Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Kehinde Ross

Dr Kehinde Ross

Telephone: 0151 231 2567

ORCID

Biography

My current research focuses on the role of microRNAs and associated pathways in skin disorders such as psoriasis, eczema, impaired wound healing and alopecia. I also have an interdisciplinary collaboration on the development of lipid and polymer nanocarriers for miRNA-directed therapy for inflammatory diseases.

I joined LJMU as a lecturer in August 2008. Prior to that I completed postdoctoral research in the Dermatological Sciences laboratory at Newcastle University under the guidance of Professor Nick Reynolds. For my PhD at the University of Sheffield, I studied cytokine signalling proteins associated with inflammatory diseases, under the supervision of Dr François Guesdon and Professor Steve Dower. A year was spent at GSK Stevenage under the supervision of Dr Filippo Volpe.

Research in my laboratory is supported by the British Skin Foundation, the Cicatricial Alopecia Research Foundation, the Royal Liverpool and Broadgreen Hospitals NHS Trust and the Ministry of Health, Oman.

I have supervised 5 postdoctoral/visiting scientists and over 10 placement students on Nuffield, Erasmus, learned society or independent schemes. I am a member of the Biochemical Society, the British Society for Investigative Dermatology, the British Hair and Nail Society, the Physiological Society, the RNA Society and the European Tissue Repair Society. I am also an affiliate member of the Royal Society of Chemistry.

My teaching activities focus on signal transduction by receptor tyrosine kinases, G protein-coupled receptors and cytokine receptors. Key themes include MAP kinase cascades, PI3K signalling, store-operated calcium entry and NF-kB activation. I have supervised over 45 undergraduate project students.

A Fellow of the Higher Education Academy (FHEA), I was nominated for the Liverpool Students' Union Amazing Teacher Award in 2011, 2013, 2015 and 2016.

Degrees

2013, Liverpool John Moores University, United Kingdom, Postgraduate Certificate for Learning and Teaching in Higher Education
2001, University of Sheffield, United Kingdom, PhD
1997, Brunel University, United Kingdom, BSc (Honours)

Academic appointments

Senior Lecturer in Biochemistry and Cell Biology, Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 2008 - present
Postdoctoral Research Associate, Newcastle University, 2003 - 2008

Postgraduate training

Postdoctoral Research Associate, United Kingdom, Newcastle University, 2003 - 2008

Publications

Highlighted publications

Richardson A, Owens DJ, Ross K. 2018. MicroRNA-184 and its lncRNA sponge uca1 are induced in wounded keratinocytes in a store-operated calcium entry-dependent manner. British Journal of Dermatology, DOI Author Url Publisher Url Public Url

Ross K. 2017. Towards topical microRNA-directed therapy for epidermal disorders Journal of Controlled Release, 269 :136-147 DOI Public Url

Jans, R , Mottram, L , Johnson, DL , Brown, AM , Sikkink, S , Ross,K , Reynolds, NJ . 2012. Lysophosphatidic Acid Promotes Cell Migration through STIM1- and Orai1-Mediated Ca2+i Mobilization and NFAT2 Activation. Journal of Investigative Dermatology, 133 :793-802 DOI Publisher Url

Roberts JC, Warren RB, Griffiths CEM, Ross K. Expression of microRNA-184 in keratinocytes represses argonaute 2. Journal of Cellular Physiology, 228 :2314-2323 DOI

Ross K, Whitaker M, Reynolds NJ. Agonist-induced Calcium Entry correlates with STIM1 translocation. Journal of Cellular Physiology, 211 :569-576 DOI

Journal article

Mohamed A, Pekoz AY, Ross K, Hutcheon GA, Saleem IY. 2019. Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD. International Journal of Pharmaceutics, 569 :118524-118524 DOI Author Url Publisher Url Public Url

Mohamed A, Ross K, Saleem I, Hutcheon G. 2019. Polymeric Nanoparticles For The Pulmonary Delivery Of miRNA To Treat Chronic Obstructive Pulmonary Disease (COPD) European Journal of Pharmaceutics and Biopharmaceutics, 136 DOI Author Url Public Url

