Liverpool Skylilne

Sport and Exercise Sciences

Prof Jatin Burniston

Prof Jatin Burniston

Telephone: 0151 904 6265

Biography

My research interests centre on the use of proteomics to study muscle adaptation in the context of exercise training and the health benefits of exercise against non-communicable diseases and ageing. I established the first proteomics facility with a specific focus on exercise physiology and we published the first work reporting proteomic analysis of the responses of muscle to exercise training.

I strive to continue pioneering the field of exercise proteomics, and I consider myself a champion of the application of non-targeted '-omic' research in exercise physiology.

I serve on the Editorial Board of the American Physiological Society (APS) journal, Physiological Genomics, and I am a Fellow of the European College of Sports Sciences (ECSS) and a member of the ECSS Scientific Committee.

I lead the MSc Exercise Physiology programme at LJMU and I deliver the “Molecular Exercise Physiology" module, which includes practical training in wet laboratory techniques including proteomics. I contributed to the indicative text in this area, entitled "Molecular Exercise Physiology: An Introduction" and I regularly deliver invited presentations at national and international conferences.

Degrees

2003, Liverpool John Moores University, United Kingdom, PhD
2000, University of Portsmouth, United Kingdom, BSc (Hons)

Publications

Highlighted publications

Camera DM, Burniston JG, Pogson MA, Smiles WJ, Hawley JA. 2017. Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise. FASEB J, 31 :5478-5494 >DOI >Link

Guo H, Isserlin R, Emili A, Burniston JG. 2017. Exercise-responsive phosphoproteins in the heart Journal of Molecular and Cellular Cardiology, 111 :61-68 >DOI

Sollanek KJ, Burniston JG, Kavazis AN, Morton AB, Wiggs MP, Ahn B, Smuder AJ, Powers SK. 2017. Global proteome changes in the rat diaphragm induced by endurance exercise training PLoS ONE, 12 >DOI

Hesketh S, Srisawat K, Sutherland H, Jarvis J, Burniston J. 2016. On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat. Proteomes, 4 >DOI >Link

Burniston JG, Connolly J, Kainulainen H, Britton SL, Koch LG. 2014. Label-free profiling of skeletal muscle using high-definition mass spectrometry PROTEOMICS, 14 :2339-2344 >DOI >Link

Burniston JG, Kenyani J, Gray D, Guadagnin E, Jarman IH, Cobley JN, Cuthbertson DJ, Chen Y-W, Wastling JM, Lisboa PJ, Koch LG, Britton SL. 2014. Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity JOURNAL OF PROTEOMICS, 106 :230-245 >DOI >Link

Burniston JG, Hoffman EP. 2011. Proteomic responses of skeletal and cardiac muscle to exercise. Expert Rev Proteomics, 8 :361-377 >DOI >Link

Burniston JG, Kenyani J, Wastling JM, Burant CF, Qi NR, Koch LG, Britton SL. 2011. Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity. Proteomics, 11 :3369-3379 >DOI >Link

Burniston JG. 2009. Adaptation of the rat cardiac proteome in response to intensity-controlled endurance exercise. Proteomics, 9 :106-115 >DOI >Link

Holloway KV, O'Gorman M, Woods P, Morton JP, Evans L, Cable NT, Goldspink DF, Burniston JG. 2009. Proteomic investigation of changes in human vastus lateralis muscle in response to interval-exercise training. Proteomics, 9 :5155-5174 >DOI >Link

Burniston JG. 2008. Changes in the rat skeletal muscle proteome induced by moderate-intensity endurance exercise. Biochim Biophys Acta, 1784 :1077-1086 >DOI >Link

Journal Articles

Srisawat K, Shepherd SO, Lisboa PJ, Burniston JG. 2017. A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training. Proteomes, 5 >DOI >Link

Camera DM, Burniston JG, Pogson MA, Smiles WJ, Hawley JA. 2017. Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise. FASEB J, 31 :5478-5494 >DOI >Link

Guo H, Isserlin R, Emili A, Burniston JG. 2017. Exercise-responsive phosphoproteins in the heart Journal of Molecular and Cellular Cardiology, 111 :61-68 >DOI

