Dr Jon Ashley

Pharmacy and Biomolecular Sciences

Degrees

2021, Denmark Technical University, Denmark, UDTU Diploma in Education in University Teaching
2013, The National University of Singapore, Singapore, PhD in Analytical Chemistry
2006, The University of Newcastle Upon Tyne, United Kingdom, PGCE (QTS) Secondary Science Education
2004, Manchester University, United Kingdom, MChem Chemistry with Industrial Experience

Academic appointments

Assistant Professor, Healthcare Technology, Denmark Technical University, 2019 - 2022
NanoTRAIN for Growth Research Fellow (Marie Curie Co-Fund), Food for Growth, International Iberian Nanotechnology Labaratory, 2018 - 2019
Post Doc in Nanosensors, Nanotech, Denmark Technical University, 2016 - 2018
Research Fellow in Analytical Chemistry, School of Engineering, Cranfield University, 2014 - 2016
Post Doc, Department of Biomedicine, University Hospital Basel, 2013 - 2014

Highlighted publications

Vacacela J, Schaap-Johansen A-L, Manikova P, Marcatili P, Prado M, Sun Y, Ashley J. 2022. The Protein-Templated Synthesis of Enzyme-Generated Aptamers. Angewandte Chemie International Edition, DOI Author Url Publisher Url Public Url

Mohammadniaei M, Zhang M, Ashley J, Christensen UB, Friis-Hansen LJ, Gregersen R, Lisby JG, Benfield TL, Nielsen FE, Rasmussen JH, Pedersen EB, Olinger ACR, Kolding LT, Naseri M, Zheng T, Wang W, Gorodkin J, Sun Y. 2021. A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA Nature Communications, 12 DOI Author Url Publisher Url Public Url

Ashley J, Schaap-Johansen A-L, Mohammadniaei M, Naseri M, Marcatili P, Prado M, Sun Y. 2021. Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides Nucleic Acids Research, 49 :1065-1074 DOI Author Url Publisher Url Public Url

Journal article

Ashley J. 2022. Introducing ... ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, DOI Author Url

Vacacela J, Schaap-Johansen A-L, Manikova P, Marcatili P, Prado M, Sun Y, Ashley J. 2022. The Protein-Templated Synthesis of Enzyme-Generated Aptamers. Angewandte Chemie International Edition, DOI Author Url Publisher Url Public Url

Zheng T, Wang W, Mohammadniaei M, Ashley J, Zhang M, Zhou N, Shen J, Sun Y. 2021. Anti-MicroRNA-21 Oligonucleotide Loaded Spermine-Modified Acetalated Dextran Nanoparticles for B1 Receptor-Targeted Gene Therapy and Antiangiogenesis Therapy ADVANCED SCIENCE, 9 DOI Author Url

Naseri M, Halder A, Mohammadniaei M, Prado M, Ashley J, Sun Y. 2021. A multivalent aptamer-based electrochemical biosensor for biomarker detection in urinary tract infection ELECTROCHIMICA ACTA, 389 DOI Author Url

Mohammadniaei M, Zhang M, Ashley J, Christensen UB, Friis-Hansen LJ, Gregersen R, Lisby JG, Benfield TL, Nielsen FE, Rasmussen JH, Pedersen EB, Olinger ACR, Kolding LT, Naseri M, Zheng T, Wang W, Gorodkin J, Sun Y. 2021. A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA Nature Communications, 12 DOI Author Url Publisher Url Public Url

Zhang M, Wang W, Mohammadniaei M, Zheng T, Zhang Q, Ashley J, Liu S, Sun Y, Tang BZ. 2021. Upregulating Aggregation-Induced-Emission Nanoparticles with Blood-Tumor-Barrier Permeability for Precise Photothermal Eradication of Brain Tumors and Induction of Local Immune Responses ADVANCED MATERIALS, 33 DOI Author Url

Ashley J, Schaap-Johansen A-L, Mohammadniaei M, Naseri M, Marcatili P, Prado M, Sun Y. 2021. Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides Nucleic Acids Research, 49 :1065-1074 DOI Author Url Publisher Url Public Url

