Liverpool Skylilne

Pharmacy and Biomolecular Sciences

Dr Jari Louhelainen

Dr Jari Louhelainen

Telephone: 0151 231 2044

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Biography

Biography
Dr Jari Louhelainen is a Senior Lecturer in Molecular Biology at LJMU, as well as Associate Professor of Biochemistry at University of Helsinki, one of the world’s top universities. He has two major lines of research – mammalian/medical genetics and forensics.
In the past Dr. Louhelainen has worked for University of Oxford, Cancer Research UK, Karolinska Institute in Sweden and University of Helsinki in Finland. His research interests are gene expression systems, cDNA microarrays bioinformatics, genotyping and Single-Nucleotide Polymorphisms analysis, mutation analysis and DNA sequencing, human cell culture techniques, wildlife forensics and forensic/scientific photography. Jari Louhelainen has over 30 refereed publications, 2 edited books and one of which he has solely authored. He is a member of Royal Photographic Society Scientific and Medical Groups. He has also acted as an editor and editor-in-chief for scientific, peer-reviewed publications.
During 2014-2015 he has given more than 30 seminars all over the world and has appeared frequently at national TV channels including those of USA, UK, and most European countries. He has also been a guest in numerous TV-programmes, including BBC Crimewatch Roadshow, BBC Breakfast Show, CNN, Al-Jazeera, ITV and full-length TV documentaries. Recently his work has been featured in numerous newspapers and magazines all over the world, including many leading scientific magazines in Europe.
Languages
English
Finnish
Swedish
Degrees
2000 Karolinska Institute, Sweden PhD (Genetic Epidemiology)
1988 University of Helsinki, Finland MSc (Biochemistry)

Languages

Finnish
Swedish
English

Degrees

2000, Karolinska Institute, Sweden, PhD
1988, University of Helsinki, Finland, MSc

Publications

Conference publication

Louhelainen J, Mccoll S. 2017. ANALYSIS OF NOVEL HUMAN SEX DETERMINATION GENES FORENSIC SCIENCE INTERNATIONAL, 21st Triennial Meeting of the International-Association-of-Forensic-Sciences (IAFS) 277 :65-66 >Link

Louhelainen J, Mccoll S. 2017. EFFECT OF WASHING ON DNA ANALYSIS FROM BLOOD STAINED CLOTHING FORENSIC SCIENCE INTERNATIONAL, 21st Triennial Meeting of the International-Association-of-Forensic-Sciences (IAFS) 277 :69-69 >Link

Louhelainen J, Town N, Mccoll S. 2017. THE CHEMICAL COMPOSITION OF SOILS AS A NOVEL METHOD FOR LOCATING BURIALS FORENSIC SCIENCE INTERNATIONAL, 21st Triennial Meeting of the International-Association-of-Forensic-Sciences (IAFS) 277 :67-67 >Link

Louhelainen J, Mccoll S. 2017. THE GROWTH AND DEVELOPMENT OF LUCILLIA AND CALLIPHORA SP IN THE PRESENCE OF A RANGE OF DRUGS FORENSIC SCIENCE INTERNATIONAL, 21st Triennial Meeting of the International-Association-of-Forensic-Sciences (IAFS) 277 :65-65 >Link

Louhelainen J. 2017. THE SCIENCE BEHIND HIGH-PROFILE HISTORIC COLD CASE JACK THE RIPPER FORENSIC SCIENCE INTERNATIONAL, 21st Triennial Meeting of the International-Association-of-Forensic-Sciences (IAFS) 277 :66-66 >Link

Louhelainen J, Mccoll S. 2017. THE USE OF MICRO-ORGANISM PROFILING FOR DETERMINATION THE CAUSE AND LOCATION OF DEATH BY DROWNING FORENSIC SCIENCE INTERNATIONAL, 21st Triennial Meeting of the International-Association-of-Forensic-Sciences (IAFS) 277 :67-67 >Link

Editorial/letter to the editor

Louhelainen J. 2016. SNP Arrays. Microarrays (Basel), 5 >DOI >Link

Journal article

Joo CH, Allan R, Drust B, Close GL, Jeong TS, Bartlett JD, Mawhinney C, Louhelainen J, Morton JP, Gregson W. 2016. Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle European Journal of Applied Physiology, :1-12 >DOI

Jeong TS, Bartlett JD, Joo CH, Louhelainen J, Close GL, Morton JP, Drust B. 2015. Acute simulated soccer-specific training increases PGC-1α mRNA expression in human skeletal muscle Journal of Sports Sciences, 33 :1493-1503 >DOI

