Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr James Firman

Dr James Firman

Telephone: 0151 231 2829

ORCID

Publications

Conference publication

Yang C, Cronin MT, Ebbrell D, Firman JW, Kawamoto T, Madden JC, Magdziarz T, Mostrag A, Rathman JF, Theophilus EH. 2019. novel methods for estimating noael confidence bounds and optimising similarity measures for read-across workflows TOXICOLOGY LETTERS, 55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions 314 :S259-S260 Author Url

Cronin MTD, Bienfait B, Ebbrell DJ, Enoch SJ, Firman JW, Madden JC, Mostrag-Szlichtyng A, Rathman JF, Vitcheva V, Yang C. 2018. An extended mechanistically-based in silico profiler for liver toxicity TOXICOLOGY LETTERS, 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box 295 :S101-S101 DOI Author Url

Pletz J, Ebbrell DJ, Enoch SJ, Firman JW, Madden JC, Webb SD, Cronin MTD. 2018. Development of a Robust In Silico Profiler to Screen for Nephrotoxicity Endpoints TOXICOLOGY LETTERS, 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box 295 :S97-S97 DOI Author Url

Nepelska M, Cronin MTD, Cubberley R, Dent M, Firman JW, Fisher J, Kenna G, Mahony C, Nicol B, Piechota S, Przybylak K, Schepky A, Tozer S, Troutman J, Desprez B. 2018. Cosmetic Europe's long range science strategy - A non-animal safety assessment case study for phenoxyethanol, a cosmetic ingredient TOXICOLOGY LETTERS, 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box 295 :S171-S171 DOI Author Url

Cronin M, Belfield S, Escher S, Firman J, Lieu J, Marsaux C, Mostrag-Szlichtyng A, Przybylak K, Rathman J, Tarkhov A, Yang C. 2017. Extension of the carcinogen dose-response database for threshold of toxicological concern TOXICOLOGY LETTERS, 53rd Congress of the European-Societies-of-Toxicology (EUROTOX) 280 :S284-S284 DOI Author Url

Firman J, Cain K, Park BK, MacFarlane M, Chadwick A. Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs Toxicology Letters, 229 :S61-S62 DOI

Firman JW, MacFarlane M, Park BK, Mercer AE. Assessing the cytotoxic profile of novel endoperoxide derivatives Toxicology, 290 :138-138 DOI

Journal article

Pawar G, Madden J, Ebbrell D, Firman J, Cronin M. 2019. In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR Frontiers in Pharmacology, 10 DOI Author Url Publisher Url Public Url

Mellor C, Marchese Robinson RL, Benigni R, Ebbrell D, Enoch S, Firman J, Madden J, Pawar G, Yang C, Cronin MTD. 2019. Molecular Fingerprint-Derived Similarity Measures for Toxicological Read-Across: Recommendations for Optimal Use Regulatory Toxicology and Pharmacology, 101 :121-134 DOI Author Url Public Url

Tomlinson L, Hyndman L, Firman J, Bentley R, Kyffin J, Webb S, McGinty S, Sharma P. 2019. In vitro Liver Zonation of Primary Rat Hepatocytes Frontiers in Bioengineering and Biotechnology, 7 DOI Author Url Publisher Url Public Url

Pletz J, Enoch SJ, Jais DM, Mellor CL, Pawar G, Madden JC, Webb S, Tagliati C, Cronin MTD. 2018. A Critical Review of Adverse Effects to the Kidney: Mechanisms, Data Sources and In Silico Tools to Assist Prediction Expert Opinion on Drug Metabolism and Toxicology, DOI Author Url Publisher Url Public Url

Firman J, Patel A, Date M, Cronin MTD, Schultz TW. 2018. Read-across of 90-day rodent repeated-dose toxicity: A case study for selected simple aryl alcohol alkyl carboxylic acid esters Computational Toxicology, 7 :1-8 DOI Author Url Publisher Url Public Url

La Pensee L, Sabbani S, Sharma R, Bhamra I, Shore E, Chadwick AE, Berry NG, Firman J, Araujo NC, Cabral L, Cristiano MLS, Bateman C, Janneh O, Gavrila A, Wu YH, Hussain A, Ward SA, Stocks PA, Cosstick R, O'Neill PM. 2013. Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation CHEMMEDCHEM, 8 :709-718 DOI Author Url

Copple I, Mercer A, Firman JW, Donegan G, Herpers B, Wong M, Chadwick J, Bringela A, Cristiano M, van de Water B, Ward S, O'Neill P, Park BK. 2012. Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials Molecular Medicine, 18 :1045-1055 DOI Publisher Url Public Url

Firman JW, Belfield SJ, Chen G, Jackson M, Lam FH, Richmond C, Smith J, Steinmetz FP, Cronin MTD. Chemoinformatic Consideration of Novel Psychoactive Substances: Compilation and Preliminary Analysis of a Categorised Dataset Molecular Informatics, DOI Author Url Public Url

Chapters

Ebbrell D, Cronin M, Ellison C, Firman J, Madden J. Development of Baseline Quantitative Structure-Activity Relationships (QSARs) for the Effects of Active Pharmaceutical Ingredients (APIs) to Aquatic Species Roy K. Ecotoxicological QSARs Springer