Liverpool Skylilne

Sport and Exercise Sciences

Prof Claire Stewart

Prof Claire Stewart

Telephone: 0151 904 6234

ORCID

Publications

Highlighted publications

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Mein CA, Sharples AP. 2018. Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining Scientific Data, 5 DOI Author Url Publisher Url Public Url

Al-Dabbagh S, McPhee JS, Piasecki M, Stewart CE, Al-Shanti N. 2018. Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly. Journals of Gerontology, Series A, DOI Author Url Publisher Url Public Url

Ryan DJ, Wullens JA, Stebbings GK, Morse CI, Stewart C, Onambele-Pearson GL. 2018. Reliability and validity of the international physical activity questionnaire compared to calibrated accelerometer cut-off points in the quantification of sedentary behaviour and physical activity in older adults. PLoS ONE, 13 DOI Author Url Publisher Url Public Url

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP. 2018. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy Scientific Reports, 8 DOI Author Url Publisher Url Public Url

Fisher A, Seaborne RA, Hughes TM, Gutteridge A, Stewart CE, Coulson JM, Sharples AP, Jarvis JC. 2017. Transcriptomic and Epigenetic Regulation of Disuse Atrophy and the Return to Activity in Skeletal Muscle FASEB Journal, Epub Ahead of Print DOI Author Url Publisher Url Public Url

Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F. 2017. The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks Cell Reports, 21 :1507-1520 DOI Author Url Publisher Url Public Url

Sharples AP, Polydorou J, Hughes DC, Owens DJ, Hughes TM, Stewart CE. 2016. Skeletal muscle cells possess a memory of acute early life TNF-α exposure: Role of epigenetic adaptation Biogerontology, 17(3) :603-617 DOI Author Url Publisher Url Public Url

Saini J, McPhee JS, Al-Dabbagh S, Stewart CE, Al-Shanti N. 2016. Regenerative function of immune system: Modulation of muscle stem cells Ageing Research Reviews, 27 :67-76 DOI Author Url Public Url

Sharples AP, Stewart CE, Seaborne RA. 2016. Does skeletal muscle have an ‘epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise Aging Cell, 4 :603-616 DOI Author Url Publisher Url Public Url

Owens D, Sharples AP, Polydorou I, Alwan N, Donovan TD, Tang J, Fraser WD, Cooper RG, Morton J, Stewart CE, Close GL. 2015. A Systems Based Investigation into Vitamin D and Skeletal Muscle Repair, Regeneration and Hypertrophy American Journal of Physiology: Endocrinology and Metabolism, Epub Ahead of Print DOI Author Url Publisher Url Public Url

Sharples AP, Hughes DC, Deane CD, Saini A, Selman C, Stewart CE. 2015. Longevity and Skeletal Muscle Mass: The role of IGF signalling, the Sirtuins, dietary restriction and protein intake. Aging Cell, 14 :511-523 DOI Author Url Publisher Url Public Url

Al-Shanti N, Stewart CE. Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3. J Cell Biochem, 113 :923-933 DOI Author Url Publisher Url

Saini A, Al-Shanti N, Sharples AP, Stewart CE. Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Exp Physiol, 97 :400-418 DOI Author Url Publisher Url

Sharples AP, Al-Shanti N, Stewart CE. C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing? J Cell Physiol, 225 :240-250 DOI Author Url Publisher Url

Saini A, Al-Shanti N, Faulkner SH, Stewart CE. Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism. Growth Factors, 26 :239-253 DOI Author Url Publisher Url

Journal article

Morehen JC, Clarke J, Batsford J, Barrow S, Brown AD, Stewart CE, Morton JP, Close GL. 2020. Montmorency tart cherry juice does not reduce markers of muscle soreness, function and inflammation following professional male rugby League match-play EUROPEAN JOURNAL OF SPORT SCIENCE, DOI Author Url

Nolan A, Brett R, Strauss JA, Stewart CE, Shepherd SO. 2020. Short-term, but not acute, intake of New Zealand blackcurrant extract improves insulin sensitivity and free-living postprandial glucose excursions in individuals with overweight or obesity EUROPEAN JOURNAL OF NUTRITION, DOI Author Url

Hudson JF, Cole M, Morton JP, Stewart CE, Close GL. 2020. Daily Changes of Resting Metabolic Rate in Elite Rugby Union Players Medicine and Science in Sports and Exercise, 52 :637-644 DOI Author Url

Ryan DJ, Wullems JA, Stebbings GK, Morse CI, Stewart CE, Onambele-Pearson GL. 2020. The difference in sleep, sedentary behaviour, and physical activity between older adults with 'healthy' and 'unhealthy' cardiometabolic profiles: a cross-sectional compositional data analysis approach (vol 16, 25, 2019) EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY, 17 DOI Author Url

Ryan DJ, Wullems JA, Stebbings GK, Morse CI, Stewart CE, Onambele-Pearson GL. 2019. The difference in sleep, sedentary behaviour, and physical activity between older adults with 'healthy' and 'unhealthy' cardiometabolic profiles: a cross-sectional compositional data analysis approach EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY, 16 DOI Author Url

Calimport SRG, Bentley BL, Stewart C, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhaes JP, Campisi J, Church G. 2019. To help aging populations, classify organismal senescence SCIENCE, 366 :576-+ DOI Author Url

Ryan DJ, Wullems JA, Stebbings GK, Morse CI, Stewart CE, Onambele-Pearson GL. 2019. Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles PLoS ONE, 14 DOI Author Url Public Url

Hammond KM, Sale C, Fraser W, Tang J, Shepherd SO, Strauss JA, Close GL, Cocks M, Louis J, Pugh J, Stewart C, Sharples AP, Morton JP. 2019. Post-exercise carbohydrate and energy availability induce independent effects on skeletal muscle cell signalling and bone turnover: implications for training adaptation Journal of Physiology, 597 :4779-4796 DOI Author Url Publisher Url Public Url

Shelley J, Boddy L, Knowles Z, Stewart C, Dawson E. 2019. Physical activity and associations with clinical outcome measures in adults with cystic fibrosis; A systematic review Journal of Cystic Fibrosis, DOI Author Url Publisher Url Public Url

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Mein CA, Sharples AP. 2018. Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining Scientific Data, 5 DOI Author Url Publisher Url Public Url

Al-Dabbagh S, McPhee JS, Piasecki M, Stewart CE, Al-Shanti N. 2018. Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly. Journals of Gerontology, Series A, DOI Author Url Publisher Url Public Url

Baumert P, G-REX Consortium , Stewart C, Lake M, Drust B, Erskine RM. 2018. Variations of Collagen-Encoding Genes are Associated with Exercise-Induced Muscle Damage Physiological Genomics, 50 :691-693 DOI Author Url Publisher Url Public Url

