Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Imran Saleem

Dr Imran Saleem

Telephone: 0151 231 2265

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Biography

Biosketch
I am a Professor in Nanomedicine within the School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, UK. I obtained my Pharmacy degree from the same university and am a registered pharmacist. In 2004, I received my Doctor of Philosphy (Ph.D) in drug delivery from Aston University, UK, entitled Improving diagnosis and vaccination strategies against Bovine Tuberculosis. Upon completing my Ph.D I went on to undertake a Postdoctoral Research Fellow at University of New Mexico in the Advanced Drug Delivery Laboratory of Dr H Smyth, working in the area of dry powder inhalation of anticancer agents for treatment of lung cancer.

Research
My research group transgresses multiple disciplines including formulation, drug delivery, nanotechnology, polymer science, chemistry, cell and molecular biology, and have published extensively in peer-reviewed journals, conference abstracts and book chapters. The groups work is involved in the application and understanding of novel nanocarrier systems in overcoming biological barriers for the targeted delivery of small molecules and macromolecules (proteins, peptides, siRNA, miRNA) for human and veterinary use. This nanotechnology is applied in the following areas:

Lipid and polymer based nanocarriers for pulmonary delivery of vaccines.
Lipid and polymer based nanocarriers for targeted delivery of small molecules and macromolecules (proteins, peptides, siRNA, miRNA) in treatment of pulmonary diseases (lung cancer, asthma, COPD, fungal and bacterial infections).
Producing fast disintegrating tablets, thin-films and wafers for delivery of nanocarriers via oral delivery.
Smart responsive nanocarriers to biological and external factors.
Regenerative medicine.
Nanoparticle toxicology.
Extracellular vesicles as alternative delivery systems.

Degrees

1998, Liverpool John Moores University, United Kingdom, BSc (hons) 2:1, Pharmacy

Academic appointments

Professor in Nanomedicine, School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, 2019 - present
Reader in Nanomedicine, School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, 2016 - 2019
Senior Lecturer in Pharmaceutical Technology, School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, 2008 - 2016
Lecturer in Pharmaceutical Technology, School of Pharmacy & Chemistry, Liverpool John Moores University, 2008 - 2008
Postdoctoral Research Fellow, College of Pharmacy, University of New Mexico, 2006 - 2007

Postgraduate training

Improving diagnosis and vaccination strategies against Bovine Tuberculosis, United Kingdom, Aston University, 1999 - 2003

Publications

Journal article

Osman NM, Sexton DW, Saleem IY. 2019. Toxicological assessment of nanoparticle interactions with the pulmonary system NANOTOXICOLOGY, DOI Author Url

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O'Neill F, Roberts M. 2019. Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic Journal of Pharmacy and Pharmacology, DOI Author Url Publisher Url Public Url

Gonçalves VM, Kaneko K, Solórzano C, MacLoughlin R, Saleem I, Miyaji EN. 2019. Progress in mucosal immunization for protection against pneumococcal pneumonia. Expert Review of Vaccines, :1-12 DOI Author Url Publisher Url Public Url

Mohamed A, Pekoz AY, Ross K, Hutcheon GA, Saleem IY. 2019. Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD. International Journal of Pharmaceutics, 569 :118524-118524 DOI Author Url Publisher Url Public Url

Saleem I, Coombes AGA, Chambers MA. 2019. In Vitro Evaluation of Eudragit Matrices for Oral Delivery of BCG Vaccine to Animals Pharmaceutics, 11 :270-270 DOI Author Url Publisher Url Public Url

Muller AG, Sarker SD, Saleem IY, Hutcheon GA. 2019. Delivery of natural phenolic compounds for the potential treatment of lung cancer. DARU Journal of Faculty of Pharmacy, DOI Author Url Publisher Url Public Url

Abdelrady H, Hathout RM, Osman R, Saleem I, Mortada ND. 2019. Exploiting gelatin nanocarriers in the pulmonary delivery of methotrexate for lung cancer therapy European Journal of Pharmaceutical Sciences, 133 :115-126 DOI Author Url Publisher Url Public Url

Mohamed A, Ross K, Saleem I, Hutcheon G. 2019. Polymeric Nanoparticles For The Pulmonary Delivery Of miRNA To Treat Chronic Obstructive Pulmonary Disease (COPD) European Journal of Pharmaceutics and Biopharmaceutics, 136 DOI Author Url Public Url

Osman N, Kaneko K, Carini V, Saleem I. 2018. Carriers for the Targeted Delivery of Aerosolized Macromolecules for Pulmonary Pathologies. Expert Opin Drug Deliv, DOI Author Url Public Url

Almurshedi AS, Radwan M, Omar S, Alaiya AA, Badran MM, Elsaghire H, Saleem IY, Hutcheon G. 2018. A novel Ph-sensitive liposome to trigger delivery of afatinib to cancer cells: Impact on lung cancer therapy Journal of Molecular lipids, :154-166 DOI Author Url Publisher Url Public Url

