Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Gillian Hutcheon

Dr Gillian Hutcheon

Telephone: 0151 231 2130

Biography

I am leader of the Formulation and Drug Delivery Research Group. The focus of this group is towards the successful delivery of therapeutic agents in a controlled and targeted manner and the development of advanced delivery systems for a variety of applications. Projects ranging from fundamental science to industrially relevant applications are undertaken by postgraduate students and researchers within the group. My research interests include the use of biodegradable polymers for the micro and nanoparticle delivery of drugs and proteins particularly for pulmonary delivery. Specific examples of ongoing projects include the delivery of vaccines, anti-cancer drugs and RNA. The investigation of clays for antimicrobial and modified release therapeutics is a further avenue of research.
I contribute towards the modular delivery of general chemistry, bio-organic chemistry, polymer chemistry and drug delivery topics. My teaching interests concentrate on the integration of teaching and research particularly within final year module and also the development of the final year ACAPS project and research methods module.

Degrees

1996, University of Strathclyde, United Kingdom, PhD: Fundamental studies of protein hydration and solvation in organic media
1993, University of Strathclyde, United Kingdom, B.Sc. (Hons) Forensic and Analytical Chemistry

Publications

Journal Articles

Hutcheon G, Dempster NM, Roberts M, Gaskell EE, Kianfar F. 2017. Lyophilised Biopolymer-Clay Hydrogels for Drug Delivery Journal of Novel Drug Research, 1 >DOI

Alfagih I, Kunda N, Alanazi F, Dennison SR, Somavarapu S, Hutcheon GA, Saleem IY. 2015. Pulmonary Delivery of Proteins Using Nanocomposite Microcarriers JOURNAL OF PHARMACEUTICAL SCIENCES, 104 :4386-4398 >DOI >Link

Kunda NK, Alfagih IM, Miyaji EN, Figueiredo DB, Goncalves VM, Ferreira DM, Dennison SR, Somavarapu S, Hutcheon GA, Saleem IY. 2015. Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles INTERNATIONAL JOURNAL OF PHARMACEUTICS, 495 :903-912 >DOI >Link

Ghazal HS, Dyas AM, Ford JL, Hutcheon GA. 2015. The impact of food components on the intrinsic dissolution rate of ketoconazole DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 41 :1647-1654 >DOI >Link

Kunda NK, Alfagih IM, Dennison SR, Somavarapu S, Merchant Z, Hutcheon GA, Saleem IY. 2015. Dry powder pulmonary delivery of cationic PGA-co-PDL nanoparticles with surface adsorbed model protein INTERNATIONAL JOURNAL OF PHARMACEUTICS, 492 :213-222 >DOI >Link

Kunda NK, Alfagih IM, Dennison SR, Tawfeek HM, Somavarapu S, Hutcheon GA, Saleem IY. 2015. Bovine Serum Albumin Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery via Dry Powder Inhalation PHARMACEUTICAL RESEARCH, 32 :1341-1353 >DOI >Link

Hamilton AR, Hutcheon GA, Roberts M, Gaskell EE. 2014. Formulation and antibacterial profiles of clay-ciprofloxacin composites APPLIED CLAY SCIENCE, 87 :129-135 >DOI >Link

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Gaskell EE, Hutcheon GA. 2014. Evaluation of biodegradable polyester-co-lactone microparticles for protein delivery. Drug Dev Ind Pharm, 40 :1213-1222 >DOI >Link

Jan SU, Khan GM, Hussain I, Gaskell EE, Hutcheon GH. 2013. Synthesis, conjugation and evaluation of some novel polymers and their micro particles for sustained release drug formulations Pakistan Journal of Pharmaceutical Sciences, 26 :741-746

Tawfeek HM, Evans AR, Iftikhar A, Mohammed AR, Shabir A, Somavarapu S, Hutcheon GA, Saleem IY. 2013. Dry powder inhalation of macromolecules using novel PEG-co-polyester microparticle carriers. Int J Pharm, 441 :611-619 >DOI >Link

Kunda NK, Somavarapu S, Gordon SB, Hutcheon GA, Saleem IY. 2013. Nanocarriers targeting dendritic cells for pulmonary vaccine delivery. Pharm Res, 30 :325-341 >DOI >Link

