Liverpool Skylilne

Sport and Exercise Sciences

Prof Claire Stewart

Prof Claire Stewart

Telephone: 0151 904 6234

Publications

Highlighted publications

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP. 2018. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy Scientific Reports, 8 >DOI

Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F. 2017. The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks Cell Reports, 21 :1507-1520 >DOI

Brown AD, Close GL, Sharples AP, Stewart CE. 2017. Murine myoblast migration: influence of replicative ageing and nutrition Biogerontology, >DOI >Link

Saini A, Sharples AP, Al-Shanti N, Stewart CE. 2016. Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation BIOGERONTOLOGY, 18(1) :109-129 >DOI >Link

Girven M, Dugdale HF, Owens D, Hughes DC, Stewart CE, Sharples AP. 2016. L-glutamine improves skeletal muscle cell differentiation and prevents myotube atrophy after cytokine (TNF-α) stress via reduced p38 MAPK signal transduction Journal of Cellular Physiology, 12 :2720-2732 >DOI >Link

Sharples AP, Polydorou J, Hughes DC, Owens DJ, Hughes TM, Stewart CE. 2015. Skeletal muscle cells possess a memory of acute early life TNF-α exposure: Role of epigenetic adaptation Biogerontology, 17(3) :603-617 >DOI >Link

Owens D, Sharples AP, Polydorou I, Alwan N, Donovan TD, Tang J, Fraser WD, Cooper RG, Morton J, Stewart CE, Close GL. 2015. A Systems Based Investigation into Vitamin D and Skeletal Muscle Repair, Regeneration and Hypertrophy American Journal of Physiology Endocrinology and Metabolism, Epub Ahead of Print >DOI >Link

Saini A, Al-Shanti N, Sharples AP, Stewart CE. 2012. Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Exp Physiol, 97 :400-418 >DOI >Link

Al-Shanti N, Stewart CE. 2012. Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3. J Cell Biochem, 113 :923-933 >DOI >Link

Sharples AP, Al-Shanti N, Stewart CE. 2010. C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing? J Cell Physiol, 225 :240-250 >DOI >Link

Saini A, Al-Shanti N, Faulkner SH, Stewart CE. 2008. Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism. Growth Factors, 26 :239-253 >DOI >Link

Fisher A, Seaborne RA, Hughes TM, Gutteridge A, Stewart CE, Coulson JM, Sharples AP, Jarvis JC. Transcriptomic and Epigenetic Regulation of Disuse Atrophy and the Return to Activity in Skeletal Muscle FASEB Journal, Epub Ahead of Print >DOI >Link

Journal article

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP. 2018. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy Scientific Reports, 8 >DOI

Baumert P, G-REX Consortium , Lake M, Drust B, Stewart C, Erskine RM. 2017. TRIM63 (MuRF-1) Gene Polymorphism is Associated with Biomarkers of Exercise-Induced Muscle Damage Physiological Genomics, >DOI

Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F. 2017. The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks Cell Reports, 21 :1507-1520 >DOI

Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples AP. 2017. The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction Molecular and Cellular Biochemistry, >DOI >Link

Brown AD, Close GL, Sharples AP, Stewart CE. 2017. Murine myoblast migration: influence of replicative ageing and nutrition Biogerontology, >DOI >Link

Saini A, Sharples AP, Al-Shanti N, Stewart CE. 2016. Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation BIOGERONTOLOGY, 18(1) :109-129 >DOI >Link

Baumert P, Lake MJ, Stewart CE, Drust B, Erskine RM. 2016. Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing European Journal of Applied Physiology, :1-31 >DOI

Saini J, McPhee JS, Al-Dabbagh S, Stewart CE, Al-Shanti N. 2016. Regenerative function of immune system: Modulation of muscle stem cells Ageing Research Reviews, 27 :67-76 >DOI

Girven M, Dugdale HF, Owens D, Hughes DC, Stewart CE, Sharples AP. 2016. L-glutamine improves skeletal muscle cell differentiation and prevents myotube atrophy after cytokine (TNF-α) stress via reduced p38 MAPK signal transduction Journal of Cellular Physiology, 12 :2720-2732 >DOI >Link

Sharples AP, Stewart CE, Seaborne RA. 2016. Does skeletal muscle have an ‘epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise Aging Cell, 4 :603-616 >DOI >Link

Impey S, Hammond K, Shepherd S, Sharples AP, Stewart CE, Limb M, Smith K, Philp A, Jeromson S, Hamilton DL, Close GL, Morton JP. 2016. Fuel for the work required: a practical approach to amalgamating train-low paradigms for endurance athletes Physiological Reports, 4 :e12803-e12803 >DOI >Link

Okoro T, Stewart C, Al-Shanti N, Lemmey A, Maddison P, Andrew JG. 2015. Objective function, lean mass, and associated genetic adaptations of the operated leg following total hip arthroplasty Journal of Musculoskeletal Research, 18 >DOI

