Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Matt Roberts

Dr Matt Roberts

Telephone: 0151 231 2036

Biography

Matt Roberts is Senior Lecturer in Pharmaceutics within the School of Pharmacy and Biomolecular Sciences and has been a member of the academic staff since 2003. He is Programme Leader for two of the postgraduate degree courses within the School: MSc 'Drug Discovery & Design' and MSc 'Pharmaceutical Manufacture & Quality Control'. Matt also teaches a wide range of topics on all levels of the undergraduate MPharm and BSc 'Applied Chemical & Pharmaceutical Science' programmes within the school, including aspects of pharmaceutical formulation, drug delivery and industrial pharmacy.

Matt is a member of the Formulation and Drug Delivery research group. His research background is in the field of solid dosage formulation and manufacture having completed a PhD investigating the influence of formulation and process parameters on the problem of punch sticking during tablet manufacture. He has expertise in the use of compaction simulation for evaluating the compression properties of drugs and excipients and in recent years, Matt's research has focussed on hydrophilic and hydrophobic polymeric matrices for sustained drug release and the development of formulations for improved paediatric drug delivery.

Publications

Highlighted publications

Ford JL, Madathilethu J, Roberts M, Matthew P, Blair J, Prescott R. 2018. Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing BMJ Paediatrics, 2 :1-1 >DOI

Tawfeek HM, Saleem IY, Roberts M. 2014. Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets JOURNAL OF PHARMACEUTICAL SCIENCES, 103 :2470-2483 >DOI >Link

Cespi M, Bonacucina G, Roberts M, Hanson S, Jones S, Makevica E, Casettari L, Palmieri GF. 2014. Evaluation of Citrus Fibers as a Tablet Excipient AAPS PHARMSCITECH, 15 :279-286 >DOI >Link

Hamilton AR, Hutcheon GA, Roberts M, Gaskell EE. 2014. Formulation and antibacterial profiles of clay-ciprofloxacin composites APPLIED CLAY SCIENCE, 87 :129-135 >DOI >Link

Journal article

Tawfeek HM, Roberts M, El Hamd MA, Abdellatif AAH, Younis MA. 2018. Glibenclamide Mini-tablets with an Enhanced Pharmacokinetic and Pharmacodynamic Performance. AAPS PharmSciTech, >DOI >Link

Ford JL, Madathilethu J, Roberts M, Matthew P, Blair J, Prescott R. 2018. Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing BMJ Paediatrics, 2 :1-1 >DOI

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O'Neill F, Roberts M. 2018. Surfactant Effects on Lipid-Based Vesicles Properties JOURNAL OF PHARMACEUTICAL SCIENCES, 107 :1237-1246 >DOI >Link

Ehtezazi T, Algellay M, Islam Y, Roberts M, Dempster NM, Sarker SD. 2018. The Application of 3D Printing in the Formulation of Multilayered Fast Dissolving Oral Films JOURNAL OF PHARMACEUTICAL SCIENCES, 107 :1076-1085 >DOI >Link

Hutcheon G, Dempster NM, Roberts M, Gaskell EE, Kianfar F. 2017. Lyophilised Biopolymer-Clay Hydrogels for Drug Delivery Journal of Novel Drug Research, 1 >DOI

Ainscough LP, Roberts M, Ford JL, Morecroft CW, Peak M, Turner MA, Nunn AJ. 2017. Accuracy of Intravenous and Enteral Preparations Involving Small Volumes for Paediatric Use: A Review European Journal of Hospital Pharmacy, >DOI

Roberts M, Pulcini L, Mostafa S, Cuppok-Rosiaux Y, Marchaud D. 2015. Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium. Pharm Dev Technol, 20 :507-512 >DOI >Link

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. 2015. The effect of HPMC particle size on the drug release rate and the percolation threshold in extended-release mini-tablets. Drug Dev Ind Pharm, 41 :70-78 >DOI >Link

Tawfeek HM, Saleem IY, Roberts M. 2014. Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets JOURNAL OF PHARMACEUTICAL SCIENCES, 103 :2470-2483 >DOI >Link