D'Aurelio R, Ashley J, Rodgers TL, Trinh L, Temblay J, Pleasants M, Tothill IE. 2020. Development of a NanoMIPs-SPR-Based Sensor for beta-Lactoglobulin Detection CHEMOSENSORS, 8 DOI Author Url

Liu Y, Zhang Q, Zhou N, Tan J, Ashley J, Wang W, Wu F, Shen J, Zhang M. 2020. Study on a novel poly (vinyl alcohol)/graphene oxide-citicoline sodium-lanthanum wound dressing: Biocompatibility, bioactivity, antimicrobial activity, and wound healing effect CHEMICAL ENGINEERING JOURNAL, 395 DOI Author Url

Zhang M, Wang W, Wu F, Zheng T, Ashley J, Mohammadniaei M, Zhang Q, Wang M, Li L, Shen J, Sun Y. 2020. Biodegradable Poly(gamma-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy BIOMATERIALS, 252 DOI Author Url

Zheng T, Wang W, Ashley J, Zhang M, Feng X, Shen J, Sun Y. 2020. Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment NANO-MICRO LETTERS, 12 DOI Author Url

Naseri M, Mohammadniaei M, Sun Y, Ashley J. 2020. The Use of Aptamers and Molecularly Imprinted Polymers in Biosensors for Environmental Monitoring: A Tale of Two Receptors CHEMOSENSORS, 8 DOI Author Url

Zhang M, Sheng B, Ashley J, Zheng T, Wang W, Zhang Q, Zhang J, Zhou N, Shen J, Sun Y. 2020. Manganese ion chelated FeOCl@PB@PDA@BPQDs nanocomposites as a tumor microenvironment-mediated nanoplatform for enhanced tumor imaging and therapy SENSORS AND ACTUATORS B-CHEMICAL, 307 DOI Author Url

Klingler C, Ashley J, Shi K, Stiefvater A, Kyba M, Sinnreich M, Aihara H, Kinter J. 2020. DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD FASEB JOURNAL, 34 :4573-4590 DOI Author Url

Yan C, Krasnoperov LN. 2019. Pressure-Dependent Kinetics of the Reaction between CH3O2 and OH: TRIOX Formation JOURNAL OF PHYSICAL CHEMISTRY A, 123 :8349-8357 DOI Author Url

Yan C, Krasnoperov LN. 2019. Pressure-Dependent Kinetics of the Reaction between CH3O2 and OH: TRIOX Formation. The journal of physical chemistry. A, 123 :8349-8357 DOI Author Url

Shah F, Shi A, Ashley J, Kronfel C, Wang Q, Maleki SJ, Adhikari B, Zhang J. 2019. Peanut Allergy: Characteristics and Approaches for Mitigation COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, 18 :1361-1387 DOI Author Url

Ren Z, Trinh L, Cooke M, De Hert SC, Silvaluengo J, Ashley J, Tothill IE, Rodgers TL. 2019. Development of a Novel Linear ERT Sensor to Measure Surface Deposits IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 68 :754-761 DOI Author Url

Zhou T, Ashley J, Feng X, Sun Y. 2018. Detection of hemoglobin using hybrid molecularly imprinted polymers/carbon quantum dots-based nanobiosensor prepared from surfactant-free Pickering emulsion TALANTA, 190 :443-449 DOI Author Url

Feng X, Ashley J, Zhou T, Sun Y. 2018. Fluorometric determination of doxycycline based on the use of carbon quantum dots incorporated into a molecularly imprinted polymer MICROCHIMICA ACTA, 185 DOI Author Url

Hemben A, Ashley J, Tothill IE. 2018. An immunosensor for parasite lactate dehydrogenase detection as a malaria biomarker - Comparison with commercial test kit TALANTA, 187 :321-329 DOI Author Url

Halder A, Godoy-Gallardo M, Ashley J, Feng X, Zhou T, Hosta-Rigau L, Sun Y. 2018. One-pot green synthesis of biocompatible graphene quantum dots and their cell uptake studies ACS Applied Bio Materials, 1 :452-461 DOI Author Url

Feng X, Ashley J, Zhou T, Halder A, Sun Y. 2018. Molecularly imprinted nanoparticles for inhibiting ribonuclease in reverse transcriptase polymerase chain reaction ANALYST, 143 :2750-2754 DOI Author Url

