on the Properties of Inkjet Produced Liposomes DARU : Journal of Pharmaceutical Sciences, DOI Author Url Public Url

Poster

Apostolou M, Assi S, Fatokun AA, Khan I. 2021. The effects of lipids and surfactants on the physicochemical properties of nanostructured lipid carriers for pulmonary drug delivery Joint Pharmaceutical Analysis Group (JPAG), London, UK

Assi S, Khan I, Edwards A, Al Obaidi H, Osselton D. 2021. Non-destructive quantification of modafinil tablets using handheld Raman spectroscopy IACFT Virtual Meeting

Robson R, Ginige T, Mansour S, Khan I, Assi S. 2020. Analysis of latent fingerprint constituents: A systematic review of quantitative studies Joint Pharmaceutical Analysis Group (JPAG), London, UK

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O’Neill, F, Roberts M. 2019. A novel carrier system via deformable liposomes using local anaesthetic for buccal delivery PharmSci conference Greenwich, UK

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O’Neill, F, Roberts M. 2019. Transfersomes for buccal delivery of local anaesthetic United Kingdom and Ireland Controlled Release Society (UKICRS) Symposium, Liverpool, UK

Bnyan R, Khan I, Ehtezazi T, Saleem I, Roberts M. 2018. Transfersomes as novel carriers for sustained buccal delivery of local anaesthetic 16th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems, Berlin, Germany

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O'Neill F, Roberts M. 2018. Dentist Fear OR Needle Phobia … NOT ANYMORE ! Local Anaesthetic Transfersomes International women day, celebrating women in research held by Liverpool John Moores University (LJMU), Liverpool, UK

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O'Neill F, Roberts M. 2018. ‘#Dentist Fear… #Needle Phobia … NO MORE! Local Anaesthetic Transfersomes 4th Annual keele Nanopharmaceutics Symposium, Keele, UK

Bnyan R, Khan I, Ehtezazi T, Saleem I, Roberts M. 2017. Formulation and optimization of transfersomesfor sustained buccal delivery of local anaesthetic The pharmaceutical analysis postgraduate research awards and careers Symposium held by the Joint Pharmaceutical Analysis Group (JPAG), London, UK

Bnyan R, Khan I, Ehtezazi T, Saleem I, Roberts M. 2017. Optimised formulation and characterisation of transfersomesfor sustained buccal delivery of local anaesthetic Faculty of science research and seminar day at Liverpool John Moores University (LJMU), Liverpool, UK

Yousaf S, Khan I, Alhnan M. 2016. Hybrid-Suspensions: Theory to Practice American Association of pharmaceutical scientists (AAPS), Colorado Convention Center, Denver, USA

Yousaf S, Khan I, Alhnan M. 2016. Impact of Nano-Sizing upon the Properties of Aqueous Based Polymethacylate Films American Association of pharmaceutical scientists (AAPS), Colorado Convention Center, Denver, USA

Yousaf S, Khan I, Alhnan M. 2016. Micro-Suspensions vs Nano-Suspensions: Impact of Particle Size on the Properties of Feed Liquid during Fluidized-Bed Coating American Association of pharmaceutical scientists (AAPS), Colorado Convention Center, Denver, USA

Khan I, Yousaf S, Alhnan M, Elhissi A. 2015. Entrapment quantification in liposomal vesicles: A novel approach 10th Nanosmat International Conference on Surfaces, Coating and Nanostructured materials, Manchester, UK

Korale O, Subramanian S, Khan I, Alhnan M, Ahmed W, Elhissi A. 2014. The effect of different effervescent proliposome formulations on the aerosolization properties using a Pari Sinus nebulizer American Association of pharmaceutical scientists (AAPS), San Diego, USA

Subramanian S, Khan I, Korale O, Alhnan M, Ahmed W, Elhissi A. 2014. Study and Comparison of Entrapment of Hydrophilic and Hydrophobic Drug in Proliposomes and Protransferosomes American Association of pharmaceutical scientists (AAPS), San Diego, USA

Korale O, Subramanian S, Khan I, Alhnan M, Ahmed W, Elhissi A. 2014. Effervescent Proliposome Formulations for Delivery of Xylometazoline Hydrochloride American Association of pharmaceutical scientists (AAPS), San Diego, USA

Khan I, Yousaf S, Subramanian S, Abdallah B, Alhnan M, Ahmed W, Elhissi A. 2014. Proliposomes made using different carbohydrate carriers for pulmonary delivery of steroid-loaded liposomes American Association of pharmaceutical scientists (AAPS), San Diego, USA

Subramanian S, Korale O, Khan I, Alhnan M, Ahmed W, Elhissi W. 2014. Delivery of Beclometasone Dipropionate to twin stage impinger via vibrating mesh nebuliser using Liposomes and Ultradeformable vesicles American Association of pharmaceutical scientists (AAPS), San Diego, USA

Khan I, Yousaf S, Korale O, Subramanian S, Abdallah B, Alhnan M, Ahmed W, Elhissi A. 2014. Novel proliposome formulations for pulmonary drug delivery The Academy of Pharmaceutical Sciences (APS), Univeristy of Hertfordshire, UK

Subramanian S, Khan I, Korale O, Alhnan M, Ahmed W, Elhissi A. 2014. Delivery of Beclometasone dipropionate to twin impinger via Vibrating mesh and Air jet nebuliser using proliposomes and prosurfactosomes British Pharmacology Society, London, UK

Subramanian S, Korale O, Khan I, Alhnan M, Ahmed W, Elhissi A. 2014. Development and Characterization of Elastic Stress Responsive Vesicles with Potential Application in Pulmonary Drug Delivery Academy of Pharmaceutical Sciences (APS), University of Hertfordshire, UK

