Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Matt Roberts

Dr Matt Roberts

Telephone: 0151 231 2036

Biography

Matt Roberts is a Reader in Pharmaceutics within the School of Pharmacy and Biomolecular Sciences and has been a member of the academic staff since 2003. He is the Programme Leader for the BSc Pharmaceutical Science degree course. Matt also teaches a range of topics on the MPharm and MSc programmes within the school, including aspects of pharmaceutical formulation, drug delivery and industrial pharmacy.

Matt is a member of the Formulation and Drug Delivery research group. His research background is in the field of solid dosage formulation and manufacture having completed a PhD investigating the influence of formulation and process parameters on the problem of punch sticking during tablet manufacture. He has expertise in the use of compaction simulation for evaluating the compression properties of drugs and excipients and in recent years, Matt's research has focused on hydrophilic and hydrophobic polymeric matrices for sustained drug release and the development of formulations for improved paediatric drug delivery.

Publications

Highlighted publications

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O'Neill F, Roberts M. 2019. Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic Journal of Pharmacy and Pharmacology, DOI Author Url Publisher Url Public Url

Tawfeek HM, Roberts M, El Hamd MA, Abdellatif AAH, Younis MA. 2018. Glibenclamide Mini-tablets with an Enhanced Pharmacokinetic and Pharmacodynamic Performance. AAPS PharmSciTech, DOI Author Url Publisher Url Public Url

Tawfeek HM, Saleem IY, Roberts M. 2014. Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets Journal of Pharmaceutical Sciences, 103 :2470-2483 DOI Author Url Publisher Url Public Url

Hamilton AR, Roberts M, Hutcheon GA, Gaskell EE. Formulation and antibacterial properties of clay mineral-tetracycline and -doxycycline composites Applied Clay Science, 179 DOI Author Url Publisher Url Public Url

Ford JL, Madathilethu J, Roberts M, Matthew P, Blair J, Prescott R. Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing BMJ Paediatrics, 2 :1-1 DOI Author Url Public Url

Journal article

Khan I, Lau K, Bnyan R, Houacine C, Roberts M, Isreb A, Elhissi A, Yousaf S. 2020. A Facile and Novel Approach to Manufacture Paclitaxel-Loaded Proliposome Tablet Formulations of Micro or Nano Vesicles for Nebulization. Pharmaceutical Research, 37 :116-116 DOI Author Url Publisher Url Public Url

Ehtezazi T, Bnyan R, Khan I, Roberts M, Cesarini L. 2020. The Effect of Ethanol Evaporation on the Properties of Inkjet Produced Liposomes DARU : Journal of Pharmaceutical Sciences, DOI Author Url Public Url

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O'Neill F, Roberts M. 2019. Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic Journal of Pharmacy and Pharmacology, DOI Author Url Publisher Url Public Url

Tawfeek HM, Roberts M, El Hamd MA, Abdellatif AAH, Younis MA. 2018. Glibenclamide Mini-tablets with an Enhanced Pharmacokinetic and Pharmacodynamic Performance. AAPS PharmSciTech, DOI Author Url Publisher Url Public Url

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O'Neill F, Roberts M. 2018. Surfactant Effects on Lipid-Based Vesicles Properties JOURNAL OF PHARMACEUTICAL SCIENCES, 107 :1237-1246 DOI Author Url Public Url

Ehtezazi T, Algellay M, Islam Y, Roberts M, Dempster NM, Sarker SD. 2018. The Application of 3D Printing in the Formulation of Multilayered Fast Dissolving Oral Films Journal of Pharmaceutical Sciences, 107 :1076-1085 DOI Author Url Publisher Url Public Url

Hutcheon G, Dempster NM, Roberts M, Gaskell EE, Kianfar F. 2017. Lyophilised Biopolymer-Clay Hydrogels for Drug Delivery Journal of Novel Drug Research, 1 DOI Public Url

Ainscough LP, Roberts M, Ford JL, Morecroft CW, Peak M, Turner MA, Nunn AJ. 2017. Accuracy of Intravenous and Enteral Preparations Involving Small Volumes for Paediatric Use: A Review European Journal of Hospital Pharmacy, DOI Author Url Public Url

Tawfeek HM, Saleem IY, Roberts M. 2014. Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets Journal of Pharmaceutical Sciences, 103 :2470-2483 DOI Author Url Publisher Url Public Url

