Liverpool Skylilne

Sport and Exercise Sciences

Prof Jatin Burniston

Prof Jatin Burniston

Telephone: 0151 904 6265

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Biography

My research interests centre on the use of proteomics to study muscle adaptation in the context of exercise training and the health benefits of exercise against non-communicable diseases and ageing. I established the first proteomics facility with a specific focus on exercise physiology and we published the first work reporting proteomic analysis of the responses of muscle to exercise training.

I strive to continue pioneering the field of exercise proteomics, and I consider myself a champion of the application of non-targeted '-omic' research in exercise physiology.

I serve on the Editorial Board of the American Physiological Society (APS) journal, Physiological Genomics, and I am a Fellow of the European College of Sports Sciences (ECSS) and a member of the ECSS Scientific Committee.

I lead the MSc Exercise Physiology programme at LJMU and I deliver the “Molecular Exercise Physiology" module, which includes practical training in wet laboratory techniques including proteomics. I contributed to the indicative text in this area, entitled "Molecular Exercise Physiology: An Introduction" and I regularly deliver invited presentations at national and international conferences.

Degrees

2003, Liverpool John Moores University, United Kingdom, PhD
2000, University of Portsmouth, United Kingdom, BSc (Hons)

Academic appointments

Professor of Proteomics, Liverpool John Moores University, 2015 - present
Reader in Molecular Physiology, Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, 2010 - 2015
Honorary Fellow, School of Clinical Sciences, University of Liverpool, 2010 - present

Publications

Highlighted publications

Camera DM, Burniston JG, Pogson MA, Smiles WJ, Hawley JA. 2017. Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise FASEB JOURNAL, 31 :5478-5494 DOI Author Url Public Url

Guo H, Isserlin R, Emili A, Burniston JG. 2017. Exercise-responsive phosphoproteins in the heart Journal of Molecular and Cellular Cardiology, 111 :61-68 DOI Author Url Public Url

Sollanek KJ, Burniston JG, Kavazis AN, Morton AB, Wiggs MP, Ahn B, Smuder AJ, Powers SK. 2017. global proteome changes in the rat diaphragm induced by endurance exercise training PLoS ONE, 12 DOI Author Url Publisher Url Public Url

Burniston JG. Adaptation of the rat cardiac proteome in response to intensity-controlled endurance exercise. Proteomics, 9 :106-115 DOI Author Url

Holloway KV, O'Gorman M, Woods P, Morton JP, Evans L, Cable NT, Goldspink DF, Burniston JG. Proteomic investigation of changes in human vastus lateralis muscle in response to interval-exercise training. Proteomics, 9 :5155-5174 DOI Author Url

Burniston JG. Changes in the rat skeletal muscle proteome induced by moderate-intensity endurance exercise. Biochim Biophys Acta, 1784 :1077-1086 DOI Author Url

Burniston JG, Hoffman EP. Proteomic responses of skeletal and cardiac muscle to exercise. Expert Rev Proteomics, 8 :361-377 DOI Author Url

Burniston JG, Kenyani J, Wastling JM, Burant CF, Qi NR, Koch LG, Britton SL. Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity. Proteomics, 11 :3369-3379 DOI Author Url

Journal article

Srisawat K, Hesketh K, Cocks M, Strauss J, Edwards BJ, Lisboa PJ, Shepherd S, Burniston JG. 2019. Reliability of Protein Abundance and Synthesis Measurements in Human Skeletal Muscle. Proteomics, :e1900194-e1900194 DOI Author Url Public Url

Pullinger S, Bradley P, Causer J, Ford P, Newlove A, Patel K, Reid K, Doran D, Burniston J, Robertson C, Waterhouse J, Edwards B. 2019. Football-induced fatigue in hypoxia impairs repeated sprint ability and perceptual-cognitive skills. Science and Medicine in Football, DOI Publisher Url Public Url

Pullinger S, Robertson CM, Oakley AJ, Hobbs R, Hughes M, Burniston JG, Edwards BJ. 2019. Effects of an active warm-up on variation in bench press and back squat (upper and lower body measures) Chronobiology International, DOI Author Url

Brotherton EJ, Moseley SE, Langan-Evans C, Pullinger SA, Robertson CM, Burniston JG, Edwards BJ. 2019. Effects of two nights partial sleep deprivation on an evening submaximal weightlifting performance; are 1 h powernaps useful on the day of competition? Chronobiology International, DOI Author Url

