Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr James Firman

Dr James Firman


Journal article

Pletz J, Enoch SJ, Jais DM, Mellor CL, Pawar G, Madden JC, Webb S, Tagliati C, Cronin MTD. 2018. A Critical Review of Adverse Effects to the Kidney: Mechanisms, Data Sources and In Silico Tools to Assist Prediction Expert Opinion on Drug Metabolism and Toxicology,

La Pensee L, Sabbani S, Sharma R, Bhamra I, Shore E, Chadwick AE, Berry NG, Firman J, Araujo NC, Cabral L, Cristiano MLS, Bateman C, Janneh O, Gavrila A, Wu YH, Hussain A, Ward SA, Stocks PA, Cosstick R, O'Neill PM. 2013. Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation CHEMMEDCHEM, 8 :709-718 >DOI >Link

Copple I, Mercer A, Firman JW, Donegan G, Herpers B, Wong M, Chadwick J, Bringela A, Cristiano M, van de Water B, Ward S, O'Neill P, Park BK. 2012. Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials Molecular Medicine, 18 :1045-1055 >DOI

Mellor C, Marchese Robinson RL, Benigni R, Ebbrell D, Enoch S, Firman J, Madden J, Pawar G, Yang C, Cronin MTD. Molecular Fingerprint-Derived Similarity Measures for Toxicological Read-Across: Recommendations for Optimal Use Regulatory Toxicology and Pharmacology,

Firman J, Patel A, Date M, Cronin MTD, Schultz TW. Read-across of 90-day rodent repeated-dose toxicity: A case study for selected simple aryl alcohol alkyl carboxylic acid esters Computational Toxicology, 7 :1-8 >DOI >Link

Conference publication

Cronin M, Belfield S, Escher S, Firman J, Lieu J, Marsaux C, Mostrag-Szlichtyng A, Przybylak K, Rathman J, Tarkhov A, Yang C. 2017. Extension of the carcinogen dose-response database for threshold of toxicological concern TOXICOLOGY LETTERS, 53rd Congress of the European-Societies-of-Toxicology (EUROTOX) 280 :S284-S284 >DOI >Link

Firman J, Cain K, Park BK, MacFarlane M, Chadwick A. 2014. Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs Toxicology Letters, 229 :S61-S62 >DOI

Firman JW, MacFarlane M, Park BK, Mercer AE. 2011. Assessing the cytotoxic profile of novel endoperoxide derivatives Toxicology, 290 :138-138 >DOI