Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Simon Brandt

Dr Simon Brandt

Telephone: 0151 231 2184

ORCID

Biography

Simon D. Brandt is a Reader in Bioactive Drug Chemistry. His research activities and interests focus on the chemistry, analytical and pharmacological properties of psychoactive substances, "legal highs", drugs of abuse and so-called designer drugs, within the context of (psycho)pharmacology, medicinal chemistry, psychiatry, forensic science and public health.

He obtained a Diploma in Biochemistry/Molecular Biology (1999) with further specialisation in cell structures and pharmacology/toxicology at the University of Hamburg (Germany). He holds a PhD in Analytical Chemistry (2004) from The University of Manchester (formerly UMIST) (United Kingdom). He serves as an Associate Editor of the Wiley journal “Drug Testing and Analysis”. Since 2011, and in collaboration with LJMU’s Public Health Institute, Simon functions as a coordinator of the UK Early-Warning System on New Psychoactive Substances run by Public Health England.

Simon serves as a scientific advisor in questions related to risk assessment and scheduling recommendations associated with new psychoactive substances. He is an extended Member of the Scientific Committee of the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) and serves as an expert technical advisor to the World Health Organisation’s (WHO) Expert Committee on Drug Dependence (ECDD). In June 2016, Simon was awarded the LJMU Impact Award 2016 for his contributions made to the fields of international drugs legislation and policy making.

A book entitled "New Psychoactive Substances: Pharmacology, Clinical, Forensic and Analytical Toxicology" (edited by Hans H. Maurer and Simon D. Brandt) has been published as part of the "Handbook of Experimental Pharmacology" (volume 252) book series produced by Springer.

Publications

Journal article

Richter LHJ, Menges J, Wagmann L, Brandt SD, Stratford A, Westphal F, Flockerzi V, Meyer MR. 2019. In vitro toxicokinetics and analytical toxicology of three novel NBOMe derivatives - Phase I and II metabolism, plasma protein binding, and detectability in standard urine screening approaches studied by means of hyphenated mass spectrometry Forensic Toxicology, DOI Publisher Url Public Url

Wagmann L, Hempel N, Richter LHJ, Brandt SD, Stratford A, Meyer MR. 2019. Phenethylamine-derived new psychoactive substances 2C-E-FLY, 2C-EF-FLY, and 2C-T-7-FLY: Investigations on their metabolic fate including isoenzyme activities and their toxicological detectability in urine screenings Drug Testing and Analysis, DOI Author Url Public Url

Wallach J, Colestock T, Agramunt J, Claydon MDB, Dybek M, Filemban N, Chatha M, Halberstadt AL, Brandt SD, Lodge D, Bortolotto ZA, Adejare A. 2019. Pharmacological characterizations of the legal high fluorolintane and isomers European Journal of Pharmacology, DOI Author Url Publisher Url Public Url

Grumann C, Henkel K, Stratford A, Hermanns-Clausen M, Passie T, Brandt SD, Auwärter V. 2019. Validation of an LC-MS/MS method for the quantitative analysis of 1P-LSD and its tentative metabolite LSD in fortified urine and serum samples including stability tests for 1P-LSD under different storage conditions Journal of Pharmaceutical and Biomedical Analysis, DOI Author Url Publisher Url Public Url

Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Dowling G, Wallach J, Halberstadt AL. 2019. Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD) Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Dybek M, Wallach J, Kavanagh PV, Colestock T, Filbman N, Dowling G, Westphal F, Elliott SP, Adejare A, Brandt SD. 2019. Syntheses and analytical characterizations of the research chemical 1-[1-(2-fluorophenyl)-2-phenylethyl]pyrrolidine (fluorolintane) and five of its isomers Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Halberstadt AL, Brandt SD, Walther D, Baumann MH. 2019. 2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and α2-adrenergic receptors Psychopharmacology, DOI Author Url Public Url

Wagmann L, Richter LHJ, Kehl T, Wack F, Pettersson Bergstrand M, Brandt SD, Stratford A, Maurer HH, Meyer MR. 2019. In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures Analytical and Bioanalytical Chemistry, DOI Author Url Publisher Url Public Url

Halberstadt AL, Chatha M, Stratford A, Grill M, Brandt SD. 2018. Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran (“FLY”) and benzodifuran (“DragonFLY”) analogs Neuropharmacology, DOI Author Url Publisher Url Public Url