Robertson CM, Pullinger SA, Robinson WR, Smith ME, Burniston JG, Waterhouse JM, Edwards BJ. 2018. Is the diurnal variation in muscle force output detected/detectable when multi-joint movements are analysed using the musclelab force–velocity encoder? Chronobiology International, :1-11 DOI Author Url Public Url

Pullinger S, Oksa J, Brocklehurst EL, Iveson RP, Newlove A, Burniston J, Doran DA, Waterhouse J, Edwards B. 2018. Controlling rectal and muscle temperatures: Can we offset diurnal variation in repeated sprint performance? Chronobiology International, 35 :959-968 DOI Author Url

Camera DM, Burniston JG, Pogson MA, Smiles WJ, Hawley JA. 2017. Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise FASEB JOURNAL, 31 :5478-5494 DOI Author Url Public Url

Srisawat K, Shepherd SO, Lisboa PJ, Burniston JG. 2017. A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training. Proteomes, 5 DOI Author Url Public Url

Guo H, Isserlin R, Emili A, Burniston JG. 2017. Exercise-responsive phosphoproteins in the heart Journal of Molecular and Cellular Cardiology, 111 :61-68 DOI Author Url Public Url

Burniston JG. 2017. How many phosphoproteins does it take to make muscle grow? The Journal of Physiology, DOI Author Url Public Url

Sollanek KJ, Burniston JG, Kavazis AN, Morton AB, Wiggs MP, Ahn B, Smuder AJ, Powers SK. 2017. global proteome changes in the rat diaphragm induced by endurance exercise training PLoS ONE, 12 DOI Author Url Publisher Url Public Url

Cobley , Ab Malik , Close G, Morton J, Edwards B, Burniston JG. 2016. Age- and Activity-Related Differences in the Abundance of Myosin Essential and Regulatory Light Chains in Human Muscle Wisniewsk JR. Proteomes, 4 DOI Author Url Publisher Url Public Url

hesketh S, srisawat K, sutherland H, jarvis , Burniston JG. 2016. On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat Proteomes, DOI Author Url Publisher Url Public Url

Bowden-Davies K, Connolly J, Burghardt P, Koch LG, Britton SL, Burniston JG. 2015. Label-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity PROTEOMICS, 15 :2342-2349 DOI Author Url Public Url

Cobley JN, Moult PR, Burniston JG, Morton JP, Close GL. 2015. Exercise improves mitochondrial and redox-regulated stress responses in the elderly: better late than never! BIOGERONTOLOGY, 16 :249-264 DOI Author Url

Seetho IW, Ramírez-Torres A, Albalat A, Mullen W, Mischak H, Parker RJ, Craig S, Duffy N, Hardy KJ, Burniston JG, Wilding JPH. 2015. Urinary proteomic profiling in severe obesity and obstructive sleep apnoea with CPAP treatment Sleep Science, 8 :58-67 DOI Author Url Public Url

Seetho IW, Siwy J, Albalat A, Mullen W, Mischak H, Parker RJ, Craig S, Duffy N, Hardy KJ, Burniston JG, Wilding JPH. 2014. Urinary proteomics in obstructive sleep apnoea and obesity EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44 :1104-1115 DOI Author Url

Burniston JG, Connolly J, Kainulainen H, Britton SL, Koch LG. 2014. Label-free profiling of skeletal muscle using high-definition mass spectrometry PROTEOMICS, 14 :2339-2344 DOI Author Url

Burniston JG, Kenyani J, Gray D, Guadagnin E, Jarman IH, Cobley JN, Cuthbertson DJ, Chen Y-W, Wastling JM, Lisboa PJ, Koch LG, Britton SL. 2014. Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity JOURNAL OF PROTEOMICS, 106 :230-245 DOI Author Url

Cobley JN, Sakellariou GK, Owens DJ, Murray S, Waldron S, Gregson W, Fraser WD, Burniston JG, Iwanejko LA, McArdle A, Morton JP, Jackson MJ, Close GL. 2014. Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle FREE RADICAL BIOLOGY AND MEDICINE, 70 :23-32 DOI Author Url

Burniston JG, Gramolini AO, Solaro RJ. 2014. Cardiac proteomics BioMed Research International, 2014 DOI Author Url

Ab Malik Z, Cobley JN, Morton JP, Close GL, Edwards BJ, Koch LG, Brittons SL, Burniston JG. 2013. Label-Free LC-MS Profiling of Skeletal Muscle Reveals Heart-Type Fatty Acid Binding Protein as a Candidate Biomarker of Aerobic Capacity Proteomes, 1 :290-308 DOI Author Url Publisher Url