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O'Neill F, Roberts M. 2018. Surfactant Effects on Lipid-Based Vesicles Properties JOURNAL OF PHARMACEUTICAL SCIENCES, 107 :1237-1246 DOI Author Url Public Url

Petkar KC, Chavhan S, Kunda N, Saleem I, Somavarapu S, Taylor KMG, Sawant KK. 2018. Development of Novel Octanoyl Chitosan Nanoparticles for Improved Rifampicin Pulmonary Delivery: Optimization by Factorial Design AAPS PharmSciTech, 19 :1758-1772 DOI Author Url Publisher Url Public Url

Iyire A, Russell C, Dennison T, Rajoli R, Saleem I, Rahman A, Mohammed A. 2018. Development, Optimisation, Validation and Inter-Laboratory Verification of a Reversed Phase HPLC Method for Quantification of Human Recombinant Insulin Journal Of Advances In Biotechnology, 7 :984-998 DOI Publisher Url Public Url

Rodrigues T, Oliveira ML, Soares-Schanoski A, Chavez-Rico S, Figueiredo D, Gonçalves V, Ferreira D, Kunda N, Saleem I, Miyaji E. 2018. Mucosal immunization with PspA (Pneumococcal surface protein A)-adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection PLoS ONE, e0191692 DOI Author Url Publisher Url Public Url

Tawfeek HM, Abdellatif AAH, Dennison TJ, Mohammed AR, Sadiq Y, Saleem IY. 2017. Colonic delivery of indometacin loaded PGA-co-PDL microparticles coated with Eudragit L100-55 from fast disintegrating tablets International Journal of Pharmaceutics, 531 :80-89 DOI Author Url Public Url

Wagner Q, Offner D, Idoux-Gillet Y, Saleem I, Somavarapu S, Schwinte P, Benkirane-Jessel N, Keller L. 2016. Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered tissue vascularization NANOMEDICINE, 11 :2419-2430 DOI Author Url Public Url

Merchant Z, Buckton G, Taylor KMG, Stapleton P, Saleem IY, Zariwala MG, Somavarapu S. 2016. A new era of pulmonary delivery of nano-antimicrobial therapeutics to treat chronic pulmonary infections Current Pharmaceutical Design, 22 :2577-2598 DOI Author Url Public Url

Abdellatif AA, Zayed G, El-Bakry A, Zaky A, Saleem IY, Tawfeek HM. 2016. Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors. Drug development and industrial pharmacy, :1-37 DOI Author Url Public Url

Kunda NK, Alfagih IM, Miyaji EN, Figueiredo DB, Goncalves VM, Ferreira DM, Dennison SR, Somavarapu S, Hutcheon GA, Saleem IY. 2015. Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles INTERNATIONAL JOURNAL OF PHARMACEUTICS, 495 :903-912 DOI Author Url Public Url

Alfagih I, Kunda N, Alanazi F, Dennison SR, Somavarapu S, Hutcheon GA, Saleem IY. 2015. Pulmonary Delivery of Proteins Using Nanocomposite Microcarriers. Journal of pharmaceutical sciences, DOI Author Url Public Url

Kunda NK, Alfagih IM, Dennison SR, Somavarapu S, Merchant Z, Hutcheon GA, Saleem IY. 2015. Dry powder pulmonary delivery of cationic PGA-co-PDL nanoparticles with surface adsorbed model protein. Int J Pharm, 492 :213-222 DOI Author Url Public Url

Saleem IY, Diez F, Jones BE, Kayali N, Polo L. 2015. Investigation on the aerosol performance of dry powder inhalation hypromellose capsules with different lubricant levels INTERNATIONAL JOURNAL OF PHARMACEUTICS, 492 :258-263 DOI Author Url Public Url

Merchant Z, Taylor KMG, Stapleton P, Razak SA, Kunda N, Alfagih I, Sheikh K, Saleem IY, Somavarapu S. 2014. Engineering hydrophobically modified chitosan for enhancing the dispersion of respirable microparticles of levofloxacin EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 88 :816-829 DOI Author Url Public Url

Tawfeek HM, Saleem IY, Roberts M. 2014. Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets JOURNAL OF PHARMACEUTICAL SCIENCES, 103 :2470-2483 DOI Author Url Public Url

Vadana CD, Taylor KMG, Saleem IY, Elsaid Z, Somavarapu S. 2013. SPICING UP THE LUNGS: DESIGN AND CHARACTERIZATION OF DRY POWDER FORMULATIONS OF CURCUMIN FOR LUNG DELIVERY JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 26 :A250-A250 Author Url

Chavan T, Taylor KMG, Saleem IY, Randle LE, Elsaid Z, Somavarapu S. 2013. O-PALMITOYL CHITOSAN-PEG MICELLES FOR AMPHOTERICIN B DELIVERY TO THE LUNG JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 26 :A249-A250 Author Url

Saleem I, smyth HD. 2013. Tuning aerosol particle size distribution of metered dose inhalers using cosolvents and surfactants Duf`es . BioMed Research International, 2013 DOI Public Url

