Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Nicholas Bryan

Dr Nicholas Bryan

Publications

Journal Articles

Bryan N, Ashwin H, Chen R, Smart NJ, Bayon Y, Wohlert S, Hunt JA. 2016. Evaluation of six synthetic surgical meshes implanted subcutaneously in a rat model JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 10 :E305-E315 >DOI >Link

Bryan N, Ashwin H, Smart N, Weyhe D, Wohlert S, Bayon Y, Hunt JA. 2015. Systemic inflammatory cytokine analysis to monitor biomaterial augmented tissue healing INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 38 :651-658 >DOI >Link

Battersby CLF, Bryan N, Hunt JA. 2015. Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: A randomized placebocontrolled trial Annals of Surgery, 262 :e95 >DOI

Bryan N, Ashwin H, Smart NJ, Wohlert S, Bayon Y, Hunt JA. 2015. Characterisation and comparison of the host response of 6 tissue-based surgical implants in a subcutaneous in vivo rat model JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 13 :35-42 >DOI >Link

Bryan N, Battersby C, Smart N, Hunt J. 2015. A review of biocompatibility in hernia repair; considerations in vitro and in vivo for selecting the most appropriate repair material HERNIA, 19 :169-178 >DOI >Link

Smart NJ, Bryan N, Hunt JA, Daniels IR. 2014. Porcine dermis implants in soft-tissue reconstruction: Current status Biologics: Targets and Therapy, 8 :83-90 >DOI

Bryan N, Ahswin H, Smart N, Bayon Y, Wohlert S, Hunt JA. 2014. The in vivo evaluation of tissue-based biomaterials in a rat full-thickness abdominal wall defect model JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 102 :709-720 >DOI >Link

Hunt JA, Chen R, van Veen T, Bryan N. 2014. Hydrogels for tissue engineering and regenerative medicine JOURNAL OF MATERIALS CHEMISTRY B, 2 :5319-5338 >DOI >Link

Bryan N, Birch P, Stanley C, Bond D, Hunt JA. 2013. The use of acoustic force capture to ultra-purify lymphocyte subpopulations from human adult whole blood JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 7 :812-818 >DOI >Link

Bryan N, Lewis FC, Bond D, Stanley C, Hunt JA. 2013. Evaluation of a Novel Non-Destructive Catch and Release Technology for Harvesting Autologous Adult Stem Cells PLOS ONE, 8 >DOI >Link

Hunt JA, Fok M, Bryan N. 2013. Impact of cell purification technique of autologous human adult stem cells on inflammatory reaction BIOMATERIALS, 34 :7626-7631 >DOI >Link

Lewis FC, Bryan N, Hunt JA. 2012. A feeder-free, human plasma-derived hydrogel for maintenance of a human embryonic stem cell phenotype in vitro Cell Regeneration, 1 >DOI

Bryan N, Ahswin H, Smart NJ, Bayon Y, Hunt JA. 2012. In vitro activation of human leukocytes in response to contact with synthetic hernia meshes CLINICAL BIOCHEMISTRY, 45 :672-676 >DOI >Link

Bryan N, Ahswin H, Smart N, Bayon Y, Wohlert S, Hunt JA. 2012. REACTIVE OXYGEN SPECIES (ROS) - A FAMILY OF FATE DECIDING MOLECULES PIVOTAL IN CONSTRUCTIVE INFLAMMATION AND WOUND HEALING EUROPEAN CELLS & MATERIALS, 24 :249-265 >Link

Bryan N, Ashwin H, Smart N, Bayon Y, Scarborough N, Hunt JA. 2012. The innate oxygen dependant immune pathway as a sensitive parameter to predict the performance of biological graft materials BIOMATERIALS, 33 :6380-6392 >DOI >Link

Bryan N, Ashwin H, Chen R, Bayon Y, Hunt JA. 2012. In vivo characterisation of the inflammatory kinetics of biologic and synthetic abdominal wall repair biomaterials JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6 :217-217 >Link

Lewis FC, Bryan N, Bond D, Stanley C, Hunt JA. 2012. Evaluation of a novel, rapid method to catch and release therapeutic numbers of viable adult stem cells from adipose JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6 :268-268 >Link

Bryan N, Ashwin H, Bayon Y, Hunt JA. 2012. Evaluation & validation of an in vitro system for predicting the acute inflammatory reaction elicited by biomaterials JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6 :356-356 >Link

Smart NJ, Bryan N, Hunt JA. 2012. A scientific evidence for the efficacy of biologic implants for soft tissue reconstruction COLORECTAL DISEASE, 14 :1-6 >DOI >Link

Bryan N, Bayon Y, Scarborough N, Hunt JA. 2011. The prediction of the acute inflammatory characteristics of prospective implantable biomaterials using in vitro chemiluminescence 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials,

Bryan N, Ashwin H, Bayon Y, Hunt JA. 2011. Evaluation of the inflammatory response characteristics, magnitude and kinetics for implantable synthetic and tissue-based biologic biomaterials in a subcutaneous tissue in vivo model 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials,

Bryan N, Andrews KD, Loughran MJ, Rhodes NP, Hunt JA. 2011. Elucidating the contribution of the elemental composition of fetal calf serum to antigenic expression of primary human umbilical-vein endothelial cells in vitro BIOSCIENCE REPORTS, 31 :199-210 >DOI >Link