Cespi M, Bonacucina G, Roberts M, Hanson S, Jones S, Makevica E, Casettari L, Palmieri GF. 2014. Evaluation of Citrus Fibers as a Tablet Excipient AAPS PHARMSCITECH, 15 :279-286 >DOI >Link

Hamilton AR, Hutcheon GA, Roberts M, Gaskell EE. 2014. Formulation and antibacterial profiles of clay-ciprofloxacin composites APPLIED CLAY SCIENCE, 87 :129-135 >DOI >Link

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. 2013. The influence of HPMC concentration on release of theophylline or hydrocortisone from extended release mini-tablets DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 39 :1167-1174 >DOI >Link

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. 2013. Production of extended release mini-tablets using directly compressible grades of HPMC. Drug Dev Ind Pharm, 39 :1690-1697 >DOI >Link

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. 2013. The influence of HPMC concentration on release of theophylline or hydrocortisone from extended release mini-tablets. Drug Dev Ind Pharm, 39 :1167-1174 >DOI >Link

Roberts M, Vellucci D, Mostafa S, Miolane C, Marchaud D. 2012. Development and evaluation of sustained-release Compritol® 888 ATO matrix mini-tablets. Drug Dev Ind Pharm, 38 :1068-1076 >DOI >Link

Roberts M, Ehtezazi T, Compernolle A, Amin K. 2011. The effect of spray drying on the compaction properties of hypromellose acetate succinate. Drug Dev Ind Pharm, 37 :268-273 >DOI >Link

Shah UU, Roberts M, Orlu Gul M, Tuleu C, Beresford MW, NIHR MCRN/Arthritis Research UK Paediatric Rheumatology Clinical Studies Group . 2011. Needle-free and microneedle drug delivery in children: a case for disease-modifying antirheumatic drugs (DMARDs). Int J Pharm, 416 :1-11 >DOI >Link

Seton L, Roberts M, Ur-Rehman F. 2010. Compaction of recrystallised ibuprofen CHEMICAL ENGINEERING JOURNAL, 164 :449-452 >DOI >Link

Broadhurst EC, Ford JL, Nunn AJ, Rowe PH, Roberts M. 2008. Dose uniformity of samples prepared from dispersible aspirin tablets for paediatric use European Journal of Hospital Pharmacy Science, 14 :27-31

Denton P, Madden J, Roberts M, Rowe P. 2008. Students' response to traditional and computer-assisted formative feedback: A comparative case study BRITISH JOURNAL OF EDUCATIONAL TECHNOLOGY, 39 :486-500 >DOI >Link

Ernest TB, Elder DP, Martini LG, Roberts M, Ford JL. 2007. Developing paediatric medicines: identifying the needs and recognizing the challenges JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 :1043-1055 >DOI >Link

Roberts M, Cespi M, Ford JL, Dyas AM, Downing J, Martini LG, Crowley PJ. 2007. Influence of ethanol on aspirin release from hypromellose matrices. Int J Pharm, 332 :31-37 >DOI >Link

Li CL, Martini LG, Ford JL, Roberts M. 2005. The use of hypromellose in oral drug delivery JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :533-546 >DOI >Link

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH, Dyas AM. 2004. Effect of punch tip geometry and embossment on the punch tip adherence of a model ibuprofen formulation. J Pharm Pharmacol, 56 :947-950 >DOI >Link

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH, Dyas AM. 2004. Effect of lubricant type and concentration on the punch tip adherence of model ibuprofen formulations. J Pharm Pharmacol, 56 :299-305 >DOI >Link

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH. 2003. Effects of surface roughness and chrome plating of punch tips on the sticking tendencies of model ibuprofen formulations. J Pharm Pharmacol, 55 :1223-1228 >DOI >Link

Seton L, Mohamed FAAM, Roberts M, Ford JL, Levina M, Rajabi-Siahboomi AR. Film-coated matrix mini-tablets for the extended release of a water-soluble drug Drug Dev Ind Pharm, >DOI