Cespi M, Bonacucina G, Roberts M, Hanson S, Jones S, Makevica E, Casettari L, Palmieri GF. 2014. Evaluation of Citrus Fibers as a Tablet Excipient AAPS PHARMSCITECH, 15 :279-286 DOI Author Url

Hamilton AR, Hutcheon GA, Roberts M, Gaskell EE. 2014. Formulation and antibacterial profiles of clay-ciprofloxacin composites APPLIED CLAY SCIENCE, 87 :129-135 DOI Author Url

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. 2013. The influence of HPMC concentration on release of theophylline or hydrocortisone from extended release mini-tablets DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 39 :1167-1174 DOI Author Url

Shah UU, Roberts M, Orlu Gul M, Tuleu C, Beresford MW, NIHR MCRN/Arthritis Research UK Paediatric Rheumatology Clinical Studies Group . 2011. Needle-free and microneedle drug delivery in children: a case for disease-modifying antirheumatic drugs (DMARDs). Int J Pharm, 416 :1-11 DOI Author Url

Seton L, Roberts M, Ur-Rehman F. 2010. Compaction of recrystallised ibuprofen CHEMICAL ENGINEERING JOURNAL, 164 :449-452 DOI Author Url

Denton P, Madden J, Roberts M, Rowe P. 2008. Students' response to traditional and computer-assisted formative feedback: A comparative case study BRITISH JOURNAL OF EDUCATIONAL TECHNOLOGY, 39 :486-500 DOI Author Url

Ernest TB, Elder DP, Martini LG, Roberts M, Ford JL. 2007. Developing paediatric medicines: identifying the needs and recognizing the challenges JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 :1043-1055 DOI Author Url

Roberts M, Cespi M, Ford JL, Dyas AM, Downing J, Martini LG, Crowley PJ. 2007. Influence of ethanol on aspirin release from hypromellose matrices. Int J Pharm, 332 :31-37 DOI Author Url

Li CL, Martini LG, Ford JL, Roberts M. 2005. The use of hypromellose in oral drug delivery JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :533-546 DOI Author Url

Roberts M, Vellucci D, Mostafa S, Miolane C, Marchaud D. Development and evaluation of sustained-release Compritol® 888 ATO matrix mini-tablets. Drug Dev Ind Pharm, 38 :1068-1076 DOI Author Url

Roberts M, Ehtezazi T, Compernolle A, Amin K. The effect of spray drying on the compaction properties of hypromellose acetate succinate. Drug Dev Ind Pharm, 37 :268-273 DOI Author Url

Broadhurst EC, Ford JL, Nunn AJ, Rowe PH, Roberts M. Dose uniformity of samples prepared from dispersible aspirin tablets for paediatric use European Journal of Hospital Pharmacy Science, 14 :27-31

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH, Dyas AM. Effect of lubricant type and concentration on the punch tip adherence of model ibuprofen formulations. J Pharm Pharmacol, 56 :299-305 DOI Author Url

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH, Dyas AM. Effect of punch tip geometry and embossment on the punch tip adherence of a model ibuprofen formulation. J Pharm Pharmacol, 56 :947-950 DOI Author Url

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH. Effects of surface roughness and chrome plating of punch tips on the sticking tendencies of model ibuprofen formulations. J Pharm Pharmacol, 55 :1223-1228 DOI Author Url

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. The effect of HPMC particle size on the drug release rate and the percolation threshold in extended-release mini-tablets. Drug Dev Ind Pharm, 41 :70-78 DOI Author Url

Roberts M, Pulcini L, Mostafa S, Cuppok-Rosiaux Y, Marchaud D. Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium. Pharm Dev Technol, 20 :507-512 DOI Author Url

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. The influence of HPMC concentration on release of theophylline or hydrocortisone from extended release mini-tablets. Drug Dev Ind Pharm, 39 :1167-1174 DOI Author Url

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. Production of extended release mini-tablets using directly compressible grades of HPMC. Drug Dev Ind Pharm, 39 :1690-1697 DOI Author Url

Seton L, Mohamed FAAM, Roberts M, Ford JL, Levina M, Rajabi-Siahboomi AR. Film-coated matrix mini-tablets for the extended release of a water-soluble drug Drug Dev Ind Pharm, DOI Author Url

