Liverpool Skylilne

Sport and Exercise Sciences

Dr Thomas O'Brien

Dr Thomas O'Brien

Telephone: 0151 904 6262

Publications

Highlighted publications

Kalkman BM, Bar-On L, Cenni F, Maganaris CN, Bass A, Holmes G, Desloovere K, Barton GJ, O'Brien TD. 2018. Medial gastrocnemius muscle stiffness cannot explain the increased ankle joint range of motion following passive stretching in children with cerebral palsy EXPERIMENTAL PHYSIOLOGY, 103 :350-357 DOI Author Url Public Url

Noyes J, Spencer LH, Bray N, Kubis H-P, Hastings RP, Jackson M, O'Brien TD. 2017. Conceptualization of physical exercise and keeping fit by child wheelchair users and their parents. Journal of Advanced Nursing, :1111-1123 DOI Author Url Public Url

Apps C, Sterzing T, O'Brien T, Lake M. 2016. Lower limb joint stiffness and muscle co-contraction adaptations to instability footwear during locomotion Journal of Electromyography and Kinesiology, 31 :55-62 DOI Author Url

Wilkinson TJ, Lemmey AB, Jones JG, Sheikh F, Ahmad YA, Chitale S, Maddison PJ, O'Brien TD. 2016. Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis Patients? A Randomized Controlled Trial Arthritis Care and Research, 68 :729-737 DOI Author Url Public Url

King SL, Vanicek N, O'Brien TD. 2015. Gastrocnemius muscle architecture and Achilles tendon properties influence walking distance in claudicants with peripheral arterial disease. Muscle & nerve, DOI Author Url Public Url

King SL, Vanicek N, O'Brien TD. Dynamic muscle quality of the plantarflexors is impaired in claudicants with peripheral arterial disease and associated with poorer walking endurance Journal of Vascular Surgery, DOI Author Url Public Url

Lemmey AB, Wilkinson T, Clayton B, Sheikh F, Whale J, Jones H, Ahmed Y, Chitale S, Jones J, Maddison PJ, O'Brien TD. Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients Rheumatology, DOI Author Url Public Url

Kalkman B, Bar-On L, Cenni F, Maganaris C, Bass A, Holmes G, Deslovere K, Barton GJ, O'Brien T. Achilles tendon moment arm length is smaller in children with cerebral palsy than in typically developing children Journal of Biomechanics, DOI Author Url Public Url

Journal article

Ackermans TMA, Francksen NC, Casana-Eslava R, Lees C, Baltzopoulos V, Lisboa PJG, Hollands MA, O'Brien TD, Maganaris CN. 2019. A novel multivariate approach for biomechanical profiling of stair negotiation EXPERIMENTAL GERONTOLOGY, 124 DOI Author Url Public Url

Kalkman BM, Holmes G, Bar-On L, Maganaris CN, Barton GJ, Bass A, Wright DM, Walton R, O'Brien TD. 2019. Resistance Training Combined With Stretching Increases Tendon Stiffness and Is More Effective Than Stretching Alone in Children With Cerebral Palsy: A Randomized Controlled Trial Frontiers in Pediatrics, 7 DOI Author Url Publisher Url Public Url

Apps C, Lake M, O'Brien TD, Sterzing T. 2019. Unpredictable shoe midsole perturbations provide an instability stimulus to train ankle posture and motion during forward and lateral gym lunges JOURNAL OF SPORTS SCIENCES, DOI Author Url

Alcock L, O'Brien TD, Vanicek N. 2018. Association between somatosensory, visual and vestibular contributions to postural control, reactive balance capacity and healthy ageing in older women. Health Care for Women International, :1-15 DOI Author Url Publisher Url Public Url

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Mein CA, Sharples AP. 2018. Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining Scientific Data, 5 DOI Author Url Publisher Url Public Url

Schless SH, Cenni F, Bar-On L, Hanssen B, Kalkman B, O'brien T, Aertbeliën E, Van Campenhout A, Molenaers G, Desloovere K. 2018. Medial gastrocnemius volume and echo-intensity after botulinum neurotoxin A interventions in children with spastic cerebral palsy Developmental Medicine and Child Neurology, DOI Author Url Publisher Url Public Url