Conference publication

Peak M, Madathilethu J, Prescott R, Ford J, Blair J, Roberts M. 2017. Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing JOURNAL OF PHARMACY AND PHARMACOLOGY, 69 :4-5 >Link

Riby P, Roberts M, Thiab S, Salmon P. 2016. Analysis of elemental impurities in pharmceutical formulations - How to deal with the regulations Biennial National Atomic Spectrscopy Symposium

saleem IY, Patel T, Roberts M. 2010. Surface Coated Lactose Carrier Dry Powder Inhalation Particles using a Fluid Bed System

Williams R, Roberts M, Riby P, Readdie S, O'Brien M. 2010. Stability of pharmaceutical products in multi-compartment compliance aids International Journal of Pharmacy Practice, 18 supplement 2 :93-94 >DOI

Mohamed F, Saleem R, Roberts M, Shah UU, Seton L, Ford JL. 2010. Hydrocortisone Mini-Tablets for Pediatric Delivery JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1441-1441 >Link

Treanor G, Roberts M, Mostafa S, Miolane C. 2010. Diluent Effects on Drug Release from Sustained-Release Compritol (R) 888 ATO Tablets JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1419-1420 >Link

Ernest T, Martini L, Roberts M, Ford JL. 2010. Effects of Drug Solubility and Concentration on Phase Transformations of Hydroxypropyl Cellulose Aqueous Solutions JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1328-1329 >Link

Saleem IY, Patel T, Roberts M. 2010. Surface Coated Lactose Carrier Dry Powder Inhalation Particles using a Fluid Bed System JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1301-1302 >Link

Roberts M, Teall J, Hughes K, Rajabi-Siahboomi A. 2009. Investigation of compression behaviour of a co-processed mixture of corn starch and pregelatinized starch as a direct compression excipient. AAPS

Roberts M, Chanda R, Berardi A, Ford JL, Martini LG. 2008. The influence of ethanol on diltiazem hydrochloride release from matrix and multiparticulate modified-release systems JOURNAL OF PHARMACY AND PHARMACOLOGY, 60 :A47-A47 >Link

Roberts M. 2007. The influence of alcohol on drug release from modified release oral dosage forms JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 :A75-A76 >Link

Ernest TB, Martini LG, Elder DP, Roberts M, Ford JL. 2007. The influence of spray drying on the physical properties of hydroxypropyl cellulose and hypromellose JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 :A41-A41 >Link

Ernest IB, Elder DP, Martini LG, Roberts M, Ford JL. 2006. Ion exchange resins: improving palatability without compromising bioequivalence JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A78-A79 >Link

Cespi M, Roberts M, Ford JL, Dyas AM, Martini LG, Crowley PJ. 2006. The influence of alcohol on aspirin release from hypromellose matrix tablets JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A26-A26 >Link

Parmar MM, Seton L, Roberts M, Ford JL. 2005. Polymorph selection using solvents JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S62-S62 >Link

Roberts M, Thompson M, O'Donoghue I, Ford JL. 2005. Compression and re-compression properties of hypromellose/lactose mixtures JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S29-S29 >Link

Samar S, Roberts M, Riby P. Analysis of Arsenic and Other ICH Q3D Metals in Pharmaceutical Formulations Pittsburgh Conference and Exhibition

Riby P, Salmon P, Roberts M, Brandt S, Wainwright M. Trace Metal Analysis in Pharmaceutical Formulations Biennial National Atomic Spectroscopy/Trace Spec Meeting

Roberts M, Messina M, Mostafa S, Cuppok Y. Sustained release levodopa mini-tablets containing Compritol®888: a viable approach for special patient populations American Association of Pharmaceutical Scientists Annual Meeting and Exposition

Levina M, Roberts M, Vass S, Farrell T, Rajabi-Siahboomi AR. The investigation of synergetic behaviour of excipients in direct compression using a rotary press simulator . American Association of Pharmaceutical Scientists Annual Meeting and Exposition