Hamilton AR, Roberts M, Hutcheon GA, Gaskell EE. Formulation and antibacterial properties of clay mineral-tetracycline and -doxycycline composites Applied Clay Science, 179 DOI Author Url Publisher Url Public Url

Ford JL, Madathilethu J, Roberts M, Matthew P, Blair J, Prescott R. Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing BMJ Paediatrics, 2 :1-1 DOI Author Url Public Url

Conference publication

Peak M, Madathilethu J, Prescott R, Ford J, Blair J, Roberts M. 2017. Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing JOURNAL OF PHARMACY AND PHARMACOLOGY, 69 :4-5 DOI Author Url

Riby P, Roberts M, Thiab S, Salmon P. 2016. Analysis of elemental impurities in pharmceutical formulations - How to deal with the regulations Biennial National Atomic Spectrscopy Symposium

Saleem IY, Patel T, Roberts M. 2010. Surface Coated Lactose Carrier Dry Powder Inhalation Particles using a Fluid Bed System JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1301-1302 Author Url

Ernest T, Martini L, Roberts M, Ford JL. 2010. Effects of Drug Solubility and Concentration on Phase Transformations of Hydroxypropyl Cellulose Aqueous Solutions JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1328-1329 Author Url

Treanor G, Roberts M, Mostafa S, Miolane C. 2010. Diluent Effects on Drug Release from Sustained-Release Compritol (R) 888 ATO Tablets JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1419-1420 Author Url

Mohamed F, Saleem R, Roberts M, Shah UU, Seton L, Ford JL. 2010. Hydrocortisone Mini-Tablets for Pediatric Delivery JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1441-1441 Author Url

Williams R, Roberts M, Riby P, Readdie S, O'Brien M. 2010. Stability of pharmaceutical products in multi-compartment compliance aids International Journal of Pharmacy Practice, 18 supplement 2 :93-94 DOI

Roberts M, Chanda R, Berardi A, Ford JL, Martini LG. 2008. The influence of ethanol on diltiazem hydrochloride release from matrix and multiparticulate modified-release systems JOURNAL OF PHARMACY AND PHARMACOLOGY, 60 :A47-A47 Author Url

Ernest TB, Martini LG, Elder DP, Roberts M, Ford JL. 2007. The influence of spray drying on the physical properties of hydroxypropyl cellulose and hypromellose JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 :A41-A41 Author Url

Roberts M. 2007. The influence of alcohol on drug release from modified release oral dosage forms JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 :A75-A76 Author Url

Cespi M, Roberts M, Ford JL, Dyas AM, Martini LG, Crowley PJ. 2006. The influence of alcohol on aspirin release from hypromellose matrix tablets JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A26-A26 Author Url

Ernest IB, Elder DP, Martini LG, Roberts M, Ford JL. 2006. Ion exchange resins: improving palatability without compromising bioequivalence JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A78-A79 Author Url

Roberts M, Thompson M, O'Donoghue I, Ford JL. 2005. Compression and re-compression properties of hypromellose/lactose mixtures JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S29-S29 Author Url

Parmar MM, Seton L, Roberts M, Ford JL. 2005. Polymorph selection using solvents JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S62-S62 Author Url

Roberts M, Teall J, Hughes K, Rajabi-Siahboomi A. Investigation of compression behaviour of a co-processed mixture of corn starch and pregelatinized starch as a direct compression excipient. AAPS Publisher Url

Mohamed FA, Saleem R, Roberts M, Shah UU, Seton L, Ford JL. Development Of Hydrocortisone Mini-Tablets For Improved Paediatric Dosing 2nd Conference of the European Paediatric Formulation Initiative (EuPFI)

Vellucci D, Roberts M, Mostafa S, Miolane C, Marchaud D. Formulation effects on drug release from sustained-release Compritol® 888 ATO tablets and mini-tablets 38th Annual Meeting & Exposition of the Controlled Release Society (CRS)

Ernest TB, Martini LG, Roberts M, Ford JL. Characterisation and Modified Release Properties of Hydroxypropyl Cellulose Films PharmSci

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. Effect of Polymer Concentration and Tablet Size on Hydrocortisone Release from Hypromellose Extended Release Mini-Tablets PharmSci

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. Extended Release HPMC Mini-Tablets For Paediatric Delivery Of Hydrocortisone 3rd Conference of the European Paediatric Formulation Initiative (EuPFI)