Tawfeek HM, Evans AR, Iftikhar A, Mohammed AR, Shabir A, Somavarapu S, Hutcheon GA, Saleem IY. 2013. Dry powder inhalation of macromolecules using novel PEG-co-polyester microparticle carriers. Int J Pharm, 441 :611-619 DOI Author Url Public Url

Tawfeek H, Khidr S, Samy E, Ahmed S, Murphy M, Mohammed A, Shabir A, Hutcheon G, Saleem I. 2011. Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery Pharmaceutical Research, 28 :2086-2097 Author Url Public Url

Saleem I, Boardman K. 2009. Improving the aerosolisation properties and lung deposition of spray-dried powders for inhalation JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A117-A118 Author Url

Saleem I, Smyth H. 2009. Influence of surfactant (pluronic I81) and cosolvent ethanol on their ability to modulate particle size distribution and lung deposition of pressurised metered dose inhalers JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A119-A120 Author Url

Saleem I, Donovan MJ, Smyth HDC. 2007. Particle size analysis: From microparticles to nanosystems American Pharmaceutical Review, 10 :126-130

Saleem IY, Vordermeier M, Barralet JE, AGA C. 2005. Improving peptide-based assays to differentiate between vaccination and Mycobacterium bovis infection in cattle using nanoparticle carriers for adsorbed antigens JOURNAL OF CONTROLLED RELEASE, 102 :551-561 DOI Author Url

Saleem IY, Vordermeier M, Chambers MA, Coombes AGA. 2000. Improving the sensitivity of polypeptide-based diagnostic assays Journal of Pharmacy and Pharmacology, 52 :33

Khan S, Batchelor H, Hanson P, Saleem IY, Perrie Y, Mohammed AR. Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions. Drug Dev Ind Pharm, 39 :704-715 DOI Author Url

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Murphy MF, Mohammad A, Shabir A, Hutcheon GA, Saleem IY. Poly(glycerol adipate-co-ω-pentadecalactone) spray dried microparticles as carriers for pulmonary delivery Pharmacological Research, :1-12 DOI

Al-Fagih IM, Alanazi FK, Hutcheon GA, Saleem IY. Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations Drug Delivery Letters, 1 :128-134 Public Url

Ehtezazi T, Saleem I, Shrubb I, Allanson DR, Jenkinson ID, O'Callaghan C. The interaction between the oropharyngeal geometry and aerosols via pressurised metered dose inhalers. Pharm Res, 27 :175-186 DOI Author Url

Saleem IY, Smyth HDC. Micronization of a soft material: air-jet and micro-ball milling. AAPS PharmSciTech, 11 :1642-1649 DOI Author Url Public Url

Saleem I, Smyth H, Telko M. Prediction of dry powder inhaler formulation performance from surface energetics and blending dynamics DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 34 :1002-1010 DOI Author Url Public Url

Saleem IY, HDC S. Prediction of dry powder dispersion performance from blending studies using budesonicle as model drug JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A79-A79 Author Url

Tawfeek H, Khidr S, Samy E, Ahmed S, Murphy M, Mohammed A, Shabir A, Hutcheon G, Saleem I. Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery Pharmaceutical Research, 28 :2086-2097 DOI Author Url

Kunda NK, Alfagih IM, Dennison SR, Tawfeek HM, Somavarapu S, Hutcheon GA, Saleem IY. Bovine serum albumin adsorbed PGA-CO-PDL nanocarriers for vaccine delivery via dry powder inhalation Pharmaceutical Research, 32 :1341-1353 DOI Author Url Public Url

Kunda NK, Somavarapu S, Gordon SB, Hutcheon GA, Saleem IY. Nanocarriers targeting dendritic cells for pulmonary vaccine delivery. Pharm Res, 30 :325-341 DOI Author Url Public Url

Saleem IY, Smyth HDC. Tuning aerosol particle size distribution of metered dose inhalers using cosolvents and surfactants. BioMed research international, 2013 :574310 DOI Author Url

Neelima T, Taylor KMG, Saleem I, Randle L, Elsaid Z, Somavarapu S. Amphotericin polygamma glutamic acid derivatives for the delivery of amikacin to the lung Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 :A-1-A-27 DOI

Ali HRH, Saleem IY, Tawfeek HM. Insight into inclusion complexation of indomethacin nicotinamide cocrystals Journal of Inclusion Phenomena and Macrocyclic Chemistry, DOI Author Url Public Url

Papay Z, Kosa A, Boddi B, Merchant Z, Saleem I, Zariwala M, Klebovich I, Somavarapu S, Antal I. Study on the pulmonary delivery system of apigenin loaded albumin nanocarriers with antioxidant activity Journal of Aerosol Medicine and Pulmonary Drug Delivery, DOI Author Url

Donovan M, Saleem I, Smyth H. Spectroscopy of Pharmaceutical Solids Drug Development and Industrial Pharmacy, 33

Conference publication

Zallocco N, Miyaji EN, Goncalves VM, Figueiredo DB, Saleem IY, MacLoughlin R. 2017. CHITOSAN NANOCARRIER SYSTEMS FOR DELIVERY OF PNEUMOCOCCAL VACCINE VIA NEBULIZATION JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 30 :A16-A16 Author Url

