Dr Matthew Cocks

Sport and Exercise Sciences

Dr Matt Cocks (Reader in Exercise Physiology) is an academic member of staff with teaching duties. Matt's research focuses on three key areas:

1. The skeletal muscle microvasculature and how changes in activity can influence delivery of nutrients to the skeletal muscle.

2. Innovative methods to increase exercise adherence and compliance. In particular Matt's work has focused on 1) the use of high intensity interval training as a time efficient exercise mode, 2) how home-based exercise can be effectively incorporated into guidelines reducing barriers to exercise and 3) the use of mobile health biometrics to increase exercise adherence through improved feedback to participant.

3. Exercise strategies for people with Type 1 diabetes, with the aim of reducing barriers to exercise in this population through the use of innovative exercise protocols, for example fasted exercise and high intensity interval training which we have shown are both effective strategies for maintaining blood glucose levels during exercise in people with Type 1 diabetes.

Highlighted publications

Scott SN, Shepherd SO, Andrews RC, Narendran P, Purewal TS, Kinnafick F, Cuthbertson DJ, Atkinson-Goulding S, Noon T, Wagenmakers AJM, Cocks MS. 2019. A Multidisciplinary Evaluation of a Virtually Supervised Home-Based High-Intensity Interval Training Intervention in People With Type 1 Diabetes. Diabetes Care, DOI Author Url Publisher Url Public Url

Scott SN, Shepherd SO, Hopkins ND, Dawson EA, Strauss JA, Wright DJ, Cooper RG, Kumar P, Wagenmakers AJM, Cocks MS. 2019. Home-HIT improves muscle capillarisation and eNOS/NAD(P)Hoxidase protein ratio in obese individuals with elevated cardiovascular disease risk. Journal of Physiology, DOI Author Url Publisher Url Public Url

Hesketh K, Shepherd SO, Strauss JA, Low DA, Cooper RG, Wagenmakers AJM, Cocks MS. 2019. Passive Heat Therapy in Sedentary Humans Increases Skeletal Muscle Capillarisation and eNOS Content but Not Mitochondrial Density or GLUT4 Content. AJP - Heart and Circulatory Physiology, 317 :H114-H123 DOI Author Url Publisher Url Public Url

Gliemann L, Rytter N, Piil P, Nilton J, Lind T, Nyberg M, Cocks MS, Hellsten Y. 2018. The Endothelial Mechanotransduction Protein Platelet Endothelial Cell Adhesion Molecule-1 Is Influenced by Aging and Exercise Training in Human Skeletal Muscle Frontiers in Physiology, DOI Author Url Publisher Url Public Url

Cocks MS, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe A, Baker TA, Wagenmakers AJM. 2015. Sprint interval and moderate-intensity continuous training have equal benefits on aerobic capacity, insulin sensitivity, muscle capillarisation and endothelial eNOS/NAD(P)Hoxidase protein ratio in obese men The Journal of Physiology, 594 :2307-2321 DOI Author Url Publisher Url Public Url

Journal article

Baumert P, Cocks MS, Strauss JA, Shepherd SO, Drust B, Lake MJ, Stewart CE, Erskine RM. 2022. Polygenic Mechanisms Underpinning the Response to Exercise-Induced Muscle Damage in Humans: in vivo and in vitro Evidence Journal of Cellular Physiology, DOI Author Url Publisher Url Public Url

Tryfonos A, Rasoul D, Sadler D, Shelley J, Mills J, Green DJ, Dawson EA, Cocks MS. 2022. Elevated shear rate-induced by exercise increases eNOS ser(1177) but not PECAM-1 Tyr(713) phosphorylation in human conduit artery endothelial cells European Journal of Sport Science, DOI Author Url Publisher Url Public Url

Hesketh KL, Low J, Andrews R, Jones CA, Jones H, Jung ME, Little J, Mateus C, Pulsford R, Singer J, Sprung VS, McManus AM, Cocks MS. 2021. Mobile Health Biometrics to Enhance Exercise and Physical Activity Adherence in Type 2 Diabetes (MOTIVATE-T2D): protocol for a feasibility randomised controlled trial BMJ Open, 11 DOI Author Url Publisher Url Public Url

Hesketh KL, Jones H, Kinnafick F, Shepherd SO, Wagenmakers AJM, Strauss JA, Cocks MS. 2021. Home-Based HIIT and Traditional MICT Prescriptions Improve Cardiorespiratory Fitness to a Similar Extent Within an Exercise Referral Scheme for At-Risk Individuals Frontiers in Physiology, 12 DOI Author Url Publisher Url Public Url