Bar-On L, Kalkman BM, Cenni F, Schless S-H, Molenaers G, Maganaris CN, Bass A, Holmes G, Barton GJ, O'Brien TD, Desloovere K. 2018. The Relationship Between Medial Gastrocnemius Lengthening Properties and Stretch Reflexes in Cerebral Palsy Frontiers in Pediatrics, 6 DOI Author Url Publisher Url Public Url

Kalkman BM, Bar-On L, Cenni F, Maganaris CN, Bass A, Holmes G, Desloovere K, Barton GJ, O'Brien TD. 2018. Muscle and tendon lengthening behaviour of the medial gastrocnemius during ankle joint rotation in children with cerebral palsy Experimental Physiology, DOI Author Url Publisher Url Public Url

Lemmey AB, Wilkinson TJ, Perkins CM, Nixon LA, Sheikh F, Jones JG, Ahmad YA, O'brien TD. 2018. Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoid arthritis. European Journal of Rheumatology, 5 :160-164 DOI Author Url Publisher Url Public Url

Carruth H, Barton G, Trinca D, Holmes G, Bass A, Baltzopoulos V, Maganaris C, O'Brien TD. 2018. P 065 - Influence of equinus correction on mechanical advantage of the plantarflexors during gait in children with cerebral palsy Gait and Posture, 65 :340-341 DOI Author Url

King SL, Vanicek N, O'Brien TD. 2018. Joint moment strategies during stair descent in patients with peripheral arterial disease and intermittent claudication GAIT & POSTURE, 62 :359-365 DOI Author Url Public Url

Kalkman BM, Bar-On L, Cenni F, Maganaris CN, Bass A, Holmes G, Desloovere K, Barton GJ, O'Brien TD. 2018. Medial gastrocnemius muscle stiffness cannot explain the increased ankle joint range of motion following passive stretching in children with cerebral palsy EXPERIMENTAL PHYSIOLOGY, 103 :350-357 DOI Author Url Public Url

Wilkinson TJ, Lemmey AB, Clayton RJ, Jones JG, O'Brien TD. 2018. The 8-foot up and go test is the best way to assess physical function in the rheumatoid arthritis clinic Rheumatology Advances in Practice, 2 :1-8 DOI Author Url

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP. 2018. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy Scientific Reports, 8 DOI Author Url Publisher Url Public Url

King SL, Vanicek N, O'Brien TD. 2017. Sagittal plane joint kinetics during stair ascent in patients with peripheral arterial disease and intermittent claudication GAIT & POSTURE, 55 :81-86 DOI Author Url Public Url

Apps C, Sterzing T, O'Brien T, Ding R, Lake M. 2017. Biomechanical locomotion adaptations on uneven surfaces can be simulated with a randomly deforming shoe midsole Footwear Science, 9 :65-77 DOI Publisher Url

Noyes J, Spencer LH, Bray N, Kubis H-P, Hastings RP, Jackson M, O'Brien TD. 2017. Conceptualization of physical exercise and keeping fit by child wheelchair users and their parents. Journal of Advanced Nursing, :1111-1123 DOI Author Url Public Url

Long D, Dotan R, Pitt B, McKinlay B, O'Brien TD, Tokuno C, Falk B. 2017. The Electromyographic Threshold in Girls and Women. Pediatric Exercise Science, 29 :84-93 DOI Author Url Publisher Url Public Url

Apps C, Sterzing T, O'Brien T, Lake M. 2016. Lower limb joint stiffness and muscle co-contraction adaptations to instability footwear during locomotion Journal of Electromyography and Kinesiology, 31 :55-62 DOI Author Url

O'Brien TD, Noyes J, Spencer LH, Kubis H-P, Hastings RP, Whitaker R. 2016. Systematic review of physical activity and exercise interventions to improve health, fitness and well-being of children and young people who use wheelchairs. BMJ Open Sport Exerc Med, 2 :e000109-e000109 DOI Author Url Public Url

Wilkinson T, Lemmey A, Sheikh F, Ahmad Y, Chitale S, Jones J, Maddison P, O'Brien TD. 2016. Effects of oral creatine supplementation on body composition and objective physical function in rheumatoid arthritis patients. A randomised controlled trial World Biomedical Frontiers, Publisher Url Public Url