Burniston JG. 2017. How many phosphoproteins does it take to make muscle grow? Journal of Physiology, 595 :5009-5010 >DOI

Sollanek KJ, Burniston JG, Kavazis AN, Morton AB, Wiggs MP, Ahn B, Smuder AJ, Powers SK. 2017. Global proteome changes in the rat diaphragm induced by endurance exercise training PLoS ONE, 12 >DOI

Cobley JN, Ab Malik Z, Morton JP, Close GL, Edwards BJ, Burniston JG. 2016. Age- and Activity-Related Differences in the Abundance of Myosin Essential and Regulatory Light Chains in Human Muscle. Proteomes, 4 >DOI >Link

Hesketh S, Srisawat K, Sutherland H, Jarvis J, Burniston J. 2016. On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat. Proteomes, 4 >DOI >Link

Seetho IW, Ramírez-Torres A, Albalat A, Mullen W, Mischak H, Parker RJ, Craig S, Duffy N, Hardy KJ, Burniston JG, Wilding JPH. 2015. Urinary proteomic profiling in severe obesity and obstructive sleep apnoea with CPAP treatment Sleep Science, 8 :58-67 >DOI

Bowden-Davies K, Connolly J, Burghardt P, Koch LG, Britton SL, Burniston JG. 2015. Label-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity PROTEOMICS, 15 :2342-2349 >DOI >Link

Cobley JN, Moult PR, Burniston JG, Morton JP, Close GL. 2015. Exercise improves mitochondrial and redox-regulated stress responses in the elderly: better late than never! BIOGERONTOLOGY, 16 :249-264 >DOI >Link

Seetho IW, Siwy J, Albalat A, Mullen W, Mischak H, Parker RJ, Craig S, Duffy N, Hardy KJ, Burniston JG, Wilding JPH. 2014. Urinary proteomics in obstructive sleep apnoea and obesity EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44 :1104-1115 >DOI >Link

Burniston JG, Connolly J, Kainulainen H, Britton SL, Koch LG. 2014. Label-free profiling of skeletal muscle using high-definition mass spectrometry PROTEOMICS, 14 :2339-2344 >DOI >Link

Burniston JG, Gramolini AO, Solaro RJ. 2014. Cardiac proteomics BioMed Research International, 2014 >DOI

Burniston JG, Kenyani J, Gray D, Guadagnin E, Jarman IH, Cobley JN, Cuthbertson DJ, Chen Y-W, Wastling JM, Lisboa PJ, Koch LG, Britton SL. 2014. Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity JOURNAL OF PROTEOMICS, 106 :230-245 >DOI >Link

Cobley JN, Sakellariou GK, Owens DJ, Murray S, Waldron S, Gregson W, Fraser WD, Burniston JG, Iwanejko LA, McArdle A, Morton JP, Jackson MJ, Close GL. 2014. Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle FREE RADICAL BIOLOGY AND MEDICINE, 70 :23-32 >DOI >Link

Pullinger SA, Brocklehurst EL, Iveson RP, Burniston JG, Doran DA, Waterhouse JM, Edwards BJ. 2014. Is there a diurnal variation in repeated sprint ability on a non-motorised treadmill? Chronobiol Int, 31 :421-432 >DOI >Link

Malik ZA, Cobley JN, Morton JP, Close GL, Edwards BJ, Koch LG, Britton SL, Burniston JG. 2013. Label-Free LC-MS Profiling of Skeletal Muscle Reveals Heart-Type Fatty Acid Binding Protein as a Candidate Biomarker of Aerobic Capacity. Proteomes, 1 :290-308

Cobley JN, Sakellariou GK, Murray S, Waldron S, Gregson W, Burniston JG, Morton JP, Iwanejko LA, Close GL. 2013. Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle. Longevity & healthspan, 2 :11

Robinson WR, Pullinger SA, Kerry JW, Giacomoni M, Robertson CM, Burniston JG, Waterhouse JM, Edwards BJ. 2013. Does lowering evening rectal temperature to morning levels offset the diurnal variation in muscle force production? Chronobiol Int, 30 :998-1010 >DOI >Link