Ryan DJ, Wullens JA, Stebbings GK, Morse CI, Stewart C, Onambele-Pearson GL. 2018. Segregating the Distinct Effects of Sedentary Behavior and Physical Activity on Older Adults' Cardiovascular Profile: Part 2-Isotemporal Substitution Approach. Journal of Physical Activity and Health, 15 :537-542 DOI Author Url Publisher Url Public Url

Ryan D, Wullems J, Stebbings G, Morse C, Stewart C, Onambele-Pearson G. 2018. Segregating the Distinct Effects of Sedentary Behavior and Physical Activity on Older Adults' Cardiovascular Structure and Function: Part 1-Linear Regression Analysis Approach JOURNAL OF PHYSICAL ACTIVITY & HEALTH, 15 :499-509 DOI Author Url Public Url

Ryan DJ, Wullens JA, Stebbings GK, Morse CI, Stewart C, Onambele-Pearson GL. 2018. Reliability and validity of the international physical activity questionnaire compared to calibrated accelerometer cut-off points in the quantification of sedentary behaviour and physical activity in older adults. PLoS ONE, 13 DOI Author Url Publisher Url Public Url

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP. 2018. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy Scientific Reports, 8 DOI Author Url Publisher Url Public Url

Baumert P, G-REX Consortium , Lake M, Drust B, Stewart C, Erskine RM. 2017. TRIM63 (MuRF-1) Gene Polymorphism is Associated with Biomarkers of Exercise-Induced Muscle Damage Physiological Genomics, DOI Author Url Publisher Url Public Url

Fisher A, Seaborne RA, Hughes TM, Gutteridge A, Stewart CE, Coulson JM, Sharples AP, Jarvis JC. 2017. Transcriptomic and Epigenetic Regulation of Disuse Atrophy and the Return to Activity in Skeletal Muscle FASEB Journal, Epub Ahead of Print DOI Author Url Publisher Url Public Url

Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples AP. 2017. The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction Molecular and Cellular Biochemistry, DOI Author Url Public Url

Brown AD, Close GL, Sharples AP, Stewart CE. 2017. Murine myoblast migration: influence of replicative ageing and nutrition Biogerontology, DOI Author Url Publisher Url Public Url

Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F. 2017. The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks Cell Reports, 21 :1507-1520 DOI Author Url Publisher Url Public Url

Saini A, Sharples AP, Al-Shanti N, Stewart CE. 2016. Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation BIOGERONTOLOGY, 18(1) :109-129 DOI Author Url Publisher Url Public Url

Baumert P, Lake MJ, Stewart CE, Drust B, Erskine RM. 2016. Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing European Journal of Applied Physiology, :1-31 DOI Author Url Public Url

Sharples AP, Polydorou J, Hughes DC, Owens DJ, Hughes TM, Stewart CE. 2016. Skeletal muscle cells possess a memory of acute early life TNF-α exposure: Role of epigenetic adaptation Biogerontology, 17(3) :603-617 DOI Author Url Publisher Url Public Url

Impey S, Hammond K, Shepherd S, Sharples AP, Stewart CE, Limb M, Smith K, Philp A, Jeromson S, Hamilton DL, Close GL, Morton JP. 2016. Fuel for the work required: a practical approach to amalgamating train-low paradigms for endurance athletes Physiological Reports, 4 :e12803-e12803 DOI Author Url Publisher Url Public Url

Saini J, McPhee JS, Al-Dabbagh S, Stewart CE, Al-Shanti N. 2016. Regenerative function of immune system: Modulation of muscle stem cells Ageing Research Reviews, 27 :67-76 DOI Author Url Public Url

Sharples AP, Stewart CE, Seaborne RA. 2016. Does skeletal muscle have an ‘epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise Aging Cell, 4 :603-616 DOI Author Url Publisher Url Public Url

Girven M, Dugdale HF, Owens D, Hughes DC, Stewart CE, Sharples AP. 2016. L-glutamine improves skeletal muscle cell differentiation and prevents myotube atrophy after cytokine (TNF-α) stress via reduced p38 MAPK signal transduction Journal of Cellular Physiology, 12 :2720-2732 DOI Author Url Publisher Url Public Url

Owens D, Sharples AP, Polydorou I, Alwan N, Donovan TD, Tang J, Fraser WD, Cooper RG, Morton J, Stewart CE, Close GL. 2015. A Systems Based Investigation into Vitamin D and Skeletal Muscle Repair, Regeneration and Hypertrophy American Journal of Physiology: Endocrinology and Metabolism, Epub Ahead of Print DOI Author Url Publisher Url Public Url

Hughes DH, Stewart CE, Sculthorpe N, Dugdale HF, Yousefian F, Lewis MP, Sharples AP. 2015. Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors Biogerontology, 17(3) :619-639 DOI Author Url Publisher Url Public Url

Davis NL, Stewart CE, Moss AD, Woltersdorf WWW, Hunt LP, Elson RA, Cornish JM, Stevens MCG, Crowne EC. 2015. Growth hormone deficiency after childhood bone marrow transplantation with total body irradiation: interaction with adiposity and age CLINICAL ENDOCRINOLOGY, 83 :508-517 DOI Author Url

Sharples AP, Stewart CE. 2015. Comments on the CrossTalk proposal and opposing view: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis/proteolysis Journal of Physiology, DOI Author Url Publisher Url

Okoro T, Stewart C, Al-Shanti N, Lemmey A, Maddison P, Andrew JG. 2015. Objective function, lean mass, and associated genetic adaptations of the operated leg following total hip arthroplasty Journal of Musculoskeletal Research, 18 DOI

Sharples AP, Hughes DC, Deane CD, Saini A, Selman C, Stewart CE. 2015. Longevity and Skeletal Muscle Mass: The role of IGF signalling, the Sirtuins, dietary restriction and protein intake. Aging Cell, 14 :511-523 DOI Author Url Publisher Url Public Url

Patel HP, Al-Shanti N, Davies LC, Barton SJ, Grounds MD, Tellam RL, Stewart CE, Cooper C, Sayer AA. 2014. Lean Mass, Muscle Strength and Gene Expression in Community Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS) CALCIFIED TISSUE INTERNATIONAL, 95 :308-316 DOI Author Url

Grosset JF, Breen L, Stewart CEH, Burgess KE, Onambele GL. 2014. Influence of exercise intensity on training-induced tendon mechanical properties changes in older individuals. Age, 36 :1433-1442 DOI Author Url