Seton L, Khamar D, Bradshaw I, Hutcheon G. 2012. Processing induced transformations: Phase impurities introduced during hydration/dehydration CHEMICAL ENGINEERING SCIENCE, 77 :57-64 >DOI >Link

Khamar D, Bradshaw IJ, Hutcheon GA, Seton L. 2012. Solid State Transformations Mediated by a Kinetically Stable Form CRYSTAL GROWTH & DESIGN, 12 :109-118 >DOI >Link

Tawfeek H, Khidr SH, Samy EM, Ahmed SM, Hutcheon G, Saleem I. 2011. Effect of PEGylation on spray dried PGA-co-PDL pulmonary carrier microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 :303-334

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Murphy MF, Mohammad A, Shabir A, Hutcheon GA, Saleem IY. 2011. Poly(glycerol adipate-co-ω-pentadecalactone) spray dried microparticles as carriers for pulmonary delivery Pharmacological Research, :1-12 >DOI

Al-Fagih IM, Alanazi FK, Hutcheon GA, Saleem IY. 2011. Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations Drug Delivery Letters, 1 :128-134

Khamar D, Pritchard RG, Bradshaw IJ, Hutcheon GA, Seton L. 2011. Polymorphs of anhydrous theophylline: stable form IV consists of dimer pairs and metastable form I consists of hydrogen-bonded chains. Acta Crystallogr C, 67 :o496-o499 >DOI >Link

Tawfeek H, Khidr S, Samy E, Ahmed S, Murphy M, Mohammed A, Shabir A, Hutcheon G, Saleem I. 2011. Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery Pharmaceutical Research, 28 :2086-2097 >Link

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Akram K, Mohammed AR, Gaskel EE, Hutcheon GA, Saleem IY. 2010. Optimisation of Polyester Based Microparticles as Carriers for Pulmonary Drug Delivery JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 23 :430-430

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Shabir A, Mohammed AR, Hutcheon GA, Saleem I. 2010. Pulmonary delivery of alpha-chymotrypsin via novel polyester microparticles JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1294-1295 >Link

Seton L, Khamar D, Bradshaw IJ, Hutcheon GA. 2010. Solid State Forms of Theophylline: Presenting a New Anhydrous Polymorph CRYSTAL GROWTH & DESIGN, 10 :3879-3886 >DOI >Link

Gaskell EE, Sihanonth P, Rostron C, Hutcheon GA, Hobbs G. 2010. Isolation and identification of mucinolytic actinomycetes. Antonie Van Leeuwenhoek, 97 :211-220 >DOI >Link

Thompson CJ, Hansford D, Higgins S, Rostron C, Hutcheon GA, Munday DL. 2009. Preparation and evaluation of microspheres prepared from novel polyester-ibuprofen conjugates blended with non-conjugated ibuprofen. J Microencapsul, 26 :676-683 >DOI >Link

Thompson CJ, Hansford D, Higgins S, Rostron C, Hutcheon GA, Munday DL. 2009. Preparation and evaluation of microspheres prepared from novel polyester-ibuprofen conjugates blended with non-conjugated ibuprofen. J Microencapsul, :1-8 >DOI

Ghazal HS, Dyas AM, Ford JL, Hutcheon GA. 2009. In vitro evaluation of the dissolution behaviour of itraconazole in bio-relevant media. Int J Pharm, 366 :117-123 >DOI >Link

Puri S, Kallinteri P, Higgins S, Hutcheon GA, Garnett MC. 2008. Drug incorporation and release of water soluble drugs from novel functionalized poly(glycerol adipate) nanoparticles. J Control Release, 125 :59-67 >DOI >Link

Thompson CJ, Hansford D, Munday DL, Higgins S, Rostron C, Hutcheon GA. 2008. Synthesis and evaluation of novel polyester-ibuprofen conjugates for modified drug release. Drug Dev Ind Pharm, 34 :877-884 >DOI >Link

Gaskell EE, Hobbs G, Rostron C, Hutcheon GA. 2008. Encapsulation and release of alpha-chymotrypsin from poly(glycerol adipate-co-omega-pentadecalactone) microparticles. J Microencapsul, 25 :187-195 >DOI >Link