Seton L, Kumar D, Roberts M, Patel S, Pritchard R, Bradshaw IJ, Hutcheon GA. Solid state characterisation of a highly polymorphic system to explain differences in tabletting and dissolution properties 10th International Symposium on the Crystal Growth of Organic Materials

Roberts M, Gilani A, Ganthan B, Shah UU. Diclofenac sodium mini-tablets for flexible paediatric dosing 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Hamilton AR, Roberts M, Hutcheon GA, Gaskell EE. Utilising montmorillonite K-10 and Laponite for delivery of ciprofloxacin UK & Ireland Controlled Release Society

Pulcini L, Roberts M, Mostafa S, Cuppok Y. The utility of wet granulation to produce Compritol® 888 ATO matrix tablets for the sustained release of Diclofenac Sodium 39th Annual Meeting & Exposition of the Controlled Release Society

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. The use of a rotary press simulator for production of extended release mini-tablets containing hypromellose . American Association of Pharmaceutical Scientists Annual Meeting and Exposition

Levina M, Roberts M, Vass S, Farrell T, Rajabi-Siahboomi AR. The investigation of synergetic behaviour of excipients in direct compression using a rotary press simulator . American Association of Pharmaceutical Scientists Annual Meeting and Exposition

Roberts M, Messina M, Mostafa S, Cuppok Y. Sustained release levodopa mini-tablets containing Compritol®888: a viable approach for special patient populations American Association of Pharmaceutical Scientists Annual Meeting and Exposition

Riby P, Salmon P, Roberts M, Brandt S, Wainwright M. Trace Metal Analysis in Pharmaceutical Formulations Biennial National Atomic Spectroscopy/Trace Spec Meeting

Samar S, Roberts M, Riby P. Analysis of Arsenic and Other ICH Q3D Metals in Pharmaceutical Formulations Pittsburgh Conference and Exhibition

Saleem I, Patel T, Roberts M. Surface coated lactose carrier dry powder inhalation particles using a fluid bed system Journal of Pharmacy and Pharmacology, 62

Chapters

Shah UU, Roberts M. 2014. Parenteral Liquids for Intravenous and Transdermal Use Bar-Shalom D, Rose K. Pediatric Formulations: A Roadmap 11 Springer. New York 978-1-4899-8011-3

Bar-Shalom D, Roberts M, Ford JL. 2011. Extrudable Technologies for Controlling Drug Release and Absorption Wilson CG, Crowley PJ. Controlled Release in Oral Drug Delivery :239-256 Springer Verlag 9781461410034 DOI

Roberts M. Liquids Denton P, Rostron C. Pharmaceutics: The Science Of Medicine Design :35-50 Oxford University Press 9780199655311

Engagement & Impact

External PGR examinations performed:

University of Nottingham, PhD, Correlating drug release with microstructure of hydrogel-based delivery systems. 2019

University of Wolverhampton, PhD, Towards a more efficacious treatment for Oropharyngeal Candidiasis (OPC): Hydrogel-forming tablets for the controlled release delivery of antifungals. 2018

University College London, PhD, Flexible solid oral dosage forms (FSODs) as the preferred formulations for children: feasibility study in Nigeria as a model tropical developing country.. 2015

University of Nottingham, PhD, Mixed polymer hydrophilic matrices containing HPMC and PEO University of Nottingham. 2015

University of Camerino, PhD, Mechanical and compression characterization of pellets prepared by extrusion – spheronization.. 2008

Membership of professional bodies:

FHEA, Higher Education Academy. 2013

MRSC, Royal Society of Chemistry.

External collaboration:

Alder Hey Children's NHS Foundation Trust, Paediatric Medicines Research Unit (PMRU). 2010

Assiut University, Egypt, Dr Hesham Tawfeek.

University of Camerino, Prof Giovanni Palmieri.

Industrial connections:

Colorcon, UK, Development of extended-release hydrophilic matrix mini-tablets for paediatric delivery. 2010

Gattefosse, France, Investigation of glyceryl behenate (Compritol 888 ATO) in sustained release tablets and mini-tablets. 2010

Janssen Pharmaceutica, Belgium, The effect of spray drying on the compaction properties of hypromellose acetace succinate. 2009

GlaxoSmithKline, UK, PhD (p/t) - Studies into the development of a polymeric dosage form for paediatric drug delivery.. 2005

Manesty.