Al-Shanti N, Durcan P, Al-Dabbagh S, Dimchev GA, Stewart CE. 2014. Activated Lymphocytes Secretome Inhibits Differentiation and Induces Proliferation of C2C12 Myoblasts CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 33 :117-128 DOI Author Url

Deane CS, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP. 2013. Impaired hypertrophy in myoblasts is improved with testosterone administration Journal of Steroid Biochemistry and Molecular Biology, 138 :152-161 DOI Author Url

Stewart CEH, Durcan PJ , Al-Shanti N. 2013. Identification and characterization of novel Kirrel isoform during myogenesis. Physiological Reports, 1 DOI

Stewart CE. 2013. Immobility and diminished skeletal muscle recovery with age: The sedentary myoblast Journal of Physiology, 591 :3671-3672 DOI Author Url

Deane CD, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP. 2013. Impaired hypertrophy in myoblasts is improved with testosterone administration The Journal of Steroid Biochemistry and Molecular Biology, 138 :152-161 DOI Author Url Publisher Url Public Url

Dimchev GA, Al-Shanti N, Stewart CE. 2013. Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways Journal of Muscle Research and Cell Motility, 34 :125-136 DOI Author Url

Sharples AP, Al-Shanti N, Hughes DC, Lewis MP, Stewart CE. 2013. The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy Growth Hormone and IGF Research, 23 :53-61 DOI Author Url Publisher Url

Sharples AP, Stewart CE. 2011. Myoblast models of skeletal muscle hypertrophy and atrophy Current Opinion in Clinical Nutrition and Metabolic Care, 14 :230-236 DOI Author Url Publisher Url Public Url

Atkinson RA, Srinivas-Shankar U, Roberts SA, Connolly MJ, Adams JE, Oldham JA, Wu FCW, Seynnes OR, Stewart CEH, Maganaris CN, Narici MV. 2010. Effects of testosterone on skeletal muscle architecture in intermediate-frail and frail elderly men Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 65 A :1215-1219 DOI

Patel HP, Syddall HE, Martin HJ, Cooper C, Stewart C, Sayer AA. 2010. The feasibility and acceptability of muscle biopsy in epidemiological studies: Findings from the hertfordshire sarcopenia study (HSS) Journal of Nutrition, Health and Aging, :1-6 DOI

Stewart CE, Pell JM. 2010. Last Word on Point: Counterpoint: IGF is the major physiological regulator of muscle mass JOURNAL OF APPLIED PHYSIOLOGY, 108 :1832-1832 DOI Author Url

Al-Shanti N, Saini A, Stewart CE. 2009. Two-step versus one-step RNA-to-CT™ 2-step and one-step RNA-to-CT™ 1-Step: Validity, sensitivity, and efficiency Journal of Biomolecular Techniques, 20 :172-179 Author Url Publisher Url

Saini A, Faulkner S, Al-Shanti N, Stewart C. 2009. Powerful signals for weak muscles Ageing Research Reviews, 8 :251-267 DOI Author Url Publisher Url

Saini A, Al-Shanti N, Stewart CEH. 2007. Waste management - Cytokines, growth factors and cachexia (vol 17, pg 475, 2006) CYTOKINE & GROWTH FACTOR REVIEWS, 18 :345-345 DOI Author Url

Wong CKM, Lai T, Holly JMP, Wheeler MH, Stewart CEH, Farndon JR. 2006. The effects of retinoic acid on the insulin-like growth factor axis in primary tissue culture from hyperparathyroidism WORLD JOURNAL OF SURGERY, 30 :714-720 DOI Author Url Publisher Url

Wong CKM, Lai T, Holly JMP, Wheeler MH, Stewart CEH, Farndon JR. 2006. Insulin-like growth factors (IGF) I and II utilize different calcium signaling pathways in a primary human parathyroid cell culture model WORLD JOURNAL OF SURGERY, 30 :333-345 DOI Author Url Publisher Url

Grohmann M, Foulstone E, Welsh G, Holly J, Shield J, Crowne E, Stewart C. 2005. Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF-I, IGFBP-3 and TNFalpha. J Physiol, 568 :229-242 DOI Author Url Publisher Url

Grohmann M, Foulstone E, Welsh G, Holly J, Shield J, Crowne E, Stewart C. 2005. Isolation and validation of human prepubertal skeletal muscle cells: Maturation and metabolic effects of IGF-I, IGFBP-3 and TNFα Journal of Physiology, 568 :229-242 DOI

Foulstone EJ, Huser C, Crown AL, Holly JMP, Stewart CEH. 2004. Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNFalpha. Exp Cell Res, 294 :223-235 DOI Author Url Publisher Url

Foulstone EJ, Savage PB, Crown AL, Holly JMP, Stewart CEH. 2003. Adaptations of the IGF system during malignancy: Human skeletal muscle versus the systemic environment HORMONE AND METABOLIC RESEARCH, 35 :667-674 Author Url

Meadows KA, Holly JMP, Stewart CEH. 2000. Tumor necrosis factor-α-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts Journal of Cellular Physiology, 183 :330-337 DOI Author Url

Pell JM, Hill RA, Stewart CEH, Weston CR, Flick-Smith HC. 2000. Enhancement of insulin-like growth factor I activity by novel antisera: Potential structure/function interactions ENDOCRINOLOGY, 141 :741-751 DOI Author Url

Stewart CEH, James PL, Fant ME, Rotwein P. 1996. Overexpression of insulin-like growth factor-II induces accelerated myoblast differentiation Journal of Cellular Physiology, 169 :23-32 DOI Author Url

STEWART CEH, BATES PC, CALDER TA, WOODALL SM, PELL JM. 1993. POTENTIATION OF INSULIN-LIKE GROWTH FACTOR-I (IGF-I) ACTIVITY BY AN ANTIBODY - SUPPORTIVE EVIDENCE FOR ENHANCEMENT OF IGF-I BIOAVAILABILITY IN-VIVO BY IGF BINDING-PROTEINS ENDOCRINOLOGY, 133 :1462-1465 DOI Author Url

Sharples AP, Player DJ, Martin NRW, Mudera V, Stewart CE, Lewis MP. Modelling in vivo skeletal muscle ageing in vitro using three-dimensional bioengineered constructs. Aging Cell, 11 :986-995 DOI Author Url Publisher Url Public Url

Al-Shanti N, Stewart CE. Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3. J Cell Biochem, 113 :923-933 DOI Author Url Publisher Url

Saini A, Al-Shanti N, Sharples AP, Stewart CE. Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Exp Physiol, 97 :400-418 DOI Author Url Publisher Url

Sharples AP, Al-Shanti N, Lewis MP, Stewart CE. Reduction of myoblast differentiation following multiple population doublings in mouse C2 C12 cells: a model to investigate ageing? J Cell Biochem, 112 :3773-3785 DOI Author Url Publisher Url