Orafai H, Kallinteri P, Garnett M, Huggins S, Hutcheon G, Pourcain C. 2008. Novel poly (glycerol-adipate) polymers used for nanoparticle making: A study of surface free energy IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 7 :11-19 >Link

Long J, Hutcheon GA, Cooper AI. 2007. Combinatorial discovery of reusable noncovalent supports for enzyme immobilization and nonaqueous catalysis. J Comb Chem, 9 :399-406 >DOI >Link

Thompson CJ, Hansford D, Higgins S, Rostron C, Hutcheon GA, Munday DL. 2007. Evaluation of ibuprofen-loaded microspheres prepared from novel copolyesters. Int J Pharm, 329 :53-61 >DOI >Link

Meng W, Parker TL, Kallinteri P, Walker DA, Higgins S, Hutcheon GA, Garnett MC. 2006. Uptake and metabolism of novel biodegradable poly (glycerol-adipate) nanoparticles in DAOY monolayer. J Control Release, 116 :314-321 >DOI >Link

Thompson CJ, Hansford D, Higgins S, Hutcheon GA, Rostron C, Munday DL. 2006. Enzymatic synthesis and evaluation of new novel omega-pentadecalactone polymers for the production of biodegradable microspheres. J Microencapsul, 23 :213-226 >DOI >Link

Kallinteri P, Higgins S, Hutcheon GA, St Pourçain CB, Garnett MC. 2005. Novel functionalized biodegradable polymers for nanoparticle drug delivery systems. Biomacromolecules, 6 :1885-1894 >DOI >Link

Hutcheon GA, Messiou C, Wyre RM, Davies MC, Downes S. 2001. Water absorption and surface properties of novel poly(ethylmethacrylate) polymer systems for use in bone and cartilage repair. Biomaterials, 22 :667-676 >Link

Hutcheon GA, Parker MC, Moore BD. 2000. Measuring enzyme motility in organic media using novel H-D exchange methodology. Biotechnol Bioeng, 70 :262-269 >Link

Moore BD, Hutcheon GA, Koechlin A. 1998. Probing enzyme active sites in organic solvents using electrospray ionisation mass spectrometry. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 216 :U255-U255 >Link

Hutcheon GA, Downes S, Davies MC. 1998. Interactions of chondrocytes with methacrylate copolymers. J Mater Sci Mater Med, 9 :815-818 >Link

Hutcheon GA, Halling PJ, Moore BD. 1997. [21] Measurement and control of hydration in nonaqueous biocatalysis. Methods Enzymol, 286C :465-472 >DOI

Hutcheon GA, Parker MC, James A, Moore BD. 1997. Methanol dramatically enhances serine protease activity under anhydrous conditions CHEMICAL COMMUNICATIONS, :931-932 >DOI >Link

Hutcheon GA, Halling PJ, Moore BD. 1997. Measurement and control of hydration in nonaqueous biocatalysis Rubin B, Dennis EA. LIPASES, PT B, 286 :465-472 >Link

Partridge J, Hutcheon GA, Moore BD, Halling PJ. 1996. Exploiting hydration hysteresis for high activity of cross-linked subtilisin crystals in acetonitrile JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 118 :12873-12877 >DOI >Link

alfagih I, Alanazi FK, kunda N, hutcheon G, saleem I. Protein loaded nancomposite microparticles for inhalation Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 >DOI

Conference Publication (journal proceedings)

Osman N, Sexton D, Hutcheon G, Saleem I. 2017. COMPARATIVE NANOTOXICOLOGY OF POLYMERIC NANOCARRIERS WITH DIFFERENT SURFACE CHARGE AGAINST HUMAN LUNG EPITHELIAL CELLS JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 30 :A17-A18 >Link

Carini V, Pekoz AY, Hutcheon GA, Saleem IY, Mohamed AA. 2017. DRY POWDER INTENDED FOR PULMONARY DELIVERY: COMPARISON BETWEEN PGA-CO-PDL AND CHITOSAN NANO COMPOSITE MICROPARTICLES JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 30 :A19-A19 >Link

