Prof Kelvin Chan

Pharmacy and Biomolecular Sciences

Faculty: Faculty of Science

School: Pharmacy and Biomolecular Sciences

Email address: K.K.Chan@ljmu.ac.uk

See My Tutor

ORCID

Professor Chan is Visiting Professor in Natural Products & TCM Research in the School of Pharmacy & Biomolecular Sciences. He is currently Adjunct Professor in TCM at the National Institute of Complementary Medicine, Western Sydney University, and holds the position of Professor - Joint Chair in Traditional Chinese Medicine at CompleMED, University of Western Sydney, and the Herbal Medicine Research & Education Centre, University of Sydney.

Professor Chan is a Charted Biologist (UK), Clinical Pharmacologist (UK and USA) and Registered Pharmacist (UK). He is a Fellow of the following academic institutes: Royal Pharmaceutical Society of Great Britain; the Society of Biology, UK; the Royal Society of Medicine, UK and the American College of Clinical Pharmacology, USA.

Formerly, he was Founding Chair Professor in Pharmacy & Pharmacology, Head and then Director of Pharmacy & Pharmaceutical Sciences at University of Wolverhampton, UK (2005 to 2009); Chair Professor of Biomedical Sciences and Director of R&D at the Institute for the Advancement of Chinese Medicine, Hong Kong Baptist University (2000 - 2005) and Chair Professor of Biomedical Science and Research Director of the School of Pharmacy at the Liverpool Johns Moores University. He held Visiting Professorships at the University of Liverpool and Middlesex University in the UK; Institute of Pharmacognosy & Pharmacy, University of Vienna, Austria; Pharmaceutical University in Nanjing and Shenyang Pharmaceutical University in Shenyang in PR China. He is currently Visiting Professor at the Institute of Medicinal Plant Development in Beijing and JiNan University in Guangzhou, PR China as well as at the University of Wolverhampton, UK.

Professor Chan's has over 220 peer-reviewed full papers, and those published from the early 1990s are mainly related to mechanistic studies of interactions between herbal medicines and pharmaceuticals. His research directions and interests have since changed towards medicinal and pharmaceutical development of Chinese herbal medicines and natural products.

Journal article

Jiang H, Wang XJ, Yang L, Zhang JX, Hou AJ, Man WJ, Wang S, Yang BY, Chan K, Wang QH, Kuang HX. 2020. The fruits of Xanthium sibiricum Patr: A review on phytochemistry, pharmacological activities, and toxicity World Journal of Traditional Chinese Medicine, 6 :408-422 DOI Publisher Url Public Url

Razmovski-Naumovski V, Zhou X, Wong HY, Kam A, Pearson J, Chan K. 2020. Chromatographic, Chemometric and Antioxidant Assessment of the Equivalence of Granules and Herbal Materials of Angelicae sinensis Radix. Medicines (Basel, Switzerland), 7 DOI Author Url

Gong G, Huang J, Yang Y, Qi B, Han G, Zheng Y, He H, Chan K, Tsim KWK, Dong TTX. 2020. Saussureae involucratae Herba (Snow Lotus): Review of chemical compositions and pharmacological properties Frontiers in Pharmacology, 10 DOI Author Url Publisher Url Public Url

Jiang H, Hou AJ, Zhang YY, Man WJ, Yang L, Meng YH, Guo XY, Wang S, Zhang JX, Yang BY, Wang QH, Chan K, Kuang HX. 2019. Simultaneous determination of six compounds in rat plasma by ultra-performance liquid chromatography with tandem mass spectrometry: Application in the pharmacokinetic study of Qing Gan-Shu Yu-Fang World Journal of Traditional Chinese Medicine, 5 :250-259 DOI Publisher Url Public Url

Zhou X, Razmovski-Naumovski V, Kam A, Chang D, Li CG, Chan K, Bensoussan A. 2019. Synergistic study of a Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination on cell survival in EA.hy926 cells BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 19 DOI Author Url

Gong AGW, Duan R, Wang HY, Kong XP, Dong TTX, Tsim KWK, Chan K. 2018. Evaluation of the Pharmaceutical Properties and Value of Astragali Radix. Medicines (Basel, Switzerland), 5 DOI Author Url

Zhou X, Razmovski-Naumovski V, Kam A, Chang D, Li C, Bensoussan A, Chan K. 2017. Synergistic Effects of Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) Combination in Angiogenesis Behavior in EAhy 926 Cells. Medicines (Basel, Switzerland), 4 DOI Author Url

Wong KH, Li GQ, Li KM, Razmovski-Naumovski V, Chan K. 2017. Optimisation of Pueraria isoflavonoids by response surface methodology using ultrasonic-assisted extraction FOOD CHEMISTRY, 231 :231-237 DOI Author Url

Chan K. 2016. The evolutional development of traditional chinese medicine (TCM) outside the chinese mainland: Challenges, training, practice, research, and future development World Journal of Traditional Chinese Medicine, 2 :6-28 DOI Publisher Url Public Url