Al-Shanti N, Faulkner SH, Saini A, Loram I, Stewart CE. A semi-automated programme for tracking myoblast migration following mechanical damage: manipulation by chemical inhibitors. Cell Physiol Biochem, 27 :625-636 DOI Author Url Publisher Url

Sharples AP, Al-Shanti N, Stewart CE. C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing? J Cell Physiol, 225 :240-250 DOI Author Url Publisher Url

Onambélé-Pearson GL, Breen L, Stewart CE. Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations. Age (Dordr), 32 :139-153 DOI Author Url Publisher Url

Saini A, Al-Shanti N, Stewart C. C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d. Cell Physiol Biochem, 25 :253-262 DOI Author Url Publisher Url

Stewart CE, Pell JM. Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. Point: IGF is the major physiological regulator of muscle mass. J Appl Physiol (1985), 108 :1820-1821 DOI Author Url Publisher Url

Al-Shanti N, Stewart CE. Ca2+/calmodulin-dependent transcriptional pathways: potential mediators of skeletal muscle growth and development. Biol Rev Camb Philos Soc, 84 :637-652 DOI Author Url Publisher Url

Saini A, Al-Shanti N, Faulkner SH, Stewart CE. Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism. Growth Factors, 26 :239-253 DOI Author Url Publisher Url

Al-Shanti N, Stewart CE. PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059. J Endocrinol, 198 :243-252 DOI Author Url Publisher Url

Al-Shanti N, Saini A, Faulkner SH, Stewart CE. Beneficial synergistic interactions of TNF-alpha and IL-6 in C2 skeletal myoblasts--potential cross-talk with IGF system. Growth Factors, 26 :61-73 DOI Author Url Publisher Url

Suleiman M-S, Singh RJR, Stewart CEH. Apoptosis and the cardiac action of insulin-like growth factor I. Pharmacol Ther, 114 :278-294 DOI Author Url Publisher Url

Saini A, Al-Shanti N, Stewart CEH. Waste management - cytokines, growth factors and cachexia. Cytokine Growth Factor Rev, 17 :475-486 DOI Author Url Publisher Url

Stewart CEH, Rittweger J. Adaptive processes in skeletal muscle: molecular regulators and genetic influences. J Musculoskelet Neuronal Interact, 6 :73-86 Author Url Publisher Url

Grohmann M, Sabin M, Holly J, Shield J, Crowne E, Stewart C. Characterization of differentiated subcutaneous and visceral adipose tissue from children: the influences of TNF-alpha and IGF-I. J Lipid Res, 46 :93-103 DOI Author Url Publisher Url

Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE. Adaptations of the IGF system during malignancy: human skeletal muscle versus the systemic environment. Horm Metab Res, 35 :667-674 DOI Author Url Publisher Url

Foulstone EJ, Savage PB, Crown AL, Holly JMP, Stewart CEH. Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts. J Cell Physiol, 195 :70-79 DOI Author Url Publisher Url

Foulstone EJ, Meadows KA, Holly JM, Stewart CE. Insulin-like growth factors (IGF-I and IGF-II) inhibit C2 skeletal myoblast differentiation and enhance TNF alpha-induced apoptosis. J Cell Physiol, 189 :207-215 DOI Author Url Publisher Url

Crown AL, He XL, Holly JM, Lightman SL, Stewart CE. Characterisation of the IGF system in a primary adult human skeletal muscle cell model, and comparison of the effects of insulin and IGF-I on protein metabolism. J Endocrinol, 167 :403-415 DOI Author Url Publisher Url

Erskine RM, Williams AG, Jones DA, Stewart CE, Degens H. Do PTK2 gene polymorphisms contribute to the interindividual variability in muscle strength and the response to resistance training? A preliminary report Journal of applied physiology, 112 :1329-1334 DOI Author Url Publisher Url Public Url

Patel HP, Jameson KA, Syddall HE, Martin HJ, Stewart CE, Cooper C, Sayer AA. Developmental influences, muscle morphology, and sarcopenia in community-dwelling older men The journals of gerontology. Series A, Biological sciences and medical sciences, 67 :82-87 DOI Author Url Publisher Url

Erskine RM, Jones DA, Maffulli N, Williams AG, Stewart CE, Degens H. What causes in vivo muscle specific tension to increase following resistance training? Experimental physiology, 96 :145-155 DOI Author Url Publisher Url

Patel H, Syddall HE, Martin HJ, Cooper C, Stewart C, Sayer AA. The feasibility and acceptability of muscle biopsy in epidemiological studies: findings from the Hertfordshire Sarcopenia Study (HSS) The journal of nutrition, health & aging, 15 :10-15 DOI Author Url Publisher Url

Atkinson RA, Srinivas-Shankar U, Roberts SA, Connolly MJ, Adams JE, Oldham JA, Wu FCW, Seynnes OR, Stewart CEH, Maganaris CN, Narici MV. Effects of testosterone on skeletal muscle architecture in intermediate-frail and frail elderly men. J Gerontol A Biol Sci Med Sci, 65 :1215-1219 DOI Author Url Publisher Url

Erskine RM, Jones DA, Williams AG, Stewart CE, Degens H. Inter-individual variability in the adaptation of human muscle specific tension to progressive resistance training European journal of applied physiology, 110 :1117-1125 DOI Author Url Publisher Url

Erskine RM, Jones DA, Williams AG, Stewart CE, Degens H. Resistance training increases in vivo quadriceps femoris muscle specific tension in young men Acta physiologica, 199 :83-89 DOI Author Url Publisher Url

Onambele-Pearson GL, Breen L, Stewart CE. Influences of carbohydrate plus amino acid supplementation on differing exercise intensity adaptations in older persons: skeletal muscle and endocrine responses Age, 32 :125-138 DOI Author Url Publisher Url

Patel HP, Syddall HE, Martin HJ, Stewart CE, Cooper C, Sayer AA. Hertfordshire sarcopenia study: design and methods BMC geriatrics, 10 :43 DOI Author Url Publisher Url

Rittweger J, Moss AD, Colier W, Stewart C, Degens H. Muscle tissue oxygenation and VEGF in VO-matched vibration and squatting exercise Clinical physiology and functional imaging, 30 :269-278 DOI Author Url Publisher Url

McPhee JS, Williams AG, Stewart C, Baar K, Schindler JP, Aldred S, Maffulli N, Sargeant AJ, Jones DA. The training stimulus experienced by the leg muscles during cycling in humans Experimental physiology, 94 :684-694 DOI Author Url Publisher Url