Burniston JG, Meek TH, Pandey SN, Broitman-Maduro G, Maduro MF, Bronikowski AM, Garland T, Chen Y-W. 2013. Gene expression profiling of gastrocnemius of "minimuscle" mice. Physiol Genomics, 45 :228-236 DOI Author Url

Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJM, Shaw CS. 2013. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5. J Physiol, 591 :657-675 DOI Author Url

Burniston JG, Connolly JB. 2010. Characterisation of isoform-specific tryptic peptides of rat cardiac myosin heavy chains using automated liquid chromatography-matrix assisted laser desorption ionisation (LC-MALDI) mass spectrometry. Int J Cardiol, 140 :363-366 DOI Author Url

Watt KI, Judson R, Medlow P, Reid K, Kurth TB, Burniston JG, Ratkevicius A, De Bari C, Wackerhage H. 2010. Yap is a novel regulator of C2C12 myogenesis. Biochem Biophys Res Commun, 393 :619-624 DOI Author Url

Burniston JG. 2007. Left ventricular assist devices and drug therapy in heart failure. N Engl J Med, 356 :870 Author Url

Vanderwilt GJ. 2007. Left ventricular assist devices and drug therapy in heart failure NEW ENGLAND JOURNAL OF MEDICINE, 356 :871-871 Author Url

Connolly JB, Burniston JG. 2006. LC-MALDI investigation of membrane-enriched protein fraction of rat heart muscle MOLECULAR & CELLULAR PROTEOMICS, 5 :S12-S12 Author Url

Burniston JG. Adaptation of the rat cardiac proteome in response to intensity-controlled endurance exercise. Proteomics, 9 :106-115 DOI Author Url

Holloway KV, O'Gorman M, Woods P, Morton JP, Evans L, Cable NT, Goldspink DF, Burniston JG. Proteomic investigation of changes in human vastus lateralis muscle in response to interval-exercise training. Proteomics, 9 :5155-5174 DOI Author Url

Morton JP, Holloway K, Woods P, Cable NT, Burniston J, Evans L, Kayani AC, McArdle A. Exercise training-induced gender-specific heat shock protein adaptations in human skeletal muscle. Muscle Nerve, 39 :230-233 DOI Author Url

Burniston JG. Changes in the rat skeletal muscle proteome induced by moderate-intensity endurance exercise. Biochim Biophys Acta, 1784 :1077-1086 DOI Author Url

Burniston JG, McLean L, Beynon RJ, Goldspink DF. Anabolic effects of a non-myotoxic dose of the beta2-adrenergic receptor agonist clenbuterol on rat plantaris muscle. Muscle Nerve, 35 :217-223 DOI Author Url

Burniston JG, Clark WA, Tan L-B, Goldspink DF. Dose-dependent separation of the hypertrophic and myotoxic effects of the beta(2)-adrenergic receptor agonist clenbuterol in rat striated muscles. Muscle Nerve, 33 :655-663 DOI Author Url

Burniston JG, Tan L-B, Goldspink DF. Relative myotoxic and haemodynamic effects of the beta-agonists fenoterol and clenbuterol measured in conscious unrestrained rats. Exp Physiol, 91 :1041-1049 DOI Author Url

Burniston JG, Tan L-B, Goldspink DF. beta2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle. J Appl Physiol (1985), 98 :1379-1386 DOI Author Url

Burniston JG, Saini A, Tan L-B, Goldspink DF. Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo. J Mol Cell Cardiol, 39 :395-399 DOI Author Url

Burniston JG, Saini A, Tan L-B, Goldspink DF. Angiotensin II induces apoptosis in vivo in skeletal, as well as cardiac, muscle of the rat. Exp Physiol, 90 :755-761 DOI Author Url

Burniston JG, Chester N, Clark WA, Tan L-B, Goldspink DF. Dose-dependent apoptotic and necrotic myocyte death induced by the beta2-adrenergic receptor agonist, clenbuterol. Muscle Nerve, 32 :767-774 DOI Author Url

Burniston JG, Ellison GM, Clark WA, Goldspink DF, Tan L-B. Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others. Cardiovasc Toxicol, 5 :355-364 DOI Author Url

Goldspink DF, Burniston JG, Ellison GM, Clark WA, Tan L-B. Catecholamine-induced apoptosis and necrosis in cardiac and skeletal myocytes of the rat in vivo: the same or separate death pathways? Exp Physiol, 89 :407-416 DOI Author Url