Zhou X, Seto SW, Chang D, Kiat H, Razmovski-Naumovski V, Chan K, Bensoussan A. 2016. Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research FRONTIERS IN PHARMACOLOGY, 7 DOI Author Url

Chan CC, Zhang HW, Chan K, Lin ZX. 2016. Xiaoke Pill (消渴丸) and anti-diabetic drugs: A review on clinical evidence of possible herb-drug interactions Chinese Journal of Integrative Medicine, :1-8 DOI Author Url

Zhou X, Razmovski-Naumovski V, Chang D, Li C, Kam A, Low M, Bensoussan A, Chan K. 2016. Synergistic Effects of Danshen (Salvia Miltiorrhiza Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) Combination in Inhibiting Inflammation Mediators in RAW264.7 Cells BIOMED RESEARCH INTERNATIONAL, 2016 DOI Author Url

Alqahtani A, Tongkao-on W, Li KM, Razmovski-Naumovski V, Chan K, Li GQ. 2015. Seasonal Variation of Triterpenes and Phenolic Compounds in Australian Centella asiatica (L.) Urb PHYTOCHEMICAL ANALYSIS, 26 :436-443 DOI Author Url

Chan K, Zhang H, Lin Z-X. 2015. An overview on adverse drug reactions to traditional Chinese medicines BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80 :834-843 DOI Author Url

Zhou X, Razmovski-Naumovski V, Chan K. 2015. A multivariate analysis on the comparison of raw notoginseng (Sanqi) and its granule products by thin-layer chromatography and ultra-performance liquid chromatography CHINESE MEDICINE, 10 DOI Author Url Public Url

Wong KH, Razmovski-Naumovski V, Li KM, Li GQ, Chan K. 2015. Comparing morphological, chemical and anti-diabetic characteristics of Puerariae Lobatae Radix and Puerariae Thomsonii Radix JOURNAL OF ETHNOPHARMACOLOGY, 164 :53-63 DOI Author Url

Wong KH, Razmovski-Naumovski V, Li KM, Li GQ, Chan K. 2015. The quality control of two Pueraria species using Raman spectroscopy coupled with partial least squares analysis JOURNAL OF RAMAN SPECTROSCOPY, 46 :361-368 DOI Author Url

Chan K. 2015. Understanding interactions between Chinese medicines and pharmaceutical drugs in integrative healthcare CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 21 :83-89 DOI Author Url

Chan K, Hu X-Y, Razmovski-Naumovski V, Robinson N. 2015. Challenges and opportunities of integrating traditional Chinese medicine into mainstream medicine: A review of the current situation EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE, 7 :67-75 DOI Author Url

Williamson EM, Chan K, Xu Q, Nachtergae A, Bune V, Zhang L, Ouedraogo M, Nortier J, Qu F, Shaw D, Liu X, Stevigny C, Kahumba J, Pelkonen O, Duez P. 2015. Evaluating the safety of herbal medicines: Integrated toxicological approaches SCIENCE, 347 :S47-S49 Author Url

Kam A, Razmovski-Naumovski V, Zhou X, Truong J, Chan K. 2015. Nucleoside Transport Inhibition by Dipyridamole Prevents Angiogenesis Impairment by Homocysteine and Adenosine JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 18 :871-881 DOI Author Url Public Url

Jia W, Lu A, Chan K, Gustafsson MG, Liu P. 2015. Translational Research in Complementary and Alternative Medicine 2014 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015 DOI Author Url

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Grau GE, Li GQ. 2015. Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 18 :424-433 DOI Author Url Public Url

Wong KH, Razmovski-Naumovski V, Li KM, Li GQ, Chan K. 2014. Differentiating Puerariae Lobatae Radix and Puerariae Thomsonii Radix using HPTLC coupled with multivariate classification analyses JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 95 :11-19 DOI Author Url

Chui SH, Chow FC, Szeto YT, Chan K, Lam CWK. 2014. A case series of acupuncture treatment for female infertility with some cases supplemented with Chinese medicines EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE, 6 :337-341 DOI Author Url

Wang Q, Wang C, Shu Z, Chan K, Huang S, Li Y, Xiao Y, Wu L, Kuang H, Sun X. 2014. Valeriana amurensis improves Amyloid-beta 1-42 induced cognitive deficit by enhancing cerebral cholinergic function and protecting the brain neurons from apoptosis in mice JOURNAL OF ETHNOPHARMACOLOGY, 153 :318-325 DOI Author Url

Su Y, Wang Q, Wang C, Chan K, Sun Y, Kuang H. 2014. The treatment of Alzheimer's disease using Chinese Medicinal Plants: From disease models to potential clinical applications JOURNAL OF ETHNOPHARMACOLOGY, 152 :403-423 DOI Author Url

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li GQ. 2014. Gallic acid protects against endothelial injury by restoring the depletion of DNA methyltransferase 1 and inhibiting proteasome activities INTERNATIONAL JOURNAL OF CARDIOLOGY, 171 :231-242 DOI Author Url

