Janine Zylstra

Sport and Exercise Sciences

Journal article

Bott RK, Beckmann K, Zylstra J, Wilkinson MJ, Knight WRC, Baker CR, Kelly M, Maisey N, Waters J, Van Hemelrijck M, Smyth EC, Allum WH, Lagergren J, Gossage JA, Cunningham D, Davies AR. 2021. Adjuvant therapy following neoadjuvant chemotherapy and surgery for oesophageal adenocarcinoma in patients with clear resection margins ACTA ONCOLOGICA, DOI Author Url

Knight WRC, McEwen R, Byrne BE, Habib W, Bott R, Zylstra J, Mahadeva U, Gossage JA. 2020. Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus EJSO, 46 :2257-2261 DOI Author Url

Bott RK, Beckmann K, Zylstra J, Wilkinson MJ, Knight WRC, Baker CR, Kelly M, Maisey N, Qureshi A, Sevitt T, Van Hemelrijck M, Smyth EC, Allum WH, Lagergren J, Gossage JA, Cunningham D, Davies AR, McEwan R, Jacques A, Griffin N, Goh V, Ngan S, Owczarczyk K, Deere H, Green M, Chang F, Mahadeva U, Gill-Barman B, George S, Meenan J, Hill M, Waters J, Cominos M, Hynes O, Coombes A, Tham G, Iezzi C, Reyhani A, Dunn JM, Zeki SS. 2020. Adjuvant therapy following oesophagectomy for adenocarcinoma in patients with a positive resection margin British Journal of Surgery, 107 :1801-1810 DOI Author Url Publisher Url Public Url

Reyhani A, Zylstra J, Davies AR, Gossage JA. 2020. Laparoscopic-assisted left thoracoabdominal esophagectomy (LLTA): an innovative approach for locally advanced tumors of the gastroesophageal junction Diseases of the Esophagus, 33 DOI Author Url

Backemar L, Johar A, Wikman A, Zylstra J, Gossage J, Davies A, Lagergren J, Lagergren P. 2020. The Influence of Comorbidity on Health-Related Quality of Life After Esophageal Cancer Surgery Annals of Surgical Oncology, 27 :2637-2645 DOI Author Url

Rahman SA, Walker RC, Lloyd MA, Grace BL, van Boxel GI, Kingma BF, Ruurda JP, van Hillegersberg R, Harris S, Parsons S, Mercer S, Griffiths EA, O'Neill JR, Turkington R, Fitzgerald RC, Underwood TJ. 2020. Machine learning to predict early recurrence after oesophageal cancer surgery BRITISH JOURNAL OF SURGERY, 107 :1042-1052 DOI Author Url

Jammula SG, Biasci D, Devonshire G, Eldridge MD, Tavaré S, Katz-Summercorn AC, Li X, Linossi C, Smyth E, Killcoyne S, Subash VV, Abbas S, Blasko A, Grantham A, Wronowski F, Grehan N, Fitzgerald RC, O'Donovan M, Noorani A, Edwards PAW, Nutzinger B, Hughes C, Fidziukiewicz E, Bornschein J, MacRae S, Crawte J, Northrop A, Contino G, de la Rue R, Miremadi A, Malhotra S, Tripathi M, Lynch AG, Eldridge M, Secrier M, Bower L, Perner J, Davies J, Crichton C, Carroll N, Safranek P, Hindmarsh A, Sujendran V, Hayes SJ, Ang Y, Preston SR, Oakes S, Bagwan I, Save V, Skipworth RJE, Hupp TR, O'Neill JR, Tucker O, Beggs A, Taniere P, Puig S, Underwood TJ, Noble F, Owsley J, Barr H, Shepherd N, Old O, Lagergren J, Gossage J, Davies A, Chang F, Zylstra J, Mahadeva U, Sanders G, Berrisford R, Harden C, Lewis M, Cheong E, Kumar B, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Igali L, Scott M, Goh V, Ciccarelli FD, Sothi S, Suortamo S, Lishman S, Hanna GB, Moorthy K, Peters CJ, Grabowska A, Turkington R. 2020. Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data Gastroenterology, 158 :1682-1697.e1 DOI Author Url