Osman N, Sexton D, Hutcheon G, Saleem I. 2017. COMPARATIVE NANOTOXICOLOGY OF POLYMERIC NANOCARRIERS WITH DIFFERENT SURFACE CHARGE AGAINST HUMAN LUNG EPITHELIAL CELLS JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 30 :A17-A18 Author Url

Osman N, Hilal M, Mohamed S, Dawood A, ritchie K, Saleem I, hutcheon G. 2015. In-vitro Stability and Degradation of PLGA and PGA-co-PDL Microparticles for Pulmonary Drug Delivery Drug Delivery to the Lungs

Saleem I, Rajoli R, Jones B, Diez F. 2015. Investigation of dry powder inhalation aerosolisation performance at different flow rates from a conventional capsule-based inhaler device Drug Delivery to the Lungs Author Url

Osman N, Hilal M, Mohamed S, Dawood A, Ritchie K, Saleem I, hutcheon G. 2015. In vitro Stability and Degradation of PLGA and PGA-co-PDL Microparticles for Drug Delivery Controlled Release Annual Meeting Author Url

kunda N, alfagih I, Alanazi F, hutcheon G, saleem I. 2015. Comparison of Protein Delivery via Nanocomposite Microcarriers for Pulmonary Vaccine Delivery

Alfagih IM. 2014. Cationic PGA-co-PDL nanocomposite microparticles for antigen delivery via inhalation Drug Delivery to the Lungs DDL25 Author Url

Alfagih I, Kunda N, Alanazi F, Hutcheon G, saleem I. 2014. Cationic PGA-co-PDL nanocomposite microparticles for antigen delivery via inhalation

kunda N, Somavarapu S, Gordon SB, Hutcheon G, Saleem I. 2013. Protein Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery AAPS Annual Meeting and Exposition

kunda NK, Alfagih IM, Somavarapu S, Hutcheon GA, Saleem I. 2012. Pulmonary Vaccine Delivery of Protein Adsorbed PGA-co-PDL Nanocomposite Microparticles Drug Delivery to the Lungs - DDL23 Author Url

Alfagih IM, Alanazi FK, Kunda NK, Hutcheon GA, Saleem IY. 2012. Protein Loaded PGA-co-PDL Nanocomposite Microparticles for Inhalation Drug Delivery to the Lungs DDL23 Author Url

ALfagih IM, Alanzi FK, Satyanarayana S, Chavan T, Hutcheon GA, Saleem IY. 2012. PGA-co-PDL NANOCOMPOSITE MICROPARTICLES AS CARRIERS OF PROTEIN FOR PULMONARY DELIVERY 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Chandra VD, Taylor KMG, saleem I, Somavarapu S. 2011. Design and Development of Dry Powder Formulations of Curcumin for Lung Delivery – Spicing up the Lungs Drug Delivery to the Lungs

Neelima T, Taylor KMG, Saleem I, Randle L, Somavarapu S. 2011. Amphiphilic polygamma glutamic acid derivatives for delivery of amikacin to the lung Drug Delivery to the Lungs

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Hutcheon GA, Saleem IY. 2010. Effect of PEGylation on spray dried PGA-co-PDL pulmonary carrier microparticles and In-vitro transport Drug Delivery to the Lungs

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Akram K, Mohammed AR, Gaskell EE, Hutcheon G, Saleem I. 2010. Optimisation of polyester based microparticles as carriers for pulmonary drug delivery Drug Delivery to the Lungs

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Shabir A, Mohammed AR, Hutcheon GA, Saleem I. 2010. Pulmonary delivery of alpha-chymotrypsin via novel polyester microparticles JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1294-1295 Author Url

Saleem IY, Patel T, Roberts M. 2010. Surface Coated Lactose Carrier Dry Powder Inhalation Particles using a Fluid Bed System JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1301-1302 Author Url

Saleem I. 2010. Pulmonary delivery of alpha-chymotrypsin via novel polyester microparticles Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Shabir A, Mohammed AR.

Tawfeek H, Khidr S, Samy E, Ahmed S, Hutcheon G, Saleem I. 2010. Enhancing the Aerosolisation Proprieties of Polyester based Microparticles as Novel Carriers for Dry Powder Inhalation 37th Annual Meeting & Exposition of the Controlled Release Society

Tawfeek H, Khidr S, Samy EM, Ahmed SM, Gaskell EE, Hutcheon G, Saleem I. 2010. PGA-co-PDL as a Novel Carrier for Pulmonary Drug Delivery 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

saleem I, Boardman K. 2009. Improving the aerosolisation properties and lung deposition of spray-dried powders for inhalation

Saleem I, smyth HD. 2009. Influence of surfactant (pluronic I81) and cosolvent ethanol on their ability to modulate particle size distribution and lung deposition of pressurised metered dose inhalers

Saleem I, Liu H, Smyth H. 2007. Permeability of anticancer agents through airway epithelia AAPS Annual Meeting and Exposition