Pan S-Y, Litscher G, Chan K, Yu Z-L, Chen H-Q, Ko K-M. 2014. Traditional Medicines in the World: Where to Go Next? EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014 DOI Author Url

Ip PS-P, Tsim KW-K, Chan K, Bauer R. 2014. Application of Complementary and Alternative Medicine on Neurodegenerative Disorders 2013 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014 DOI Author Url

Chan K, Zhang HW, Lin ZX. 2014. Treatments used in complementary and alternative medicine 36 :717-724 DOI

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Shi J, Chan K, Li GQ. 2013. A Comparative Study on the Inhibitory Effects of Different Parts and Chemical Constituents of Pomegranate on alpha-Amylase and alpha-Glucosidase PHYTOTHERAPY RESEARCH, 27 :1614-1620 DOI Author Url

Wong KH, Razmovski-Naumovski V, Li KM, Li GQ, Chan K. 2013. Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA) JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 84 :5-13 DOI Author Url

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li GQ. 2013. Variability of the Polyphenolic Content and Antioxidant Capacity of Methanolic Extracts of Pomegranate Peel NATURAL PRODUCT COMMUNICATIONS, 8 :707-710 DOI Author Url

Chong C-M, Zhou Z-Y, Razmovski-Naumovski V, Cui G-Z, Zhang L-Q, Sa F, Hoi P-M, Chan K, Lee SM-Y. 2013. Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish NEUROSCIENCE LETTERS, 543 :121-125 DOI Author Url

Kim EJY, Chen Y, Huang JQ, Li KM, Razmovski-Naumovski V, Poon J, Chan K, Roufogalis BD, McLachlan AJ, Mo S-L, Yang D, Yao M, Liu Z, Liu J, Li GQ. 2013. Evidence-based toxicity evaluation and scheduling of Chinese herbal medicines JOURNAL OF ETHNOPHARMACOLOGY, 146 :40-61 DOI Author Url

Wang Q, Kuang H, Su Y, Sun Y, Feng J, Guo R, Chan K. 2013. Naturally derived anti-inflammatory compounds from Chinese medicinal plants JOURNAL OF ETHNOPHARMACOLOGY, 146 :9-39 DOI Author Url

Alqahtani A, Hamid K, Kam A, Wong KH, Abdelhak Z, Razmovski-Naumovski V, Chan K, Li KM, Groundwater PW, Li GQ. 2013. The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications CURRENT MEDICINAL CHEMISTRY, 20 :908-931 DOI Author Url

Chua M, Hocking TJ, Chan K, Baldwin TC. 2013. TEMPORAL AND SPATIAL REGULATION OF GLUCOMANNAN DEPOSITION AND MOBILIZATION IN CORMS OF AMORPHOPHALLUS KONJAC (ARACEAE) AMERICAN JOURNAL OF BOTANY, 100 :337-345 DOI Author Url

Liu ZL, Li GQ, Bensoussan A, Kiat H, Chan K, Liu JP. 2013. Chinese herbal medicines for hypertriglyceridaemia COCHRANE DATABASE OF SYSTEMATIC REVIEWS, DOI Author Url

Lu A, Jiang M, Zhang C, Chan K. 2012. An integrative approach of linking traditional Chinese medicine pattern classification and biomedicine diagnosis JOURNAL OF ETHNOPHARMACOLOGY, 141 :549-556 DOI Author Url

Chan K, Shaw D, Simmonds MSJ, Leon CJ, Xu Q, Lu A, Sutherland I, Ignatova S, Zhu Y-P, Verpoorte R, Williamson EM, Duez P. 2012. Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica JOURNAL OF ETHNOPHARMACOLOGY, 140 :469-475 DOI Author Url

Ouedraogo M, Baudoux T, Stevigny C, Nortier J, Colet J-M, Efferth T, Qu F, Zhou J, Chan K, Shaw D, Pelkonen O, Duez P. 2012. Review of current and "omics" methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms JOURNAL OF ETHNOPHARMACOLOGY, 140 :492-512 DOI Author Url

Fan T-P, Deal G, Koo H-L, Rees D, Sun H, Chen S, Dou J-H, Makarov VG, Pozharitskaya ON, Shikov AN, Kim YS, Huang Y-T, Chang YS, Jia W, Dias A, Wong VC-W, Chan K. 2012. Future development of global regulations of Chinese herbal products JOURNAL OF ETHNOPHARMACOLOGY, 140 :568-586 DOI Author Url

Zhang L, Yan J, Liu X, Ye Z, Yang X, Meyboom R, Chan K, Shaw D, Duez P. 2012. Pharmacovigilance practice and risk control of Traditional Chinese Medicine drugs in China: Current status and future perspective JOURNAL OF ETHNOPHARMACOLOGY, 140 :519-525 DOI Author Url