Halberstadt AL, Klein LM, Chatha M, Valenzuela LB, Stratford A, Wallach J, Nichols DE, Brandt SD. 2018. Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA) Psychopharmacology, DOI Publisher Url Public Url

Maier J, Mayer FP, Brandt SD, Sitte HH. 2018. DARK Classics in Chemical Neuroscience: Aminorex Analogues ACS Chemical Neuroscience, 9 :2484-2502 DOI Author Url Public Url

Wagmann L, Brandt SD, Stratford A, Maurer HH, Meyer MR. 2018. Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases Drug Testing and Analysis, 11 :318-324 DOI Author Url Publisher Url Public Url

Maier J, Mayer FP, Luethi D, Holy M, Jäntsch K, Reither H, Hirtler L, Hoener MC, Liechti ME, Pifl C, Brandt SD, Sitte HH. 2018. The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters Neuropharmacology, 138 :282-291 DOI Author Url Publisher Url Public Url

Hutter M, Broecker S, Kneisel S, Franz F, Brandt SD, Auwärter V. 2018. Metabolism of synthetic cannabinoid receptor agonists encountered in clinical casework: major in vivo phase I metabolites of JWH-007, JWH-019, JWH-203, JWH-307, UR-144, XLR-11, AM-2201, MAM-2201 and AM-694 in human urine using LC-MS/MS Current Pharmaceutical Biotechnology, DOI Author Url Publisher Url Public Url

McLaughlin G, Baumann MH, Kavanagh PV, Morris N, Power JD, Dowling G, Twamley B, O’Brien J, Hessman G, Westphal F, Walther D, Brandt SD. 2018. Synthesis, analytical characterization and monoamine transporter activity of the new psychoactive substance 4-methylphenmetrazine (4-MPM), with differentiation from its ortho- and meta- positional isomers. Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Dowling G, Kavanagh PV, Eckhardt HG, Twamley B, Hessman G, McLaughlin G, O’ Brien J, Brandt SD. 2018. An approach to shortening the timeframe between the emergence of new compounds on the drugs market and the availability of reference standards: the microscale syntheses of nitrazolam and clonazolam, for use as reference materials, utilizing polymer supported reagents Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Klein LM, Cozzi NV, Daley PF, Brandt SD, Halberstadt AL. 2018. Receptor binding profiles and behavioral pharmacology of ring-substituted N,N-diallyltryptamine analogs Neuropharmacology, DOI Author Url Publisher Url Public Url

Mayer FP, Burchardt NV, Decker AM, Partilla JS, Li Y, McLaughlin G, Kavanagh PV, Sandtner W, Baumann MH, Blough BE, Brandt SD, Sitte HH. 2017. Fluorinated phenmetrazine “legal highs” act as substrates for high-affinity monoamine transporters of the SLC6 family Neuropharmacology, DOI Author Url Publisher Url Public Url

Luethi D, Kaeser PJ, Brandt SD, Krähenbühl S, Hoener MC, Liechti ME. 2017. Pharmacological profile of methylphenidate-based designer drugs Neuropharmacology, DOI Author Url Publisher Url Public Url

Michely JA, Manier SK, Caspar AT, Brandt SD, Wallach J, Maurer HH. 2017. New psychoactive substances 3-methoxyphencyclidine (3-MeO-PCP) and 3-methoxyrolicyclidine (3-MeO-PCPy): metabolic fate elucidated with rat urine and human liver preparations and their detectability in urine by GC-MS, LC-(high resolution)-MSn, and LC-high resolution-MS/MS Current Neuropharmacology, 15 :692-712 DOI Author Url Public Url

Huestis MA, Brandt SD, Rana S, Auwärter V, Baumann MH. 2017. Impact of novel psychoactive substances on clinical and forensic toxicology and global public health Clinical Chemistry, DOI Author Url Publisher Url Public Url

Brandt SD, Kavanagh PV, Twamley B, Westphal F, Elliott SP, Wallach J, Stratford A, Klein LM, McCorvy JD, Nichols DE, Halberstadt AL. 2017. Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775) Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Colestock C, Wallach J, Mansi M, Filemban N, Morris H, Elliott SP, Westphal F, Brandt SD, Adejare A. 2017. Syntheses, analytical and pharmacological characterizations of the “legal high” 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo) and analogues Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Brunt TM, Atkinson AM, Nefau T, Martinez M, Lahaie E, Malzcewski A, Pazitny M, Belackova V, Brandt SD. 2017. Online test purchased new psychoactive substances in 5 different European countries; a snapshot study of chemical composition and price International Journal of Drug Policy, 44 :105-114 DOI Author Url Publisher Url Public Url