Moss C, Haire A, Cahill F, Enting D, Hughes S, Smith D, Sawyer E, Davies A, Zylstra J, Haire K, Rigg A, Van Hemelrijck M. 2020. Guy's cancer cohort-real world evidence for cancer pathways BMC Cancer, 20 DOI Author Url

Dellaportas D, Laliotis A, Zylstra J, Davies A, Gossage JA. 2020. Clinical significance of pulmonary nodules in decision-making and management of patients diagnosed with esophageal cancer Diseases of the Esophagus, 33 DOI Author Url

Knight WRC, Yip C, Wulaningsih W, Jacques A, Griffin N, Zylstra J, Van Hemelrijck M, Maisey N, Gaya A, Baker CR, Kelly M, Gossage JA, Lagergren J, Landau D, Goh V, Davies AR, Ngan S, Qureshi A, Deere H, Green M, Chang F, Mahadeva U, Gill-Barman B, George S, Dunn J, Zeki S, Meenan J, Hynes O, Tham G, Iezzi C. 2019. Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesophagus BJS OPEN, 3 :767-776 DOI Author Url

Mourikis TP, Benedetti L, Foxall E, Temelkovski D, Nulsen J, Perner J, Cereda M, Lagergren J, Howell M, Yau C, Fitzgerald RC, Scaffidi P, Noorani A, Edwards PAW, Elliott RF, Grehan N, Nutzinger B, Hughes C, Fidziukiewicz E, Bornschein J, MacRae S, Crawte J, Northrop A, Contino G, Li X, de la Rue R, Katz-Summercorn A, Abbas S, Loureda D, O'Donovan M, Miremadi A, Malhotra S, Tripathi M, Tavare S, Lynch AG, Eldridge M, Secrier M, Bower L, Devonshire G, Jammula S, Davies J, Crichton C, Carroll N, Safranek P, Hindmarsh A, Sujendran V, Hayes SJ, Ang Y, Sharrocks A, Preston SR, Oakes S, Bagwan I, Save V, Skipworth RJE, Hupp TR, O'Neill JR, Tucker O, Beggs A, Taniere P, Puig S, Underwood TJ, Walker RC, Grace BL, Barr H, Shepherd N, Old O, Gossage J, Davies A, Chang F, Zylstra J, Mahadeva U, Goh V, Sanders G, Berrisford R, Harden C, Lewis M, Cheong E, Kumar B, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Igali L, Scott M, Sothi S, Suortamo S, Lishman S, Hanna GB, Peters CJ, Moorthy K, Grabowska A, Turkington R, McManus D, Khoo D, Fickling W, Ciccarelli FD. 2019. Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma NATURE COMMUNICATIONS, 10 DOI Author Url

Frankell AM, Jammula S, Li X, Contino G, Killcoyne S, Abbas S, Perner J, Bower L, Devonshire G, Cocks E, Grehan N, Mok J, O'Donovan M, MacRae S, Eldridge MD, Tavare S, Fitzgerald RC, Noorani A, Edwards PAW, Grehanl N, Nutzinger B, Hughes CI, Fidziukiewicz E, Northrop A, de la Rue R, Katz-Summercorn A, Loureda D, Miremadi A, Malhotra S, Tripathi M, Lynch AG, Eldridge M, Secrier M, Davies J, Crichton C, Carro N, Safranek P, Hindmarsh A, Sujendran V, Hayes SJ, Ang Y, Sharrocks A, Preston SR, Oakes S, Bagwan I, Save V, Skipworth RJE, Hupp TR, ONeill JR, Tucker O, Beggs A, Taniere P, Puig S, Underwood T, Walker RC, Grace BL, Barr H, Shepherd N, Old O, Lagergren J, Gossage J, Davies A, Chang F, Zylstra J, Mahadeva U, Goh V, Ciccarelli FD, Sanders G, Berrisford R, Harden C, Lewis M, Cheong E, Kumar B, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Igali L, Scott M, Sothi S, Suortamo S, Lishman S, Hanna GB, Moorthy K, Peters CJ, Grabowska A, Turkington R, McManus D, Coleman H, Khoo D, Fickling W. 2019. The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic NATURE GENETICS, 51 :506-+ DOI Author Url