Donovan MJ, McGill S, Saleem I, Liu H, Smyth H. 2007. Microsystems and Nanoparticles for Controlled Aerosol Drug Delivery of Chemotherapeutics to the Lung Second Annual NCI Nanotechnology Alliance Investigators Meeting

Saleem I, Smyth H. 2007. Chemosensitization of Multi-Drug Resistant Human Small Cell Lung Cancer Cells to Doxorubicin Controlled Release Society Annual Meeting

Saleem I, Smyth H. 2007. Optimization of Jet Milling Conditions for Particle Size Reduction of Soft Material Controlled Release Society Annual Meeting

Saleem I, Smyth HDC. 2006. Predicting the dispersion performance of budesonide dry powder inhaler formulations from blending studies AAPS Annual Meeting

saleem I, Smyth HDC. 2006. Modulation of dry powder inhaler performance by controlling micronized drug particle size distributions AAPS Annual Meeting

Saleem I, Smyth HDC. 2006. Prediction of dry powder dispersion performance from blending studies British Pharmaceutical Conference

Ismail FMD, Tawfeek HM, Hutcheon GA, Saleem IY . Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 :303-334

Ismail FMD, Tawfeek HM, Hutcheon GW, Saleem IY. Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers DDL conference

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Akram K, Mohammed AR, Gaskel EE, Hutcheon GA, Saleem IY. Optimisation of Polyester Based Microparticles as Carriers for Pulmonary Drug Delivery JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 23 :430-430

Saleem IY, Hutcheon GA, Satyanarayana S. Pulmonary Delivery of Beclometasone Loaded PGA-co-PDL Nanocomposite Microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, Drug Delivery to the Lungs Author Url

Chandra Vadana D, Taylor KMG, Saleem IY, Somavarapu S. DESIGN AND DEVELOPMENT OF DRY POWDER FORMULATIONS OF CURCUMIN FOR LUNG DELIVERY- SPICING UP THE LUNGS Drug Delivery to the Lungs

Neelima T, Taylor KMG, Saleem IY, Randle LE, Somavarapu S. Amphiphilic polygamma glutamic acid derivatives for delivery of amikacin to the lung Journal of Aerosol Medicine and Pulmonary Drug Delivery, Drug Delivery to the Lungs Author Url

Kunda NK, Chavan T, Somavarapu S, Hutcheon GA, Saleem IY. PGA-co-PDL nanoparticles coated with protein formulated as dry powder nanocomposite microparticles for pulmonary vaccine delivery AAPS National Biotechnology Conference

Kunda NK, Chavan T, Somavarapu S, Hutcheon GA, Saleem IY. PGA-co-PDL nanoparticles coated with protein formulated as dry powder nanocomposite microparticles for pulmonary vaccine delivery 2012 AAPS National Biotechnology Conference

Saleem I, Diez F, Jones B. A Comparison of Two Different Types of Inhalation Capsules & Inhaler Device on Powder Aerosolisation 2012 AAPS Annual Meeting and Exposition

Saleem I, Kunda NK, Somavarapu S, Gordon SB, Hutcheon GA. Protein Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery Saleem IY. AAPS Annual Meeting and Exposition

Saleem I, Diez F, Jones B. A comparison of two different types of inhalation capsules and type of administration device on powder aerosolisation Saleem IY. AAPS Annual Meeting and Exposition

Saleem I, Kunda NK, Somavarapu S, Gordon SB, Hutcheon GA. Protein Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery Saleem IY. AAPS Annual Meeting and Exposition

Saleem I, Diez F, Jones B. Influence of internal lubricant on powder aerosolization properties from inhalation grade hypromellose capsules (Quali-V-I®) Saleem IY. AAPS Annual Meeting and Exposition

Kunda NK, Somavarapu S, Gordon SB, Hutcheon GA, Saleem I. Protein Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery AAPS Annual Meeting and Exposition

Saleem I, Diez F, Jones B. Influence of internal lubricant on powder aerosolization properties from inhalation grade hypromellose capsules (Quali-V-I®) AAPS Annual Meeting and Exposition

Kunda NK, Alfagih I, Somavarapu S, Hutcheon G, Saleem I. Pulmonary vaccine delivery of protein adsorbed PGA-co-PDL nanocomposite microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 :A-1-A-29 DOI

saleem I, hutcheon G, Satyanarayana S. Pulmonary delivery of beclometasone loaded PGA-co-PDL nanocomposite microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 :A-1-A-27 DOI

Tawfeek H, Khidr SH, Samy EM, Ahmed SM, Hutcheon G, Saleem I. Effect of PEGylation on spray dried PGA-co-PDL pulmonary carrier microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 :303-334

alfagih I, Alanazi FK, kunda N, hutcheon G, saleem I. Protein loaded nancomposite microparticles for inhalation Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 DOI

Valeria C, Ayca P, Gillian H, Saleem I, Adel M. Dry powder intended for pulmonary delivery: Comparison between PGA-co-PDL and chitosan Nano Composite Microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, Author Url