Davis NL, Stewart CE, Moss AD, Woltersdorf WWW, Hunt LP, Elson RA, Cornish JM, Stevens MCG, Crowne EC. 2015. Growth hormone deficiency after childhood bone marrow transplantation with total body irradiation: interaction with adiposity and age CLINICAL ENDOCRINOLOGY, 83 :508-517 >DOI >Link

Hughes DH, Stewart CE, Sculthorpe N, Dugdale HF, Yousefian F, Lewis MP, Sharples AP. 2015. Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors Biogerontology, 17(3) :619-639 >DOI >Link

Sharples AP, Polydorou J, Hughes DC, Owens DJ, Hughes TM, Stewart CE. 2015. Skeletal muscle cells possess a memory of acute early life TNF-α exposure: Role of epigenetic adaptation Biogerontology, 17(3) :603-617 >DOI >Link

Owens D, Sharples AP, Polydorou I, Alwan N, Donovan TD, Tang J, Fraser WD, Cooper RG, Morton J, Stewart CE, Close GL. 2015. A Systems Based Investigation into Vitamin D and Skeletal Muscle Repair, Regeneration and Hypertrophy American Journal of Physiology Endocrinology and Metabolism, Epub Ahead of Print >DOI >Link

Sharples AP, Hughes DC, Deane CD, Saini A, Selman C, Stewart CE. 2015. Longevity and Skeletal Muscle Mass: The role of IGF signalling, the Sirtuins, dietary restriction and protein intake. Aging Cell, 14 :511-523 >DOI >Link

Sharples AP, Stewart CE. 2015. Comments on the CrossTalk proposal and opposing view: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis/proteolysis Journal of Physiology, >DOI >Link

Patel HP, Al-Shanti N, Davies LC, Barton SJ, Grounds MD, Tellam RL, Stewart CE, Cooper C, Sayer AA. 2014. Lean Mass, Muscle Strength and Gene Expression in Community Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS) CALCIFIED TISSUE INTERNATIONAL, 95 :308-316 >DOI >Link

Grosset JF, Breen L, Stewart CEH, Burgess KE, Onambele GL. 2014. Influence of exercise intensity on training-induced tendon mechanical properties changes in older individuals. Age, 36 :1433-1442 >DOI

Al-Shanti N, Durcan P, Al-Dabbagh S, Dimchev GA, Stewart CE. 2014. Activated Lymphocytes Secretome Inhibits Differentiation and Induces Proliferation of C2C12 Myoblasts CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 33 :117-128 >DOI >Link

Erskine RM, Williams AG, Jones DA, Stewart CE, Degens H. 2014. The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training. Scand J Med Sci Sports, 24 :642-648 >DOI >Link

Deane CD, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP. 2013. Impaired hypertrophy in myoblasts is improved with testosterone administration The Journal of Steroid Biochemistry and Molecular Biology, 138 :152-161 >DOI >Link

Stewart CEH, Durcan PJ , Al-Shanti N. 2013. Identification and characterization of novel Kirrel isoform during myogenesis. Physiological Reports, 1 >DOI

Deane CS, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP. 2013. Impaired hypertrophy in myoblasts is improved with testosterone administration Journal of Steroid Biochemistry and Molecular Biology, 138 :152-161 >DOI

Dimchev GA, Al-Shanti N, Stewart CE. 2013. Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways Journal of Muscle Research and Cell Motility, 34 :125-136 >DOI

Barberi L, Scicchitano BM, De Rossi M, Bigot A, Duguez S, Wielgosik A, Stewart C, McPhee J, Conte M, Narici M, Franceschi C, Mouly V, Butler-Browne G, Musaro A. 2013. Age-dependent alteration in muscle regeneration: the critical role of tissue niche BIOGERONTOLOGY, 14 :273-292 >DOI >Link

Stewart CE. 2013. Immobility and diminished skeletal muscle recovery with age: The sedentary myoblast Journal of Physiology, 591 :3671-3672 >DOI

Sharples AP, Al-Shanti N, Hughes DC, Lewis MP, Stewart CE. 2013. The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy Growth Hormone and IGF Research, 23 :53-61 >DOI >Link

Patel HP, Jameson KA, Syddall HE, Martin HJ, Stewart CE, Cooper C, Sayer AA. 2012. Developmental influences, muscle morphology, and sarcopenia in community-dwelling older men The journals of gerontology. Series A, Biological sciences and medical sciences, 67 :82-87 >DOI >Link

Erskine RM, Williams AG, Jones DA, Stewart CE, Degens H. 2012. Do PTK2 gene polymorphisms contribute to the interindividual variability in muscle strength and the response to resistance training? A preliminary report Journal of applied physiology, 112 :1329-1334 >DOI >Link

Saini A, Al-Shanti N, Sharples AP, Stewart CE. 2012. Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Exp Physiol, 97 :400-418 >DOI >Link

Al-Shanti N, Stewart CE. 2012. Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3. J Cell Biochem, 113 :923-933 >DOI >Link