Dotan R, Jenkins G, O'Brien TD, Hansen S, Falk B. 2016. Torque-onset determination: Unintended consequences of the threshold method. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology, 31 :7-13 DOI Author Url Public Url

Wilkinson TJ, Lemmey AB, Jones JG, Sheikh F, Ahmad YA, Chitale S, Maddison PJ, O'Brien TD. 2016. Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis Patients? A Randomized Controlled Trial Arthritis Care and Research, 68 :729-737 DOI Author Url Public Url

Alcock L, O'Brien TD, Vanicek N. 2015. Biomechanical demands of the 2-step transitional gait cycles linking level gait and stair descent gait in older women JOURNAL OF BIOMECHANICS, 48 :4191-4197 DOI Author Url Public Url

King SL, Vanicek N, O'Brien TD. 2015. Gastrocnemius muscle architecture and Achilles tendon properties influence walking distance in claudicants with peripheral arterial disease. Muscle & nerve, DOI Author Url Public Url

Alcock L, O'Brien TD, Vanicek N. 2015. Age-related changes in physical functioning: correlates between objective and self-reported outcomes PHYSIOTHERAPY, 101 :204-213 DOI Author Url Public Url

O'Brien TD, Noyes J, Spencer LH, Kubis H-P, Edwards RT, Bray N, Whitaker R. 2015. Well-being, health and fitness of children who use wheelchairs: Feasibility study protocol to develop child-centred 'keep-fit' exercise interventions JOURNAL OF ADVANCED NURSING, 71 :430-440 DOI Author Url

Apps C, Sterzing T, O'Brien T, Cheung J, Lake M. 2015. Irregular shoe midsole deformations simulate the movement variability of running on uneven surfaces Footwear Science, 7 :S109-S110 DOI

O'Brien TD, Noyes J, Spencer LH, Kubis HP, Hastings RP, Edwards RT, Bray N, Whitaker R. 2014. 'Keep fit' exercise interventions to improve health, fitness and well-being of children and young people who use wheelchairs: Mixed-method systematic review protocol Journal of Advanced Nursing, 70 :2942-2951 DOI

O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN. 2011. Quantification of human muscle specific tension in vivo: A methodologically challenging and some times impossible exercise Journal of Applied Physiology, 110 :1752-1753 DOI Author Url

O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN. 2010. Mechanical properties of the patellar tendon in adults and children. J Biomech, 43 :1190-1195 DOI Author Url

O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN. 2010. In vivo measurements of muscle specific tension in adults and children Experimental Physiology, 95 :202-210 DOI Author Url

O'Brien TD, Noyes J, Spencer LH, KUBIS HP, HASTINGS RP, EDWARDS RT, BRAY N, WHITAKER R. ‘Keep fit’ exercise interventions to improve health, fitness and wellbeing of children and young people who use wheelchairs: Mixed- method systematic review protocol Journal of Advanced Nursing, DOI Author Url

Alcock L, Vanicek N, O'Brien TD. Alterations in gait speed and age do not fully explain the changes in gait mechanics associated with healthy older women. Gait Posture, 37 :586-592 DOI Author Url

Alcock L, Vanicek N, O'Brien TD. Biomechanical demands differentiate transitioning vs. continuous stair ascent gait in older women Clinical Biomechanics, DOI Author Url

Herzog W, Sartorio A, Lafortuna CL, Kanehisa H, Fukunaga T, Dotan R, Falk B, Wood LE, Tonson A, Le Fur Y, Cozzone PJ, Bendahan D, Tolfrey K, Morse CI, O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN, Lambertz D, Grosset J-F, Perot C. Commentaries on Viewpoint: can muscle size fully account for strength differences between children and adults? J Appl Physiol (1985), 110 :1750-1753 DOI Author Url

O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN. Muscle-tendon structure and dimensions in adults and children. J Anat, 216 :631-642 DOI Author Url

O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN. Moment arms of the knee extensor mechanism in children and adults. J Anat, 215 :198-205 DOI Author Url

O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN. The effects of agonist and antagonist muscle activation on the knee extension moment-angle relationship in adults and children. Eur J Appl Physiol, 106 :849-856 DOI Author Url