Wallach J, Morris H, Brandt SD. 2017. Is nitrogen mustard contamination responsible for the reported MT-45 toxicity? British Journal of Dermatology, DOI Author Url Publisher Url Public Url

Texter KB, Waymach R, Kavanagh PV, O’Brien JE, Talbot B, Brandt SD, Gardner EA. 2017. Identification of pyrolysis products of the new psychoactive substance 2-amino-1-(4-bromo-2,5- dimethoxyphenyl)ethan-1-one (bk-2C-B) and its iodo analog bk-2C-I Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Stratford A, Nichols DE, Halberstadt AL. 2017. Return of the lysergamides. Part III: Analytical characterization of N6-ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD) Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Caspar AT, Gaab JB, Michely JA, Brandt SD, Meyer MR, Maurer HH. 2017. Metabolism of the tryptamine-derived new psychoactive substances 5-MeO-2-Me-DALT, 5-MeO-2-Me-ALCHT, and 5- MeO-2-Me-DIPT and their detectability in urine studied by GC-MS, LC-MSn, and LC-HR-MS/MS Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Power JD, Kavanagh P, McLaughlin G, Barry M, Dowling D, Brandt SD. 2017. ‘APAAN in the neck’ - A reflection on some novel impurities found in seized materials containing amphetamine in Ireland during routine forensic analysis. Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Wagmann L, Brandt SD, Kavanagh PV, Maurer HH, Meyer MR. 2017. In vitro monoamine oxidase inhibition potential of alpha- methyltryptamine analog new psychoactive substances for assessing possible toxic risks Toxicology Letters, DOI Author Url Publisher Url Public Url

Caspar AT, Brandt SD, Stoever AE, Meyer MR, Maurer HH. 2017. Metabolic fate and detectability of the new psychoactive substances 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethan-amine (25B-NBOMe) and 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25C-NBOMe) in human and rat urine by GC-MS, LC-MSn, and LC-HR-MS/MS approaches. Journal of Pharmaceutical and Biomedical Analysis, 134 :158-169 DOI Author Url Publisher Url Public Url

Shekar A, Aguilar JI, Galli G, Cozzi NV, Brandt SD, Ruoho AE, Baumann MH, Matthies HJG, Galli A. 2017. Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporter Journal of Chemical Neuroanatomy, DOI Author Url Publisher Url Public Url

McLaughlin G, Morris N, Kavanagh PV, Power JD, Dowling G, Twamley B, O’Brien J, Hessman G, Murphy B, Walther D, Partilla JS, Baumann MH, Brandt SD. 2017. Analytical characterization and pharmacological evaluation of the new psychoactive substance 4-fluoromethylphenidate (4F-MPH) and differentiation between the (±)-threo- and (±)-erythro- diastereomers Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Klare H, Neudörfl JM, Brandt SD, Mischler E, Meier-Giebing S, Deluweit K, Westphal F, Laussmann T. 2017. Analysis of six “neuro-enhancing” phenidate analogs Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Michely JA, Brandt SD, Meyer MR, Maurer HH. 2016. Biotransformation and detectability of the new psychoactive substances N,N-diallyltryptamine (DALT) derivatives 5-fluoro-DALT, 7-methyl-DALT, and 5,6-methylenedioxy-DALT in urine using GC-MS, LC-MSn, and LC-HR-MS/MS Analytical and Bioanalytical Chemistry, DOI Author Url Public Url

Dowling G, Kavanagh PV, Talbot B, O’Brien J, Hessman G, McLaughlin G, Twamley B, Brandt SD. 2016. Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog. Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, Lodge D, Halberstadt AL, Brandt SD, Adejare A. 2016. Pharmacological investigations of the dissociative ‘Legal Highs’ diphenidine, methoxphenidine and analogues PLoS One, 11 :e0157021-e0157021 DOI Publisher Url Public Url

Elliott SP, Brandt SD, Smith C. 2016. The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis Drug Testing and Analysis, DOI Publisher Url Public Url

Cohen PA, Venhuis BJ, Brandt SD. 2016. Advancing supplement science: challenges and solutions Drug Testing and Analysis, 8 :e1-e3 DOI Author Url Publisher Url

Cohen PA, Venhuis BJ, Brandt SD. 2016. Advancing supplement science: challenges and solutions Drug testing and analysis, 8