Scagnetti G, Verhook S, Killoran P, Coxon C, Osman N, Gordon S, Chaudary S, Saleem I. Antimicrobial Activity of Peptide Aurein 3.1 Complexed in Chitosan Nanoparticle for Pulmonary Delivery - 11th PBP World Meeting

Carini V, Esenturk I, Scagnetti G, Saleem I. PREPARATION AND OPTIMIZATION OF CHITOSAN NANOPARTICLES THROUGH MIROFLUIDICS MIXING TECHNOLOGY 2018 UKICRS Workshop & Symposium

Kaneko K, Miyaji E, Goncalves V, Ferreira D, Solorzano-Gonzalez C, MacLoughlin R, Sexton D, Saleem I. Evaluation of PLGA polymers for nanoparticle immunogenicity

Alfagih I, Kunda N, Alanazi F, Hutcheon G, Saleem I. CATIONIC PGA-CO-PDL NANOCOMPOSITE MICROPARTICLES FOR ANTIGEN DELIVERY VIA INHALATION Journal of Aerosol Medicine and Pulmonary Drug Delivery,

Saleem I, Patel T, Roberts M. Surface coated lactose carrier dry powder inhalation particles using a fluid bed system Journal of Pharmacy and Pharmacology, 62

Tawfeek H, Khidr S, Samy E, Ahmed S, Shabir A, Mohammed A, Hutcheon G, Saleem I. pulmonary delivery of α-chymotrypsin via novel polyester microparticles Journal of Pharmacy and Pharmacology, 62

Saleem I, Smyth H. prediction of dry powder dispersion performance from blending studies using budesonide as model drug

Saleem I, Smyth H. Prediction of dry powder dispersion performance from blending studies using budesonide as model drug

Poster

Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2016. Pulmonary Delivery of Therapeutic miR-146a Nanoparticles. AAPS National Biotechnology Conference, Boston, USA.

Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2015. Polymeric Nanoparticles for the Pulmonary Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). 42nd Annual Meeting & Exposition of the Controlled Release Society, Edinburgh.

Chapters

Kunda N, Alfagih I, Saleem I, Hutcheon G. 2015. Polymer-based Delivery Systems for the Pulmonary Delivery of Biopharmaceuticals Nokhodchi A, Martin G. Pulmonary Drug Delivery: Advances and Challenges John Wiley & Sons, Ltd DOI

Saleem I, Al-Khattawi A. 2013. Surface Phenomena Denton P, Rostron C. Pharmaceutics the science of medicine design Oxford University Press

Smyth HDC, Saleem I, Donovan M, Verschraegen CF. 2007. Pulmonary Delivery of Anti-Cancer Agents Williams RO, Taft DR, McConville JT. Advanced drug formulation design to optimize therapeutic outcomes 172 :81-113 Informa HealthCare 9781420043877

Smyth HDC, Saleem I, Donovan M, Verschraegen CF. Pulmonary delivery of anti-cancer agents 172 :81-111 Taylor & Francis

Saleem I, Pektar K, Somavarapu S. Rationale for pulmonary vaccine delivery – formulation and device considerations Skwarcynski M, Toth I. In micro- and nanotechnology in vaccine development DOI

Internet publication

Jones B, Saleem I, Diez F. 2013. Aerosolisation Properties of Quali-V®-I versus Gelatin Capsules: an Improvement in Inhalation Drug Delivery Author Url Publisher Url

Patent

Saleem I, Kaneko K. Nanoparticles and Uses Thereof

Engagement & Impact

Editorial boards:

MDPI Pharmaceutics, Editorial Board Member. 2019

International Journal of Nanotechnology and Nanomedicine Research, Editorial Board member. 2016

Drug Delivery Letters, Editorial Advisory Board Member. 2011

Industrial connections:

Precision Nanosystems, Development of nano carriers using micro fluidic technology. 2018

Polypharmakos Ltd, spray drying of nano carriers incorporating traditional Chinese medicine products. 2018

ACG-Worldwide, Investigation of capsules used in dry powder formulations for capsule-based inhaler devices. 2016

Aerogen Ltd. Galway Business Park, Dangan, Galway, Ireland., Investigating nanocarrier formulations for delivery of biomacromolecules in the treatment / prevention of lung diseases and vaccination. 2016

Qualicaps® Europe, S.A.U. Avenida Monte Valdelatas, 4 28108 Alcobendas (Madrid) Spain, Investigating capsules for use in dry powder inhalers. 2011

Qualicaps Europe, Investigation of different capsules for dry powder inhalation. 2010

Conference presentation:

Dry Powder Delivery of Biologicals using Nanocarrier Systems, Knowledge Transfer Network (KTN) Biopharmaceutical Formulation Group (BFG), Formulation challenges for traditional and next generation biopharmaceuticals, Manchester, UK, Oral presentation. 2018

Lung Mucosal Delivery of Nanocarrier Pneumococcal Vaccine, International Conference on Vaccines and Immunology, Amsterdam, Netherlands, Oral presentation. 2018

