Dr Yusuke Nishimura

Sport and Exercise Sciences

Dr Yusuke Nishimura is a Postdoctoral Research Associate in Muscle Proteomics with a primary interest in the molecular and cellular mechanisms in the regulation of skeletal muscle protein turnover and mass in health and disease. His current research focuses on understanding the mechanisms of facioscapulohumeral muscular dystrophy (FSHD) in collaboration with Prof Jatin Burniston and Dr Yi-Wen Chen (Children’s National Hospital, Washington, D.C., USA). In addition, Yusuke is working on the ART of Healthy Ageing Network-funded project: "Proteome dynamics to inform healthy muscle ageing"

Yusuke serves on the Editorial Board of the American Journal of Physiology - Cell Physiology. He also reviews international peer-reviewed journals, including FASEB Journal, Journal of Cachexia, Sarcopenia and Muscle, American Journal of Physiology - Endocrinology and Metabolism, Journal of Nutrition, Experimental Gerontology, Clinical Nutrition, Clinical Nutrition ESPEN, European Journal of Nutrition, Nutrition & Metabolism, and Biochimie.

Research interests:
FSHD, Skeletal muscle, Protein turnover, Proteomics, Ubiquitin Proteasome System, Cell Signaling, Dietary Protein, Exercise, Ageing

Languages

Japanese
English

Degrees

2022, University of Birmingham, United Kingdom, PhD
2018, University of Birmingham, United Kingdom, MRes
2016, Ritsumeikan University, Japan, BSc

Postgraduate training

Postdoctoral Research Associate in Muscle Proteomics, United Kingdom, Liverpool John Moores University, 2022 - present

Highlighted publications

Nishimura Y, Bittel AJ, Stead CA, Chen Y-W, Burniston JG. 2023. Facioscapulohumeral muscular dystrophy is associated with altered myoblast proteome dynamics Molecular & Cellular Proteomics, 22 DOI Author Url Publisher Url Public Url

Nishimura Y, Chunthorng-Orn J, Lord S, Musa I, Dawson P, Holm L, Lai YC. 2022. Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 muscle cells American Journal of Physiology: Cell Physiology, 323 :C215-C225 DOI Author Url Publisher Url Public Url

Nishimura Y, Jensen M, Bülow J, Thomsen TT, Arimitsu T, van Hall G, Fujita S, Holm L. 2022. Co-ingestion of cluster dextrin carbohydrate does not increase exogenous protein-derived amino acid release or myofibrillar protein synthesis following a whole-body resistance exercise in moderately trained younger males: a double-blinded randomized controlled crossover trial European Journal of Nutrition, DOI Author Url Publisher Url Public Url

Nishimura Y, Højfeldt G, Breen L, Tetens I, Holm L. 2021. Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence. Nutrition research reviews, :1-17 DOI Author Url Publisher Url Public Url

Nishimura Y, Musa I, Holm L, Lai YC. 2021. Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle American Journal of Physiology: Cell Physiology, 321 :C276-C287 DOI Author Url Publisher Url Public Url

Journal article

Nishimura Y, Bittel AJ, Stead CA, Chen Y-W, Burniston JG. 2023. Facioscapulohumeral muscular dystrophy is associated with altered myoblast proteome dynamics Molecular & Cellular Proteomics, 22 DOI Author Url Publisher Url Public Url

Nishimura Y, Chunthorng-Orn J, Lord S, Musa I, Dawson P, Holm L, Lai YC. 2022. Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 muscle cells American Journal of Physiology: Cell Physiology, 323 :C215-C225 DOI Author Url Publisher Url Public Url

Nishimura Y, Jensen M, Bülow J, Thomsen TT, Arimitsu T, van Hall G, Fujita S, Holm L. 2022. Co-ingestion of cluster dextrin carbohydrate does not increase exogenous protein-derived amino acid release or myofibrillar protein synthesis following a whole-body resistance exercise in moderately trained younger males: a double-blinded randomized controlled crossover trial European Journal of Nutrition, DOI Author Url Publisher Url Public Url

Nishimura Y, Højfeldt G, Breen L, Tetens I, Holm L. 2021. Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence. Nutrition research reviews, :1-17 DOI Author Url Publisher Url Public Url

Nishimura Y, Musa I, Holm L, Lai YC. 2021. Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle American Journal of Physiology: Cell Physiology, 321 :C276-C287 DOI Author Url Publisher Url Public Url

Edwards SJ, Smeuninx B, McKendry J, Nishimura Y, Luo D, Marshall RN, Perkins M, Ramsay J, Joanisse S, Philp A, Breen L. 2020. High-dose leucine supplementation does not prevent muscle atrophy or strength loss over 7 days of immobilization in healthy young males American Journal of Clinical Nutrition, 112 :1368-1381 DOI Author Url Publisher Url

Højfeldt G, Nishimura Y, Mertz K, Schacht SR, Lindberg J, Jensen M, Hjulmand M, Lind MV, Jensen T, Jespersen AP, Reitelseder S, Tetens I, Holm L. 2020. Daily protein and energy intake are not associated with muscle mass and physical function in healthy older individuals—a cross-sectional study Nutrients, 12 :1-16 DOI Author Url Publisher Url

Luo D, Edwards S, Smeuninx B, McKendry J, Nishimura Y, Perkins M, Philp A, Joanisse S, Breen L. 2020. Immobilization leads to alterations in intracellular phosphagen and creatine transporter content in human skeletal muscle American Journal of Physiology - Cell Physiology, 318 :C34-C44 DOI Author Url Publisher Url