Jiang M, Lu C, Zhang C, Yang J, Tan Y, Lu A, Chan K. 2012. Syndrome differentiation in modern research of traditional Chinese medicine JOURNAL OF ETHNOPHARMACOLOGY, 140 :634-642 DOI Author Url

Pelkonen O, Pasanen M, Lindon JC, Chan K, Zhao L, Deal G, Xu Q, Fan T-P. 2012. Omics and its potential impact on R&D and regulation of complex herbal products JOURNAL OF ETHNOPHARMACOLOGY, 140 :587-593 DOI Author Url

Shaw D, Graeme L, Pierre D, Elizabeth W, Kelvin C. 2012. Pharmacovigilance of herbal medicine Journal of Ethnopharmacology, 140 :513-518 DOI Author Url

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li Y, Li GQ. 2012. The Protective Effects of Natural Products on Blood-Brain Barrier Breakdown CURRENT MEDICINAL CHEMISTRY, 19 :1830-1845 DOI Author Url

Zhou X, Chan K, Yeung JHK. 2012. Herb-drug interactions with Danshen (Salvia miltiorrhiza): A review on the role of cytochrome P450 enzymes Drug Metabolism and Drug Interactions, 27 :9-18 DOI Author Url

Chua M, Chan K, Hocking TJ, Williams PA, Perry CJ, Baldwin TC. 2012. Methodologies for the extraction and analysis of konjac glucomannan from corms of Amorphophallus konjac K. Koch CARBOHYDRATE POLYMERS, 87 :2202-2210 DOI Author Url

Ip PS-P, Tsim KW-K, Chan K, Bauer R. 2012. Application of Complementary and Alternative Medicine on Neurodegenerative Disorders: Current Status and Future Prospects EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012 DOI Author Url

Hung MW, Zhang ZJ, Li S, Lei B, Yuan S, Cui GZ, Hoi PM, Chan K, Lee SMY. 2012. From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012 DOI Author Url

Jiang M, Zhang C, Cao H, Chan K, Lu A. 2011. The Role of Chinese Medicine in the Treatment of Chronic Diseases in China PLANTA MEDICA, 77 :873-881 DOI Author Url

Yeh J-C, Cindrova-Davies T, Belleri M, Morbidelli L, Miller N, Cho C-WC, Chan K, Wang Y-T, Luo G-A, Ziche M, Presta M, Charnock-Jones DS, Fan T-P. 2011. The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo ANGIOGENESIS, 14 :187-197 DOI Author Url

Wong KH, Li GQ, Li KM, Razmovski-Naumovski V, Chan K. 2011. Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases JOURNAL OF ETHNOPHARMACOLOGY, 134 :584-607 DOI Author Url

Poon SK, Poon J, McGrane M, Zhou X, Kwan P, Zhang R, Liu B, Gao J, Loy C, Chan K, Sze DM-Y. 2011. A novel approach in discovering significant interactions from TCM patient prescription data INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS, 5 :353-368 DOI Author Url

Sun S, Chen J, Zhou Q, Lu G, Chan K. 2010. Application of Mid-Infrared Spectroscopy in the Quality Control of Traditional Chinese Medicines PLANTA MEDICA, 76 :1987-1996 DOI Author Url

Liang Y-Z, Xie P-S, Chan K. 2010. Chromatographic Fingerprinting and Metabolomics for Quality Control of TCM COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 13 :943-953 DOI Author Url

Jiang M, Yang J, Zhang C, Liu B, Chan K, Cao H, Lu A. 2010. Clinical Studies with Traditional Chinese Medicine in the Past Decade and Future Research and Development PLANTA MEDICA, 76 :2048-2064 DOI Author Url

Chan K. 2010. Side Effects of Drugs Essay. Regulating complementary and alternative medicines Side Effects of Drugs Annual, 32 DOI

Zhao Z, Liang Z, Chan K, Lu G, Lee ELM, Chen H, Li L. 2010. A Unique Issue in the Standardization of Chinese Materia Medica: Processing PLANTA MEDICA, 76 :1975-1986 DOI Author Url

Liang Y-Z, Xie P-S, Chan K. 2010. Perspective of Chemical Fingerprinting of Chinese Herbs PLANTA MEDICA, 76 :1997-2003 DOI Author Url

Chua M, Baldwin TC, Hocking TJ, Chan K. 2010. Traditional uses and potential health benefits of Amorphophallus konjac K. Koch ex NEBr. JOURNAL OF ETHNOPHARMACOLOGY, 128 :268-278 DOI Author Url

Leung KS-Y, Chan K, Bensoussan A, Munroe MJ. 2007. Application of atmospheric pressure chemical ionisation mass spectrometry in the identification and differentiation of Panax species PHYTOCHEMICAL ANALYSIS, 18 :146-150 DOI Author Url

Wong MH, Bridges J, Bridges O, Cai ZW, Chan KKK, Dickinson NM, Gu JD, Ling YC, Morikawa H, Naidu R, Ng J, Shao Q, Wong PK, Wang XR, Yang SS, Zhang J. 2003. Special issue: Environmental and public health management - Preface CHEMOSPHERE, 52 :1345-1346 DOI Author Url