Grohmann M, Stewart C, Welsh G, Hunt L, Tavare J, Holly J, Shield J, Sabin M, Crowne E. Site-specific differences of insulin action in adipose tissue derived from normal prepubertal children Experimental cell research, 308 :469-478 DOI Author Url Publisher Url

Louafi F, Stewart CE, Perks CM, Thomas MG, Holly JM. Role of the IGF-II receptor in mediating acute, non-genomic effects of retinoids and IGF-II on keratinocyte cell death Experimental dermatology, 12 :426-434 DOI Author Url Publisher Url

Hollowood AD, Stewart CE, Perks CM, Pell JM, Lai T, Alderson D, Holly JM. Evidence implicating a mid-region sequence of IGFBP-3 in its specific IGF-independent actions Journal of cellular biochemistry, 86 :583-589 DOI Author Url Publisher Url

Pell JM, Hill RA, Stewart CE, Weston CR, Flick-Smith HC. Enhancement of insulin-like growth factor I activity by novel antisera: potential structure/function interactions. Endocrinology, 141 :741-751 DOI Author Url Publisher Url

Lawlor MA, Feng X, Everding DR, Sieger K, Stewart CE, Rotwein P. Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways Molecular and cellular biology, 20 :3256-3265 DOI Author Url Publisher Url

Maile R, Elsegood KA, Harding TC, Uney JB, Stewart CE, Banting G, Dayan CM. Effective formation of major histocompatibility complex class II-peptide complexes from endogenous antigen by thyroid epithelial cells Immunology, 99 :367-374 DOI Author Url Publisher Url

Meadows KA, Holly JM, Stewart CE. Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts Journal of cellular physiology, 183 :330-337 DOI Author Url Publisher Url

James PL, Stewart CE, Rotwein P. Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism The Journal of cell biology, 133 :683-693 DOI Author Url Publisher Url Public Url

Lau MM, Stewart CE, Liu Z, Bhatt H, Rotwein P, Stewart CL. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality Genes & development, 8 :2953-2963 DOI Author Url Publisher Url

Erskine RM, Williams AG, Jones DA, Stewart CE, Degens H. The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training. Scand J Med Sci Sports, 24 :642-648 DOI Author Url Public Url

Stewart CEH, Sayer AA, Patel H, Cooper C. The developmental origins of sarcopenia: from epidemiological evidence to underlying mechanisms Journal of Developmental Origins of Health and Disease, 1 :150-157

Stewart CEH, Pell JM. Last Word on Point:Counterpoint: IGF is the major physiological regulator of muscle mass. Journal of Applied Physiology, 6 :1832

Sabin MA, Crowne EC, Stewart CE, Hunt LP, Turner SJ, Welsh GI, Grohmann MJ, Holly JM, Shield JP. Depot-specific effects of fatty acids on lipid accumulation in children's adipocytes Biochemical and biophysical research communications, 361 :356-361 DOI Author Url Publisher Url

Sabin MA, Stewart CE, Crowne EC, Turner SJ, Hunt LP, Welsh GI, Grohmann MJ, Holly JM, Shield JP. Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid Journal of cellular physiology, 211 :244-252 DOI Author Url Publisher Url

Wong CK, Lai T, White S, Sheffield E, Wheeler MH, Stewart CE, Farndon JR. Characterization of the insulin-like growth factor axis and Wilms' tumour suppressor gene in hyperparathyroidism The British journal of surgery, 94 :1232-1241 DOI Author Url Publisher Url

Sabin MA, Holly JM, Shield JP, Turner SJ, Grohmann MJ, Stewart CE, Crowne EC. Mature subcutaneous and visceral adipocyte concentrations of adiponectin are highly correlated in prepubertal children and inversely related to body mass index standard deviation score The Journal of clinical endocrinology and metabolism, 91 :332-335 DOI Author Url Publisher Url

Saini A, Stewart CE. Adult stem cells: the therapeutic potential of skeletal muscle Current stem cell research & therapy, 1 :157-171 DOI Author Url Publisher Url

Stewart CE. The physiology of stem cells: potential for the elderly patient Journal of musculoskeletal & neuronal interactions, 4 :179-183 Author Url Publisher Url

Stewart CE, Newcomb PV, Holly JM. Multifaceted roles of TNF-alpha in myoblast destruction: a multitude of signal transduction pathways Journal of cellular physiology, 198 :237-247 DOI Author Url Publisher Url

Wong C, Lai T, Hilly JM, Stewart CE, Farndon JR. Selective estrogen receptor modulators inhibit the effects of insulin-like growth factors in hyperparathyroidism Surgery, 132 :998-1006 DOI Author Url Publisher Url

Stewart CE, Mihai R, Holly JM. Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis Experimental cell research, 250 :329-338 DOI Author Url Publisher Url

Stewart CE, Newcomb PV, Savage PB, Dickens M, Tavare J, Holly JM. Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 9 :131-142 DOI Author Url Publisher Url

Stewart CE, James PL, Fant ME, Rotwein P. Overexpression of insulin-like growth factor-II induces accelerated myoblast differentiation Journal of cellular physiology, 169 :23-32 DOI Author Url Publisher Url

Stewart CE, Rotwein P. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors Physiological reviews, 76 :1005-1026 DOI Author Url Publisher Url

Stewart CE, Rotwein P. Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts The Journal of biological chemistry, 271 :11330-11338 DOI Author Url Publisher Url

Stewart CE, Bates PC, Calder TA, Woodall SM, Pell JM. Potentiation of insulin-like growth factor-I (IGF-I) activity by an antibody: supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins Endocrinology, 133 :1462-1465 DOI Author Url Publisher Url

Barberi L, Scicchitano BM, De Rossi M, Bigot A, Duguez S, Wielgosik A, Stewart C, McPhee J, Conte M, Narici M, Franceschi C, Mouly V, Butler-Browne G, Musaro A. Age-dependent alteration in muscle regeneration: the critical role of tissue niche BIOGERONTOLOGY, 14 :273-292 DOI Author Url

Stewart CE. The lymphocyte secretome from young adults enhances skeletal muscle proliferation and migration, but effects are attenuated in the secretome of older adults Physiological Reports, DOI Author Url

Stewart CEH, Breen L, Onambélé GL. Functional benefits of combined resistance training with nutritional interventions in older adults: A review Geriatrics & Gerontology International, 7 :326-340 DOI Author Url

Holly JM, Perks CM, Stewart CE. Overview of insulin-like growth factor physiology Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 10 Suppl A :S8-S9 DOI Author Url Publisher Url

Other

Baumert P, Temple S, Stanley JM, Cocks M, Strauss JA, Shepherd SO, Drust B, Lake MJ, Stewart CE, Erskine RM. 2019. Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics DOI