Garcia E, Hayden A, Birts C, Britton E, Rogerson C, Bleaney CW, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ, MacRae S, Grehan N, Abdullahi Z, de la Rue R, Noorani A, Elliott RF, de Silva N, Bornschein J, O'Donovan M, Contino G, Yang T-P, Chettouh H, Crawte J, Nutzinger B, Edwards PAW, Smith L, Miremadi A, Malhotra S, Cluroe A, Hardwick R, Davies J, Ford H, Gilligan D, Safranek P, Hindmarsh A, Sujendran V, Carroll N, Turkington R, Hayes SJ, Ang Y, Preston SR, Oakes S, Bagwan I, Save V, Skipworth RJE, Hupp TR, O'Neill JR, Tucker O, Taniere P, Owsley J, Crichton C, Schusterreiter C, Barr H, Shepherd N, Old O, Lagergren J, Gossage J, Davies A, Chang F, Zylstra J, Sanders G, Berrisford R, Harden C, Bunting D, Lewis M, Cheong E, Kumar B, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Eneh V, Igali L, Welch I, Scott M, Sothi S, Suortamo S, Lishman S, Beardsmore D, Anderson C, Smith ML, Secrier M, Eldridge MD, Bower L, Achilleos A, Lynch AG, Tavare S. 2019. Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1 (vol 6, 32417, 2016) SCIENTIFIC REPORTS, 9 DOI Author Url

Dellaportas D, Zylstra J, Gossage J, Baker C, Kelly M, Van Hemelrijck M, Griffin N, Lagergren J, Davies AR. 2019. The prognostic role of pre-operative positron emission tomography-computed tomography and endoscopic ultrasound parameters in oesophageal adenocarcinoma Chirurgia (Romania), 114 :443-450 DOI Author Url

Zylstra J, Boshier P, Whyte GP, Low DE, Davies AR. 2018. Peri-operative patient optimization for oesophageal cancer surgery - From prehabilitation to enhanced recovery BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 36-37 :61-73 DOI Author Url

Smyth EC, Nyamundanda G, Cunningham D, Fontana E, Ragulan C, Tan IB, Lin SJ, Wotherspoon A, Nankivell M, Fassan M, Lampis A, Hahne JC, Davies AR, Lagergren J, Gossage JA, Maisey N, Green M, Zylstra JL, Allum WH, Langley RE, Tan P, Valeri N, Sadanandam A. 2018. A seven-Gene Signature assay improves prognostic risk stratification of perioperative chemotherapy treated gastroesophageal cancer patients from the MAGIC trial ANNALS OF ONCOLOGY, 29 :2356-2362 DOI Author Url

Sawas T, Killcoyne S, Iyer PG, Wang KK, Smyrk TC, Kisiel JB, Qin Y, Ahlquist DA, Rustgi AK, Costa RJ, Gerstung M, Fitzgerald RC, Katzka DA. 2018. Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts GASTROENTEROLOGY, 155 :1720-+ DOI Author Url

Davies AR, Myoteri D, Zylstra J, Baker CR, Wulaningsih W, Van Hemelrijck M, Maisey N, Allum WH, Smyth E, Gossage JA, Lagergren J, Cunningham D, Green M. 2018. Lymph node regression and survival following neoadjuvant chemotherapy in oesophageal adenocarcinoma BRITISH JOURNAL OF SURGERY, 105 :1639-1649 DOI Author Url

Knight WRC, Zylstra J, Wulaningsih W, Van Hemelrijck M, Landau D, Maisey N, Gaya A, Baker CR, Gossage JA, Largergren J, Davies AR, Kelly M, Hynes O, Tham G, Iezzi C, Cowie A, Ngan S, Qureshi A, Green M, Griffin N, Jacques A, Goh V, Deere H, Chang F, Mahadeva U, Gill‐Barman B, George S, Dunn J, Zeki S, Meenan J. 2018. Impact of incremental circumferential resection margin distance on overall survival and recurrence in oesophageal adenocarcinoma BJS Open, 2 :229-237 DOI