Tan L-B, Burniston JG, Clark WA, Ng Y, Goldspink DF. Characterization of adrenoceptor involvement in skeletal and cardiac myotoxicity Induced by sympathomimetic agents: toward a new bioassay for beta-blockers. J Cardiovasc Pharmacol, 41 :518-525 DOI Author Url

Goldspink DF, Burniston JG, Tan L-B. Cardiomyocyte death and the ageing and failing heart. Exp Physiol, 88 :447-458 DOI Author Url

Burniston JG, Ng Y, Clark WA, Colyer J, Tan L-B, Goldspink DF. Myotoxic effects of clenbuterol in the rat heart and soleus muscle. J Appl Physiol (1985), 93 :1824-1832 DOI Author Url

Ng Y, Goldspink DF, Burniston JG, Clark WA, Colyer J, Tan LB. Characterisation of isoprenaline myotoxicity on slow-twitch skeletal versus cardiac muscle. Int J Cardiol, 86 :299-309 DOI Author Url

Pullinger SA, Brocklehurst EL, Iveson RP, Burniston JG, Doran DA, Waterhouse JM, Edwards BJ. Is there a diurnal variation in repeated sprint ability on a non-motorised treadmill? Chronobiol Int, 31 :421-432 DOI Author Url

Robinson WR, Pullinger SA, Kerry JW, Giacomoni M, Robertson CM, Burniston JG, Waterhouse JM, Edwards BJ. Does lowering evening rectal temperature to morning levels offset the diurnal variation in muscle force production? Chronobiol Int, 30 :998-1010 DOI Author Url

Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJM, Shaw CS. Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise. Exp Physiol, 97 :970-980 DOI Author Url

Cobley JN, Bartlett JD, Gregson W, Burniston JG, Morton JP, Close GL, Kayani A, Murray SW, Louhelainen J, Donovan T, Waldron S. PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males Biogerontology, :1-11 DOI

Cobley JN, Bartlett JD, Kayani A, Murray SW, Louhelainen J, Donovan T, Waldron S, Gregson W, Burniston JG, Morton JP, Close GL. PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males. Biogerontology, 13 :621-631 DOI Author Url

Burniston JG, Hoffman EP. Proteomic responses of skeletal and cardiac muscle to exercise. Expert Rev Proteomics, 8 :361-377 DOI Author Url

Burniston JG, Kenyani J, Wastling JM, Burant CF, Qi NR, Koch LG, Britton SL. Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity. Proteomics, 11 :3369-3379 DOI Author Url

Burniston J, Kenyani J, Wastling J, Koch L, Britton S. Differences in the cardiac proteome in rats selected for either low or high running capacity FASEB JOURNAL, 24 Author Url

Burniston JG, Connolly JB. Characterisation of isoform-specific tryptic peptides of rat cardiac myosin heavy chains using automated liquid chromatography-matrix assisted laser desorption ionisation (LC-MALDI) mass spectrometry International Journal of Cardiology,

Cobley JN, Sakellariou GK, Murray S, Waldron S, Gregson W, Burniston JG, Morton JP, Iwanejko LA, Close GL. Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle Longevity and Healthspan, 11 :1-8 DOI Author Url

Pullinger S, Oska J, Clark L, Guyatt JWF, Newlove A, Burniston J, Doran D, Waterhouse J, Edwards B. Diurnal Variation in repeated sprint performance cannot be offset when rectal and muscle temperatures are at optimal levels (38.5 C) Chronobiology International, DOI Author Url

Kusić D, Connolly J, Kainulainen H, Semenova E, Borisov O, Larin A, Popov D, Generozov E, Ahmetov I, Britton S, Koch L, Burniston J. Striated muscle-specific serine/threonine-protein kinase beta (SPEGβ) segregates with high- versus low-responsiveness to endurance exercise training Physiological Genomics, DOI Author Url Publisher Url Public Url

Book

Wackerhage H. 2014. Molecular Exercise Physiology Routledge 9780415607889 Publisher Url

Conference publication

Burniston JG, Tan L-B, Goldspink DF. 2006. Relative cardiotoxic and haemodynamic effects of the beta-agonists fenoterol and clenbuterol measured in conscious unrestrained rats JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 28th Annual International-Society-for-Heart-Research North American Section Meeting 40 :1010-1011 DOI Author Url