Sharples AP, Player DJ, Martin NRW, Mudera V, Stewart CE, Lewis MP. 2012. Modelling in vivo skeletal muscle ageing in vitro using three-dimensional bioengineered constructs. Aging Cell, 11 :986-995 >DOI >Link

Patel H, Syddall HE, Martin HJ, Cooper C, Stewart C, Sayer AA. 2011. The feasibility and acceptability of muscle biopsy in epidemiological studies: findings from the Hertfordshire Sarcopenia Study (HSS) The journal of nutrition, health & aging, 15 :10-15 >Link

Erskine RM, Jones DA, Maffulli N, Williams AG, Stewart CE, Degens H. 2011. What causes in vivo muscle specific tension to increase following resistance training? Experimental physiology, 96 :145-155 >DOI >Link

Sharples AP, Stewart CE. 2011. Myoblast models of skeletal muscle hypertrophy and atrophy Current Opinion in Clinical Nutrition and Metabolic Care, 14 :230-236 >DOI

Al-Shanti N, Faulkner SH, Saini A, Loram I, Stewart CE. 2011. A semi-automated programme for tracking myoblast migration following mechanical damage: manipulation by chemical inhibitors. Cell Physiol Biochem, 27 :625-636 >DOI >Link

Sharples AP, Al-Shanti N, Lewis MP, Stewart CE. 2011. Reduction of myoblast differentiation following multiple population doublings in mouse C2 C12 cells: a model to investigate ageing? J Cell Biochem, 112 :3773-3785 >DOI >Link

Stewart CE, Pell JM. 2010. Last Word on Point: Counterpoint: IGF is the major physiological regulator of muscle mass JOURNAL OF APPLIED PHYSIOLOGY, 108 :1832-1832 >DOI >Link

Patel HP, Syddall HE, Martin HJ, Cooper C, Stewart C, Sayer AA. 2010. The feasibility and acceptability of muscle biopsy in epidemiological studies: Findings from the hertfordshire sarcopenia study (HSS) Journal of Nutrition, Health and Aging, :1-6 >DOI

Atkinson RA, Srinivas-Shankar U, Roberts SA, Connolly MJ, Adams JE, Oldham JA, Wu FCW, Seynnes OR, Stewart CEH, Maganaris CN, Narici MV. 2010. Effects of testosterone on skeletal muscle architecture in intermediate-frail and frail elderly men Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 65 A :1215-1219 >DOI

Stewart CEH, Pell JM. 2010. Last Word on Point:Counterpoint: IGF is the major physiological regulator of muscle mass. Journal of Applied Physiology, 6 :1832

Stewart CEH, Sayer AA, Patel H, Cooper C. 2010. The developmental origins of sarcopenia: from epidemiological evidence to underlying mechanisms Journal of Developmental Origins of Health and Disease, 1 :150-157

Rittweger J, Moss AD, Colier W, Stewart C, Degens H. 2010. Muscle tissue oxygenation and VEGF in VO-matched vibration and squatting exercise Clinical physiology and functional imaging, 30 :269-278 >DOI >Link

Patel HP, Syddall HE, Martin HJ, Stewart CE, Cooper C, Sayer AA. 2010. Hertfordshire sarcopenia study: design and methods BMC geriatrics, 10 :43 >DOI >Link

Onambele-Pearson GL, Breen L, Stewart CE. 2010. Influences of carbohydrate plus amino acid supplementation on differing exercise intensity adaptations in older persons: skeletal muscle and endocrine responses Age, 32 :125-138 >DOI >Link

Erskine RM, Jones DA, Williams AG, Stewart CE, Degens H. 2010. Resistance training increases in vivo quadriceps femoris muscle specific tension in young men Acta physiologica, 199 :83-89 >DOI >Link

Erskine RM, Jones DA, Williams AG, Stewart CE, Degens H. 2010. Inter-individual variability in the adaptation of human muscle specific tension to progressive resistance training European journal of applied physiology, 110 :1117-1125 >DOI >Link

Atkinson RA, Srinivas-Shankar U, Roberts SA, Connolly MJ, Adams JE, Oldham JA, Wu FCW, Seynnes OR, Stewart CEH, Maganaris CN, Narici MV. 2010. Effects of testosterone on skeletal muscle architecture in intermediate-frail and frail elderly men. J Gerontol A Biol Sci Med Sci, 65 :1215-1219 >DOI >Link

Stewart CE, Pell JM. 2010. Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. Point: IGF is the major physiological regulator of muscle mass. J Appl Physiol (1985), 108 :1820-1821 >DOI >Link

Saini A, Al-Shanti N, Stewart C. 2010. C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d. Cell Physiol Biochem, 25 :253-262 >DOI >Link

Onambélé-Pearson GL, Breen L, Stewart CE. 2010. Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations. Age (Dordr), 32 :139-153 >DOI >Link