Islam MW, Zakaria MNM, Radhakrishnan R, Liu XM, Ismail A, Chan K, Al-Attas A. 2000. Safety evaluation studies of Portulaca oleracea vs sativa Journal of Pharmacy and Pharmacology, 52 :282

Kamil M, Jayaraj AF, Ahmad F, Gunasekhar C, Samuel S, Chan K, Habibullah M, Attas A. 2000. Separation of flavonoids from Caralluma arabica using high-speed counter-current chromatography Journal of Pharmacy and Pharmacology, 52 :265

Zakaria MNM, Islam MW, Radhakrishnan R, Chen HB, Liu XM, Chan K, Al-Attas A. 2000. Cardiovascular effects of Ammi visnaga extract in rat Journal of Pharmacy and Pharmacology, 52 :267

Radhakrishnan R, Zakaria MNM, Islam MW, Liu XM, Chen HB, Chan K, Al-Attas A. 2000. Inhibitory effects of Ruta chalepensis on isolated rabbit jejunum Journal of Pharmacy and Pharmacology, 52 :280

Radhakrishnan R, Zakaria MNM, Islam MW, Ismail A, Chen HB, Chan K, Al-Attas A. 2000. Relaxant effects of Ammi visnaga and Ruta chalepensis on guinea-pig tracheal smooth muscle Journal of Pharmacy and Pharmacology, 52 :277

Zakaria MNM, Islam MW, Radhakrishnan R, Liu XM, Chen HB, Chan K, Al-Attas A. 2000. Hypotensive effects of Ammi visnaga and Ruta chalepensis extracts in DOCA-salt treated rats Journal of Pharmacy and Pharmacology, 52 :268

Islam MW, Zakaria MNM, Radhakrishnan R, Liu XM, Ismail A, Chan K, Al-Attas A. 2000. Galangal (Alpinia galanga Willed.,) and Black seeds (Nigella sativa Linn.) and sexual stimulation in male mice Journal of Pharmacy and Pharmacology, 52 :278

Kamil M, Jayaraj AF, Ahmad F, Gunasekhar C, Samuel S, Chan K, Habibullah M, Attas A. 2000. Pharmacognostic and phytochemical standardization of Calligonum comosum Journal of Pharmacy and Pharmacology, 52 :262

Islam MW, Zakaria MNM, Radhakrishnan R, Liu XM, Chen HB, Chan K, Al-Attas A. 2000. Evaluation of Portulaca oleracea for anti-gastric ulcer and cytoprotective activity in rats Journal of Pharmacy and Pharmacology, 52 :258

Islam MW, Zakaria MNM, Radhakrishnan R, Liu XM, Chan K, Al-Attas A. 2000. Anti-gastric ulcer and cytoprotective properties of Aarak tree (Salvadora persica) and Purslane (Portulaca oleracea) in rats Journal of Pharmacy and Pharmacology, 52 :269

Kamil M, Elsheikh MO, Jayaraj AF, Ahmad F, Gunasekhar C, Samuel S, Chan K, Habibullah M, Attas A. 2000. Quality control studies of Ammi majus based on pharmacognostic and phytochemical protocols Journal of Pharmacy and Pharmacology, 52 :276

Zakaria MNM, Islam MW, Radhakrishnan R, Chen HB, Ismail A, Chan K, Habibullah M. 1999. Evaluation of antinociceptive and anti-inflammatory properties of Caralluma arabica Journal of Pharmacy and Pharmacology, 51 :117

Islam MW, Zakaria MNM, Radhakrishnan R, Ismail A, Liu XM, Chan K, Habibullah M. 1999. Preliminary studies on the anti-diabetic effect of Teucrium stocksianum Boiss. (fam. Labiatae) in streptozotocin diabetic mice Journal of Pharmacy and Pharmacology, 51 :342

Radhakrishnan R, Zakaria MNM, Islam MW, Chen HB, Liu XM, Chan K, Habibullah M. 1999. Cardiovascular effects of Calligonum comosum extract in rat Journal of Pharmacy and Pharmacology, 51 :119

Zakaria MNM, Islam MW, Radhakrishnan R, Chen HB, Ismail A, Chan K, Habibullah M. 1999. Pharmacological evaluation of anti-inflammatory activity of Alhagi maurorum Journal of Pharmacy and Pharmacology, 51 :118

Kamil M, Jayaraj AF, Ahmad F, Gunasekhar C, Samuel S, Chan K, Habibullah M. 1999. Identification and quantification of flavonoids from Caralluma arabica and its quality control studies Journal of Pharmacy and Pharmacology, 51 :225

Kamil M, Ahmed F, Jayaraj AF, Gunasekhar CJ, Samuel S, Chan K, Habibullah M. 1999. Choice of solvents in spectrophotometric assay using Beer-Lambert law Journal of Pharmacy and Pharmacology, 51 :223

