Dr Mosharraf Sarker

Pharmacy and Biomolecular Sciences

Dr. Mosharraf Sarker is a Human Physiologist with a keen focus on unravelling the intricate mechanisms of mammalian cell signalling in response to oxidative stress, inflammation, and microvascular permeability. He is also interested in the role of the microbiome in the regulation of inflammation. His academic journey began with undergraduate and Master of Science degrees in Medical Physiology from the Institute of Postgraduate Medicine and Research, Dhaka, Bangladesh, spanning from 1982 to 1987. Dr. Sarker earned his PhD in vascular Physiology from King’s College London in 1995, delving deep into the complexities of brain microvascular permeability regulation to inflammatory mediators. Following his PhD, he embarked on two postdoctoral research fellowships supported by the Wellcome Trust, honing his expertise in the field, including islet microcirculation in the pancreas. Dr. Sarker's academic contributions extended globally, encompassing teaching roles at the Pharmacy Department, Jahangirnagar University, Dhaka, Bangladesh, and honorary lectureships at the Institute of Ophthalmology, University College London (UCL, 2010-2020), and the Cardiovascular Division, King’s College London (until 2023). His tenure at Teesside University, from 2001 to 2023, saw him as a dedicated lecturer in Human Biology, actively engaged in research management as a postgraduate tutor and chairing the research degrees subcommittee. Additionally, he led undergraduate final-year research projects, served as a module leader, and contributed as a program leader for the MRes in Science, BSc Human Biology, and BSc Health Sciences programs. In July 2023, Dr. Sarker transitioned to Liverpool John Moores University, joining the faculty of Pharmacy and Biomolecular Sciences. Throughout his career, he has demonstrated a steadfast commitment to advancing scientific understanding and nurturing the next generation of researchers and academics.

Degrees

1995, King's College London, United Kingdom, PhD
1987, Institute of Post Graduate Medicine and Research (IPGMR), Bangladesh, Msc
1985, Institute of postgraduate Medicine and Research (IPGMR), Bangladesh, BSc (Hons.) in Physiology

Other

Hira MT, Razzaque MA, Angione C, Scrivens J, Sawan S, Sarker M. 2021. Author Correction: Integrated multi‑omics analysis of ovarian cancer using variational autoencoders (Scientific Reports, (2021), 11, 1, (6265), 10.1038/s41598-021-85285-4) Scientific Reports, 11 DOI Author Url Publisher Url

Journal article

Estevao C, Bowers CE, Luo D, Sarker M, Hoeh AE, Frudd K, Turowski P, Greenwood J. 2021. CCL4 induces inflammatory signalling and barrier disruption in the neurovascular endothelium Brain, Behavior, and Immunity - Health, 18 DOI Author Url Publisher Url Public Url

Dragoni S, Caridi B, Karatsai E, Burgoyne T, Sarker MH, Turowski P. 2021. AMP-activated protein kinase is a key regulator of acute neurovascular permeability Journal of Cell Science, 134 :jcs253179 DOI Author Url Publisher Url Public Url

Hira MT, Razzaque MA, Angione C, Scrivens J, Sawan S, Sarker M. 2021. Integrated multi‑omics analysis of ovarian cancer using variational autoencoders Scientific Reports, 11 DOI Publisher Url Public Url

Nanjundaiah YS, Wright DA, Baydoun AR, Khaled Z, Ali Z, Dean P, Sarker MH. 2020. Modulation of Macrophage Function by Lactobacillus-Conditioned Medium Frontiers in Cell and Developmental Biology, 8 :723 DOI Author Url Publisher Url Public Url

Oluwadare DA, Carney HE, Sarker MH, Ennis CJ. 2020. Kinetics of water-extractable zinc release from seaweed (Fucus serratus) as soil amendment Journal of Plant Nutrition and Soil Science, 183 :136-143 DOI Publisher Url

Canning P, Kenny BA, Prise V, Glenn J, Sarker MH, Hudson N, Brandt M, Lopez FJ, Gale D, Luthert PJ, Adamson P, Turowski P, Stitt AW. 2016. Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes Proceedings of the National Academy of Sciences of the United States of America, 113 :7213-7218 DOI Author Url Publisher Url

Seenappanahalli Nanjundaiah Y, Wright DA, Baydoun AR, O'Hare WT, Ali Z, Khaled Z, Sarker MH. 2016. Lactobacillus rhamnosus GG conditioned media modulates acute reactive oxygen species and nitric oxide in J774 murine macrophages Biochemistry and Biophysics Reports, 6 :68-75 DOI Author Url Publisher Url Public Url

Greenwell M, Sarker M, Rahman PKSM. 2016. Biosurfactant production and biodegradation of leather dust from tannery Open Biotechnology Journal, 10 :312-325 DOI Publisher Url