Sharples AP, Al-Shanti N, Stewart CE. 2010. C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing? J Cell Physiol, 225 :240-250 >DOI >Link

McPhee JS, Williams AG, Stewart C, Baar K, Schindler JP, Aldred S, Maffulli N, Sargeant AJ, Jones DA. 2009. The training stimulus experienced by the leg muscles during cycling in humans Experimental physiology, 94 :684-694 >DOI >Link

Saini A, Faulkner S, Al-Shanti N, Stewart C. 2009. Powerful signals for weak muscles Ageing Research Reviews, 8 :251-267 >DOI

Al-Shanti N, Saini A, Stewart CE. 2009. Two-step versus one-step RNA-to-CT™ 2-step and one-step RNA-to-CT™ 1-Step: Validity, sensitivity, and efficiency Journal of Biomolecular Techniques, 20 :172-179

Al-Shanti N, Stewart CE. 2009. Ca2+/calmodulin-dependent transcriptional pathways: potential mediators of skeletal muscle growth and development. Biol Rev Camb Philos Soc, 84 :637-652 >DOI >Link

Al-Shanti N, Saini A, Faulkner SH, Stewart CE. 2008. Beneficial synergistic interactions of TNF-alpha and IL-6 in C2 skeletal myoblasts--potential cross-talk with IGF system. Growth Factors, 26 :61-73 >DOI >Link

Al-Shanti N, Stewart CE. 2008. PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059. J Endocrinol, 198 :243-252 >DOI >Link

Saini A, Al-Shanti N, Faulkner SH, Stewart CE. 2008. Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism. Growth Factors, 26 :239-253 >DOI >Link

Saini A, Al-Shanti N, Stewart CEH. 2007. Waste management - Cytokines, growth factors and cachexia (vol 17, pg 475, 2006) CYTOKINE & GROWTH FACTOR REVIEWS, 18 :345-345 >DOI >Link

Stewart CEH, Breen L, Onambélé GL. 2007. Functional benefits of combined resistance training with nutritional interventions in older adults: A review Geriatrics & Gerontology International, 7 :326-340

Wong CK, Lai T, White S, Sheffield E, Wheeler MH, Stewart CE, Farndon JR. 2007. Characterization of the insulin-like growth factor axis and Wilms' tumour suppressor gene in hyperparathyroidism The British journal of surgery, 94 :1232-1241 >DOI >Link

Sabin MA, Stewart CE, Crowne EC, Turner SJ, Hunt LP, Welsh GI, Grohmann MJ, Holly JM, Shield JP. 2007. Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid Journal of cellular physiology, 211 :244-252 >DOI >Link

Sabin MA, Crowne EC, Stewart CE, Hunt LP, Turner SJ, Welsh GI, Grohmann MJ, Holly JM, Shield JP. 2007. Depot-specific effects of fatty acids on lipid accumulation in children's adipocytes Biochemical and biophysical research communications, 361 :356-361 >DOI >Link

Suleiman M-S, Singh RJR, Stewart CEH. 2007. Apoptosis and the cardiac action of insulin-like growth factor I. Pharmacol Ther, 114 :278-294 >DOI >Link

Saini A, Stewart CE. 2006. Adult stem cells: the therapeutic potential of skeletal muscle Current stem cell research & therapy, 1 :157-171 >Link

Sabin MA, Holly JM, Shield JP, Turner SJ, Grohmann MJ, Stewart CE, Crowne EC. 2006. Mature subcutaneous and visceral adipocyte concentrations of adiponectin are highly correlated in prepubertal children and inversely related to body mass index standard deviation score The Journal of clinical endocrinology and metabolism, 91 :332-335 >DOI >Link

Stewart CEH, Rittweger J. 2006. Adaptive processes in skeletal muscle: molecular regulators and genetic influences. J Musculoskelet Neuronal Interact, 6 :73-86 >Link

Saini A, Al-Shanti N, Stewart CEH. 2006. Waste management - cytokines, growth factors and cachexia. Cytokine Growth Factor Rev, 17 :475-486 >DOI >Link

Wong CKM, Lai T, Holly JMP, Wheeler MH, Stewart CEH, Farndon JR. 2006. The effects of retinoic acid on the insulin-like growth factor axis in primary tissue culture from hyperparathyroidism WORLD JOURNAL OF SURGERY, 30 :714-720 >DOI >Link

Wong CKM, Lai T, Holly JMP, Wheeler MH, Stewart CEH, Farndon JR. 2006. Insulin-like growth factors (IGF) I and II utilize different calcium signaling pathways in a primary human parathyroid cell culture model WORLD JOURNAL OF SURGERY, 30 :333-345 >DOI >Link

Grohmann M, Stewart C, Welsh G, Hunt L, Tavare J, Holly J, Shield J, Sabin M, Crowne E. 2005. Site-specific differences of insulin action in adipose tissue derived from normal prepubertal children Experimental cell research, 308 :469-478 >DOI >Link