Baumert P, Lake MJ, Stewart CE, Drust B, Erskine RM. 2016. Inter-individual variability in the response to maximal eccentric exercise EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 116 :2055-2056 DOI Author Url

Chapters

Turner DC, Kasper AM, Seaborne RA, Brown AD, Close GL, Murphy M, Stewart CE, Martin NRW, Sharples AP. 2019. Exercising Bioengineered Skeletal Muscle In Vitro: Biopsy to Bioreactor Beate Ronning S. Myogenesis: Methods and Protocols vol. 1889 Springer Nature 978-1-4939-8896-9 DOI Author Url Publisher Url Public Url

Sharples AP, Seaborne RA, Stewart CE. 2017. Epigenetics of skeletal muscle aging Moskalev A, Vaiserman AM. Epigenetics of Aging and Longevity :365-365 Elsevier 978-0-12-811060-7 DOI Author Url Publisher Url

Stewart CE, Jones DA. 2012. Myogenesis Mooren FC. Encyclopedia of Exercise Medicine in Health and Disease Springer 9783540360650

Stewart CEH. 2006. Stem cells and stem cell therapies: The future of regenerative medicine? Greer EV. Stem Cell Therapy Nova Biomedical 9781594548482

Stewart CEH, Narici M, di Prampero PE. Detraining, Bed Rest and Adaptations to Microgravity Nigel A S Taylor PD, Herbert Groeller PD. Physiological Bases of Human Performance During Work and Exercise Elsevier Publications 9780443102714

Conference publication

McCullough D, Harrison T, Lane K, Boddy L, Stewart C, Enright KJ, Amirabdollahian F, Schmidt M, Davies I. 2018. The association between dietary macronutrient intake and fibrogen growth factor 21 in a sample of White UK adults with elevated cardiometabolic risk markers The Nutrition society Conference, 10th-12th July DOI Author Url

Harrison T, McCullough D, Lane K, Boddy L, Stewart C, Enright KJ, Amirabdollahian, F, Schmidt M, Davies I. 2018. Dietary carbohydrate intake, visceral adipose tissue and associated markers of cardiometabolic risk. The Nutrition society Conference, 10 - 12 July DOI Author Url

Brown A, Close G, Sharples A, Stewart C. 2017. Mechanisms underpinning enhanced migration capabilities of replicatively aged C2C12 myoblasts British Society for Research on Ageing (BSRA)

Dugdale HF, Stewart CE, Sharples AP. 2016. Resveratrol enables myotube survival under nutrient stress. European Muscle Conference

Owens DJ, Polydorou I, Alwan N, Fraser WD, Tang J, Morton J, Sharples AP, Stewart CE, Close GL. 2015. The Role of Vitamin D in Skeletal Muscle Repair: A Systems Biology Approach European College of Sport Science (ECSS)

Patel HP, Al-Shanti N, Davies LC, Barton SJ, Grounds MD, Tellam RL, Stewart CE, Cooper C, Sayer AA. 2014. LEAN MASS, MUSCLE STRENGTH AND GENE EXPRESSION IN COMMUNITY DWELLING OLDER MEN AGE AND AGEING, 43 :28-28 Author Url

Patel HP, Al-Shanti N, Barton SJ, Stewart CE, Grounds MD, Tellam RL, Cooper C, Sayer AA. 2011. Developmental Influences on Skeletal Muscle Gene Expression in Older Men: Findings from the Hertfordshire Sarcopenia Study JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 2 :S130-S130 Author Url

Sharpies AP, Player DJ, Martin NRW, Passey S, Stewart CE, Lewis MP. 2011. Replicative ageing of myoblast in 3-D tissue engineered collagen constructs European Cells and Materials, 22 :39 Author Url Publisher Url

Davis NL, Stewart CE, Cornish JM, Wei C, Elson RA, Stevens MCG, Crowne EC. 2009. Survivors of bone marrow transplantation (BMT) in childhood with total body irradiation (TBI) have a high prevalence of glucose intolerance relative to their degree of adiposity HORMONE RESEARCH, 72 :192-192 Author Url

Sabin MA, Grohmann MJ, Welsh GI, Shield JPH, Holly JMP, Stewart CEH, Crowne EC. 2005. Saturated and unsaturated fatty acids exert differential effects on intramyocellular lipid accumulation and insulin signaling in primary muscle cultures derived from prepubertal children DIABETES, 65th Annual Meeting of the American-Diabetes-Association 54 :A321-A321 Author Url

Wong C, Lai T, Stewart CEH, Farndon JR. 2003. IGF I & II induced proliferation utilise different calcium signalling pathways in a primary human parathyroid cell culture model BRITISH JOURNAL OF SURGERY, 3rd Meeting of the Society-of-Academic-and-Research-Surgery 90 :638-638 Author Url

Wong C, Lai T, Stewart CEH, Holly JMP, Farndon JR. 2002. Selective oestrogen receptor modulators inhibit the effects of insulin-like growth factors in hyperparathyroidism BRITISH JOURNAL OF SURGERY, 89 :1336-1336 Author Url

Wong C, Lai T, Stewart CEH, Farndon JR, Holly JMP. 2002. Selective estrogen receptor modulators (SERMS) inhibit the effects of insulin-like growth factors in hyperparathyroidism (HPT) BRITISH JOURNAL OF SURGERY, 89 :15-15 Author Url

Wong CKM, Lai T, Stewart CEH, Holly JMP, Farndon JR. 2002. Effects of retinoic acid and insulin-like growth factors in primary hyperparathyroidism BRITISH JOURNAL OF SURGERY, 89 :668-669 Author Url

Singh RJR, Stewart CEH, Johnson JL, Holly JMP, Suleiman MS. 2001. Insulin and insulin-like growth factor I (IGF-I) reduce apoptosis in Langendorff perfused rat hearts exposed to ischaemia and reperfusion JOURNAL OF PHYSIOLOGY-LONDON, Scientific Meeting of the Physiological-Society 536 :84P-85P Author Url

Bobrow CS, Stewart CEH, Murphy DJ, Soothill PW. 2000. The insulin-like growth factor type 1 receptor in the syncytiotrophoblast microvillous membrane of the placenta: is it altered in small for gestational age pregnancies? JOURNAL OF PHYSIOLOGY-LONDON, 528P :24P-25P Author Url

Meadows KA, Lin H, Singh RJR, Suleiman MS, Holly JMP, Stewart CEH. 2000. Establishment and characterisation of adult rat cardiomyocyte suspension cultures JOURNAL OF PHYSIOLOGY-LONDON, 526 :100P-100P Author Url