Osman N, Hilal M, Mohamed S, Dawood A, Ritchie K, Saleem I, Hutcheon G. 2016. IN-VITRO STABILITY AND DEGRADATION OF PLGA AND PGA-CO-PDL MICROPARTICLES FOR PULMONARY DRUG DELIVERY JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 29 :A5-A5 >Link

kunda N, alfagih I, Alanazi F, hutcheon G, saleem I. 2015. Comparison of Protein Delivery via Nanocomposite Microcarriers for Pulmonary Vaccine Delivery

Mohamed A, Ross K, Saleem I, Hutcheon G. 2015. Polymeric Nanoparticles For The Pulmonary Delivery Of miRNA To Treat Chronic Obstructive Pulmonary Disease (COPD) Controlled Release Society Annual Meeting

Osman N, Hilal M, Mohamed S, Dawood A, ritchie K, Saleem I, hutcheon G. 2015. In-vitro Stability and Degradation of PLGA and PGA-co-PDL Microparticles for Pulmonary Drug Delivery Drug Delivery to the Lungs

Alfagih IM, Kunda NK, Alanazi FK, Hutcheon GA, Saleem IY. 2015. CATIONIC PGA-CO-PDL NANOCOMPOSITE MICROPARTICLES FOR ANTIGEN DELIVERY VIA INHALATION JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 28 :A16-A16 >Link

Alfagih I, Kunda N, Alanazi F, Hutcheon G, saleem I. 2014. Cationic PGA-co-PDL nanocomposite microparticles for antigen delivery via inhalation

kunda N, Somavarapu S, Gordon SB, Hutcheon G, Saleem I. 2013. Protein Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery AAPS Annual Meeting and Exposition

kunda NK, Alfagih IM, Somavarapu S, Hutcheon GA, Saleem I. 2012. Pulmonary Vaccine Delivery of Protein Adsorbed PGA-co-PDL Nanocomposite Microparticles Drug Delivery to the Lungs - DDL23

Alfagih IM, Alanazi FK, Kunda NK, Hutcheon GA, Saleem IY. 2012. Protein Loaded PGA-co-PDL Nanocomposite Microparticles for Inhalation Drug Delivery to the Lungs DDL23

Ismail FMD, Tawfeek HM, Hutcheon GA, Saleem IY . 2011. Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 :303-334

Tawfeek H, Khidr S, Samy EM, Ahmed SM, Gaskell EE, Hutcheon G, Saleem I. 2010. PGA-co-PDL as a Novel Carrier for Pulmonary Drug Delivery 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Tawfeek H, Khidr S, Samy E, Ahmed S, Hutcheon G, Saleem I. 2010. Enhancing the Aerosolisation Proprieties of Polyester based Microparticles as Novel Carriers for Dry Powder Inhalation 37th Annual Meeting & Exposition of the Controlled Release Society

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Akram K, Mohammed AR, Gaskell EE, Hutcheon G, Saleem I. 2010. Optimisation of polyester based microparticles as carriers for pulmonary drug delivery Drug Delivery to the Lungs

Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Evans A, Gaskell EE, Hutcheon GA. 2010. Encapsulation, release, bioactivity and cytotoxicity of lysozyme loaded poly(glycerol adipte-co-omega-pentadecalactone) microparticles JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1431-1432 >Link

Khamar D, Seton L, Bradshaw I, Hutcheon G. 2010. Generation and characterisation of new anhydrous polymorph of theophylline JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1333-1334 >Link

McAllister L, Evans A, Hutcheon G, Gaskell E. 2009. Encapsulation of epirubicin for the treatment of cancer JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A82-A82 >Link

Iftikhar A, Gaskell E, Hutcheon GA, Rostron C. 2008. The stability of biodegradable polyesters and polyester-co-lactones utilized for drug delivery JOURNAL OF PHARMACY AND PHARMACOLOGY, 60 :A58-A58 >Link

Hutcheon GA, Gaskell E, Iftikhar A, Rostron C. 2008. Overcoming the mucin barrier in the treatment of pulmonary cystic fibrosis JOURNAL OF PHARMACY AND PHARMACOLOGY, 60 :A11-A11 >Link

Ghazal H, Dyas AM, Ford JL, Hutcheon GA. 2007. The intrinsic dissolution rate of ketoconazole in proteinaceous biorelevant media JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 :A46-A46 >Link