Grohmann M, Foulstone E, Welsh G, Holly J, Shield J, Crowne E, Stewart C. 2005. Isolation and validation of human prepubertal skeletal muscle cells: Maturation and metabolic effects of IGF-I, IGFBP-3 and TNFα Journal of Physiology, 568 :229-242 >DOI

Grohmann M, Sabin M, Holly J, Shield J, Crowne E, Stewart C. 2005. Characterization of differentiated subcutaneous and visceral adipose tissue from children: the influences of TNF-alpha and IGF-I. J Lipid Res, 46 :93-103 >DOI >Link

Grohmann M, Foulstone E, Welsh G, Holly J, Shield J, Crowne E, Stewart C. 2005. Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF-I, IGFBP-3 and TNFalpha. J Physiol, 568 :229-242 >DOI >Link

Stewart CE, Newcomb PV, Holly JM. 2004. Multifaceted roles of TNF-alpha in myoblast destruction: a multitude of signal transduction pathways Journal of cellular physiology, 198 :237-247 >DOI >Link

Stewart CE. 2004. The physiology of stem cells: potential for the elderly patient Journal of musculoskeletal & neuronal interactions, 4 :179-183 >Link

Foulstone EJ, Huser C, Crown AL, Holly JMP, Stewart CEH. 2004. Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNFalpha. Exp Cell Res, 294 :223-235 >DOI >Link

Foulstone EJ, Savage PB, Crown AL, Holly JMP, Stewart CEH. 2003. Adaptations of the IGF system during malignancy: Human skeletal muscle versus the systemic environment HORMONE AND METABOLIC RESEARCH, 35 :667-674 >Link

Louafi F, Stewart CE, Perks CM, Thomas MG, Holly JM. 2003. Role of the IGF-II receptor in mediating acute, non-genomic effects of retinoids and IGF-II on keratinocyte cell death Experimental dermatology, 12 :426-434 >Link

Foulstone EJ, Savage PB, Crown AL, Holly JMP, Stewart CEH. 2003. Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts. J Cell Physiol, 195 :70-79 >DOI >Link

Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE. 2003. Adaptations of the IGF system during malignancy: human skeletal muscle versus the systemic environment. Horm Metab Res, 35 :667-674 >DOI >Link

Wong C, Lai T, Hilly JM, Stewart CE, Farndon JR. 2002. Selective estrogen receptor modulators inhibit the effects of insulin-like growth factors in hyperparathyroidism Surgery, 132 :998-1006 >DOI >Link

Hollowood AD, Stewart CE, Perks CM, Pell JM, Lai T, Alderson D, Holly JM. 2002. Evidence implicating a mid-region sequence of IGFBP-3 in its specific IGF-independent actions Journal of cellular biochemistry, 86 :583-589 >DOI >Link

Foulstone EJ, Meadows KA, Holly JM, Stewart CE. 2001. Insulin-like growth factors (IGF-I and IGF-II) inhibit C2 skeletal myoblast differentiation and enhance TNF alpha-induced apoptosis. J Cell Physiol, 189 :207-215 >DOI >Link

Meadows KA, Holly JMP, Stewart CEH. 2000. Tumor necrosis factor-α-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts Journal of Cellular Physiology, 183 :330-337 >DOI

Pell JM, Hill RA, Stewart CEH, Weston CR, Flick-Smith HC. 2000. Enhancement of insulin-like growth factor I activity by novel antisera: Potential structure/function interactions ENDOCRINOLOGY, 141 :741-751 >DOI >Link

Meadows KA, Holly JM, Stewart CE. 2000. Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts Journal of cellular physiology, 183 :330-337 >DOI >Link

Maile R, Elsegood KA, Harding TC, Uney JB, Stewart CE, Banting G, Dayan CM. 2000. Effective formation of major histocompatibility complex class II-peptide complexes from endogenous antigen by thyroid epithelial cells Immunology, 99 :367-374 >Link

Lawlor MA, Feng X, Everding DR, Sieger K, Stewart CE, Rotwein P. 2000. Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways Molecular and cellular biology, 20 :3256-3265 >Link

Holly JM, Perks CM, Stewart CE. 2000. Overview of insulin-like growth factor physiology Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 10 Suppl A :S8-S9 >Link

Pell JM, Hill RA, Stewart CE, Weston CR, Flick-Smith HC. 2000. Enhancement of insulin-like growth factor I activity by novel antisera: potential structure/function interactions. Endocrinology, 141 :741-751 >DOI >Link

Crown AL, He XL, Holly JM, Lightman SL, Stewart CE. 2000. Characterisation of the IGF system in a primary adult human skeletal muscle cell model, and comparison of the effects of insulin and IGF-I on protein metabolism. J Endocrinol, 167 :403-415 >Link

Stewart CE, Newcomb PV, Savage PB, Dickens M, Tavare J, Holly JM. 1999. Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 9 :131-142 >DOI >Link

Stewart CE, Mihai R, Holly JM. 1999. Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis Experimental cell research, 250 :329-338 >DOI >Link