Burniston JG, Meek TH, Pandey SN, Broitman-Maduro G, Maduro MF, Bronikowski AM, Garland T, Chen Y-W. 2013. Gene expression profiling of gastrocnemius of "minimuscle" mice. Physiol Genomics, 45 :228-236 >DOI >Link

Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJM, Shaw CS. 2013. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5. J Physiol, 591 :657-675 >DOI >Link

Cobley JN, Bartlett JD, Kayani A, Murray SW, Louhelainen J, Donovan T, Waldron S, Gregson W, Burniston JG, Morton JP, Close GL. 2012. PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males. Biogerontology, 13 :621-631 >DOI >Link

Cobley JN, Bartlett JD, Gregson W, Burniston JG, Morton JP, Close GL, Kayani A, Murray SW, Louhelainen J, Donovan T, Waldron S. 2012. PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males Biogerontology, :1-11 >DOI

Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJM, Shaw CS. 2012. Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise. Exp Physiol, 97 :970-980 >DOI >Link

Burniston JG, Hoffman EP. 2011. Proteomic responses of skeletal and cardiac muscle to exercise. Expert Rev Proteomics, 8 :361-377 >DOI >Link

Burniston JG, Kenyani J, Wastling JM, Burant CF, Qi NR, Koch LG, Britton SL. 2011. Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity. Proteomics, 11 :3369-3379 >DOI >Link

Burniston J, Kenyani J, Wastling J, Koch L, Britton S. 2010. Differences in the cardiac proteome in rats selected for either low or high running capacity FASEB JOURNAL, 24 >Link

Burniston JG, Connolly JB. 2010. Characterisation of isoform-specific tryptic peptides of rat cardiac myosin heavy chains using automated liquid chromatography-matrix assisted laser desorption ionisation (LC-MALDI) mass spectrometry. Int J Cardiol, 140 :363-366 >DOI >Link

Watt KI, Judson R, Medlow P, Reid K, Kurth TB, Burniston JG, Ratkevicius A, De Bari C, Wackerhage H. 2010. Yap is a novel regulator of C2C12 myogenesis. Biochem Biophys Res Commun, 393 :619-624 >DOI >Link

Morton JP, Holloway K, Woods P, Cable NT, Burniston J, Evans L, Kayani AC, McArdle A. 2009. Exercise training-induced gender-specific heat shock protein adaptations in human skeletal muscle. Muscle Nerve, 39 :230-233 >DOI >Link

Burniston JG. 2009. Adaptation of the rat cardiac proteome in response to intensity-controlled endurance exercise. Proteomics, 9 :106-115 >DOI >Link

Holloway KV, O'Gorman M, Woods P, Morton JP, Evans L, Cable NT, Goldspink DF, Burniston JG. 2009. Proteomic investigation of changes in human vastus lateralis muscle in response to interval-exercise training. Proteomics, 9 :5155-5174 >DOI >Link

Burniston JG, Connolly JB. 2008. Characterisation of isoform-specific tryptic peptides of rat cardiac myosin heavy chains using automated liquid chromatography-matrix assisted laser desorption ionisation (LC-MALDI) mass spectrometry International Journal of Cardiology,

Burniston JG. 2008. Changes in the rat skeletal muscle proteome induced by moderate-intensity endurance exercise. Biochim Biophys Acta, 1784 :1077-1086 >DOI >Link

Burniston JG, McLean L, Beynon RJ, Goldspink DF. 2007. Anabolic effects of a non-myotoxic dose of the beta2-adrenergic receptor agonist clenbuterol on rat plantaris muscle. Muscle Nerve, 35 :217-223 >DOI >Link

Burniston JG. 2007. Left ventricular assist devices and drug therapy in heart failure. N Engl J Med, 356 :870 >Link

Burniston JG, Tan L-B, Goldspink DF. 2006. Relative myotoxic and haemodynamic effects of the beta-agonists fenoterol and clenbuterol measured in conscious unrestrained rats. Exp Physiol, 91 :1041-1049 >DOI >Link