Richardson A, Muir L, Mousdell S, Sexton D, Jones S, Howl J, Ross K. 2018. Modulation of mitochondrial activity in HaCaT keratinocytes by the cell penetrating peptide Z-Gly-RGD(DPhe)-mitoparan BMC Research Notes, 11 :82-82 DOI Author Url Public Url

Richardson A, Powell A, Sexton D, Parsons J, Reynolds N, Ross K. 2018. MicroRNA-184 Is Induced By Store-Operated Calcium Entry And Regulates Early Keratinocyte Differentiation bioRxiv, :319541-319541

Ross K. 2017. Towards topical microRNA-directed therapy for epidermal disorders Journal of Controlled Release, 269 :136-147 DOI Public Url

Farrer DJ, Roberts JC, Ross K. 2016. MicroRNA-9 represses sirtuin 1 (SIRT1) in human keratinocytes. Scholars Bulletin, 2 :525-529 DOI Public Url

Jans, R , Mottram, L , Johnson, DL , Brown, AM , Sikkink, S , Ross,K , Reynolds, NJ . 2012. Lysophosphatidic Acid Promotes Cell Migration through STIM1- and Orai1-Mediated Ca2+i Mobilization and NFAT2 Activation. Journal of Investigative Dermatology, 133 :793-802 DOI Publisher Url

Fearon P, Lonsdale-Eccles AA, Ross OK, Todd C, Sinha A, Allain F, Reynolds NJ. 2011. Keratinocyte Secretion of Cyclophilin B via the Constitutive Pathway Is Regulated through Its Cyclosporin-Binding Site. Journal of Investigative Dermatology, 131 :1085-1094 DOI

Hampton P, Ross OK, Reynolds NJ. 2007. Increased nuclear beta-catenin in suprabasal involved psoriatic epidermis British Journal of Dermatology, 157 :1168-1177 DOI

Hoogduijn MJ, Cemeli E, Ross K, Anderson, D , Thody AJ, Wood JM. 2004. Melanin Protects Melanocytes and Keratinocytes Against H2O2-induced DNA Strand Breaks Through its Ability to Bind Ca2+. Experimental Cell Research, 294 :60-67 DOI

Ross K, Yang L, Dower S, Volpe F, Guesdon F. 2002. Identification of Threonine 66 as a Functionally Critical Residue of the Interleukin-1 Receptor-associated Kinase (IRAK). Journal of Biological Chemistry, 277 :37414-37421 Publisher Url

Roberts JC, Warren RB, Griffiths CEM, Ross K. Expression of microRNA-184 in keratinocytes represses argonaute 2. Journal of Cellular Physiology, 228 :2314-2323 DOI

Ross K, Parker G, Whitaker M, Reynolds NJ. Inhibition of calcium-independent phospholipase A impairs agonist-induced calcium entry in keratinocytes. British Journal of Dermatology, 158 :31-37 DOI

Ross K, Whitaker M, Reynolds NJ. Agonist-induced Calcium Entry correlates with STIM1 translocation. Journal of Cellular Physiology, 211 :569-576 DOI

Yang L, Ross K, Qwarnstrom EE. RelA Control Of IkBa Phosphorylation: A Positive Feedback Loop For High Affinity NF-kB Complexes. Journal of Biological Chemistry, 278 :30881-30888 DOI

Editorial/letter to the editor

Richardson A, Owens DJ, Ross K. 2018. MicroRNA-184 and its lncRNA sponge uca1 are induced in wounded keratinocytes in a store-operated calcium entry-dependent manner. British Journal of Dermatology, DOI Author Url Publisher Url Public Url

Poster

Richardson A, Sexton D, Powell AK, Ross K. 2017. A store-operated calcium entry-dependent regulatory loop between nuclear factor of activated T-cells 1 and miR-184 in keratinocytes Non-Coding RNA: Recent Insights into the Mechanism of Action, Biochemical Society Conference, Edinburgh, UK