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. The use of a rotary press simulator for production of extended release mini-tablets containing hypromellose . American Association of Pharmaceutical Scientists Annual Meeting and Exposition

Pulcini L, Roberts M, Mostafa S, Cuppok Y. The utility of wet granulation to produce Compritol® 888 ATO matrix tablets for the sustained release of Diclofenac Sodium 39th Annual Meeting & Exposition of the Controlled Release Society

Hamilton AR, Roberts M, Hutcheon GA, Gaskell EE. Utilising montmorillonite K-10 and Laponite for delivery of ciprofloxacin UK & Ireland Controlled Release Society

Roberts M, Gilani A, Ganthan B, Shah UU. Diclofenac sodium mini-tablets for flexible paediatric dosing 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Seton L, Kumar D, Roberts M, Patel S, Pritchard R, Bradshaw IJ, Hutcheon GA. Solid state characterisation of a highly polymorphic system to explain differences in tabletting and dissolution properties 10th International Symposium on the Crystal Growth of Organic Materials

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. Extended Release HPMC Mini-Tablets For Paediatric Delivery Of Hydrocortisone 3rd Conference of the European Paediatric Formulation Initiative (EuPFI)

Mohamed FAA, Roberts M, Seton L, Ford JL, Levina M, Rajabi-Siahboomi AR. Effect of Polymer Concentration and Tablet Size on Hydrocortisone Release from Hypromellose Extended Release Mini-Tablets PharmSci

Ernest TB, Martini LG, Roberts M, Ford JL. Characterisation and Modified Release Properties of Hydroxypropyl Cellulose Films PharmSci

Vellucci D, Roberts M, Mostafa S, Miolane C, Marchaud D. Formulation effects on drug release from sustained-release Compritol® 888 ATO tablets and mini-tablets 38th Annual Meeting & Exposition of the Controlled Release Society (CRS)

Mohamed FA, Saleem R, Roberts M, Shah UU, Seton L, Ford JL. Development Of Hydrocortisone Mini-Tablets For Improved Paediatric Dosing 2nd Conference of the European Paediatric Formulation Initiative (EuPFI)

Chapters

Shah UU, Roberts M. 2014. Parenteral Liquids for Intravenous and Transdermal Use Bar-Shalom D, Rose K. Pediatric Formulations: A Roadmap 11 Springer. New York 978-1-4899-8011-3

Roberts M. 2013. Liquids Denton P, Rostron C. Pharmaceutics: The Science Of Medicine Design :35-50 Oxford University Press 9780199655311

Bar-Shalom D, Roberts M, Ford JL. 2011. Extrudable Technologies for Controlling Drug Release and Absorption Wilson CG, Crowley PJ. Controlled Release in Oral Drug Delivery :239-256 Springer Verlag 9781461410034 >DOI

Engagement & Impact

External collaboration:

University of Camerino, Prof Giovanni Palmieri

Assiut University, Egypt, Dr Hesham Tawfeek

Alder Hey Children's NHS Foundation Trust, Paediatric Medicines Research Unit (PMRU)

External PGR examinations performed:

University of Nottingham, PhD, Mixed polymer hydrophilic matrices containing HPMC and PEO University of Nottingham

University College London, PhD, Flexible solid oral dosage forms (FSODs) as the preferred formulations for children: feasibility study in Nigeria as a model tropical developing country.

University of Camerino, PhD, Mechanical and compression characterization of pellets prepared by extrusion – spheronization.

Industrial connections:

Manesty

Colorcon, UK, Development of extended-release hydrophilic matrix mini-tablets for paediatric delivery

Gattefosse, France, Investigation of glyceryl behenate (Compritol 888 ATO) in sustained release tablets and mini-tablets

Janssen Pharmaceutica, Belgium, The effect of spray drying on the compaction properties of hypromellose acetace succinate

GlaxoSmithKline, UK, PhD (p/t) - Studies into the development of a polymeric dosage form for paediatric drug delivery.

Membership of professional bodies:

FHEA, Higher Education Academy

MRSC, Royal Society of Chemistry