Franz F, Angerer V, Brandt SD, McLaughlin G, Kavanagh PV, Moosmann B, Auwärter V. 2016. In vitro metabolism of the synthetic cannabinoid 3,5-AB-CHMFUPPYCA and its 5,3-regioisomer and investigation of their thermal stability Drug Testing and Analysis, 9 :311-316 DOI Author Url Publisher Url Public Url

McLaughlin G, Morris N, Kavanagh PV, Dowling G, Power JD, Twamley B, O'Brien J, Talbot B, Sitte HH, Brandt SD. 2016. Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Dinger J, Woods C, Brandt SD, Meyer MR, Maurer HH. 2016. Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class Toxicology Letters, 241 :82-94 DOI Author Url Publisher Url Public Url

Power JD, Kavanagh P, McLaughlin G, Dowling G, Barry M, O'Brien J, Talbot B, Twamley B, Brandt SD. 2016. Forensic analysis of P2P derived amphetamine synthesis impurities: identification and characterization of indene by-products Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Wallach J, Colestock T, Cicali B, Elliott SP, Kavanagh PV, Adejare A, Dempster NM, Brandt SD. 2015. Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

McLaughlin G, Morris N, Kavanagh PV, Power JD, Twamley B, O'Brien J, Talbot B, Dowling G, Brandt SD. 2015. The synthesis and characterization of the ‘research chemical’ N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer Drug Testing and Analysis, DOI Author Url Publisher Url Public Url

Marusich JA, Antonazzo KR, Blough BE, Brandt SD, Kavanagh PV, Partilla JS, Baumann MH. 2015. The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue Neuropharmacology, DOI Author Url Publisher Url Public Url

Nichols DE, Sassano MF, Halberstadt AL, Klein LM, Brandt SD, Elliott SP, Fiedler WJ. 2015. N -Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT<inf>2</inf> Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues ACS Chemical Neuroscience, 6 :1165-1175 DOI Author Url Publisher Url Public Url

Elliott SP, Brandt SD, Wallach J, Morris H, Kavanagh PV. 2015. First Reported Fatalities Associated with the 'Research Chemical' 2-Methoxydiphenidine Journal of Analytical Toxicology, 39 :287-293 DOI Author Url Publisher Url Public Url

Wallach J, Kavanagh PV, Mclaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM, Brandt SD. 2015. Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers Drug Testing and Analysis, 7 :358-367 DOI Public Url

Brandt SD, Elliott SP, Kavanagh PV, Dempster NM, Meyer MR, Maurer HH, Nichols DE. 2015. Analytical characterization of bioactive N-benzyl-substituted phenethylamines and 5-methoxytryptamines Rapid Communications in Mass Spectrometry, 29 :573-584 DOI Author Url Publisher Url Public Url

Cosbey S, Kirk S, McNaul M, Peters L, Prentice B, Quinn A, Elliott SP, Brandt SD, Archer RP. 2014. Multiple Fatalities Involving a New Designer Drug: Para-Methyl-4-Methylaminorex Journal of Analytical Toxicology, 38 :383-384 DOI Author Url Publisher Url

Evans-Brown M, Kimergård A, McVeigh J, Chandler M, Brandt SD. 2014. Is the breast cancer drug tamoxifen being sold as a bodybuilding dietary supplement? British Medical Journal, 348 :g1476 DOI Author Url Publisher Url

Gaujac A, Ford JL, Dempster NM, de Andrade JB, Brandt SD. 2013. Investigations into the polymorphic properties of N,N-dimethyltryptamine by X-ray diffraction and differential scanning calorimetry Microchemical Journal, 110 :146-157 DOI Author Url

Kanu AB, Brandt SD, Williams MD, Zhang N, Hill HH. 2013. Analysis of psychoactive cathinones and tryptamines by electrospray ionization atmospheric pressure ion mobility time-of-flight mass spectrometry Analytical Chemistry, 85 :8535-8542 DOI Publisher Url

De Paoli G, Brandt SD, Wallach J, Archer RP, Pounder DJ. 2013. From the Street to the Laboratory: Analytical Profiles of Methoxetamine, 3-Methoxyeticyclidine and 3-Methoxyphencyclidine and their Determination in Three Biological Matrices Journal of Analytical Toxicology, 37 :277-283 DOI Author Url

Elliott SP, Brandt SD, Freeman S, Archer RP. 2013. AMT (3-(2-aminopropyl)indole) and 5-IT (5-(2-aminopropyl)indole): An analytical challenge and implications for forensic analysis Drug Testing and Analysis, 5 :196-202 DOI