Richardson A, Ross K. 2017. Conservation and number of microRNA-21 binding sites correlates with interferon gamma-dependent suppression of target transcripts Non-Coding RNA: Recent Insights into the Mechanisms of Action. A Biochemical Society Focused Meeting. Royal College of Surgeons of Edinburgh, Edinburgh, UK

Richardson A, Ross K. 2017. Transforming Growth Factor Beta Induces MicroRNA-21 and TIMP-3 in Human Keratinocytes British Society for Investigative Dermatology Annual Meeting, Manchester, UK

Richardson A, Sexton D, Powell AK, Ross K. 2017. Defining the Role of Argonautes in Human Epidermal Keratinocytes British Society for Investigative Dermatology Annual Meeting, Manchester, UK

Richardson A, Sexton D, Powell AK, Ross K. 2016. Argonaute Expression in Psoriasis and Epidermal Keratinocytes. Inflammatory diseases - mechanisms and clinical perspectives, Maynooth University, Ireland. A Biochemical Society Focused Meeting.

Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2016. Pulmonary Delivery of Therapeutic miR-146a Nanoparticles. AAPS National Biotechnology Conference, Boston, USA.

Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2015. Polymeric Nanoparticles for the Pulmonary Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). 42nd Annual Meeting & Exposition of the Controlled Release Society, Edinburgh.

Tusubira D, Wabinga H, Ross K, Masembe C. 2012. The Potential of Serum micro-RNAs in the Screening and early detection of Breast Cancer. Advanced Summer School on Nutrition and Disease: Biochemical and Molecular Insights. South Africa.

Coyne V, Ross K, Shriver Z, Wills B, Powell AK. 2012. Applying an HPLC structural glycomics strategy to investigate triggers of changes in HS structure. Biochemical Society/Royal Society of Chemistry workshop. London.

Report

Wise A, Ross K. 2016. Biochemical Society Summer Vacation Studentship Report Amino Acid Signaling in Skin: SLC38A9 Expression in Keratinocytes Author Url

Conference publication

Ross K, Richardson A, Tan TH, Roberts JC. 2016. Argonautes and the human keratinocyte: the microRNA connection. British Journal of Dermatology, British Skin Foundation, Skin Deep - 20 Years of Research, 20th Anniversary Conference 175 :61-61 DOI Author Url

Tan TH, Yesudian, PD, West, L, Al-Sharqi, A, Parslew R, Ross K. 2016. Evaluation of the relationship between aquaporin-9 and microRNA-205 expression in psoriatic epidermis. British Journal of Dermatology, British Association of Dermatologists 96th Annual Meeting 175 :52-52 DOI Publisher Url

Jans R, Mottram L, Johnson J, Brown AM, Sikkink S, Ross K, Reynolds NJ. 2012. Lysophosphatidic acid promotes keratinocyte migration through STIM1-regulated Orai1-Ca2+ channels and NFAT2 activation. Journal of Investigative Dermatology, 42nd Annual Meeting of the European Society for Dermatological Research (ESDR) 132 :S101-S101

Fearon P, Lonsdale-Eccles AA, Ross K, Todd C, Allain A, Reynolds NJ. 2009. Secretion of chemotactic cyclophilin B by keratinocytes is regulated through its cyclosporin binding site. Journal of Investigative Dermatology, 37th Annual Meeting of the European Society for Dermatological Research (ESDR 2007) 127 :S39-S39

Jans R, Brown AM, Ross K, Reynolds NJ. 2009. Lysophosphatidic acid-evoked calcium fluxes promote keratinocyte migration through Orai1, lipid rafts and NFAT. Journal of Investigative Dermatology, 69th Annual Meeting of the Society of Investigative Dermatology 129 :S90-S90 Publisher Url

Jans R, Brown A, Sikkink S, Ross K, Reynolds NJ. 2009. Lysophosphatidic acid-evoked calcium fluxes promote NFAT-mediated keratinocyte migration. British Journal of Dermatology, British Society for Investigative Dermatology Annual Meeting 160 :903-904