Hesketh KL, Church H, Kinnafick F, Shepherd SO, Wagenmakers AJM, Cocks MS, Strauss JA. 2021. Evidence-based vs. social media based high-intensity interval training protocols: Physiological and perceptual responses. PLoS One, 16 DOI Author Url Publisher Url Public Url

Fell JM, Hearris MA, Ellis DG, Moran JEP, Jevons EFP, Owens DJ, Strauss JA, Cocks MS, Louis JB, Shepherd SO, Morton JP. 2021. Carbohydrate improves exercise capacity but does not affect subcellular lipid droplet morphology, AMPK and p53 signalling in human skeletal muscle The Journal of Physiology, DOI Author Url Publisher Url Public Url

Scott SN, Fontana FY, Cocks M, Morton JP, Jeukendrup A, Dragulin R, Wojtaszewski JFP, Jensen J, Castol R, Riddell MC, Stettler C. 2021. Post-exercise recovery for the endurance athlete with type 1 diabetes: a consensus statement The Lancet Diabetes and Endocrinology, 9 :304-317 DOI Author Url Publisher Url Public Url

Baumert P, Temple S, Stanley JM, Cocks MS, Strauss JA, Shepherd SO, Drust B, Lake MJ, Stewart CE, Erskine RM. 2021. Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics. Scientific Reports, 11 DOI Author Url Publisher Url Public Url

Maasar M-F, Turner DC, Gorski PP, Seaborne RA, Strauss JA, Shepherd SO, Cocks MS, Pillon NJ, Zierath JR, Hulton AT, Drust B, Sharples AP. 2021. The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle. Frontiers in Physiology, 12 DOI Author Url Publisher Url Public Url

Tryfonos A, Cocks MS, Rasoul D, Mills J, Green DJ, Dawson EA. 2020. Impact of catheterization on shear-mediated arterial dilation in healthy young men European Journal of Applied Physiology, 120 :2525-2532 DOI Author Url Publisher Url Public Url

Whytock KL, Shepherd SO, Cocks MS, Wagenmakers AJM, Strauss JA. 2020. Young, healthy males and females present cardiometabolic protection against the detrimental effects of a 7-day high-fat high-calorie diet European Journal of Nutrition, DOI Author Url Publisher Url Public Url

Parise G, Murrant CL, Cocks M, Snijders T, Baum O, Plyley MJ. 2020. Capillary facilitation of skeletal muscle function in health and disease Applied Physiology, Nutrition, and Metabolism, 45 :453-462 DOI

Impey SG, Jevons EFP, Mees G, Cocks MS, Strauss JA, Chester N, Laurie I, Target D, Hodgson A, Shepherd SO, Morton JP. 2020. Glycogen Utilization during Running: Intensity, Sex, and Muscle-specific Responses. Medicine and Science in Sports and Exercise, DOI Author Url Publisher Url Public Url

Whytock KL, Parry SA, Turner MC, Woods RM, James LJ, Ferguson RA, Ståhlman M, Borén J, Strauss JA, Cocks MS, Wagenmakers AJM, Hulston CJ, Shepherd SO. 2020. A 7-day high-fat, high-calorie diet induces fibre-specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal muscle Journal of Physiology, 598 :1151-1167 DOI Author Url Publisher Url Public Url

Tryfonos A, Cocks MS, Mills J, Green DJ, Dawson EA. 2020. Exercise-induced vasodilation is not impaired following radial artery catheterization in coronary artery disease patients. Journal of Applied Physiology (1985), 128 :422-428 DOI Author Url Publisher Url Public Url

Roerink SHPP, Cocks MS, Wagenmakers MAEM, Rodighiero RP, Strauss JA, Shepherd SO, Plantinga TS, Thijssen DHJ, Hopman MTE, Pereira AM, Smit JW, Wagenmakers AJM, Netea-Maier RT, Hermus ARMM. 2019. Decreased Aerobic Exercise Capacity After Long-Term Remission From Cushing Syndrome: Exploration of Mechanisms. Journal of Clinical Endocrinology and Metabolism, 105 DOI Author Url Publisher Url Public Url

Srisawat K, Hesketh KL, Cocks MS, Strauss JA, Edwards BJ, Lisboa PJ, Shepherd SO, Burniston JG. 2019. Reliability of Protein Abundance and Synthesis Measurements in Human Skeletal Muscle. Proteomics, 20 DOI Author Url Publisher Url Public Url

Elia A, Wilson OJ, Lees M, Parker PJ, Barlow MJ, Cocks M, O'Hara JP. 2019. Skeletal muscle, haematological and splenic volume characteristics of elite breath-hold divers European Journal of Applied Physiology, 119 :2499-2511 DOI Author Url Publisher Url Public Url