Cozzi NV, Brandt SD, Daley PF, Partilla JS, Rothman RB, Tulzer A, Sitte HH, Baumann MH. 2013. Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs European Journal of Pharmacology, 699 :180-187 DOI Author Url

Gaujac A, Navickiene S, Collins MI, Brandt SD, de Andrade JB. 2012. Analytical techniques for the determination of tryptamines and β-carbolines in plant matrices and in psychoactive beverages consumed during religious ceremonies and neo-shamanic urban practices. Drug testing and analysis, 4 :636-648

Passie T, Emrich HM, Karst M, Brandt SD, Halpern JH. 2012. Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence. Drug testing and analysis, 4 :649-659

Baumann MH, Ayestas MA, Partilla JS, Sink JR, Shulgin AT, Daley PF, Brandt SD, Rothman RB, Ruoho AE, Cozzi NV. 2012. The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue Neuropsychopharmacology, 37 :1192-1203 DOI

Brandt SD, Passie T. 2012. Research on psychedelic substances. Drug testing and analysis, 4 :539-542

Passie T, Emrich HM, Karst M, Brandt SD, Halpern JH. 2012. Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence. Drug testing and analysis, 4 :649-659

Gaujac A, Navickiene S, Collins MI, Brandt SD, de Andrade JB. 2012. Analytical techniques for the determination of tryptamines and β-carbolines in plant matrices and in psychoactive beverages consumed during religious ceremonies and neo-shamanic urban practices. Drug testing and analysis, 4 :636-648

De Paoli G, Brandt SD, Pounder DJ. 2011. Mephedrone. Banned but still available on the internet. BMJ, 342 :d1629 DOI Author Url

Brandt SD, Sumnall HR, Measham F, Cole J. 2010. Second generation mephedrone The confusing case of NRG-1 BRITISH MEDICAL JOURNAL, 341 DOI Author Url

Brandt SD, Martins CPB. 2010. Analytical methods for psychoactive N,N-dialkylated tryptamines TRAC-TREND ANAL CHEM, 29 :858-869 DOI

Mansell D, Brandt SD, Nasima S, Turvey N, Alder JF, Freeman S, Schwalbe CH. 2009. Conformational Evaluation of Indol-3-yl-N-alkyl-glyoxalylamides and Indol-3-yl-N,N-dialkyl-glyoxalylamides Spectroscopy Letters, 42 :156-166 DOI Author Url

Brandt SD, Tirunarayanapuram SS, Freeman S, Dempster N, Barker SA, Daley PF, Cozzi NV, Martins CPB. 2008. Microwave-accelerated synthesis of psychoactive deuterated N,N-dialkylated-[α,α,β,β-d4]-tryptamines Journal of Labelled Compounds and Radiopharmaceuticals, 51 :423-429 DOI Author Url

Guy M, Freeman S, Alder J, Brandt S. 2008. The Henry reaction: spectroscopic studies of nitrile and hydroxylamine by-products formed during synthesis of psychoactive phenylalkylamines Open Chemistry, 6 DOI Author Url

Sumnall HR, Measham F, Brandt SD, Cole JC. Salvia divinorumuse and phenomenology: results from an online survey Journal of Psychopharmacology, 25 :1496-1507 DOI Author Url

Wainwright M, Brandt SD, Smith A, Styles A, Meegan K, Loughran C. Phenothiazinium photosensitisers VII: Novel substituted asymmetric N-benzylphenothiaziniums as photoantimicrobial agents Journal of Photochemistry and Photobiology B: Biology, 99 :74-77 DOI Author Url

Kanu AB, Hampikian G, Brandt SD, Hill HH. Ribonucleotide and ribonucleoside determination by ambient pressure ion mobility spectrometry Analytica Chimica Acta, 658 :91-97 DOI Author Url

Martins CPB, Freeman S, Alder JF, Passie T, Brandt SD. Profiling psychoactive tryptamine-drug synthesis by focusing on detection using mass spectrometry TrAC Trends in Analytical Chemistry, 29 :285-296 DOI Author Url

Brandt SD, Moore SA, Freeman S, Kanu AB. Characterization of the synthesis of N,N-dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry. Drug Test Anal, 2 :330-338 DOI Author Url

Brandt SD, Sumnall HR, Measham F, Cole J. Analyses of second-generation 'legal highs' in the UK: initial findings. Drug Test Anal, 2 :377-382 DOI Author Url