Burniston JG, Clark WA, Tan L-B, Goldspink DF. 2006. Dose-dependent separation of the hypertrophic and myotoxic effects of the beta(2)-adrenergic receptor agonist clenbuterol in rat striated muscles. Muscle Nerve, 33 :655-663 >DOI >Link

Connolly JB, Burniston JG. 2006. LC-MALDI investigation of membrane-enriched protein fraction of rat heart muscle MOLECULAR & CELLULAR PROTEOMICS, 5 :S12-S12 >Link

Burniston JG, Tan L-B, Goldspink DF. 2005. beta2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle. J Appl Physiol (1985), 98 :1379-1386 >DOI >Link

Burniston JG, Saini A, Tan L-B, Goldspink DF. 2005. Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo. J Mol Cell Cardiol, 39 :395-399 >DOI >Link

Burniston JG, Ellison GM, Clark WA, Goldspink DF, Tan L-B. 2005. Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others. Cardiovasc Toxicol, 5 :355-364 >Link

Burniston JG, Saini A, Tan L-B, Goldspink DF. 2005. Angiotensin II induces apoptosis in vivo in skeletal, as well as cardiac, muscle of the rat. Exp Physiol, 90 :755-761 >DOI >Link

Burniston JG, Chester N, Clark WA, Tan L-B, Goldspink DF. 2005. Dose-dependent apoptotic and necrotic myocyte death induced by the beta2-adrenergic receptor agonist, clenbuterol. Muscle Nerve, 32 :767-774 >DOI >Link

Goldspink DF, Burniston JG, Ellison GM, Clark WA, Tan L-B. 2004. Catecholamine-induced apoptosis and necrosis in cardiac and skeletal myocytes of the rat in vivo: the same or separate death pathways? Exp Physiol, 89 :407-416 >DOI >Link

Tan L-B, Burniston JG, Clark WA, Ng Y, Goldspink DF. 2003. Characterization of adrenoceptor involvement in skeletal and cardiac myotoxicity Induced by sympathomimetic agents: toward a new bioassay for beta-blockers. J Cardiovasc Pharmacol, 41 :518-525 >Link

Goldspink DF, Burniston JG, Tan L-B. 2003. Cardiomyocyte death and the ageing and failing heart. Exp Physiol, 88 :447-458 >Link

Burniston JG, Ng Y, Clark WA, Colyer J, Tan L-B, Goldspink DF. 2002. Myotoxic effects of clenbuterol in the rat heart and soleus muscle. J Appl Physiol (1985), 93 :1824-1832 >DOI >Link

Ng Y, Goldspink DF, Burniston JG, Clark WA, Colyer J, Tan LB. 2002. Characterisation of isoprenaline myotoxicity on slow-twitch skeletal versus cardiac muscle. Int J Cardiol, 86 :299-309 >Link

Books

Wackerhage H. 2014. Molecular Exercise Physiology Routledge 9780415607889

Conference Publication (journal proceedings)

Burniston JG, McLean L, Beynon R, Goldspink D. 2006. Functional, cellular and molecular changes induced in the rat plantaris muscle by a low, non-myotoxic dose of the beta(2)-agonist clenbuterol FASEB JOURNAL, Experimental Biology 2006 Meeting 20 :A808-A808 >Link

Burniston JG, Tan L-B, Goldspink DF. 2006. Relative cardiotoxic and haemodynamic effects of the beta-agonists fenoterol and clenbuterol measured in conscious unrestrained rats JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 28th Annual International-Society-for-Heart-Research North American Section Meeting 40 :1010-1011 >DOI >Link

Burniston J, Tan LB, Goldspink D. 2003. Is the anabolic adrenergic agonist clenbuterol safe? JOURNAL OF SPORTS SCIENCES, 12th Commonwealth International Sport Conference 21 :312-313 >Link

Goldspink D, Burniston J, Cox H, Clark W, Colyer J, Tan LB. 2002. Catecholamine-induced myocyte necrosis in cardiac and skeletal muscles of the rat JOURNAL OF PHYSIOLOGY-LONDON, Conference of the Physiological-Society 543 :99P-100P >Link