Pulmonary Delivery of Biologicals using Polymer-Based Nanocarriers, 3rd Annual Inhalation and Respiratory Drug Delivery congress, London, Oral presentation. 2018

Nanoparticulate Carriers for the Delivery of Biopharmaceuticals, 4th Workshop on Pulmonary Drug Delivery, Istanbul, Turkey, Oral presentation. 2017

Pulmonary Delivery of a Targeted Mucosal Nanocarrier Vaccine, LJMU MRC funded Open Door Even, LJMU, Oral presentation. 2017

 Pulmonary Delivery of a Mucosal Nanocarrier Vaccine for Pneumonia, 15th Annual Summit on Vaccines and Immunization, Berlin, Germany, Oral presentation. 2017

 Dry powder inhalation of Pneumococcal protein-based nanocarrier vaccine, 10th International Conference and Exhibition on Pharmaceutics & Novel Delivery Systems, London, Oral presentation. 2017

Dry powder inhalation of Pneumococcal protein-based nanocarrier vaccine, 10th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems, London, UK, Oral presentation. 2017

Dry Powder Inhalation Of A Pneumococcal Protein-based Nano Vaccine, at 2nd Annual Inhalation and Respiratory Drug Delivery congress, London, Oral presentation. 2017

Pulmonary Delivery of Therapeutic miR-146a Nanoparticles, AAPS National Biotechnology Conference, 2016, Boston, USA, Poster presentation. 2016

 Reality of Nanotechnology for Lung Delivery, DUPHAT – Dubai International Pharmaceuticals and Technologies Conference and Exhibition, Dubai, UAE, Oral presentation. 2016

Vaccine Delivery via the Lungs, The 2nd Workshop on Pulmonary Drug Delivery, Trinity College Dublin, Ireland, Oral presentation. 2015

Dry Powder Aerosolisation, The use of capsules in pharmaceutical product development, GSK, Harlow, UK, Oral presentation. 2015

Nanocarriers for Pulmonary Vaccine Delivery, The Second International Conference on new Horizons in Basic and Applied Science, Hurghada, Egypt, Oral presentation. 2015

Key Parameters in DPI Aerosolization, Capsule-Based Inhalers – Understanding the Science, Basel, Switzerland, Oral presentation. 2014

Capsule-Based Inhalers, Understanding the Science, Basel, Switzerland, Oral presentation. 2014

New Pulmonary Drug Carriers, ISPE Turkey Affiliate, Istanbul University, Istanbul University, Istanbul, Turkey, Oral presentation. 2014

The Possibilities of Vaccination via the Lungs, Pharmaconex, The International Conference on Pharmaceutical Technologies, Cairo International Conference Center, Egypt, Oral presentation. 2014

Pulmonary Delivery Systems: Future of Vaccination, DUPHAT, Dubai International Pharmaceuticals and Technologies Conference and Exhibition, Dubai, UAE, Oral presentation. 2014

Other invited event:

International Conference on Vaccines and Immunology, Amsterdam, Netherlands, Chairperson of session entitled "Immunology of Infectious Diseases | Vaccine Adjuvants & Delivery Technologies | Human Vaccines-Infectious & Non-Infectious | Veterinary Vaccines". 2018

10th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems, London, UK, Session Chair - Nanotechnology in Drug Delivery | Pharmaceutical Nanotechnology | Biomaterials in Drug Delivery. 2017

DUPHAT – Dubai International Pharmaceuticals and Technologies Conference and Exhibition, Dubai, UAE, Chairperson of session - Nanotechnology and its Industrial Application: I. 2016

External visit to King Saud University, King Abdullah Institute for Nanotechnology, provided a presentation - Pulmonary Delivery of a Polymer-Based Nanocomposite-Microparticle Pneumococcal Vaccine. 2015

External visit to King Saud University, College of Pharmacy, Provided a presentation - Pulmonary Delivery of a Polymer-Based Nanocomposite-Microparticle Pneumococcal Vaccine. 2015

Guest lecture, King Abdullah Institute for Nanotechnology, King Saud University, Presented lecture -  Pulmonary Delivery of a Polymer-Based Nanocomposite-Microparticle Pneumococcal Vaccine. 2015

reserach visit lecture, King Saud University, College of Pharmacy, Presented guest lecture -  Pulmonary Delivery of a Polymer-Based Nanocomposite-Microparticle Pneumococcal Vaccine. 2015

MRC Workshop in Novel Tools and Technologies for Vaccines, BIS Conference Centre, 1 Victoria Street, London, SW1H 0ET, I was invited by the MRC to attend this workshop due to my research in the area of nanotechnology and applications towards vaccine delivery.. 2015

Visit King Saud University, College of Pharmacy, Visit under the EJSP scheme. I met the internal supervisor, EJSP team, other members of staff, and presented a talk on my research - Pulmonary Vaccine Delivery. 2013

Visiting Research lecture, King Saud University, College of Pharmacy, Title of talk -  Pulmonary Vaccine Delivery. 2013