Davies AR, Zylstra J, Baker CR, Gossage JA, Dellaportas D, Lagergren J, Findlay JM, Puccetti F, El Lakis M, Drummond RJ, Dutta S, Mera A, Van Hemelrijck M, Forshaw MJ, Maynard ND, Allum WH, Low D, Mason RC. 2018. A comparison of the left thoracoabdominal and Ivor-Lewis esophagectomy DISEASES OF THE ESOPHAGUS, 31 DOI Author Url

Kauppila JH, Johar A, Gossage JA, Davies AR, Zylstra J, Lagergren J, Lagergren P. 2018. Health-related quality of life after open transhiatal and transthoracic oesophagectomy for cancer BRITISH JOURNAL OF SURGERY, 105 :230-236 DOI Author Url

Cardillo L, Cahill F, Wylie H, Williams A, Zylstra J, Davies A, Fullwood L, Van Hemelrijck M. 2018. Patients' perspectives on opt-out consent for observational research: Systematic review and focus group British Journal of Nursing, 27 :1321-1329 DOI Author Url

Noble F, Lloyd MA, Turkington R, Griffiths E, O'Donovan M, O'Neill JR, Mercer S, Parsons SL, Fitzgerald RC, Underwood TJ. 2017. Multicentre cohort study to define and validate pathological assessment of response to neoadjuvant therapy in oesophagogastric adenocarcinoma BRITISH JOURNAL OF SURGERY, 104 :1816-1828 DOI Author Url

Knight WRC, Zylstra J, Van Hemelrijck M, Griffin N, Jacques AET, Maisey N, Baker CR, Gossage JA, Largergren J, Davies AR. 2017. Patterns of recurrence in oesophageal cancer following oesophagectomy in the era of neoadjuvant chemotherapy BJS Open, 1 :182-190 DOI

Noorani A, Bornschein J, Lynch AG, Secrier M, Achilleos A, Eldridge M, Bower L, Weaver JMJ, Crawte J, Ong C-A, Shannon N, MacRae S, Grehan N, Nutzinger B, O'Donovan M, Hardwick R, Tavaré S, Fitzgerald RC, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium . 2017. A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy. Genome research, 27 :902-912 DOI Author Url

Fisher RA, Griffiths EA, Evison F, Mason RC, Zylstra J, Davies AR, Alderson D, Gossage JA. 2017. A national audit of colonic interposition for esophageal replacement DISEASES OF THE ESOPHAGUS, 30 DOI Author Url

Bott R, Zylstra J, Whyte G, Davies A. 2017. Exercise Prehabilitation during Neoadjuvant Cancer Treatment in Patients with Gastrointestinal and Thoracic Cancer: A Systematic Review Gastrointestinal Cancer: Research & Therapy, 2 Publisher Url Public Url

Rice TW, Ishwaran H, Blackstone EH, Hofstetter WL, Kelsen DP, Apperson-Hansen C. 2016. Recommendations for clinical staging (cTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals DISEASES OF THE ESOPHAGUS, 29 :913-919 DOI Author Url

Rice TW, Ishwaran H, Kelsen DP, Hofstetter WL, Apperson-Hansen C, Blackstone EH. 2016. Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals DISEASES OF THE ESOPHAGUS, 29 :906-912 DOI Author Url

Rice TW, Ishwaran H, Hofstetter WL, Kelsen DP, Apperson-Hansen C, Blackstone EH. 2016. Recommendations for pathologic staging (pTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals DISEASES OF THE ESOPHAGUS, 29 :897-905 DOI Author Url

Secrier M, Li X, de Silva N, Eldridge MD, Contino G, Bornschein J, MacRae S, Grehan N, O'Donovan M, Miremadi A, Yang T-P, Bower L, Chettouh H, Crawte J, Galeano-Dalmau N, Grabowska A, Saunders J, Underwood T, Waddell N, Barbour AP, Nutzinger B, Achilleos A, Edwards PAW, Lynch AG, Tavare S, Fitzgerald RC. 2016. Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance NATURE GENETICS, 48 :1131-1141 DOI Author Url