Stewart CEH, James PL, Fant ME, Rotwein P. 1996. Overexpression of insulin-like growth factor-II induces accelerated myoblast differentiation Journal of Cellular Physiology, 169 :23-32 >DOI

Stewart CE, Rotwein P. 1996. Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts The Journal of biological chemistry, 271 :11330-11338 >Link

Stewart CE, Rotwein P. 1996. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors Physiological reviews, 76 :1005-1026 >Link

Stewart CE, James PL, Fant ME, Rotwein P. 1996. Overexpression of insulin-like growth factor-II induces accelerated myoblast differentiation Journal of cellular physiology, 169 :23-32 >DOI >Link

James PL, Stewart CE, Rotwein P. 1996. Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism The Journal of cell biology, 133 :683-693 >Link

Lau MM, Stewart CE, Liu Z, Bhatt H, Rotwein P, Stewart CL. 1994. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality Genes & development, 8 :2953-2963 >Link

STEWART CEH, BATES PC, CALDER TA, WOODALL SM, PELL JM. 1993. POTENTIATION OF INSULIN-LIKE GROWTH FACTOR-I (IGF-I) ACTIVITY BY AN ANTIBODY - SUPPORTIVE EVIDENCE FOR ENHANCEMENT OF IGF-I BIOAVAILABILITY IN-VIVO BY IGF BINDING-PROTEINS ENDOCRINOLOGY, 133 :1462-1465 >DOI >Link

Stewart CE, Bates PC, Calder TA, Woodall SM, Pell JM. 1993. Potentiation of insulin-like growth factor-I (IGF-I) activity by an antibody: supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins Endocrinology, 133 :1462-1465 >Link

Baumert P, G-REX Consortium , Stewart C, Lake M, Drust B, Erskine RM. Variations of Collagen-Encoding Genes are Associated with Exercise-Induced Muscle Damage Physiological Genomics, >DOI >Link

Fisher A, Seaborne RA, Hughes TM, Gutteridge A, Stewart CE, Coulson JM, Sharples AP, Jarvis JC. Transcriptomic and Epigenetic Regulation of Disuse Atrophy and the Return to Activity in Skeletal Muscle FASEB Journal, Epub Ahead of Print >DOI >Link

Stewart CE. The lymphocyte secretome from young adults enhances skeletal muscle proliferation and migration, but effects are attenuated in the secretome of older adults Physiological Reports,

Chapters

Sharples AP, Seaborne RA, Stewart CE. 2017. Epigenetics of skeletal muscle aging Moskalev A, Vaiserman AM. Epigenetics of Aging and Longevity :365-365 Elsevier 978-0-12-811060-7 >DOI >Link

Stewart CE, Jones DA. 2012. Myogenesis Mooren FC. Encyclopedia of Exercise Medicine in Health and Disease Springer 9783540360650

Stewart CEH, Narici M, di Prampero PE. 2008. Detraining, Bed Rest and Adaptations to Microgravity Nigel A S Taylor PD, Herbert Groeller PD. Physiological Bases of Human Performance During Work and Exercise Elsevier Publications 9780443102714

Stewart CEH. 2006. Stem cells and stem cell therapies: The future of regenerative medicine? Greer EV. Stem Cell Therapy Nova Biomedical 9781594548482

Other

Baumert P, Lake MJ, Stewart CE, Drust B, Erskine RM. 2016. Inter-individual variability in the response to maximal eccentric exercise EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 116 :2055-2056 >DOI >Link

Conference publication

Dugdale HF, Stewart CE, Sharples AP. 2016. Resveratrol enables myotube survival under nutrient stress. European Muscle Conference

Owens DJ, Polydorou I, Alwan N, Fraser WD, Tang J, Morton J, Sharples AP, Stewart CE, Close GL. 2015. The Role of Vitamin D in Skeletal Muscle Repair: A Systems Biology Approach European College of Sport Science (ECSS)

Sharpies AP, Player DJ, Martin NRW, Passey S, Stewart CE, Lewis MP. 2011. Replicative ageing of myoblast in 3-D tissue engineered collagen constructs European Cells and Materials, 22 :39

Pell JM, Saunders JC, Stewart CEH, Gilmour RS. 1992. Growth hormone (GH) and nutritional control of hepatic insulin-like growth factor-1 (IGF-1) production in the lamb Journal of Physiology, 446

Erskine RM, Jones DA, Williams AG, Stewart CE, Degens H. ACE, ACTN3 and PTK2 genotype associations with human skeletal muscle phenotypes and the responses to resistance training. Proceedings of the 16th Annual Congress of the ECSS, European College of Sport Science

Patent

Stewart CEH, Pell JM. Use of specific binding molecules in potentiating IGF-I activity

Engagement & Impact

Award:

Fellow of the Higher Education Academy, Higher Education Academy

PhD, University of London

Certificate in Immunology, Kings College, London

BSc Hons - Developmental Biology, University of Glasgow

Conference organisation:

Northern Vascular Biology Forum, Committee member, http://blogs.mhs.manchester.ac.uk/cvpostgrad/2014/09/16/northern-vascular-biology-forum-manchester-8th-december-2014/

Northern Vascular Biology Forum, Committee member, http://nvbf.org/

British Society of Research on Ageing: Durham, BSRA local conference co-organiser, https://www.dur.ac.uk/bsi/bsra-durham/

British Society for Research on Ageing, Conference organiser of 65th Annual meeting in London., https://www.regonline.co.uk/builder/site/Default.aspx?EventID=1667185

British Society for Research on ageing Annual Meeting, Co-organiser

Stem Cell Workshop, Co-Organiser

Manchester Stem Cell Meeting, Conference Organiser, http://www.manchesterstemcell.com/

Editorial boards:

Cellular and Molecular Exercise Physiology, Senior Managing Editor, http://www.cellularandmolecularexercisephysiology.com/index.php/CMEP/index

External collaboration:

Stellenbosch University, Professor Katyh Myburgh

Southampton University, Professor Richard Oreffo

Institute of Ageing and Chronic Disease, Liverpool University, Dan J. Cuthbertson

Karolinska Institutet, Dr Amarjit Saini

University of Liverpool, Prof. P Marray

Liverpool University, Prof Francesco Falciani

University of Loughborough, Professor Myra Nimmo

http://www.irm.mmu.ac.uk/staff/staff_details/?staff_id=743, MMU, N. Al-Shanti

http://www.irm.mmu.ac.uk/staff/staff_details/?staff_id=741, MMU, Dr Hans Degens

http://www.bangor.ac.uk/sport/staff-al.php, University of Bangor, Professor Andy Lemmey

http://www.lboro.ac.uk/departments/ssehs/staff/professor-mark-lewis-.html, University of Loughborough, Professor Mark lewis

http://www.babraham.ac.uk/pjl_pages/pell/index.html, Babraham Institute, Dr. Jenny pell

http://www.cheshire.mmu.ac.uk/exspsci/staffprofiles/profile.php?id=74, Manchester Metropolitan University, Dr. Gladys Pearson

http://www.lboro.ac.uk/departments/ssehs/staff/dr-amarjit-saini-.html, University of Loughborough, Dr. A. Saini

http://www.bristol.ac.uk/clinical-sciences/people/saadeh--suleiman/index.html, University of Bristol, Professor M. S. Suleiman

http://www.bristol.ac.uk/fmd/contact/az/personpages/index.html?personKey=Cx6QxvqdjlL1ZXPCI3UFj4knAkEsAc, University of Bristol, Dr. E.C. Crowne

http://www.mrc.soton.ac.uk/index.asp?page=65, University of Southampton, Prof. Avan Aihie Sayer

External committees:

External Examiner for BSc and HND Sport Science awards, University of Bangor, External Examiner

External PGR examinations performed:

University of Nottingham, PhD, Shaker Al-Doski

University of Loughborough, PhD, Mark Turner

University of Birminh=gham, PhD, Zhe Song

University of Nottingham, PhD, David Brown

Fellowships:

Fellow of the Higher Education Academy, Higher Education Academy

Industrial connections:

Unilever, BBSRC iCASE award: 4 year PhD: 'Translating effects of dietary flavonoids on energy metabolism into physical activity benefits

GSK, PhD co-funded research project: NSAIDS and eccentric damaging exercise.

Media Coverage:

http://www.prnewswire.co.uk/news-releases/live-longer-live-well-280561342.html, http://www.bsra.org.uk/, http://www.ljmu.ac.uk/newsupdate/viewarticle/1794/, Attendance at the House of Lords, representing the BSRA to raise funds for research on ageing

http://www.genengnews.com/gen-articles/stem-cell-studies-go-forward-despite-some-opposition/3147/, Genetic and Engineering Biotechnology News (GEN). Coverage of Skeletal mUscle Stem Cell work. 01.01.2010

BBC Radio Manchester Interview regarding the rolle of tooth stem cells in the cure of disease.

http://www.independent.co.uk/life-style/health-and-families/features/milk-teeth-cureall-or-fairy-tale-1776738.html, The Independent Interview regarding stem cells and cures for diseases.

http://www.dailymail.co.uk/health/diets/article-1251333/Will-keeping-childs-baby-teeth-save-life-day.html, Role of adult stem cells in disease treatment. Daily Mail Interview

Membership of professional bodies:

Committee Member, Mercia Stem Cell Alliance

Executive Committee Member, British Society for Research on Ageing

Member, Nutrition Society

Member, Mercia Stem Cell Alliance (MSCA)

Member, BACR

Member, Bichemical Society

Member, British Endocrine Society

Other invited event:

BSc external Examiner, University of Bangor, External examiner for Sport and Exercise Science BSC