Gaskell E, Hobbs G, Rostron C, Hutcheon GA. 2006. Encapsulation of mucinolytic enzymes for treatment of cystic fibrosis JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A67-A67 >Link

Thompson CJ, Hansford D, Munday DL, Higgins S, Hutcheon GA, Rostron C. 2006. Preparation and characterisation of microspheres of a novel polyester polymer conjugated to ibuprofen JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A15-A15 >Link

Meng W, Parker TL, Kallinteri P, Hutcheon GA, Higgins S, Walker DA, Walker DA, Garnett MC. 2005. Uptake and drug delivery using biodegradable nanoparticles in monolayers and organotypic brain slices NEURO-ONCOLOGY, 2nd Quadrennial Meeting of the World-Federation-of-Neuro-Oncology/6th Meeting of the European-Association-for-Neur-Oncology 7 :383-384 >Link

Puri S, Kallinteri P, Higgins SH, Hutcheon GA, Garnett MC. 2005. Drug incorporation and release from functionalized poly glycerol adipate nanoparticles JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S21-S22 >Link

Hansford D, Higgins S, Hutcheon GA, Munday DL, Rostron C, Thompson CJ. 2005. Synthesis and characterisation of novel polyesters for the production of biodegradable microspheres JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S63-S63 >Link

Gaskell E, Hobbs G, Rostron C, Hutcheon G. 2005. Use of functional polymers for treatment of pulmonary cystic fibrosis JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S60-S60 >Link

Gaskell E, Hobbs G, Rostron C, Hutcheon G. 2005. Use of functional polymers for treatment of pulmonary cystic fibrosis JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S5-S5 >Link

Garnett MC, Higgins S, Hutcheon GA, Kallinteri P. 2004. Enzymatic synthesis of novel functionalised polyesters and their use as a biodegradable nanoparticle drug delivery system JOURNAL OF PHARMACY AND PHARMACOLOGY, 56 :S49-S50 >Link

Hamilton AR, Roberts M, Hutcheon GA, Gaskell EE. Utilising montmorillonite K-10 and Laponite for delivery of ciprofloxacin UK & Ireland Controlled Release Society

Seton L, Kumar D, Roberts M, Patel S, Pritchard R, Bradshaw IJ, Hutcheon GA. Solid state characterisation of a highly polymorphic system to explain differences in tabletting and dissolution properties 10th International Symposium on the Crystal Growth of Organic Materials

Saleem I, Kunda NK, Somavarapu S, Gordon SB, Hutcheon GA. Protein Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery Saleem IY. AAPS Annual Meeting and Exposition

Saleem I, Kunda NK, Somavarapu S, Gordon SB, Hutcheon GA. Protein Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery Saleem IY. AAPS Annual Meeting and Exposition

Saleem IY, Hutcheon GA, Satyanarayana S. Pulmonary Delivery of Beclometasone Loaded PGA-co-PDL Nanocomposite Microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, Drug Delivery to the Lungs

Posters

Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2016. Pulmonary Delivery of Therapeutic miR-146a Nanoparticles. AAPS National Biotechnology Conference, Boston, USA.

Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2015. Polymeric Nanoparticles for the Pulmonary Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). 42nd Annual Meeting & Exposition of the Controlled Release Society, Edinburgh.

Chapters

Kunda N, Alfagih I, Saleem I, Hutcheon G. 2015. Polymer-based Delivery Systems for the Pulmonary Delivery of Biopharmaceuticals Nokhodchi A, Martin G. Pulmonary Drug Delivery: Advances and Challenges John Wiley & Sons, Ltd >DOI

Engagement & Impact

Conference presentation:

Title of presentation: Pulmonary Delivery of Therapeutic miR-146a Nanoparticles, Conference title: AAPS National Biotechnology Conference, 2016, Place/location of conference: Boston, USA, Presentation type: Poster presentation

Research Grants Awarded:

Innovate UK Biomedical Catalyst, Development of small peptide CGRP antagonists for migraine therapy, Prof. Dave Kendall, PharmNovo UK, Dr Chris Coxon, LJMU, Dr Imran Saleem, LJMU, Grant value (£): £195020 (£97489 to LJMU), Duration of research project: 1 year