Singh RJR, Stewart CEH, Holly JMP, Suleiman MS. 2000. Metabolic versus anti-apoptotic effects of the insulin-like growth factor system JOURNAL OF PHYSIOLOGY-LONDON, 526 :94P-94P Author Url

Stewart CEH, Meadows KA, Lin H, Singh RJR, Suleiman MS, Holly JMP. 2000. The roles of insulin-like growth factor-I and its modulatory binding proteins in an adult model of cardiac myocyte apoptosis JOURNAL OF PHYSIOLOGY-LONDON, 526 :94P-95P Author Url

Rotwein P, Gronowski AM, James PL, Lestunff C, Mittanck DW, Stewart CEH, Thomas MJ, Tollefsen SE. 1995. Phylogeny and ontogeny of insulin-like growth factors I and II Baba S, Kaneko T. DIABETES 1994, 15th International-Diabetes-Federation Congress 1100 :522-528 Author Url

BATES PC, WOODALL SM, CALDER TA, STEWART CEH, JONES AR, PELL JM. 1992. EFFECT OF MODE OF ADMINISTRATION ON INSULIN-LIKE GROWTH FACTOR-I (IGF-I) ACTIVITY JOURNAL OF ENDOCRINOLOGY, 135 :O27-O27 Author Url

PELL JM, SAUNDERS JC, STEWART CEH, GILMOUR RS. 1992. GROWTH-HORMONE (GH) AND NUTRITIONAL CONTROL OF HEPATIC INSULIN-LIKE GROWTH FACTOR-I (IGF-1) PRODUCTION IN THE LAMB JOURNAL OF PHYSIOLOGY-LONDON, 446 :P300-P300 Author Url

Erskine RM, Jones DA, Williams AG, Stewart CE, Degens H. ACE, ACTN3 and PTK2 genotype associations with human skeletal muscle phenotypes and the responses to resistance training. Proceedings of the 16th Annual Congress of the ECSS, European College of Sport Science

McCullough D, Harrison T, Lane K, Boddy L, Stewart C, Enright KJ, Amirabdollahian F, Schmidt M, Davies I. The effect of dietary carbohydrate manipulation on low-density lipoprotein-cholesterol and its associated cardiometabolic risk The Nutrition society Conference, 4th-5th December 2018 DOI Author Url

Patent

Stewart CEH, Pell JM. Use of specific binding molecules in potentiating IGF-I activity Publisher Url

Poster

Webb R, Davies I, McVeigh J, Stewart C, Kean J, Enright K, McCullough D, Alwan N. How a love of muscle can break a heart: The rationale and design of a study investigating lipid-mediated cardiovascular disease in anabolic steroid using bodybuilders Faculty of Education, Health & Community Festival of Research Conference, Place/location of conference:

Engagement & Impact

Research Grants Awarded:

UTS Foundation Matched Funded PhD, The impact of Physical activity and exercise training on physiological and psychosocial outcomes in cancer patients, Ellen Dawson, Zoe Knowles, Claire Stewart, Grant value (£): 32,522, Duration of research project: Three year PhD programme, due to start 1st March 2018. 2018

BBSRC iCASE, Translating effects of dietary flavonoids on energy metabolism into physical activity benefits., Claire Stewart, Helen Jones, Dick Thijssen, Grant value (£): 144,000, Duration of research project: 4. 2016

CCG, Physical activity and physiological adaptations in patients with Cystic Fibrosis, Claire Stewart, Zoe Knowles, Grant value (£): 13,549, Duration of research project: 1. 2016

GSK/LJMU, NSAIDs and muscle injury, Adam Sharples, Graeme Close, Ken van Smoren, Phillip Bell, Grant value (£): £59,100, Duration of research project: 3. 2016

South African Research Council, Mobility Award, Kathy Myburgh, Grant value (£): 25,000 Rand, Duration of research project: 0.5. 2015

RFU/LJMU, Personalising elite training through the use of individualised in-vitro bioengineered ‘mini-muscles, Claire Stewart, Grant value (£): £73,933, Duration of research project: 3. 2015

Aspetar, Cytokines in Academy Players, Grant value (£): £8,740, Duration of research project: 2. 2014

SMS, University of Bangor, Can creatine supplementation improve body composition and physical function in rheumatoid arthritis patients? A randomised controlled pilot trial., O’Brien, T (P.I.), Lemmey, A.B., Maddison, P., Ahmad, Y., Whittaker, R., Grant value (£): £15,000, Duration of research project: 3 years. 2012

Erasmus Mundus, MOVE-AGE. Euros 6,500,000., van Dieen, J (co-ordinator), Verschueren, S & Baltzopoulos, V, Grant value (£): Euros 6,500,000., Duration of research project: 7 years. 2011

SMS, University of Bangor, Genetic markers of Inflammation in Patients Undergoing Hip Surgery., Okoro, T (PI), Lemmey, A.B., Maddison, P., Grant value (£): £16,500., Duration of research project: 2 years. 2011

NDA, Preparatory network for research into the link between socio-ethno-economic grouping, ageing, nutrition and exercise., Pearson G (née Onambélé), Grant value (£): £25,000, Duration of research project: 12 months. 2006

SPARC, Optimisation of skeletal muscle responses and quality of life to exercise in people over 60 years old: Healthy diet vs. dietary supplementation., Pearson, G. (née Onambélé), Grant value (£): £28,245., Duration of research project: 12 months. 2006

Diabetes UK, The role of NEFAs and Adiponectin in the Development of Insulin Resistance and Diabetes in Childhood Obesity., Crowne, E (PI)., Sabin, M.A., Grant value (£): £149,214, Duration of research project: 3 years. 2004

MMU - Internal PhD competition, Growth Factor/Cytokine Interactions in Skeletal Muscle Maintenance., Grant value (£): £225,000, Duration of research project: 7 years. 2004

Choc Willson Memorial Fund, Obesity in Childhood: Mechanisms Determining Insulin Resistance and Adipose Tissue Accumulation Roles of Cytokines and the GH/IGF Axis., Crowne, E. (PI), Shield, J.P., Crown, A., Grant value (£): £53,125, Duration of research project: 4 years. 2001

Pharmacia & Upjohn, Insulin/IGF Hybrid Receptor Status & Insulin Sensitivity in Human Skeletal Muscle., Crown, A., Holly, J.M.P. & Crowne, E. (PI), Grant value (£): £14,732, Duration of research project: 12 months. 2000

Assoc. for International Cancer Research, Are the IGFs Essential for Muscle Cell Differentiation and Survival in Cancer Cachexia?, Crown, A. & Holly, J.M.P., Grant value (£): £105,209, Duration of research project: 3 years. 1999