Kamil M, Ahmed F, Jayaraj AF, Gunasekhar CJ, Samuel S, Chan K, Habibullah M. 1999. Effect of functional groups on the infrared finger printing of powdered herbal drugs Journal of Pharmacy and Pharmacology, 51 :224

Kamil M, Jayaraj AF, Armed F, Gunasekhar C, Samuel S, Habibullah M, Chan K. 1999. Pharmacocognistic protocols for standardization of Zizyphus spinachristi Journal of Pharmacy and Pharmacology, 51 :226

Islam MW, Zakaria MNM, Radhakrishnan R, Liu XM, Chen HB, Chan K, Habibullah M. 1999. Effect of ethanolic extract of Calligonum comosum (fam. Polygonaceae) Eon experimental induced gastric ulcers in Wistar albino rats Journal of Pharmacy and Pharmacology, 51 :102

Chan E, Chan K, Teoh R. 1997. Determination of phenobarbitone population clearance values for physically and mentally handicapped Chinese children with epilepsy JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 22 :399-403 DOI Author Url

Wing YK, Chan E, Chan K, Lee S, Shek CC. 1997. Lithium pharmacokinetics in Chinese manic-depressive patients JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 17 :179-184 DOI Author Url

Chen AG, Wing YK, Chiu H, Lee S, Chen CN, Chan K. 1997. Simultaneous determination of imipramine, desipramine and their 2- and 10-hydroxylated metabolites in human plasma and urine by high-performance liquid chromatography JOURNAL OF CHROMATOGRAPHY B, 693 :153-158 DOI Author Url

Lunn J, Chan K, Donoghue J, Riley B, Walley T. 1997. A study of the appropriateness of prescribing in nursing homes International Journal of Pharmacy Practice, 5 :6-10 DOI

Woo J, Cheung W, Chan R, Chan HS, Cheng A, Chan K. 1996. In vitro protein binding characteristics of isoniazid, rifampicin, and pyrazinamide to whole plasma, albumin, and alpha-1-acid glycoprotein CLINICAL BIOCHEMISTRY, 29 :175-177 DOI Author Url

CHAN K. 1995. PROGRESS IN TRADITIONAL CHINESE MEDICINE TRENDS IN PHARMACOLOGICAL SCIENCES, 16 :182-187 DOI Author Url

CHAN K, LO ACT, YEUNG JHK, WOO KS. 1995. THE EFFECTS OF DANSHEN (SALVIA-MILTIORRHIZA) ON WARFARIN PHARMACODYNAMICS AND PHARMACOKINETICS OF WARFARIN ENANTIOMERS IN RATS JOURNAL OF PHARMACY AND PHARMACOLOGY, 47 :402-406 DOI Author Url

YANG JM, CHAN K. 1995. SIMULTANEOUS DETERMINATION OF MORICIZINE AND ITS SULFOXIDATION METABOLITES IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 663 :172-176 DOI Author Url

Yang JM, Chan K. 1995. Isolation and characterization of sulphoxidation metabolites of moricizine in rat and human biological fluids Methods and Findings in Experimental and Clinical Pharmacology, 17 :415-421 Author Url

HOUGHTON IT, AUN CST, WONG YC, CHAN K, LAU JTF, OH TE. 1994. The respiratory depressant effect of morphine: A comparative study in three ethnic groups Anaesthesia, 49 :197-201 DOI Author Url

Chan K. 1994. The Pharmacology of Chinese Herbs; Kee Chang Huang Published 1993 CRC Press, Inc., Boca Raton, FL 388 pages; ISBN 0 8493 4915 X £100.00 Journal of Pharmacy and Pharmacology, 46 :159-160 DOI

Houghton IT, Aun CST, Chan K. 1993. Pethidine pharmacokinetics in a heroin addict: a case report Journal of Clinical Pharmacy and Therapeutics, 18 :139-140 DOI Author Url

DAMBISYA YM, CHAN K, WONG CL. 1992. FURTHER METABOLIC STUDIES OF CODEINE AND MORPHINE IN MICE PRETREATED WITH SYMPATHOMIMETICS METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 14 :773-780 Author Url

Houghton IT, Chan K, Wong YC, Aun CST, Lau OW, Lowe DM. 1992. Pethidine pharmacokinetics after intramuscular dose: A comparison in Caucasian, Chinese and Nepalese patients Methods and Findings in Experimental and Clinical Pharmacology, 14 :451-458 Author Url

GREGORY MA, GIN T, YAU G, LEUNG RKW, CHAN K, OH TE. 1990. PROPOFOL INFUSION ANESTHESIA FOR CESAREAN-SECTION CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 37 :514-520 DOI Author Url

Chan K, Chan G. 1987. A STUDY OF PRESCRIBED H1‐ANTIHISTAMINE PREPARATIONS OVER A PERIOD OF 12 MONTHS IN COMMUNITY PHARMACY Journal of Clinical Pharmacy and Therapeutics, 12 :1-9 DOI Author Url