Visiting reserach lecture, King Saud University, College of Pharmacy, presented lecture -  Pulmonary Inhalation. 2011

External visit to King Saud University, College of Pharmacy, This is a visit to under the External joint Supervisory Ph.D Programme. This visit was to meet internal supervisor, meet with EJSP team, meet other members of staff and present a talk on my research - "Pulmonary Inhalation". 2011

External PGR examinations performed:

UCL School of Pharmacy, PhD, Cyclodextrin-based formulations for pulmonary delivery of chemotherapeutic molecules. 2018

Ulster University, PhD, Inhibition of nuclear factor kappa beta (NF-kb) as therapeutic strategy for treatment of IBD and cancer. 2018

Brighton University, PhD, Development, characterisation and assessment of chemical stability of fast dissolving oral levothyroxine films. 2018

Kings College London, PhD, Using Ion-pairs to Modify Salbutamol Delivery to the Lungs. 2018

Aston University, PhD, Phytochemical Mediated Modulation of Breast Cancer Resistance Protein at the Blood Brain Barrier and Blood Cerebrospinal Fluid Barrier. 2016

Trinity College Dublin, School of Pharmacy & Pharmaceutical Sciences, PhD, Production of sugar-based porous particles encapsulating salmon calcitonin via spray drying for pulmonary delivery. 2012

University of Birmingham, MSc, Pectin Particles as a controlled release delivery system of a model drug, 5-aminosalicylic acid. 2011

External collaboration:

Alder Hey Children's Hospital, Professor Matthew Peak. 2017

University of Liverpool Institute of Translational Medicine Molecular & Clinical Medicine, Dr Lakis Liloglou & Dr Michael Davies. 2016

INSERM (French National Institute for Health and Medical Research), Dr. Nadia Jessel. 2015

King Saud University, College of Pharmacy, Dr Mona Elkhatib. 2014

Princess Norouah University, Prof Mahasen Radwan. 2014

University of Central Lancashire, School of Pharmacy and Biomedical Sciences, Dr Sarah Dennison. 2014

University of Liverpool, Institute of Infection and Global Health, Dr Paul Wigley. 2014

Instituto Butantan, Brazil, Dr Eliane Miyaji & Dr Viviane Gonçalves. 2013

UCL School of Pharmacy, Dr Satyanarayana Somavarapu. 2012

Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil, Dr Eliane Namie Miyaji & Dr Viviane Goncalves. 2011

King Saud University, College of Pharmacy, Professor Fars Alanazi. 2011

Assuit University, Faculty of Pharmacy, Dr Hesham Tawfeek. 2011

Hamburg University of Technology, Prof Irina Smirnova. 2010

Liverpool School of Tropical Medicine, Prof. Stephen Gordon & Dr Daniela Ferreira. 2010

Aston University, Dr Afzal Mohammed. 2009

University of Texas at Austin, USA, Dr Hugh Smyth. 2008

Award:

Vice-Chancellor's Excellence Award in Research (£1,500), Liverpool John Moores University. 2017

MRC Industrial Engagement Fund (£1,500), Liverpool John Moores University. 2017

Best academic poster award, Drug Delivery to the Lungs. 2010

LJMU Early Career Researcher Fellowship (£5,000), Liverpool John Moores University. 2010

LJMU Institute of Health research Fund (£1,576), Liverpool John Moores University. 2009

Research Grants Awarded:

MRC - Highlight Notice in novel tools and technologies for vaccinology, VACCINE FAPESP MICA: Pulmonary Delivery of a Targeted Mucosal Nanocarrier Vaccine for Pneumonia, Grant value (£): 570,000, Duration of research project: 3 years. 2017

Innovate UK/MRC - Biomedical catalyst, Development of small peptide CGRP antagonists for migraine therapy, Drs Imran Saleem, Christopher Coxon & Gillian Hutcheon, Liverpool John Moores University, Professor David Kendal, PharmaNovo AB, Grant value (£): 199,498, Duration of research project: 1 year. 2017

MRC-Brazil (FAPESP) joint funding of research, Pulmonary Delivery of a Polymer-Based Nanocomposite-Microparticle Pneumococcal Vaccine, Dr Gillian Hutcheon, Dr Viviane Goncalves, Dr Eliane Miyaji, Grant value (£): £244,398.40, Duration of research project: 2 years. 2014

Teaching qualification:

Fellow of the Higher education Academy. 2013

Fellowships:

Second Round of University Early Career Researcher Scheme for 2010-11, Liverpool John Moores University. 2011

Membership of professional bodies:

Mr, Royal Pharmaceutical Society of Great Britain. 1999

External PGR Supervision - completed students:

Assuit University, PhD, Evaluation of Novel Biodegradable Polymers for Pulmonary Protein delivery.

Sohag University, Egyt, PhD, Toxicology & cellular interactions of materials for drug delivery.

Other Professional Activity:

External programme examiner at Aston University in MSc Drug Delivery October 2015 to September 2019.

Reviewer for Academic Staff Promotion at King Suad University, Saudia Arabia December 2018 & January 2019.