Milner S, Ross K, Reynolds NJ. 2009. Inhibition of store-operated calcium entry and STIM1 translocation by dithranol is dependent upon superoxide formation. British Journal of Dermatology, Annual Meeting of the British Society for Investigative Dermatology 160 :914-914

Jans R, Sikkink S, Flockhart RJ, Al-Daraji W, Brown AM, Ross K, Reynolds NJ. 2008. NFAT2 is involved in regulating keratinocyte proliferation and differentiation. Journal of Investigative Dermatology, International Investigative Dermatology Meeting 128 :S130-S130

Milner S, Ross K, Thody A, Reynolds NJ. 2008. The anti-psoriatic drug anthralin inhibits calcium release from the endoplasmic reticulum, store-operated calcium entry and the translocation of stromal interacting molecule 1 (STIM1). International Investigative Dermatology Meeting 128 :S134-S134

Milner S, Ross K, Thody T, Reynolds NJ. 2008. The anti-psoriatic drug dithranol inhibits agonist-induced calcium flux and the translocation of stromal-interacting molecule 1. British Journal of Dermatology, Annual Meeting of the British Society for Investigative Dermatology 158 :899-899

Jans R, Sikkink S, Flockhart R, Al-Daraji W, Brown AM, Ross K, Reynolds NJ. 2008. NFAT2 – a novel regulator of both keratinocyte proliferation and differentiation. British Journal of Dermatology, Annual Meeting of the British Society for Investigative Dermatology 158 :905-905

Fearon P, Lonsdale-Eccles AA, Ross K, Todd C, Allain A, Reynolds NJ. 2007. Secretion of chemotactic cyclophilin B by keratinocytes is regulated through its cyclosporin binding site Journal of Investigative Dermatology, 37th Annual Meeting of the European Society for Dermatological Research (ESDR 2007) 127 :S39-S39

Lonsdale-Eccles AA, Fearon P, Ross K, Allain F, Reynolds NJ. 2007. Location, mobility and secretion of cyclophilin B in keratinocytes is regulated through its ciclosporin A binding site. British Journal of Dermatology, Annual Meeting of the British Society for Investigative Dermatology 156 :1097-1097

Hampton PJ, Ross K, Reynolds NJ. 2007. Lithium inhibits the transcriptional activation, mRNA and protein expression of transglutaminase 1 in keratinocytes. British Society for Investigative Dermatology 156 :1106-1106

Ross K, Reynolds NJ. 2006. Regulation of calcium entry in Keratinocytes by calcium-independent PLA2 and STIM1. Journal of Investigative Dermatology, 36th Annual European Society for Dermatological Research 126 :S94-S94

Ross K, Reynolds NJ. 2005. Inhibition of calcium-independent phospholipase A impairs lysophosphatidic acid-induced calcium entry in keratinocytes. British Journal of Dermatology, British Society for Investigative Dermatology meeting 152 :836-836

Ross K, Whitaker M, Reynolds NJ. 2004. Agonist Induced Ca2+ oscillations and Ca2+ entry in Keratinocytes. Journal of Investigative Dermatology, 34th European Society for Dermatological Research meeting 123 :pA60-pA60

Engagement & Impact

Highlighted activities

Conference presentation:

Ultraviolet radiation and trichostatin A modulate miR-9 expression in human keratinocytes, Big Roles for Small RNAs, 2016, University of East Anglia, Oral presentation. 2016

Research Grants Awarded:

British Skin Foundation, Defiuning the Role of the MicroRNA-184:Argonaute 2 axis in Psoriasis, Nicholas J Reynolds, Newcastle University, Grant value (£): £81,000, Duration of research project: 3 years. 2014

British Skin Foundation, Does interleukin-22-dependent upregulation of microRNA contribute to the psoriatic phenotype?, Grant value (£): 70K, Duration of research project: 18 months. 2008

Professional activities

Award:

RNA 2019 Travel Award, The RNA Society. 2019

Crucible Award, National Endowment for Science, Technology and Arts (NESTA). 2007

MRC Discipline Hopping Award, Medical Research Council. 2006

Research Grants Awarded:

Alopecia UK, Uncovering MicroRNA Targets in Scarring Alopecia, Grant value (£): 1000. 2019

British Skin Foundation, Defiuning the Role of the MicroRNA-184:Argonaute 2 axis in Psoriasis, Nicholas J Reynolds, Newcastle University, Grant value (£): £81,000, Duration of research project: 3 years. 2014

Biochemical Society, Analysis of serum microRNA, Grant value (£): 1000. 2010

Liverpool John Moores University Studentship (MPhil), MicroRNA Expression and Function in the Skin, Grant value (£): 45,000, Duration of research project: 18 months. 2009

British Skin Foundation, Does interleukin-22-dependent upregulation of microRNA contribute to the psoriatic phenotype?, Grant value (£): 70K, Duration of research project: 18 months. 2008

North Eastern Skin Research Fund, Regulation of keratinocyte microRNA by S100 proteins, Grant value (£): 3820. 2008

The Physiological Society, Analysis of iPLA2 mobility in keratinocytes, Grant value (£): £1200, Duration of research project: 2 months. 2006

Medical Research Council, Computational reconstruction of a TGFβ-Smad network., Nicholas Monk, University of Sheffield, Grant value (£): 84,487, Duration of research project: 1 year. 2006

Newcastle Healthcare Charity Award, Regulation of Calcium-sensing Receptor Expression in Keratinocytes and Psoriasis, Professor Nick Reynolds, Grant value (£): 39,692, Duration of research project: 1 year. 2005

Other invited event:

Dermatology Seminar, Broadgreen Hospital, Guardians of the Cutaneous Galaxy: microRNAs and Inflammatory Skin Disease. 2017

Dermatology Seminar, Broadgreen Hospital, Presentation on MicroRNA in skin disorders. 2014

miRNAs, siRNAs and non-coding RNAs in health and disease, Manchester, Conference presentation. 2010

Institute for Health Research (IHR) Conference, Liverpool, Conference presentation. 2010

Membership of professional bodies:

Member, RNA Society, http://www.rnasociety.org/. 2017

Member, British Hair and Nail Society, https://bhns.org.uk/. 2016

Member, European Tissue Repair Society, http://www.etrs.org/. 2016

Affiliate Member, Royal Society of Chemistry, http://www.rsc.org/. 2016

Member, Physiological Society, http://www.physoc.org/. 2005

Member, Biochemical Society, http://www.biochemistry.org/. 2005

Member, British Society for Investigative Dermatology, http://bsid.org.uk/. 2005

Conference presentation:

Ultraviolet radiation and trichostatin A modulate miR-9 expression in human keratinocytes, Big Roles for Small RNAs, 2016, University of East Anglia, Oral presentation. 2016

External collaboration:

Erasmus University Medical Center Rotterdam, Dr Wendy van de Sande. 2015

University of Khartoum, Professor Ahmed Fahal. 2015

Betsi Cadwaladr University Health Board, Dr Paul Yesudian Consultant Dermatologist. 2014

Salford Royal NHS Foundation Trust, Manchester, UK., Dr Matthew Harries. 2013

Professor of Cutaneous Medicine (Manchester, UK); Head, Laboratory for Hair Research and Regenerative Medicine, University of Münster (Germany)., Professor Ralf Paus. 2013

Department of Dermatology Royal Liverpool and Broadgreen University Hospitals NHS Trust Liverpool L14 3LB United Kingdom, Dr Ali Al-Sharqi. 2013

Department of Dermatology Royal Liverpool and Broadgreen University Hospitals NHS Trust Liverpool L14 3LB United Kingdom, Dr Richard Parslew. 2013

Newcastle University, Professor NJ Reynolds. 2008

External PGR examinations performed:

University of Liverpool, PhD, ATP Release in the Epidermis. 2014

Teaching qualification:

Postgraduate Certificate for Learning and Teaching in Higher Education. 2013

Media Coverage:

http://www.britishskinfoundation.org.uk/DrKehindeRossInterview.aspx, Interview with the British Skin Foundation.

Fellowships:

Fellow of the Higher Education Academy, Higher Education Academy.