O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN. Strong relationships exist between muscle volume, joint power and whole-body external mechanical power in adults and children. Exp Physiol, 94 :731-738 DOI Author Url

O'Brien TD, Reeves ND, Baltzopoulos V, Jones DA, Maganaris CN. Assessment of voluntary muscle activation using magnetic stimulation. Eur J Appl Physiol, 104 :49-55 DOI Author Url

King SL, Vanicek N, O'Brien TD. Dynamic muscle quality of the plantarflexors is impaired in claudicants with peripheral arterial disease and associated with poorer walking endurance Journal of Vascular Surgery, DOI Author Url Public Url

Pitt B, Dotan R, Millar J, Long D, Tokuno C, O’Brien T, Falk B. The electromyographic threshold in boys and men European Journal of Applied Physiology, 115 :1273-1281 DOI

Wilkinson TJ. Oral creatine supplementation: A potential adjunct therapy for rheumatoid arthritis patients World Journal of Rheumatology, 4 :22-22 DOI

Lemmey AB, Wilkinson T, Clayton B, Sheikh F, Whale J, Jones H, Ahmed Y, Chitale S, Jones J, Maddison PJ, O'Brien TD. Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients Rheumatology, DOI Author Url Public Url

Wilkinson TJ, Lemmey AB, O'Brien TD, Jones JG. Significant muscle loss following intramuscular corticosteroid injection used to treat active rheumatoid arthritis: a case report Journal of Rheumatology and Orthopedics, 2 :2-2 DOI

Kalkman B, Bar-On L, Cenni F, Maganaris C, Bass A, Holmes G, Deslovere K, Barton GJ, O'Brien T. Achilles tendon moment arm length is smaller in children with cerebral palsy than in typically developing children Journal of Biomechanics, DOI Author Url Public Url

Editorial/letter to the editor

Kalkman BM, Maganaris CN, Bar-On L, O'Brien TD. 2019. Letter to the editor regarding: Effects of cerebral palsy on Achilles tendon moment arm length - Do children with CP have larger or smaller moment arms than typically developing children? Commentary on: Alexander et al JOURNAL OF BIOMECHANICS, 92 :175-177 DOI Author Url

O'Brien TD. 2016. Musculoskeletal Proportionality, Biomechanical Considerations, and Their Contribution to Movement in Adults and Children PEDIATRIC EXERCISE SCIENCE, 28 :210-216 DOI Author Url

O'Brien TD. 2015. Biomechanics and Exercise PEDIATRIC EXERCISE SCIENCE, 27 :34-38 DOI Author Url Public Url

O'Brien TD. Commentary on: Child-Adult Differences in Muscle Activation Pediatr Exerc Sci,

Conference publication

Selvaraj M, Baltzopoulos V, Maganaris C, O'Brien T, Shaw A, Kot P, Cullen J. 2018. Stair fall risk detection using wearable sensors 11th International Conference on the Developments in eSystems Engineering (DESE) DOI Author Url

Wilkinson TJ, Lemmey AB, Sheikh F, Ahmad Y, Chitale S, Jones J, Maddison P, O'Brien TD. 2015. CAN CREATINE SUPPLEMENTATION IMPROVE BODY COMPOSITION AND OBJECTIVE PHYSICAL FUNCTION IN RHEUMATOID ARTHRITIS PATIENTS? A RANDOMIZED CONTROLLED TRIAL RHEUMATOLOGY, Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology 54 :82-82 Author Url

Cook RE, Mathew RG, O'Brien TD, Caine R, Jones JG, Ahmad Y, Lemmey AB. 2015. DEVELOPING AN INSTRUCTIONAL EXERCISE DVD FOR RHEUMATOID ARTHRITIS PATIENTS RHEUMATOLOGY, Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology 54 :144-144 Author Url

Alcock L, O'Brien TD, vanicek N. The effects of healthy ageing processes on the functional measures of level gait

Pain M, O'Brien TD. Active force enhancement as a source of stretch shorten cycle enhancement? American Society of Biomechanic

Alcock L, O'Brien TD, Vanicek N. Musculoskeletal changes in gait variables associated with stair ascent in healthy older women. In the proceedings of the XXIII Congress of the International Society of Biomechanics