Athena Swan Self Assessment Team, MMU, Self Assessment Team member for the Athena Swan Bronze award application by the faculty of Science and Engineering

MSc Validation, University of Bedford, External Assessor for validation of a new MSc, entitled: (MSc) Molecular and Cellular Exercise Physiology

Other Professional Activity:

Faculty of Science Athena Swan committee member

Deputy Chair of the Female Professoriate at LJMU

Chair of the Life Sciences User Group, LJMU

STEMNET ambassador

Research Grants Awarded:

UTS Foundation Matched Funded PhD, The impact of Physical activity and exercise training on physiological and psychosocial outcomes in cancer patients, Ellen Dawson, Zoe Knowles, Claire Stewart, Grant value (£): 32,522, Duration of research project: Three year PhD programme, due to start 1st March 2018

BBSRC iCASE, Translating effects of dietary flavonoids on energy metabolism into physical activity benefits., Claire Stewart, Helen Jones, Dick Thijssen, Grant value (£): 144,000, Duration of research project: 4

South African Research Council, Mobility Award, Kathy Myburgh, Grant value (£): 25,000 Rand, Duration of research project: 0.5

CCG, Physical activity and physiological adaptations in patients with Cystic Fibrosis, Claire Stewart, Zoe Knowles, Grant value (£): 13,549, Duration of research project: 1

GSK/LJMU, NSAIDs and muscle injury, Adam Sharples, Graeme Close, Ken van Smoren, Phillip Bell, Grant value (£): £59,100, Duration of research project: 3

RFU/LJMU, Personalising elite training through the use of individualised in-vitro bioengineered ‘mini-muscles, Claire Stewart, Grant value (£): £73,933, Duration of research project: 3

Aspetar, Cytokines in Academy Players, Grant value (£): £8,740, Duration of research project: 2

British Heart Foundation, IGFs, Apoptosis and Myocardial Protection during Ischaemia and Reperfusion., Suleiman, M.-S. (PI), & Holly, J.M.P., Grant value (£): £104,940, Duration of research project: 2 years

Needham Cooper Trust Fund, Insulin-like Growth Factors in Myocardial Protection., Suleiman, M.-S., Grant value (£): £31,125, Duration of research project: 3 years

Pharmacia and Upjohn, Insulin/IGF Hybrid Receptor Status and Insulin Sensitivity in Human Skeletal Muscle., Crown, A., Holly, J.M.P. & Crowne, E. (PI), Grant value (£): £14,732, Duration of research project: 12 months

Assoc. for International Cancer Research, Are the IGFs Essential for Muscle Cell Differentiation and Survival in Cancer Cachexia?, Crown, A. & Holly, J.M.P., Grant value (£): £105,209, Duration of research project: 3 years

Pharmacia & Upjohn, Insulin/IGF Hybrid Receptor Status & Insulin Sensitivity in Human Skeletal Muscle., Crown, A., Holly, J.M.P. & Crowne, E. (PI), Grant value (£): £14,732, Duration of research project: 12 months

Choc Willson Memorial Fund, Obesity in Childhood: Mechanisms Determining Insulin Resistance and Adipose Tissue Accumulation Roles of Cytokines and the GH/IGF Axis., Crowne, E. (PI), Shield, J.P., Crown, A., Grant value (£): £53,125, Duration of research project: 4 years

Diabetes UK, The role of NEFAs and Adiponectin in the Development of Insulin Resistance and Diabetes in Childhood Obesity., Crowne, E (PI)., Sabin, M.A., Grant value (£): £149,214, Duration of research project: 3 years

MMU - Internal PhD competition, Growth Factor/Cytokine Interactions in Skeletal Muscle Maintenance., Grant value (£): £225,000, Duration of research project: 7 years

NDA, Preparatory network for research into the link between socio-ethno-economic grouping, ageing, nutrition and exercise., Pearson G (née Onambélé), Grant value (£): £25,000, Duration of research project: 12 months

SPARC, Optimisation of skeletal muscle responses and quality of life to exercise in people over 60 years old: Healthy diet vs. dietary supplementation., Pearson, G. (née Onambélé), Grant value (£): £28,245., Duration of research project: 12 months

Erasmus Mundus, MOVE-AGE. Euros 6,500,000., van Dieen, J (co-ordinator), Verschueren, S & Baltzopoulos, V, Grant value (£): Euros 6,500,000., Duration of research project: 7 years

SMS, University of Bangor, Can creatine supplementation improve body composition and physical function in rheumatoid arthritis patients? A randomised controlled pilot trial., O’Brien, T (P.I.), Lemmey, A.B., Maddison, P., Ahmad, Y., Whittaker, R., Grant value (£): £15,000, Duration of research project: 3 years

SMS, University of Bangor, Genetic markers of Inflammation in Patients Undergoing Hip Surgery., Okoro, T (PI), Lemmey, A.B., Maddison, P., Grant value (£): £16,500., Duration of research project: 2 years

Teaching qualification:

Fellow of the Higher Education Academy