Bryan N, Rhodes NP, Hunt JA. 2009. Derivation and performance of an entirely autologous injectable hydrogel delivery system for cell-based therapies BIOMATERIALS, 30 :180-188 >DOI >Link

Bryan N, Rhodes NP, Hunt JA. 2008. Development of minimal animal product free culture parameters for the expansion and differentiation of human mesenchymal stem cells JOURNAL OF ANATOMY, 212 :73-73 >Link

Bryan N, Rhodes NP, Hunt JA. 2008. Development of chemically defined pharmacopeia grade media for the directed differentiation of human mesenchymal stem cells 8th World Biomaterials Congress 2008, 1 :255

Bryan N, Rhodes NP, Hunt JA. 2008. Development and validation of an injectable autologous patient specific hydrogel suitable for local cellular delivery across a range of biomedical applications 8th World Biomaterials Congress 2008, 1 :258

Pennick M, Chandrashekar MV, Fawcett S, Bryan N, Mitchell G, Hunt JA. Is the Reparative Efficacy of Adipose-Derived Stem Cells Affected by Anatomical Harvest Site? American Journal of Hematology Oncology, 12 :26-28

Bryan N, Smith C, Bond D, Stanley C, Hunt J. Development and Evaluation of a Bead Based Cell Capture System with a Potential Role in Circulating Tumour Cell Detection European Surgical Research, 55 :106-106

Bryan N, Hanna T, Pufal H, Yan L, Bond D, Hunt J, Stanley C, Ghaneh P, Neoptolemos J, Greenhalf W. Identification of a Molecular Signature for CTCs in Whole Blood after Resection of Primary Tumour European Surgical Reseach, 55 :27-27

Conference Publication (journal proceedings)

Bryan N, Smith C, Bond D, Stanley C, Hunt JA. 2015. Development and Evaluation of a Bead Based Cell Capture System with a Potential Role in Circulating Tumour Cell Detection European Surgical Research, 55 :106-106

Bryan N, Smith C, Bond D, Stanley C, Hunt J. 2015. Optimisation of a Negative Depletion Approach for a CTC Detection which does not rely on the Persistence of an Epithelial Phenotype European Surgical Research, European Society for Surgical Research :5-5

Bryan N, Ashwin H, Bayon Y, Smart N, Hunt JA. 2011. Validating in vitro chemiluminescence as a quantifiable predictor of in vivo acute inflammatory reaction IMMUNOLOGY, Annual Congress of the British-Society-for-Immunology 135 :106-106 >Link

Bryan N, Bayon Y, Hunt J. 2010. Quantification of leukocyte activation in response to biomaterial textiles that have applications in abdominal wall repair IMMUNOLOGY, Annual Congress of the British-Society-for-Immunology 131 :186-187 >Link

Bryan N, Bayon Y, Hunt J. 2010. Evaluation of the host response to abdominal wall repair textiles implanted subcutaneously in the rat model IMMUNOLOGY, Annual Congress of the British-Society-for-Immunology 131 :187-187 >Link

Bryan N, Andrews KD, Loughran MJ, Rhodes NP, Hunt JA. 2008. Variations in essential ion concentration across batches of foetal calf serum may influence the expression of key adhesion and regulatory molecules of human umbilical vein endothelial cells TISSUE ENGINEERING PART A, Annual Tissue-Engineering-and-Regenerative-Medicine-International-Society-European-Chapter Meeting 14 :926-926 >Link

Bryan N, Rhodes NP, Curran J, Chen R, Hunt JA. 2008. Modification of surface chemistry in conjunction with defined media to replace recombinant growth factors during in vitro expansion of mesenchymal stem cells TISSUE ENGINEERING PART A, Annual Tissue-Engineering-and-Regenerative-Medicine-International-Society-European-Chapter Meeting 14 :881-881 >Link

Bryan N, Rhodes NP, Hunt JA. 2008. Development of a patient-specific autologous hydrogel suitable for cellular delivery across a spectrum of tissue engineering applications TISSUE ENGINEERING PART A, Annual Tissue-Engineering-and-Regenerative-Medicine-International-Society-European-Chapter Meeting 14 :720-720 >Link

Bryan N, Rhodes NP, Hunt JA. 2008. Derivation of chemically defined, serum-free culture parameters for the expansion and phenotypic maintenance of clinically important lineage committed and pluripotent cell types TISSUE ENGINEERING PART A, Annual Tissue-Engineering-and-Regenerative-Medicine-International-Society-European-Chapter Meeting 14 :796-797 >Link

Bryan N, Hunt JA, Rhodes NP. 2007. Identification of minimal in vitro culture parameters necessary for the proliferation and phenotype maintenance of human mesenchymal stem cells TISSUE ENGINEERING, Conference of the Tissue-Engineering-and-Regenerative-Medicine-International-Society (TERMIS-EU) 13 :1709-1709 >Link

Engagement & Impact

Research Grants Awarded:

Clatterbridge Cancer Centre Charitable Trust, Development of new rapid detection methods for circulating tumour cells, Dr Alex Mason, Dr Nick Bryan and Dr Olga Korostynska, Grant value (£): 15000, Duration of research project: 6 months