O'Brien TD. Are adult muscles intrinsically stronger than those of children? International Society of Biomechanics

Pain M, O'Brien TD. Stretch-shorten cycle enhancement decays with increased coupling time during jumping and iso-velocity knee extensions World Congress of Biomechanics

O'Brien TD. In vivo mechanical properties of the patellar tendon in adults and pre-pubertal children European College of Sport Sciences

Alcock L, O'Brien TD, Vanicek N. KNEE AND ANKLE MECHANICS DIFFERENTIATE BETWEEN THE TRANSITIONAL STEPS OF STAIR DESCENT IN OLDER WOMEN Abstract 015, European Society of Movement Analysis in Adults and Children :40-40

King S, O'Brien TD, Vanicek N. ISOMETRIC AND ISOKINETIC STRENGTH PROFILES OF CLAUDICANTS WITH PERIPHERAL ARTERIAL DISEASE European Society of Movement Analysis in Adults and Children Abstract 037 :65-65

King SL, O'Brien TD, Vanicek N. Gastrocnemii structure and specific tension in claudicants with peripheral arterial disease European College of Sports Science Public Url

Foster RJ, Kalkman BM, Ray E, Maganaris C, Barton G, Baltzopoulos V, Holmes G, Bass A, Trinca D, O'Brien T. Centre of mass control during stair descent in children with cerebral palsy European Academy of Childhood Disability

Other

Apps C, Sterzing T, O'Brien T, Lake M. 2017. A shoe with random midsole deformations increases ankle joint variability and muscle activations during the forward lunge Footwear Science, 9 :S62-S63 DOI Publisher Url

Bar-On L, Kalkman B, Cenni F, O'Brien T, Holmes G, Bass A, Barton GJ, Maganaris C, Schless S, Molenaers G, Desloovere K. 2016. Muscle and tendon properties during fast passive stretch are different in stiff and spastic muscles in children with spastic cerebral palsy Gait and Posture, 49(S2) :11-12 DOI

kalkman B, Bar-On L, Cenni F, Holmes G, Bass A, Maganaris C, Barton G, Desloovere K, O'Brien T. 2016. Passive muscle and tendon properties during ankle joint rotation in children with cerebral palsy Gait and Posture, 49(S2) :133-134 DOI

Kalkman B, Bar-On L, Cenni F, Holmes G, Bass A, Barton GJ, Maganaris C, Desloovere K, O'Brien T. 2016. The effect of cerebral palsy on Achilles tendon moment arm length Gait and Posture, 49(S2) :135-135

Engagement & Impact

Other invited event:

British Society of Surgery in CP, Liverpool, Invited talk. Title: Muscle Architecture and Cerebral Palsy. 2014

Golden Horseshoe Paediatric Research Meeting, St Catherine's, Canada, Invited speaker on scaling of muscle and tendon with growth and maturation. 2013

Musculoskeletal system function across the lifespan: implications for improving performance and preventing injuries, Brunel University London, Invited speaker on developmental changes in muscle. 2013

Award:

Best presentaiton, BASES Biomechanics group. 2014

Experimental Physiology Early Career Author’s Prize. 2010

Research Grants Awarded:

Alder Hey-LJMU match funded PhD studentship competition, Muscle responses to stretching and developing effective interventions in children with cerebral palsy, Costis Maganaris, Gabor Barton,, Grant value (£): £76,473 secured from Alder hey, Duration of research project: 3 years. 2013

National Insitute for Social Care and Health Research, The welling, health and fitness of children with mobility impairments, Grant value (£): 208000. 2011

Action Medical Research, The Role of Morphology and Mechanical Properties of Tendon and its Insertion in the Development of Osgood-Schlatter and Sever's Diseases, Grant value (£): 119,385. 2010

Betsi Cadwaldar University Health Board, Can creatine supplementation improve body composition and physical function in rheumatoid arthritis patients? A pilot randomised control trial, Grant value (£): 17,290.

External PGR Supervision - completed students:

University of Hull, PhD. 2013

External collaboration:

Bangor University, Andy Lemmey.

Brock University, Bareket Falk.

Loughborough University, Matt Pain.

University of Sydney, Natalie Vanicek.

Membership of professional bodies:

Full member, International Society of Biomechanics.