Ashley J, D'Aurelio R, Piekarska M, Temblay J, Pleasants M, Trinh L, Rodgers TL, Tothill IE. 2018. Development of a beta-Lactoglobulin Sensor Based on SPR for Milk Allergens Detection BIOSENSORS-BASEL, 8 DOI Author Url

Ashley J, Feng X, Sun Y. 2018. A multifunctional molecularly imprinted polymer-based biosensor for direct detection of doxycycline in food samples TALANTA, 182 :49-54 DOI Author Url

Ashley J, Feng X, Halder A, Zhou T, Sun Y. 2018. Dispersive solid-phase imprinting of proteins for the production of plastic antibodies CHEMICAL COMMUNICATIONS, 54 :3355-3358 DOI Author Url

Ashley J, Shukor Y, D'Aurelio R, Trinh L, Rodgers TL, Temblay J, Pleasants M, Tothill IE. 2018. Synthesis of Molecularly Imprinted Polymer Nanoparticles for alpha-Casein Detection Using Surface Plasmon Resonance as a Milk Allergen Sensor ACS SENSORS, 3 :418-424 DOI Author Url

Feng X, Ashley J, Zhou T, Halder A, Sun Y. 2018. A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine RSC ADVANCES, 8 :2365-2372 DOI Author Url

Ashley J, Wu K, Hansen MF, Schmidt MS, Boisen A, Sun Y. 2017. Quantitative Detection of Trace Level Cloxacillin in Food Samples Using Magnetic Molecularly Imprinted Polymer Extraction and Surface-Enhanced Raman Spectroscopy Nanopillars ANALYTICAL CHEMISTRY, 89 :11484-11490 DOI Author Url

Hemben A, Ashley J, Tothill IE. 2017. Development of an Immunosensor for PfHRP 2 as a Biomarker for Malaria Detection BIOSENSORS-BASEL, 7 DOI Author Url

Trinh L, Willey AR, Martin PJ, Ashley J, Tothill IE, Rodgers TL. 2017. Rate-Based Approach to Cleaning-in-Place INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 56 :6695-6702 DOI Author Url

Ashley J, Shahbazi M-A, Kant K, Chidambara VA, Wolff A, Bang DD, Sun Y. 2017. Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives BIOSENSORS & BIOELECTRONICS, 91 :606-615 DOI Author Url

Ashley J, Piekarska M, Segers C, Trinh L, Rodgers T, Willey R, Tothill IE. 2017. An SPR based sensor for allergens detection BIOSENSORS & BIOELECTRONICS, 88 :109-113 DOI Author Url

Ashley J, Shukor Y, Tothill IE. 2016. The use of differential scanning fluorimetry in the rational design of plastic antibodies for protein targets ANALYST, 141 :6463-6470 DOI Author Url

Ashley J, Ji K, Li SFY. 2015. Selection of cholesterol esterase aptamers using a dual-partitioning approach ELECTROPHORESIS, 36 :2616-2621 DOI Author Url

Ashley J, Li SFY. 2013. An aptamer based surface plasmon resonance biosensor for the detection of bovine catalase in milk BIOSENSORS & BIOELECTRONICS, 48 :126-131 DOI Author Url

Ashley J, Li SFY. 2013. Three-dimensional selection of leptin aptamers using capillary electrophoresis and implications for clone validation ANALYTICAL BIOCHEMISTRY, 434 :146-152 DOI Author Url

Ashley J, Ji K, Li SFY. 2012. Selection of bovine catalase aptamers using non-SELEX ELECTROPHORESIS, 33 :2783-2789 DOI Author Url

Patent

Ashley J, Sun Y, Prado M. 2022. Variable Size Aptamer Libraries Publisher Url Public Url

Chapters

Ashley J. 2021. Biosensors Toldrá F, Nollet LML. Handbook of Dairy Foods Analysis CRC Press 9780429342967 Publisher Url

Ashley J, Sun Y. 2018. The use of nanomaterials and microfluidics in medical diagnostics Biosensors and Nanotechnology: Applications in Health Care Diagnostics :35-58 9781119065012 DOI

Membership of professional bodies:

Chartered Chemist CChem, Royal Society of Chemistry. 2018

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