Scott SN, Shepherd SO, Strauss JA, Wagenmakers AJM, Cocks MS. 2019. Home-based high-intensity interval training reduces barriers to exercise in people with type 1 diabetes Experimental Physiology, DOI Author Url Publisher Url Public Url

Scott SN, Shepherd SO, Andrews RC, Narendran P, Purewal TS, Kinnafick F, Cuthbertson DJ, Atkinson-Goulding S, Noon T, Wagenmakers AJM, Cocks MS. 2019. A Multidisciplinary Evaluation of a Virtually Supervised Home-Based High-Intensity Interval Training Intervention in People With Type 1 Diabetes. Diabetes Care, DOI Author Url Publisher Url Public Url

Parry SA, Turner MC, Woods RM, James LJ, Ferguson RA, Cocks M, Whytock KL, Strauss JA, Shepherd SO, Wagenmakers AJM, van Hall G, Hulston CJ. 2019. High-fat overfeeding impairs peripheral glucose metabolism and muscle microvascular eNOS Ser1177 phosphorylation. Journal of Clinical Endocrinology and Metabolism, 105 DOI Author Url Publisher Url Public Url

Hammond KM, Sale C, Fraser W, Tang J, Shepherd SO, Strauss JA, Close GL, Cocks MS, Louis J, Pugh JN, Stewart CE, Sharples AP, Morton JP. 2019. Post-exercise carbohydrate and energy availability induce independent effects on skeletal muscle cell signalling and bone turnover: implications for training adaptation The Journal of Physiology, 597 :4779-4796 DOI Author Url Publisher Url Public Url

Scott SN, Shepherd SO, Hopkins ND, Dawson EA, Strauss JA, Wright DJ, Cooper RG, Kumar P, Wagenmakers AJM, Cocks MS. 2019. Home-HIT improves muscle capillarisation and eNOS/NAD(P)Hoxidase protein ratio in obese individuals with elevated cardiovascular disease risk. Journal of Physiology, DOI Author Url Publisher Url Public Url

Routledge HE, Bradley WJ, Shepherd SO, Cocks MS, Erskine RM, Close GL, Morton JP. 2019. Ultrasound Does Not Detect Acute Changes in Glycogen in Vastus Lateralis of Man. Medicine and Science in Sports and Exercise, DOI Author Url Publisher Url Public Url

Hesketh K, Shepherd SO, Strauss JA, Low DA, Cooper RG, Wagenmakers AJM, Cocks MS. 2019. Passive Heat Therapy in Sedentary Humans Increases Skeletal Muscle Capillarisation and eNOS Content but Not Mitochondrial Density or GLUT4 Content. AJP - Heart and Circulatory Physiology, 317 :H114-H123 DOI Author Url Publisher Url Public Url

Allan R, Sharples AP, Cocks MS, Drust B, Dutton J, Dugdale HF, Mawhinney C, Clucas A, Hawkins W, Morton JP, Gregson W. 2019. Low pre-exercise muscle glycogen availability offsets the effect of post exercise cold water immersion in augmenting PGC-1α gene expression Physiological Reports, DOI Author Url Publisher Url Public Url

Gliemann L, Rytter N, Piil P, Nilton J, Lind T, Nyberg M, Cocks MS, Hellsten Y. 2018. The Endothelial Mechanotransduction Protein Platelet Endothelial Cell Adhesion Molecule-1 Is Influenced by Aging and Exercise Training in Human Skeletal Muscle Frontiers in Physiology, DOI Author Url Publisher Url Public Url

Seaborne RA, Strauss JA, Cocks MS, Shepherd SO, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Mein CA, Sharples AP. 2018. Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining Scientific Data, 5 DOI Author Url Publisher Url Public Url

Scott SN, Cocks MS, Andrews RC, Narendran P, Purewal TS, Cuthbertson DJ, Wagenmakers AJM, Shepherd SO. 2018. Hit Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People with Type 1 Diabetes. Journal of Clinical Endocrinology & Metabolism, DOI Author Url Publisher Url Public Url

Scott SN, Cocks M, Andrews RC, Narendran P, Purewal TS, Cuthbertson DJ, Wagenmakers AJM, Shepherd SO. 2018. Fasted High-Intensity Interval and Moderate-Intensity Exercise do not Lead to Detrimental 24-Hour Blood Glucose Profiles. Journal of Clinical Endocrinology and Metabolism, 104 :111-117 DOI Author Url Publisher Url Public Url