Tullie LGC, Sohn H-M, Zylstra J, Mattsson F, Griffin N, Sharma N, Porte F, Ramage L, Cook GJ, Gossage JA, Mason RC, Lagergren J, Davies AR. 2016. A Role for Tumor Volume Assessment in Resectable Esophageal Cancer ANNALS OF SURGICAL ONCOLOGY, 23 :3063-3070 DOI Author Url

Garcia E, Hayden A, Birts C, Britton E, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ. 2016. Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1 Scientific Reports, 6 DOI

Lagergren J, Mattsson F, Zylstra J, Chang F, Gossage J, Mason R, Lagergren P, Davies A. 2016. Extent of Lymphadenectomy and Prognosis After Esophageal Cancer Surgery JAMA SURGERY, 151 :32-39 DOI Author Url

Ross-Innes CS, Becq J, Warren A, Cheetham RK, Northen H, O'Donovan M, Malhotra S, di Pietro M, Ivakhno S, He M, Weaver JMJ, Lynch AG, Kingsbury Z, Ross M, Humphray S, Bentley D, Fitzgerald RC. 2015. Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma NATURE GENETICS, 47 :1038-+ DOI Author Url

Davies AR, Gossage JA, Zylstra JL, Mattsson F, Lagergren J, Maisey N, Smyth EC, Cunningham D, Allum WH, Mason RC. 2015. Reply to RC Turkington et al JOURNAL OF CLINICAL ONCOLOGY, 33 :1089-+ DOI Author Url

Davies AR, Gossage JA, Zylstra J, Mattsson F, Lagergren J, Maisey N, Smyth EC, Cunningham D, Allum WH, Mason RC. 2014. Tumor Stage After Neoadjuvant Chemotherapy Determines Survival After Surgery for Adenocarcinoma of the Esophagus and Esophagogastric Junction JOURNAL OF CLINICAL ONCOLOGY, 32 :2983-+ DOI Author Url

Weaver JMJ, Ross-Innes CS, Shannon N, Lynch AG, Forshew T, Barbera M, Murtaza M, Ong C-AJ, Lao-Sirieix P, Dunning MJ, Smith L, Smith ML, Anderson CL, Carvalho B, O'Donovan M, Underwood TJ, May AP, Grehan N, Hardwick R, Davies J, Oloumi A, Aparicio S, Caldas C, Eldridge MD, Edwards PAW, Rosenfeld N, Tavare S, Fitzgerald RC. 2014. Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis NATURE GENETICS, 46 :837-843 DOI Author Url

Hellstadius Y, Lagergren J, Zylstra J, Gossage J, Davies A, Hultman CM, Lagergren P, Wikman A. A longitudinal assessment of psychological distress after oesophageal cancer surgery ACTA ONCOLOGICA, 56 :746-752 DOI Author Url

Hellstadius Y, Lagergren J, Zylstra J, Gossage J, Davies A, Hultman CM, Lagergren P, Wikman A. Prevalence and predictors of anxiety and depression among esophageal cancer patients prior to surgery DISEASES OF THE ESOPHAGUS, 29 :1128-1134 DOI Author Url

Conference publication

Zylstra J, Davies AR, Pate J, Tham G, Maisey N, Baker CR, Kelly M, Gossage J, Browning M, Whyte G. 2019. Feasibility Of Exercise Prehabilitation During Neo-adjuvant Chemotherapy In Oesophago-gastric Cancer Surgery MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Annual Meeting of the American-College-of-Sports-Medicine (ACSM) 51 :427-427 DOI Author Url

Thesis/Dissertation

Zylstra J. STRUCTURED EXERCISE DURING NEO-ADJUVANT CHEMOTHERAPY IN PATIENTS WITH OPERABLE ADENOCARCINOMA OF THE OESOPHAGUS AND GASTRO-OESOPHAGEAL JUNCTION Whyte G, Boddy L, Davies AR. Public Url

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