Korale O, Subramanian S, Khan I, Alhnan M, Ahmed W, Elhissi A. 2014. Effervescent proliposomes: A study on the effect of lipid composition Academy of Pharmaceutical Sciences (APS), University of Hertfordshire, UK

Korale O, Alhnan M, Subramanian S, Khan I, Ahmed W, Elhissi A. 2014. Mucoadhesive effervescent liposomal formulations for the treatment of sinusitis 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, Portugal

Subramanian S, Elhissi A, Korale O, Khan I, Ahmed W, Alhnan M. 2014. Effect of liposomal formulation on lipid soluble drug 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, Portugal

Korale O, Alhnan M, Khan I, Ahmed W, Elhissi A. 2013. Effervescent Formulations for Targeting the Sinuses via Nasal Delivery American Association of pharmaceutical scientists (AAPS), San Antonio, USA

Khan I, Alhnan M, Ahmed W, Elhissi A. 2013. Development and Characterization of Anti-asthma Proliposome Formulations American Association of pharmaceutical scientists (AAPS), San Antonio, USA

Khan I, Alhnan M, Ahmed W, Elhissi A. 2013. A novel sucrose-based proliposome and the entrapment efficiency of Beclometasone dipropionate in various dispersion mediums Graduate research school, Annual Research Conference, University of Central Lancashire (Uclan)

Chapters

Khan I, Yousaf S, Alhnan MA, Ahmed W, Elhissi A, Jackson MJ. 2016. Design characteristics of inhaler devices used for pulmonary delivery of medical aerosols Surgical Tools and Medical Devices, Second Edition :573-592 9783319334875 DOI

Yousaf S, Alhnan MA, Abdallah A, Abdallah B, Khan I, Ahmed W. 2014. Nanocoatings in medicine: Antiquity and modern times Emerging Nanotechnologies for Manufacturing :418-443 9780323296434 DOI

Khan I, Elhissi A, Shah M, Alhnan MA, Ahmed W. 2013. Liposome-based carrier systems and devices used for pulmonary drug delivery Biomaterials and Medical Tribology: Research and Development :395-443 9780857090171 DOI

Research Grants Awarded:

Self funded (Megan Watson), Analysis of counterfeit anti-infectives and vaccines using conventional and enhanced spectroscopic techniques, Dr Sulaf Assi (lead supervisor), Dr Iftikhar Khan (co-supervisor), Dr Jason Birkett (co-supervisor), Grant value (£): 20,000 approx. (standard PhD studentship tuition + bench fees), Duration of research project: 3 years (PhD) + 1 year writeup. 2022

Self funded (Megan Wilson), Evaluating the feasibility of spectroscopic techniques for the detection of drugs of abuse and drug metabolites in alternative biological matrices, Dr Sulaf Assi (lead supervisor), Dr Iftikhar Khan (co-supervisor), Dr Jason Birkett (co-supervisor), Grant value (£): 20,000 approx. (standard PhD studentship tuition + bench fees), Duration of research project: 3 years (PhD) + 1 year writeup. 2022

Commonwealth Split-site PhD Scholarship, Improving Skin Penetration of Amphotericin B Against Topical Leishmaniasis Using Nanoparticles-based Topical Gel, Dr Iftikhar Khan (Liverpool John Moores University, UK), Dr Saeed Ahmad Khan (Kohat University of Science and Technology, Pakistan), Grant value (£): 14,207, Duration of research project: 12 months. 2022

Self funded (Ayub Khan), Nano-crystallisation of Pharmaceutical drugs and their employment in thin-film formation, Dr Touraj Ehtezazii (lead supervisor), Dr Iftikhar Khan (co-supervisor), Grant value (£): 4,000, Duration of research project: 12 months. 2021

Self funded (Ismail Abdulrazzaq Alsaadi), Nanotechnology formulations of solid lipid nanoparticles employing anti-cancer drug for pulmonary drug delivery, Dr Iftikhar Khan (lead supervisor), Dr Sakib Yousaf (co-supervisor), Grant value (£): 60,000, Duration of research project: 3 years (PhD). 2021

Self funded (Ravija Kadam), Skin whitening natural actives: Pharmaceutical chemistry to reduce pigmentary disorders using transferosomes carriers, Dr Iftikhar Khan (lead supervisor), Dr Sulaf Assi (co-supervisor), Dr Sandra Fawcett (co-supervisor), Grant value (£): 36,000, Duration of research project: 3 years (PhD). 2021

Faculty of Science, LJMU (PhD studentship), Nanostructured Lipid Carriers (NLCs) for Cancer Therapy via Pulmonary Drug Delivery, Dr Iftikar Khan (lead supervisor), Dr Sulaf Assi (co-supervisor), Dr Amos Fatokun (co-supervisor), Grant value (£): 65,000, Duration of research project: 3 years. 2020

LJMU seed corn funding, Developing spectroscopic libraries for raw material identification using spectroscopic techniques, Dr Sulaf Assi (lead), Dr Iftikhar Khan, Grant value (£): 10,000, Duration of research project: 12 months. 2020

QR GCRF, Investigation the quality of substandard and falsified food products in Lebanon: A collaborative approach between the UK and Lebanon, Dr Sulaf Assi, Dr Iftikhar Khan (Liverpool John Moores University, UK); Dr Ismail Abbas (Chemistry department, faculty of Sciences, Lebanon), Grant value (£): 14,821, Duration of research project: 12 months. 2020

LJMU seed corn funding, Lipid-based micro and nano formulations for pulmonary drug delivery, Dr Iftikhar Khan, Grant value (£): 10,000, Duration of research project: 12 months. 2017

Teaching qualification:

Postgraduate Certificate in Higher Education (PGCHE). 2017

Associate Fellow of the UK Higher Education Academy (AFHEA). 2013

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