Brandt SD, Wootton RCR, De Paoli G, Freeman S. The naphyrone story: The Alpha or Beta-naphthyl Isomer? Drug Testing and Analysis, 2 :496-502 DOI Author Url

Martins CPB, Freeman S, Alder JF, Brandt SD. Characterisation of a proposed internet synthesis of N,N-dimethyltryptamine using liquid chromatography/electrospray ionisation tandem mass spectrometry Journal of Chromatography A, 1216 :6119-6123 DOI Author Url

Brandt SD, Martins CPB, Freeman S, Dempster N, Wainwright M, Riby PG, Alder JF. N,N-Dimethyltryptamine and dichloromethane: Rearrangement of quaternary ammonium salt product during GC–EI and CI-MS–MS analysis Journal of Pharmaceutical and Biomedical Analysis, 47 :207-212 DOI Author Url

Brandt SD, Martins CPB, Freeman S, Dempster N, Riby PG, Gartz J, Alder JF. Halogenated solvent interactions with N,N-dimethyltryptamine: Formation of quaternary ammonium salts and their artificially induced rearrangements during analysis Forensic Science International, 178 :162-170 DOI Author Url

Martins CPB, Awan MA, Freeman S, Herraiz T, Alder JF, Brandt SD. Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils Journal of Chromatography A, 1210 :115-120 DOI Author Url

Brandt SD, Mansell D, Freeman S, Fleet IA, Alder JF. Analytical characterisation of the routes by thermolytic decarboxylation from tryptophan to tryptamine using ketone catalysts, resulting in tetrahydro-β-carboline formation Journal of Pharmaceutical and Biomedical Analysis, 41 :872-882 DOI Author Url

Brandt SD, Freeman S, Fleet IA, McGagh P, Alder JF. Analytical chemistry of synthetic routes to psychoactive tryptamines : Part II. Characterisation of the Speeter and Anthony synthetic route to N,N-dialkylated tryptamines using GC-EI-ITMS, ESI-TQ-MS-MS and NMR The Analyst, 130 :330-330 DOI Author Url

Brandt SD, Freeman S, Fleet IA, Alder JF. Analytical chemistry of synthetic routes to psychoactive tryptamines : Part III. Characterisation of the Speeter and Anthony route to N,N-dialkylated tryptamines using CI-IT-MS-MS The Analyst, 130 :1258-1258 DOI Author Url

Brandt SD, Freeman S, Fleet IA, McGagh P, Alder JF. Analytical chemistry of synthetic routes to psychoactive tryptamines : Part I. Characterisation of the Speeter and Anthony synthetic route to 5-methoxy-N,N-diisopropyltryptamine using ESI-MS-MS and ESI-TOF-MS The Analyst, 129 :1047-1047 DOI Author Url

Brandt SD, Freeman S, McGagh P, Abdul-Halim N, Alder JF. An analytical perspective on favoured synthetic routes to the psychoactive tryptamines Journal of Pharmaceutical and Biomedical Analysis, 36 :675-691 DOI Author Url

Baumann MH, Partilla JS, Lehner KR, Thorndike EB, Hoffman AF, Holy M, Rothman RB, Goldberg SR, Lupica CR, Sitte HH, Brandt SD, Tella SR, Cozzi NV, Schindler CW. Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products Neuropsychopharmacology, 38 :552-562 DOI Author Url

Brandt SD, Tearavarich R, Dempster N, Cozzi NV, Daley PF. Synthesis and characterization of 5-methoxy-2-methyl-N,N-dialkylated tryptamines Drug Testing and Analysis, 4 :24-32 DOI Author Url

Brandt SD, Daley PF, Cozzi NV. Analytical characterization of three trifluoromethyl-substituted methcathinone isomers Drug Testing and Analysis, 4 :525-529 DOI Author Url

Gaujac A, Navickiene S, Collins MI, Brandt SD, Andrade JB. Analytical techniques for the determination of tryptamines and β-carbolines in plant matrices and in psychoactive beverages consumed during religious ceremonies and neo-shamanic urban practices Drug Testing and Analysis, 4 :636-648 DOI Author Url

Passie T, Emrich HM, Karst M, Brandt SD, Halpern JH. Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence Drug Testing and Analysis, 4 :649-659 DOI Author Url

Brandt SD, Passie T. Research on psychedelic substances Drug Testing and Analysis, 4 :539-542 DOI Author Url

Brandt SD. Special issue on illicit drugs Drug Testing and Analysis, 3 :525-526 DOI Author Url

Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J. Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones. Drug testing and analysis, 3 :569-575 DOI Author Url

De Paoli G, Brandt SD, Pounder DJ. Analytical characterization and rapid determination of 2-(diphenylmethyl)pyrrolidine in blood and application to an internet product Journal of Chromatography B, 879 :3771-3774 DOI Author Url

Power JD, Kavanagh P, O'Brien J, Barry M, Twamley B, Talbot B, Dowling G, Brandt SD. Test purchase, identification and synthesis of 2‐amino‐1‐(4‐bromo‐2, 5‐dimethoxyphenyl)ethan‐1‐one (bk‐2C‐B) Drug Testing and Analysis, 7 :512-518 DOI Author Url Publisher Url

McLaughlin G, Morris N, Kavanagh PV, Power JD, Twamley B, O'Brien J, Talbot B, Dowling G, Mahony O, Brandt SD, Patrick J, Archer RP, Partilla JS, Baumann MH. Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3′,4′-methylenedioxy-4-methylaminorex (MDMAR) Drug Testing and Analysis, 7 :555-564 DOI Author Url Publisher Url

King LA, Ujváry I, Brandt SD. Drug laws and the 'derivative' problem Drug Testing and Analysis, 6 :879-883 DOI Author Url

Herraiz T, Brandt SD. 5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO) Drug Testing and Analysis, 6 :607-613 DOI Author Url Publisher Url

Meyer MR, Caspar A, Brandt SD, Maurer HH. A qualitative/quantitative approach for the detection of 37 tryptamine-derived designer drugs, 5 β-carbolines, ibogaine, and yohimbine in human urine and plasma using standard urine screening and multi-analyte approaches Analytical and Bioanalytical Chemistry, 406 :225-237 DOI Author Url Publisher Url

Nasomjai P, Arpha K, Sodngam S, Brandt SD. Potential antimalarial derivatives from astraodorol Archives of Pharmacal Research, 37 :1538-1545 DOI Author Url Publisher Url

Brandt SD, Baumann MH, Partilla JS, Kavanagh PV, Power JD, Talbot B, Twamley B, Mahony O, O'Brien J, Elliott SP, Archer RP, Patrick J, Singh K, Dempster NM, Cosbey SH. Characterization of a novel and potentially lethal designer drug(±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or ‘Serotoni’) Drug Testing and Analysis, 6 :684-695 DOI Author Url Publisher Url

Brandt SD, King LA, Evans-Brown M. The new drug phenomenon Drug Testing and Analysis, 6 :587-597 DOI Author Url Publisher Url

Gaujac A, Dempster N, Navickiene S, Brandt SD, Andrade JBD. Determination of N,N-dimethyltryptamine in beverages consumed in religious practices by headspace solid-phase microextraction followed by gas chromatography ion trap mass spectrometry Talanta, 106 :394-398 DOI Author Url Publisher Url

Wallach J, Adejare A, Paoli GD, Brandt SD. Preparation and analytical characterization of 1-(1-phenylcyclohexyl)piperidine (PCP) and 1-(1-phenylcyclohexyl)pyrrolidine (PCPy) analogues Drug Testing and Analysis, DOI Author Url Publisher Url

Brandt SD, Kavanagh PV, Dowling G, Talbot B, Westphal F, Meyer MR, Maurer HH, Halberstadt AL. Analytical characterization of N,N-diallyltryptamine (DALT) and 16 ring-substituted derivatives. Drug Test Anal, 9 :115-126 DOI Author Url Publisher Url Public Url

Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Colestock T, Burrow TE, Chapman SJ, Stratford A, Nichols DE, Halberstadt AL. Return of the lysergamides. Part II: Analytical and behavioural characterization of N6 -allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ). Drug Test Anal, 9 :38-50 DOI Author Url Publisher Url Public Url

McLaughlin G, Morris N, Kavanagh PV, Power JD, O'Brien J, Talbot B, Elliott SP, Wallach J, Hoang K, Morris H, Brandt SD. Test purchase, synthesis, and characterization of 2-methoxydiphenidine (MXP) and differentiation from its meta- and para-substituted isomers Drug Testing and Analysis, 8 :98-109 DOI Author Url Publisher Url Public Url

Schindler CW, Thorndike EB, Goldberg SR, Lehner KR, Cozzi NV, Brandt SD, Baumann MH. Reinforcing and neurochemical effects of the "bath salts" constituents 3,4-methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxy-N-methylcathinone (methylone) in male rats. Psychopharmacology, 10 :1981-1990 DOI Author Url Publisher Url Public Url

Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Hoang K, Wallach J, Halberstadt AL. Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD). Drug Test Anal, 8 :891-902 DOI Author Url Publisher Url Public Url

Welter J, Brandt SD, Kavanagh P, Meyer MR, Maurer HH. Metabolic fate, mass spectral fragmentation, detectability, and differentiation in urine of the benzofuran designer drugs 6-APB and 6-MAPB in comparison to their 5-isomers using GC-MS and LC-(HR)-MSn techniques Analytical and Bioanalytical Chemistry, 407 :3457-3470 DOI Author Url Publisher Url Public Url

Power JD, Kavanagh P, McLaughlin G, O'Brien J, Talbot B, Barry M, Twamley B, Dowling G, Brandt SD. Identification and characterization of an imidazolium by-product formed during the synthesis of 4-methylmethcathinone (mephedrone) Drug Testing and Analysis, 7 :894-902 DOI Author Url Publisher Url Public Url

Caspar AT, Helfer AG, Michely JA, Auwärter V, Brandt SD, Meyer MR, Maurer HH. Studies on the metabolism and toxicological detection of the new psychoactive designer drug 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe) in human and rat urine using GC-MS, LC-MSn, and LC-HR-MS/MS Analytical and Bioanalytical Chemistry, 407 :6697-6719 DOI Author Url Publisher Url Public Url

Michely JA, Helfer AG, Brandt SD, Meyer MR, Maurer HH. Metabolism of the new psychoactive substances N,N-diallyltryptamine (DALT) and 5-methoxy-DALT and their detectability in urine by GC–MS, LC–MS n , and LC–HR–MS–MS Analytical and Bioanalytical Chemistry, 407 :7831-7842 DOI Author Url Publisher Url Public Url

Kang H, Park P, Bortolotto ZA, Brandt SD, Colestock T, Wallach J, Collingridge GL, Lodge D. Ephenidine: A new psychoactive agent with ketamine-like NMDA receptor antagonist properties Neuropharmacology, 112 :144-149 DOI Author Url Publisher Url Public Url

McLaughlin G, Morris N, Kavanagh PV, Power JD, Dowling G, Twamley B, O'Brien J, Talbot B, Walther D, Partilla JS, Baumann MH, Brandt SD. Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone. Drug Test Anal, 9 :358-368 DOI Author Url Publisher Url Public Url

Halberstadt AL, Chatha M, Chapman SJ, Brandt SD. Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice Journal of Psychopharmacology, 33 :406-414 DOI Author Url Public Url

Other

Halberstadt AL, Klein LM, Chatha M, Valenzuela LB, Stratford A, Wallach J, Nichols DE, Brandt SD. 2019. Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA) (vol 236, pg 799, 2019) PSYCHOPHARMACOLOGY, 236 :809-809 DOI Author Url

Chapters

Passie T, Brandt SD. 2018. Self-experiments with psychoactive substances: a historical perspective Maurer HH, Brandt SD. New Psychoactive Substances. Pharmacology, Clinical, Forensic & Analytical Toxicology. Springer International Publishing AG. Cham, Switzerland DOI Author Url

Wallach J, Brandt SD. 2018. Phencyclidine-based new psychoactive substances Maurer HH, Brandt SD. New Psychoactive Substances. Pharmacology, Clinical, Forensic & Analytical Toxicology Springer International Publishing AG. Cham, Switzerland DOI Author Url

Wallach J, Brandt SD. 2018. 1,2-Diarylethylamine- and ketamine-based new psychoactive substances Maurer HH, Brandt SD. New Psychoactive Substances. Pharmacology, Clinical, Forensic & Analytical Toxicology Springer International Publishing AG. Cham, Switzerland DOI Author Url

Brandt SD, Braithwaite RA, Evans-Brown M, Kicman AT. 2013. Aminoindane Analogues Dargan PI, Wood DM. Novel Psychoactive Substances. Classification, Pharmacology and Toxicology :261-283 Academic Press 978-0124158160 DOI Publisher Url

Brandt SD. 2011. CNS stimulants and CNS-active drugs affecting the serotonergic system Watson DG. Pharmaceutical Chemistry :347-387 9780443072321

Editorial/letter to the editor

Brandt SD, Kavanagh PV. 2017. Addressing the challenges in forensic drug chemistry Drug Testing and Analysis, DOI Author Url Publisher Url