Hudson N, Powner MB, Sarker MH, Burgoyne T, Campbell M, Ockrim ZK, Martinelli R, Futter CE, Grant MB, Fraser PA, Shima DT, Greenwood J, Turowski P. 2014. Differential apicobasal VEGF signaling at vascular blood-neural barriers Developmental Cell, 30 :541-552 DOI Author Url Publisher Url Public Url

Patwary MA, O'Hare WT, Karim SA, Sarker MH. 2012. The motivations of young people moving into medical waste scavenging as a street career Journal of Youth Studies, 15 :591-604 DOI Publisher Url

Patwary MA, O'Hare WT, Sarker MH. 2012. Occupational accident: An example of fatalistic beliefs among medical waste workers in Bangladesh Safety Science, 50 :76-82 DOI Publisher Url

Patwary MA, O'Hare WT, Sarker MH. 2011. Assessment of occupational and environmental safety associated with medical waste disposal in developing countries: A qualitative approach Safety Science, 49 :1200-1207 DOI Publisher Url

Woodfin A, Hu DE, Sarker M, Kurokawa T, Fraser P. 2011. Acute NADPH oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia-reperfusion Free Radical Biology and Medicine, 50 :518-524 DOI Author Url Publisher Url

Patwary MA, O'Hare WT, Sarker MH. 2011. An illicit economy: Scavenging and recycling of medical waste Journal of Environmental Management, 92 :2900-2906 DOI Author Url Publisher Url

Sarker MH, Hu DE, Fraser PA. 2010. Regulation of cerebromicrovascular permeability by lysophosphatidic acid. Microcirculation (New York, N.Y. : 1994), 17 :39-46 DOI Author Url Publisher Url

Patwary MA, O'Hare WT, Street G, Maudood Elahi K, Hossain SS, Sarker MH. 2009. Quantitative assessment of medical waste generation in the capital city of Bangladesh Waste Management, 29 :2392-2397 DOI Author Url Publisher Url

Gauden V, Hu DE, Kurokawa T, Sarker MH, Fraser PA. 2007. Novel technique for estimating cerebrovascular permeability demonstrates capsazepine protection following ischemia-reperfusion Microcirculation, 14 :767-778 DOI Author Url Publisher Url

Sarker MH, Fraser PA. 2002. The role of guanylyl cyclases in the permeability response to inflammatory mediators in pial venular capillaries in the rat Journal of Physiology, 540 :209-218 DOI Author Url Publisher Url

Sarker MH, Hu DE, Fraser PA. 2000. Acute effects of bradykinin on cerebral microvascular permeability in the anaesthetized rat Journal of Physiology, 528 :177-187 DOI Author Url Publisher Url

Sarker MH, Easton AS, Fraser PA. 1998. Regulation of cerebral microvascular permeability by histamine in the anaesthetized rat Journal of Physiology, 507 :909-918 DOI Author Url Publisher Url

Easton AS, Sarker MH, Fraser PA. 1997. Two components of blood-brain barrier disruption in the rat Journal of Physiology, 503 :613-623 DOI Author Url Publisher Url

Wolff C, Sarker M, Fraser P. 1995. Cerebral microvascular permeability and CSF pH in anaesthetized rats Experimental Physiology, 80 :1053-1055 DOI Author Url Publisher Url

Conference publication

Noor T, Ralebitso-Senior TK, Sarker M, Wright D. 2020. Determining the impacts of environmental parameters on model microbial community dynamics isolated from Rustumihia WWTP - Iraq IOP Conference Series: Materials Science and Engineering, The First International Conference of Pure and Engineering Sciences (ICPES2020) 871 DOI Publisher Url Public Url

Noor T, Ralebitso-Senior TK, Sarker M, Wright D. 2020. Characterisation of indigenous microbial community isolated from wastewater treatment phases Baghdad/Iraq IOP Conference Series: Materials Science and Engineering, The First International Conference of Pure and Engineering Sciences (ICPES2020) 871 DOI Author Url Publisher Url Public Url

Editorial boards:

Current issue in molecular Biology, Editor, https://www.mdpi.com/journal/cimb. 2024

Frontiers in Cardiovascular Medicine, Review Editor, https://www.frontiersin.org/journals/cardiovascular-medicine.

Frontiers of Cardiovascular Medicine, Guest Associate editor, https://www.frontiersin.org/research-topics/52603/frontiers-in-cardiovascular-medicine-rising-stars-2022/magazine.

Frontiers of cell and developmental biology in molecular medicine, Review editor, https://www.frontiersin.org/journals/cell-and-developmental-biology.

Membership of professional bodies:

Senior Fellow of Higher Education Academy, AdvanceHE, https://www.advance-he.ac.uk/. 2015

Fellow, The Royal Society of Biology, https://www.rsb.org.uk/. 2009

Full Member, The Physiological Society, https://www.physoc.org/. 2000

Full Member, The British Microcirculation Society, https://www.microcirculation.org.uk/. 1992

Full Member, The European Microcirculation Society, http://www.esmicro.eu/. 1992

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