Smeuninx B, Nishimura Y, McKendry J, Limb M, Smith K, Atherton PJ, Breen L. 2019. The effect of acute oral phosphatidic acid ingestion on myofibrillar protein synthesis and intracellular signaling in older males Clinical Nutrition, 38 :1423-1432 DOI Author Url Publisher Url

Yoshii N, Sato K, Ogasawara R, Nishimura Y, Shinohara Y, Fujita S. 2018. Effect of mixed meal and leucine intake on plasma amino acid concentrations in young men Nutrients, 10 DOI Author Url Publisher Url

Other

Nishimura Y, Hojfeldt G, Breen L, Tetens I, Holm L. 2023. Erratum: Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence (Nutrition Research Reviews FirstView (2021) (1-17) DOI: 10.1017/S0954422421000329) Nutrition Research Reviews, 36 :175 DOI Author Url Publisher Url

preprint

Nishimura Y, Bittel A, Stead C, Chen Y-W, Burniston J. 2022. Facioscapulohumeral muscular dystrophy is associated with altered myoblast proteome dynamics bioRxiv DOI Publisher Url

Nishimura Y, Musa I, Dawson P, Holm L, Lai Y-C. 2021. Ubiquitin E3 ligases Atrogin-1 and MuRF1 protein contents are differentially regulated in the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 myotubes bioRxiv DOI Publisher Url

Conference publication

Nishimura Y, Hojfeldt G, Schacht SR, Mertz K, Hjulmand M, Reitelseder S, Lind MV, Tetens I, Holm L. 2020. Impact of daily protein and energy intake and distribution on muscle mass and strength in Danish older individuals-The CALM study Proceedings of the Nutrition Society, 79 DOI Publisher Url

Edwards S, Smeuninx B, McKendry J, Nishimura Y, Perkins M, Ramsay J, Joanisse S, Philp A, Breen L. Leucine Supplementation Does Not Attenuate Metabolic Or Functional Declines Following 7-days Of Unilateral Lower-limb Immobilisation Medicine and Science in Sports and Exercise, The American College of Sports Medicine 52 :507-507 DOI Author Url Publisher Url

Kido K, Ato S, Nishimura Y, Yokokawa T, Sato K, Fujita S. Chronic Resistance Training-Induced Increase in Insulin-Stimulated Akt Activation and GLUT4 Translocation Is Associated with APPL1 Expression in Skeletal Muscle of Type 2 Diabetic Rat Diabetes, 77th Scientific Sessions of the American-Diabetes-Association 66 :A191-A191 Author Url

Media Coverage:

ASBMB TODAY - Journal News 2024

Muscular Dystrophy UK, News, Blogs, and Stories 2023

Muscular Dystrophy UK, News, Blogs, and Stories 2023

External committees:

Pool of Experts, UKRI BBSRC, A member of the Pool of Experts. 2024

Award:

VC Award for Excellence - Rising Star (Faculty of Science Winner), Liverpool John Moores University. 2023

Nutrition Research Reviews - Paper of the Month for April, The Nutrition Society, https://www.cambridge.org/core/blog/2022/04/26/dietary-protein-requirements-and-recommendations-why-is-it-so-complex/. 2022

Research Grants Awarded:

The Physiological Society, Unlocking Futures Fund, Grant value (£): 1500. 2023

FSHD Society, Deciphering proteomic signatures of sexual dimorphism in FSHD, Prof Jatin Burniston, Dr Yi-Wen Chen, Dr Adam Bittel, Grant value (£): 71,426 USD, Duration of research project: 1 year. 2023

The Physiological Society, Professional Development Award, Grant value (£): 750. 2023

Institute for Food and Health Science, Yazuya Co., Ltd, Interaction between energy and protein intake on resistance exercise-induced muscle hypertrophy –Systematic review and meta-analysis, Dr Jun Yasuda, Dr Akiko Kamei, Dr Takahiro Yoshizaki, Prof Satoshi Fujita, Grant value (£): 440,000 JPY, Duration of research project: 1 year. 2020

Vanderbilt University, Scholarship for attendance to the 2019 Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis (12th Annual Course), Grant value (£): 400 USD. 2019

The Physiological Society, Travel Grant, Grant value (£): 500. 2019

Conference presentation:

Dynamic proteome profiling uncovers age-related impairments in proteostasis in human skeletal muscle, Healthy Muscle Ageing Conference, Liverpool, UK, Poster presentation. 2023

Impact of daily protein and energy intake and distribution on muscle mass and strength in Danish older individuals-The CALM study, 13th European Nutrition Conference, Dublin, Ireland, Oral presentation. 2019

Other Professional Activity:

FSHD UK, Research Strategy Group. 2023

The Research Communications Group (Muscular Dystrophy UK). 2022

Membership of professional bodies:

Full Member, British Society for Research on Ageing (BSRA). 2023

Early Career Membership, The Biochemical Society.

Full Membership, The Physiological Society.

Postdoctoral Membership, American Physiological Society.

Regular Member, The American Society for Mass Spectrometry.

Editorial boards:

American Journal of Physiology-Cell Physiology, Editorial Board, https://journals.physiology.org/ajpcell/edboard. 2023

American Journal of Physiology-Cell Physiology, Guest Editor of Call for Papers: Mechanism Underlying Diversity in Cancer Cachexia, https://journals.physiology.org/ajpcell/mechanism-underlying-diversity-in-cancer-cachexia.

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