Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr James Firman

Dr James Firman

Telephone: 0151 231 2829


Journal article

Pawar G, Madden J, Ebbrell D, Firman J, Cronin M. 2019. In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR Frontiers in Pharmacology, 10

Tomlinson L, Hyndman L, Firman J, Bentley R, Kyffin J, Webb S, McGinty S, Sharma P. 2019. In vitro Liver Zonation of Primary Rat Hepatocytes Frontiers in Bioengineering and Biotechnology, 7 >DOI >Public Url

Mellor C, Marchese Robinson RL, Benigni R, Ebbrell D, Enoch S, Firman J, Madden J, Pawar G, Yang C, Cronin MTD. 2019. Molecular Fingerprint-Derived Similarity Measures for Toxicological Read-Across: Recommendations for Optimal Use Regulatory Toxicology and Pharmacology, 101 :121-134 >DOI >Public Url

Pletz J, Enoch SJ, Jais DM, Mellor CL, Pawar G, Madden JC, Webb S, Tagliati C, Cronin MTD. 2018. A Critical Review of Adverse Effects to the Kidney: Mechanisms, Data Sources and In Silico Tools to Assist Prediction Expert Opinion on Drug Metabolism and Toxicology, >Public Url

Firman J, Patel A, Date M, Cronin MTD, Schultz TW. 2018. Read-across of 90-day rodent repeated-dose toxicity: A case study for selected simple aryl alcohol alkyl carboxylic acid esters Computational Toxicology, 7 :1-8 >DOI >Link >Public Url

La Pensee L, Sabbani S, Sharma R, Bhamra I, Shore E, Chadwick AE, Berry NG, Firman J, Araujo NC, Cabral L, Cristiano MLS, Bateman C, Janneh O, Gavrila A, Wu YH, Hussain A, Ward SA, Stocks PA, Cosstick R, O'Neill PM. 2013. Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation CHEMMEDCHEM, 8 :709-718 >DOI >Link

Copple I, Mercer A, Firman JW, Donegan G, Herpers B, Wong M, Chadwick J, Bringela A, Cristiano M, van de Water B, Ward S, O'Neill P, Park BK. 2012. Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials Molecular Medicine, 18 :1045-1055 >DOI >Public Url

Firman JW, Belfield SJ, Chen G, Jackson M, Lam FH, Richmond C, Smith J, Steinmetz FP, Cronin MTD. Chemoinformatic Consideration of Novel Psychoactive Substances: Compilation and Preliminary Analysis of a Categorised Dataset Molecular Informatics, >Public Url

Conference publication

Nepelska M, Cronin MTD, Cubberley R, Dent M, Firman JW, Fisher J, Kenna G, Mahony C, Nicol B, Piechota S, Przybylak K, Schepky A, Tozer S, Troutman J, Desprez B. 2018. Cosmetic Europe's long range science strategy - A non-animal safety assessment case study for phenoxyethanol, a cosmetic ingredient TOXICOLOGY LETTERS, 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box 295 :S171-S171 >DOI >Link

Pletz J, Ebbrell DJ, Enoch SJ, Firman JW, Madden JC, Webb SD, Cronin MTD. 2018. Development of a Robust In Silico Profiler to Screen for Nephrotoxicity Endpoints TOXICOLOGY LETTERS, 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box 295 :S97-S97 >DOI >Link

Cronin MTD, Bienfait B, Ebbrell DJ, Enoch SJ, Firman JW, Madden JC, Mostrag-Szlichtyng A, Rathman JF, Vitcheva V, Yang C. 2018. An extended mechanistically-based in silico profiler for liver toxicity TOXICOLOGY LETTERS, 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box 295 :S101-S101 >DOI >Link

Cronin M, Belfield S, Escher S, Firman J, Lieu J, Marsaux C, Mostrag-Szlichtyng A, Przybylak K, Rathman J, Tarkhov A, Yang C. 2017. Extension of the carcinogen dose-response database for threshold of toxicological concern TOXICOLOGY LETTERS, 53rd Congress of the European-Societies-of-Toxicology (EUROTOX) 280 :S284-S284 >DOI >Link

Firman J, Cain K, Park BK, MacFarlane M, Chadwick A. 2014. Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs Toxicology Letters, 229 :S61-S62 >DOI

Firman JW, MacFarlane M, Park BK, Mercer AE. 2011. Assessing the cytotoxic profile of novel endoperoxide derivatives Toxicology, 290 :138-138 >DOI