Seaborne RA, Strauss JA, Cocks MS, Shepherd SO, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP. 2018. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy Scientific Reports, 8 DOI Author Url Publisher Url Public Url

Shepherd SO, Cocks MS, Meikle PJ, Mellett NA, Ranasinghe AM, Barker TA, Wagenmakers AJM, Shaw CS. 2017. Lipid droplet remodelling and reduced muscle ceramides following sprint interval and moderate-intensity continuous exercise training in obese males. International Journal of Obesity, DOI Author Url Publisher Url Public Url

Bradley WJ, Hannon MP, Benford V, Morehen JC, Twist C, Shepherd SO, Cocks MS, Impey SG, Cooper RG, Morton JP, Close GL. 2017. Metabolic demands and replenishment of muscle glycogen after a rugby league match simulation protocol. Journal of Science and Medicine in Sport, DOI Author Url Publisher Url Public Url

Bradley WJ, Morehen JC, Haigh J, Clarke J, Donovan TF, Twist C, Cotton C, Shepherd S, Cocks M, Sharma A, Impey SG, Cooper RG, Maclaren DPM, Morton JP, Close GL. 2016. Muscle glycogen utilisation during Rugby match play: Effects of pre-game carbohydrate Journal of Science and Medicine in Sport, 19 :1033-1038 DOI Author Url

Cocks MS, Wagenmakers AJM. 2015. The effect of different training modes on skeletal muscle microvascular density and endothelial enzymes controlling NO availability The Journal of Physiology, DOI Author Url Publisher Url Public Url

Cocks MS, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe A, Baker TA, Wagenmakers AJM. 2015. Sprint interval and moderate-intensity continuous training have equal benefits on aerobic capacity, insulin sensitivity, muscle capillarisation and endothelial eNOS/NAD(P)Hoxidase protein ratio in obese men The Journal of Physiology, 594 :2307-2321 DOI Author Url Publisher Url Public Url

Wagenmakers AJM, Strauss JA, Shepherd SO, Keske MA, Cocks M. 2015. Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing. Journal of Physiology, :1-16 DOI Author Url Publisher Url Public Url

Cocks MS, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe AM, Barker TA, Tipton KD, Wagenmakers AJM. 2014. Effect of Resistance Training on Microvascular Density and eNOS Content in Skeletal Muscle of Sedentary Men MICROCIRCULATION, 21 :738-746 DOI Author Url Publisher Url Public Url

Bradley H, Shaw CS, Worthington PL, Shepherd SO, Cocks MS, Wagenmakers AJM. 2014. Quantitative immunofluorescence microscopy of subcellular GLUT4 distribution in human skeletal muscle: effects of endurance and sprint interval training. Physiological Reports, 2 DOI Author Url Publisher Url Public Url

Shepherd SO, Cocks M, Tipton KD, Witard OC, Ranasinghe AM, Barker TA, Wagenmakers AJM, Shaw CS. 2014. Resistance training increases skeletal muscle oxidative capacity and net intramuscular triglyceride breakdown in type I and II fibres of sedentary males EXPERIMENTAL PHYSIOLOGY, 99 :894-908 DOI Author Url

Cocks M, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe AM, Barker TA, Tipton KD, Wagenmakers AJM. 2013. Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males. J Physiol, 591 :641-656 DOI Author Url Publisher Url Public Url

Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJM, Shaw CS. 2013. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5. J Physiol, 591 :657-675 DOI Author Url

Cocks M, Shepherd SO, Shaw CS, Achten J, Costa ML, Wagenmakers AJM. 2012. Immunofluorescence microscopy to assess enzymes controlling nitric oxide availability and microvascular blood flow in muscle. Microcirculation, 19 :642-651 DOI Author Url

Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJM, Shaw CS. 2012. Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise. Exp Physiol, 97 :970-980 DOI Author Url

Cocks MS, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe A, baker TA, Wagenmakers AJM. Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males. The Journal of Physiology,

Chapters

Scott SN, Cocks M, Wagenmakers AJM, Shepherd SO, Riddell MC. 2020. Biochemistry of exercise training and type 1 diabetes The Routledge Handbook on Biochemistry of Exercise :479-498 9780367223830

Other

Baumert P, Temple S, Stanley JM, Cocks M, Strauss JA, Shepherd SO, Drust B, Lake MJ, Stewart CE, Erskine RM. 2019. Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics DOI

Conference publication

Tryfonos A, Rodighiero R, Cocks M, Mills J, Green DJ, Dawson EA. 2019. Vascular Responses To Acute Exercise Following Catheterization-induced Damage In Humans. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Annual Meeting of the American-College-of-Sports-Medicine (ACSM) 51 :806-807 DOI Author Url