Burniston JG, McLean L, Beynon R, Goldspink D. 2006. Functional, cellular and molecular changes induced in the rat plantaris muscle by a low, non-myotoxic dose of the beta(2)-agonist clenbuterol FASEB JOURNAL, Experimental Biology 2006 Meeting 20 :A808-A808 Author Url

Burniston J, Tan LB, Goldspink D. 2003. Is the anabolic adrenergic agonist clenbuterol safe? JOURNAL OF SPORTS SCIENCES, 12th Commonwealth International Sport Conference 21 :312-313 Author Url

Burniston JG, Tan LB, Goldspink DF. 2002. beta(2)-adrenergic receptor stimulation by clenbuterol in vivo induces apoptosis in the rat heart JOURNAL OF PHYSIOLOGY-LONDON, Conference of the Physiological-Society 543 :38P-39P Author Url

Goldspink D, Burniston J, Cox H, Clark W, Colyer J, Tan LB. 2002. Catecholamine-induced myocyte necrosis in cardiac and skeletal muscles of the rat JOURNAL OF PHYSIOLOGY-LONDON, Conference of the Physiological-Society 543 :99P-100P Author Url

Ellison G, Cox H, Goldspink D, Burniston J, Clark W, Tan LB. 2002. The synthetic catecholamine, isoprenaline, induces apoptosis and necrosis in the soleus muscle of the rat JOURNAL OF PHYSIOLOGY-LONDON, Conference of the Physiological-Society 543 :100P-100P Author Url

Burniston JG, Connolly JB, Kainulainen H, Britton SL, Koch LG. Profiling of skeletal muscle using high-definition mass spectrometry University of Florida Muscle Meeting

Engagement & Impact

Editorial boards:

Physiological Genomics, Member of the Editorial Board, http://physiolgenomics.physiology.org/. 2015

Proteomes, Associate Editor, http://www.mdpi.com/journal/proteomes. 2015

BioMed Research International, Invited lead guest editor for a special issue in cardiac proteomics, http://www.hindawi.com/journals/bmri/si/846423/cfp/. 2014

Organelles Proteomics, Editorial Advisory Board, http://www.degruyter.com/view/j/orpr. 2013

Journal of Integrated OMICS, Associate Editor, http://www.jiomics.com/index.php/jio. 2010

External PGR examinations performed:

Manchester Metropolitan University, PhD, Structure-Function Relationship and Plasticity in Old Mouse Muscle. 2015

Research Grants Awarded:

Sub-contract on National Institutes of Health R01 AR064189, Mechanisms of exercise protection against ventilator-induced diaphragm dysfunction, Scott K Powers, Grant value (£): 20,000, Duration of research project: 0/6. 2014

Teaching qualification:

Fellow of the Higher Education Authority (FHEA). 2013

External collaboration:

University of Florida, Scott Powers. 2013

http://www.liv.ac.uk/ageing-and-chronic-disease/staff/john-wilding/, University of Liverpool, Prof. John Wilding. 2011

University of Jyvaskyla, Prof. Heikki Kainulainen. 2011

http://207.96.13.115/research/faculty/bios/cgmr/Hoffman_E.aspx, Children's National Medical Center, Prof Eric Hoffman Dr Yi-Wen Chen Dr Yetrib Hathout. 2010

http://www.biology.ucr.edu/people/faculty/Garland.html, University of California-Riverside, Prof. Ted Garland. 2010

http://www.liv.ac.uk/infection-and-global-health/staff/jonathan-wastling/, University of Liverpool, Prof. Jonathan Wastling. 2009

http://www.sthk.nhs.uk/pages/Departments.aspx?iPageId=7964, St Helens and Knowsley NHS Trust, Prof. Kevin Hardy. 2008

https://www.physiology.med.umich.edu/research/profiles/sbritton.htm, University of Michigan, Prof. Steve Briton Prof. Lauren Koch. 2008

Fellowships:

Honorary Fellow, School of Clinical Sciences, University of Liverpool. 2010

External PGR Supervision - completed students:

Liverpool John Moores University, PhD. 2008

Membership of professional bodies:

Full member, American Physiological Society, http://www.the-aps.org/. 2004

Full member, Biochemical Society, http://www.biochemistry.org/. 2000

Full Member, Physiological Society, http://www.physoc.org/. 2000

Conference organisation:

16th Congress of the European College of Sport Sciences, Member of local organising committee and Scientific committee, Invited symposium speaker, http://www.ecss-congress.eu/2011/.