Chan K, Tse J, Jennings F, Orme MLE. 1987. Pharmacokinetics of Low‐Dose Intravenous Pethidine in Patients with Renal Dysfunction The Journal of Clinical Pharmacology, 27 :516-522 DOI Author Url

Murray GR, Calvey TN, Williams NE, Chan K. 1984. Quantitative capillary column gas chromatographic method for the determination of glycopyrronium in human plasma Journal of Chromatography B: Biomedical Sciences and Applications, 308 :143-151 DOI Author Url

ELLIOTT PNC, FORD JL, CHAN KKC. 1984. THE EFFECT OF INCORPORATION OF INDOMETHACIN WITH POLYETHYLENE-GLYCOL 6000 IN A SOLID DISPERSION ON ITS INVIVO PROPERTIES IN THE RAT AGENTS AND ACTIONS, 15 :367-370 DOI Author Url

Isherwood CN, Calvey TN, Williams NE, Chan K, Murray GR. 1984. Elimination of phenoperidine in liver disease British Journal of Anaesthesia, 56 :843-847 DOI

Calvey TN, Milne LA, Williams NE, Chan K, Murray GR. 1983. Effect of antacids on the plasma concentration of phenoperidine British Journal of Anaesthesia, 55 :535-539 DOI Author Url

Williams NE, Calvey TN, Chan K. 1983. Plasma concentration of pyridostigmine during the antagonism of neuromuscular block British Journal of Anaesthesia, 55 :27-31 DOI Author Url

Murray GR, Mushtaq T, Chan K, Calvey TN. 1982. PLASMA PROTEIN BINDING OF PHENOPERIDINE Journal of Pharmacy and Pharmacology, 34 :95P-95P DOI

Chan K, Tse J, Orme M, Sibeon RG. 1982. THE INFLUENCE OF URINARY pH ON THE DISPOSITION OF INDOMETHACIN IN HEALTHY VOLUNTEERS Journal of Clinical Pharmacy and Therapeutics, 7 :155-160 DOI Author Url

CHAN K, MURRAY GR, ROSTRON C, CALVEY TN, WILLIAMS NE. 1981. QUANTITATIVE GAS-LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF PHENOPERIDINE IN HUMAN-PLASMA JOURNAL OF CHROMATOGRAPHY, 223 :213-218 DOI Author Url

Chan K, Tse J. 1981. PLASMA CONCENTRATIONS OF I.V. PETHIDINE IN HEALTHY VOLUNTEERS UNDER CONDITIONS OF VARIOUS URINARY PH VALUES Journal of Pharmacy and Pharmacology, 33 :87P DOI

Calvey TN, Williams NE, Chan K, Dehghan A, Somani SM. 1981. PLASMA CONCENTRATION AND URINARY ELIMINATION OF NEOSTIGMINE AFTER INTRAMUSCULAR ADMINISTRATION TO MYASTHENIC PATIENTS Annals of the New York Academy of Sciences, 377 :816-817 DOI

Chan K. 1981. DISPOSITION OF PETHIDINE IN MAN UNDER ACIDIC URINARY PH: I. PLASMA LEVEL AND URINARY ELIMINATION OF PETHIDINE AND NORPETHIDINE Journal of Clinical Pharmacy and Therapeutics, 6 :107-116 DOI Author Url

Chan K, Li JKC, Baber N, Ohnhaus E, Orme M, Sibeon RG. 1980. THE EFFECT OF pH ON THE BUCCAL ABSORPTION AND RENAL EXCRETION OF INDOMETHACIN Journal of Pharmacy and Pharmacology, 32 :42P DOI

Chan K, Latham SM, Tse J. 1980. A RAPID AND SIMPLE METHOD FOR THE DETERMINATION OF MEXILETINE IN HUMAN PLASMA AND URINE BY GAS‐LIQUID CHROMATOGRAPHY (GLC) Journal of Pharmacy and Pharmacology, 32 :98P DOI

Somani SM, Chan K, Dehghan A, Calvey TN. 1980. Kinetics and metabolism of intramuscular neostigmine in myasthenia gravis Clinical Pharmacology & Therapeutics, 28 :64-68 DOI Author Url

Milne L, Williams NE, Calvey TN, Murray GR, Chan K. 1980. Plasma concentration and metabolism of phenoperidine in man British Journal of Anaesthesia, 52 :537-540 DOI Author Url

Chan K, McCann JF. 1979. Improved gas-liquid chromatography-electron-capture detection technique for the determination of paracetamol in human plasma and urine Journal of Chromatography B: Biomedical Sciences and Applications, 164 :394-398 DOI Author Url

Chan K. 1979. The effects of physicochemical properties of pethidine and its basic metabolites on their buccal absorption and renal elimination Journal of Pharmacy and Pharmacology, 31 :672-675 DOI Author Url

Chan K, Groves RL. 1979. THE USE OF ‘CONTROLLED DRUGS’ IN GENERAL PRACTICE Journal of Clinical Pharmacy and Therapeutics, 4 :101-113 DOI