Ellison G, Cox H, Goldspink D, Burniston J, Clark W, Tan LB. 2002. The synthetic catecholamine, isoprenaline, induces apoptosis and necrosis in the soleus muscle of the rat JOURNAL OF PHYSIOLOGY-LONDON, Conference of the Physiological-Society 543 :100P-100P >Link

Burniston JG, Tan LB, Goldspink DF. 2002. beta(2)-adrenergic receptor stimulation by clenbuterol in vivo induces apoptosis in the rat heart JOURNAL OF PHYSIOLOGY-LONDON, Conference of the Physiological-Society 543 :38P-39P >Link

Burniston JG, Connolly JB, Kainulainen H, Britton SL, Koch LG. Profiling of skeletal muscle using high-definition mass spectrometry University of Florida Muscle Meeting

Engagement & Impact

Conference organisation:

Conference name: 16th Congress of the European College of Sport Sciences, Position: Member of local organising committee and Scientific committee, Invited symposium speaker, URL: http://www.ecss-congress.eu/2011/

Editorial boards:

Publication: Physiological Genomics, Position: Member of the Editorial Board, URL: http://physiolgenomics.physiology.org/

Publication: Proteomes, Position: Associate Editor, URL: http://www.mdpi.com/journal/proteomes

Publication: BioMed Research International, Position: Invited lead guest editor for a special issue in cardiac proteomics, URL: http://www.hindawi.com/journals/bmri/si/846423/cfp/

Publication: Organelles Proteomics, Position: Editorial Advisory Board, URL: http://www.degruyter.com/view/j/orpr

Publication: Journal of Integrated OMICS, Position: Associate Editor, URL: http://www.jiomics.com/index.php/jio

External collaboration:

Institution: University of Florida, Collaborator: Scott Powers

URL: http://www.liv.ac.uk/infection-and-global-health/staff/jonathan-wastling/, Institution: University of Liverpool, Collaborator: Prof. Jonathan Wastling

URL: http://www.biology.ucr.edu/people/faculty/Garland.html, Institution: University of California-Riverside, Collaborator: Prof. Ted Garland

URL: http://www.sthk.nhs.uk/pages/Departments.aspx?iPageId=7964, Institution: St Helens and Knowsley NHS Trust, Collaborator: Prof. Kevin Hardy

URL: http://www.liv.ac.uk/ageing-and-chronic-disease/staff/john-wilding/, Institution: University of Liverpool, Collaborator: Prof. John Wilding

Institution: University of Jyvaskyla, Collaborator: Prof. Heikki Kainulainen

URL: http://207.96.13.115/research/faculty/bios/cgmr/Hoffman_E.aspx, Institution: Children's National Medical Center, Collaborator: Prof Eric Hoffman Dr Yi-Wen Chen Dr Yetrib Hathout

URL: https://www.physiology.med.umich.edu/research/profiles/sbritton.htm, Institution: University of Michigan, Collaborator: Prof. Steve Briton Prof. Lauren Koch

External PGR examinations performed:

Name of University: Manchester Metropolitan University, Award student examined for: PhD, Thesis title: Structure-Function Relationship and Plasticity in Old Mouse Muscle

External PGR Supervision - completed students:

Name of University: Liverpool John Moores University, Award gained by the student: PhD

Fellowships:

Fellowship title: Honorary Fellow, Organisation: School of Clinical Sciences, University of Liverpool

Membership of professional bodies:

Full member, American Physiological Society, http://www.the-aps.org/

Full member, Biochemical Society, http://www.biochemistry.org/

Full Member, Physiological Society, http://www.physoc.org/

Research Grants Awarded:

Sub-contract on National Institutes of Health R01 AR064189, Mechanisms of exercise protection against ventilator-induced diaphragm dysfunction, Scott K Powers, Grant value (£): 20,000, Duration of research project: 0/6

Teaching qualification:

Title of qualification gained: Fellow of the Higher Education Authority (FHEA)