British Heart Foundation, IGFs, Apoptosis and Myocardial Protection during Ischaemia and Reperfusion., Suleiman, M.-S. (PI), & Holly, J.M.P., Grant value (£): £104,940, Duration of research project: 2 years. 1998

Needham Cooper Trust Fund, Insulin-like Growth Factors in Myocardial Protection., Suleiman, M.-S., Grant value (£): £31,125, Duration of research project: 3 years. 1998

Pharmacia and Upjohn, Insulin/IGF Hybrid Receptor Status and Insulin Sensitivity in Human Skeletal Muscle., Crown, A., Holly, J.M.P. & Crowne, E. (PI), Grant value (£): £14,732, Duration of research project: 12 months. 1998

Conference organisation:

British Society of Research on Ageing: Durham, BSRA local conference co-organiser, https://www.dur.ac.uk/bsi/bsra-durham/. 2016

Northern Vascular Biology Forum, Committee member, http://nvbf.org/. 2015

British Society for Research on Ageing, Conference organiser of 65th Annual meeting in London., https://www.regonline.co.uk/builder/site/Default.aspx?EventID=1667185. 2015

Northern Vascular Biology Forum, Committee member, http://blogs.mhs.manchester.ac.uk/cvpostgrad/2014/09/16/northern-vascular-biology-forum-manchester-8th-december-2014/. 2014

British Society for Research on ageing Annual Meeting, Co-organiser. 2014

Stem Cell Workshop, Co-Organiser. 2013

Manchester Stem Cell Meeting, Conference Organiser, http://www.manchesterstemcell.com/. 2006

Industrial connections:

GSK, PhD co-funded research project: NSAIDS and eccentric damaging exercise.. 2016

Unilever, BBSRC iCASE award: 4 year PhD: 'Translating effects of dietary flavonoids on energy metabolism into physical activity benefits. 2015

External collaboration:

Southampton University, Professor Richard Oreffo. 2015

Stellenbosch University, Professor Katyh Myburgh. 2015

Institute of Ageing and Chronic Disease, Liverpool University, Dan J. Cuthbertson. 2014

Karolinska Institutet, Dr Amarjit Saini. 2013

University of Loughborough, Professor Myra Nimmo. 2011

http://www.lboro.ac.uk/departments/ssehs/staff/professor-mark-lewis-.html, University of Loughborough, Professor Mark lewis. 2010

http://www.bangor.ac.uk/sport/staff-al.php, University of Bangor, Professor Andy Lemmey. 2009

http://www.mrc.soton.ac.uk/index.asp?page=65, University of Southampton, Prof. Avan Aihie Sayer. 2007

http://www.cheshire.mmu.ac.uk/exspsci/staffprofiles/profile.php?id=74, Manchester Metropolitan University, Dr. Gladys Pearson. 2006

http://www.irm.mmu.ac.uk/staff/staff_details/?staff_id=741, MMU, Dr Hans Degens. 2006

http://www.irm.mmu.ac.uk/staff/staff_details/?staff_id=743, MMU, N. Al-Shanti. 2005

http://www.lboro.ac.uk/departments/ssehs/staff/dr-amarjit-saini-.html, University of Loughborough, Dr. A. Saini. 2004

http://www.bristol.ac.uk/fmd/contact/az/personpages/index.html?personKey=Cx6QxvqdjlL1ZXPCI3UFj4knAkEsAc, University of Bristol, Dr. E.C. Crowne. 2001

http://www.bristol.ac.uk/clinical-sciences/people/saadeh--suleiman/index.html, University of Bristol, Professor M. S. Suleiman. 1999

http://www.babraham.ac.uk/pjl_pages/pell/index.html, Babraham Institute, Dr. Jenny pell. 1989

Liverpool University, Prof Francesco Falciani.

University of Liverpool, Prof. P Marray.

External PGR examinations performed:

University of Nottingham, PhD, Shaker Al-Doski. 2015

University of Loughborough, PhD, Mark Turner. 2015

University of Birminh=gham, PhD, Zhe Song. 2015

University of Nottingham, PhD, David Brown. 2014

Membership of professional bodies:

Executive Committee Member, British Society for Research on Ageing. 2014

Committee Member, Mercia Stem Cell Alliance. 2012

Member, BACR.

Member, Bichemical Society.

Member, British Endocrine Society.

Member, Mercia Stem Cell Alliance (MSCA).

Member, Nutrition Society.

Teaching qualification:

Fellow of the Higher Education Academy. 2013

Award:

Fellow of the Higher Education Academy, Higher Education Academy. 2013

PhD, University of London. 1993

Certificate in Immunology, Kings College, London. 1989

BSc Hons - Developmental Biology, University of Glasgow. 1988

Fellowships:

Fellow of the Higher Education Academy, Higher Education Academy. 2013

Other invited event:

Athena Swan Self Assessment Team, MMU, Self Assessment Team member for the Athena Swan Bronze award application by the faculty of Science and Engineering. 2012

MSc Validation, University of Bedford, External Assessor for validation of a new MSc, entitled: (MSc) Molecular and Cellular Exercise Physiology. 2012

BSc external Examiner, University of Bangor, External examiner for Sport and Exercise Science BSC. 2011

External committees:

External Examiner for BSc and HND Sport Science awards, University of Bangor, External Examiner. 2010

Media Coverage:

http://www.dailymail.co.uk/health/diets/article-1251333/Will-keeping-childs-baby-teeth-save-life-day.html, Role of adult stem cells in disease treatment. Daily Mail Interview.

http://www.genengnews.com/gen-articles/stem-cell-studies-go-forward-despite-some-opposition/3147/, Genetic and Engineering Biotechnology News (GEN). Coverage of Skeletal mUscle Stem Cell work. 01.01.2010.

http://www.independent.co.uk/life-style/health-and-families/features/milk-teeth-cureall-or-fairy-tale-1776738.html, The Independent Interview regarding stem cells and cures for diseases..

http://www.prnewswire.co.uk/news-releases/live-longer-live-well-280561342.html, http://www.bsra.org.uk/, http://www.ljmu.ac.uk/newsupdate/viewarticle/1794/, Attendance at the House of Lords, representing the BSRA to raise funds for research on ageing.

BBC Radio Manchester Interview regarding the rolle of tooth stem cells in the cure of disease..

Editorial boards:

Cellular and Molecular Exercise Physiology, Senior Managing Editor, http://www.cellularandmolecularexercisephysiology.com/index.php/CMEP/index.

Other Professional Activity:

Chair of the Life Sciences User Group, LJMU.

Deputy Chair of the Female Professoriate at LJMU.

Faculty of Science Athena Swan committee member.

STEMNET ambassador.