Chan K, Dehghan A. 1978. The isolation and determination of neostigmine, pyridostigmine and their metabolites in human biological fluids Journal of Pharmacological Methods, 1 :311-320 DOI

Chan K, Highley MS. 1978. AN ECD‐GLC TECHNIQUE FOR THE DETERMINATION OF PARACETAMOL IN HUMAN BIOFLUIDS Journal of Pharmacy and Pharmacology, 30 :91P-91P DOI Author Url

Williams NE, Calvey TN, Chan K. 1978. Clearance of neostigmine from the circulation during the antagonism of neuromuscular block British Journal of Anaesthesia, 50 :1065-1067 DOI Author Url

Chapters

Williamson EM, Chan K. 2015. Evolution of herbal medicines in Europe and its relationship with modern medicine Phytotherapies: Efficacy, Safety, and Regulation :183-198 9781118268063 DOI

Silins G, Tan J, Chan K. 2015. Intellectual property and patent issues with phytotherapy products Phytotherapies: Efficacy, Safety, and Regulation :573-592 9781118268063 DOI

Zhang HW, Lin ZX, Chan K. 2015. Treatments Used in Complementary and Alternative Medicine Side Effects of Drugs Annual 37 :595-601 9780444635259 DOI

Zhang Z, Liang Y, Xie P, Chau F, Chan K. 2014. Chromatographic fingerprinting and chemometric techniques for quality control of herb medicines Data Analytics for Traditional Chinese Medicine Research 9783319038018 :133-153 9783319038001 DOI

Chan K, Poon J, Poon SK, Jiang M, Lu A. 2013. An overview on evidence-based medicine and medical informatics in traditional chinese medicine practice Data Analytics for Traditional Chinese Medicine Research 9783319038018 :227-248 9783319038001 DOI

Conference publication

Zhang L, Du X, Yan J, Liu X, Ye Z, Yang X, Meyboom R, Chan K, Shaw D, Duea P. 2012. Pharmacovigilance of Traditional Chinese Medicine Drugs in China DRUG SAFETY, 12th Annual Meeting of the International-Society-of-Pharmacovigilance (ISoP) on New Landscapes for Pharmacovigilance 35 :907-908 Author Url

Poon SK, Fan K, Poon J, Loy C, Chan K, Zhou X, Zhang R, Wang Y, Xie J, Liu B, Kwan P, Gao J, Sze D. 2011. Analysis of Herbal Formulation in TCM: Infertility as a case study Chen B, Chen J, Chen X, Chen Y, Cho YR, Cui J, Haspel N, He J, Hsu HH, Huang Y, Huang K, Jiang R, Khudyakov Y, Kwoh CK, Li G, Li GZ, Mandoiu I, Park T, Policriti A, Qin ZS, Reddy C, Ressom H, Satten G, Schonbach C, Shehu A, Song M, Song X, Tseng V, Xiong Z, Yoo I, Zelikovsky A, Zhang G, Zhang J, Zhao S, Zhao Z, Zheng J, Zhu D. 2011 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE WORKSHOPS, IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) :868-872 DOI Author Url

Poon J, Poon S, Yin D, Chan K, Loy C, Zhou X, Zhang R, Liu B, Kwan P, Sze D, Gao J. 2010. Studying Herb-Herb Interaction for Insomnia through the theory of Complementarities DiBernardo D, Chan TF, Chen J, Chen X, Chen X, Chen Y, Cheng X, Cho HG, Cho YR, Couto F, Davuluri RV, Gao L, Guzzi PH, Hsiao CK, Hsu HH, Huan LJ, Huang K, Huang Y, Jiang R, Klement W, Li GZ, Luo B, Michalowski M, Ott J, Pan Q, Park T, Pattini L, Potetz B, Song X, OSullivan D, Sun H, Tseng VS, Wang Y, Wu F, Xi D, Yiu SM, Zhang S, Zhao Z, Zheng H. 2010 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE WORKSHOPS (BIBMW), IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) :722-726 DOI Author Url

McGrane M, Poon S, Poon J, Chan K, Loy C, Zhou X, Zhang R, Liu B, Kwan P, Sze D, Gao J. 2010. Analysis of Synergistic and Antagonistic Effects of TCM: Cases on Diabetes and Insomnia DiBernardo D, Chan TF, Chen J, Chen X, Chen X, Chen Y, Cheng X, Cho HG, Cho YR, Couto F, Davuluri RV, Gao L, Guzzi PH, Hsiao CK, Hsu HH, Huan LJ, Huang K, Huang Y, Jiang R, Klement W, Li GZ, Luo B, Michalowski M, Ott J, Pan Q, Park T, Pattini L, Potetz B, Song X, OSullivan D, Sun H, Tseng VS, Wang Y, Wu F, Xi D, Yiu SM, Zhang S, Zhao Z, Zheng H. 2010 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE WORKSHOPS (BIBMW), IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) :620-624 DOI Author Url

Top