Wagenmakers AJM, Hesketh K, Shepherd SO, Strauss JA, Low DA, Cooper RJ, Cocks M. 2019. Passive Heat Therapy in Sedentary Humans Improves Aerobic Capacity and Insulin Sensitivity via Increases in Skeletal Muscle Capillarisation and eNOS FASEB JOURNAL, Experimental Biology Meeting (EB) 33 Author Url

Scott S, Shepherd S, Hopkins N, Dawson E, Wright D, Cooper B, Wagenmakers A, Cocks M. 2019. Home-Based High-Intensity Interval Training Improves Muscle Capillarisation and eNOS/NAD(P)Hoxidase Protein Ratio in Obese Individuals with Elevated Cardiovascular Disease Risk FASEB JOURNAL, Experimental Biology Meeting (EB) 33 Author Url

Shepherd SO, Cocks M, Mellett NA, Meikle PJ, Wagenmakers AJM, Shaw CS. 2015. Increased PLIN Expression in Skeletal Muscle following Short-Term Exercise Training Is Linked to Lower Ceramide Concentrations and Improved Insulin Sensitivity DIABETES, 75th Scientific Sessions of the American-Diabetes-Association 64 :A77-A77 Author Url

Cocks M, Stride AE, Macdonald R, Shaw CS, Marshall JM, Poucher SM, Wagenmakers AJM. 2015. Impaired Insulin-mediated ser1176 Phosphorylation of eNOS and Elevated NAD(P) Hoxidase Content in Skeletal Muscle Terminal Arterioles of Obese Zucker Rats DIABETES, 75th Scientific Sessions of the American-Diabetes-Association 64 :A521-A521 Author Url

Shepherd S, Cocks M, Ranasinghe A, Barker T, McClean A, Wagenmakers AJM, Shaw CS. 2014. High intensity interval and traditional endurance training both increase insulin sensitivity, V̇O2peak and skeletal muscle perilipin 2 and perilipin 5 content in sedentary obese males Japanese Journal of Physical Fitness and Sports Medicine, 63 :163 DOI

Research Grants Awarded:

Office for Health Improvement & Disparities, Mobile health biometrics to enhance exercise and physical activity adherence for weight management (Motivate_Sefton), Heather Redhead (Active Sefton, Sefton Council); Dr Matthew Cocks, Professor Helen Jones, Dr Lee Graves, Dr Katie Hesketh (all LJMU), Grant value (£): 90,000, Duration of research project: 18 months. 2021

Malaysian government agency: Majlis Amanah Rakyat, (MARA), Effect of Exercise Training on cardiometabolic risk factors in individuals with hypertension, Dr Matthew Cocks, LJMU; Professor Dick Thijssen, LJMU., Grant value (£): 54,300, Duration of research project: 3 years. 2021

Liverpool John Moores University, Faculty of Science, Patient Derived Endothelial Cells: A Model to Increase Our Understanding of Arterial Ageing in Humans, Grant value (£): 66,705. 2015

LJMU ECR Fellowship, Development of endothelial biopsy technique at LJMU, Grant value (£): 3,492.65. 2015

Liverpool John Moores University, High intensity interval training to improve glucose control in diabetes: Efficacy and mechanisms, Grant value (£): 56,205. 2015

NIHR, Acceptability of Home Based High Intensity Interval Training to People with Type II Diabetes, Grant value (£): 313. 2015

Liverpool John Moores University, Why are women at lower risk of obesity-induced insulin resistance and type 2 diabetes than men?, Grant value (£): 56,205. 2015

Diabetes research wellness foundation, Is high intensity interval training an efficient and effective form of exercise for people with type 1 diabetes?, Grant value (£): 19,811.00. 2014

The Physiological Society, The effect of home-based high intensity interval training on microvascular insulin response, Grant value (£): 9,875. 2014

Other invited event:

Physiology 2014, London, Effect of Different Training Modes on Skeletal Muscle Microvascular Density and Endothelial Enzymes Controlling NO Production. 2016

19th Annual Conference of the European Collage of Sport and Exercise Science, Amsterdam, Effect of Different Training Modes on Skeletal Muscle Microvascular Density and Endothelial Enzymes Controlling NO Production. 2015

Award:

YIA winner for oral presentation, European College of Sport and Exercise Sciences. 2011

External collaboration:

Liverpool Centre for Cardiovascular Sciences, Dr Ben Buckley.

University of British Columbia, Professor Ali McManus, Dr Jonathan Little, Dr Mary Jung.

University of Exeter, Dr Rob Andrews.

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