Jeong T-S, Bartlett JD, Joo C-H, Louhelainen J, Close GL, Morton JP, Drust B. 2015. Acute simulated soccer-specific training increases PGC-1 alpha mRNA expression in human skeletal muscle JOURNAL OF SPORTS SCIENCES, 33 :1493-1503 >DOI >Link

Bartlett JD, Louhelainen J, Iqbal Z, Cochran AJ, Gibala MJ, Gregson W, Close GL, Drust B, Morton JP. 2013. Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis. Am J Physiol Regul Integr Comp Physiol, 304 :R450-R458 >DOI >Link

Taylor C, Bartlett JD, van de Graaf CS, Louhelainen J, Coyne V, Iqbal Z, Maclaren DPM, Gregson W, Close GL, Morton JP. 2013. Protein ingestion does not impair exercise-induced AMPK signalling when in a glycogen-depleted state: implications for train-low compete-high. Eur J Appl Physiol, 113 :1457-1468 >DOI >Link

Cobley JN, Bartlett JD, Kayani A, Murray SW, Louhelainen J, Donovan T, Waldron S, Gregson W, Burniston JG, Morton JP, Close GL. 2012. PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males. Biogerontology, 13 :621-631 >DOI >Link

Cobley JN, Bartlett JD, Gregson W, Burniston JG, Morton JP, Close GL, Kayani A, Murray SW, Louhelainen J, Donovan T, Waldron S. 2012. PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males Biogerontology, :1-11 >DOI

Bartlett JD, Joo CH, Jeong TS, Louhelainen J, Cochran AJ, Gibala MJ, Gregson W, Close GL, Drust B, Morton JP. 2012. Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38 and p53 phosphorylation in human skeletal muscle Journal of Applied Physiology, 112 :1125-1143 >DOI

Hampson C, Louhelainen J, McColl S. 2011. An RNA expression method for aging forensic hair samples. J Forensic Sci, 56 :359-365 >DOI >Link

Louhelainen JP, Hurst CD, Pitt E, Nishiyama H, Pickett HA, Knowles MA. 2006. DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. Oncogene, 25 :2409-2419 >DOI >Link

Wild PJ, Krieg RC, Seidl J, Stoehr R, Reher K, Hofmann C, Louhelainen J, Rosenthal A, Hartmann A, Pilarsky C, Bosserhoff AK, Knuechel R. 2005. RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid-induced protoporphyrin IX in vitro. Mol Cancer Ther, 4 :516-528 >DOI >Link

Natrajan R, Louhelainen J, Williams S, Laye J, Knowles MA. 2003. High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder. Cancer Res, 63 :7657-7662 >Link

Louhelainen J, Gill J, Hornigold N, Pitt E, Knowles MA. 2001. cDNA microarray analysis of transfected bladder cancer cell lines BRITISH JOURNAL OF CANCER, 85 :75-75 >Link

Natrajan R, Louhelainen J, Knowles MA. 2001. Loss of heterozygosity at a common region of deletion on 15q14-q15.2 in transitional cell carcinomas. BRITISH JOURNAL OF CANCER, 85 :74-74 >Link

Kimura F, Florl AR, Seifert HH, Louhelainen J, Maas S, Knowles MA, Schulz WA. 2001. Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder. Br J Cancer, 85 :1887-1893 >DOI >Link

Försti A, Louhelainen J, Söderberg M, Wijkström H, Hemminki K. 2001. Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer. Eur J Cancer, 37 :1372-1380 >Link

Wada T, Louhelainen J, Hemminki K, Adolfsson J, Wijkström H, Norming U, Borgström E, Hansson J, Steineck G. 2001. The prevalence of loss of heterozygosity in chromosome 3, including FHIT, in bladder cancer, using the fluorescent multiplex polymerase chain reaction. BJU Int, 87 :876-881 >Link

Louhelainen J, Wijkström H, Hemminki K. 2001. Multiple regions with allelic loss at chromosome 3 in superficial multifocal bladder tumors. Int J Oncol, 18 :203-210 >Link

Louhelainen J, Wijkström H, Hemminki K. 2000. Allelic losses demonstrate monoclonality of multifocal bladder tumors. Int J Cancer, 87 :522-527 >Link

Louhelainen J, Wijkström H, Hemminki K. 2000. Initiation-development modelling of allelic losses on chromosome 9 in multifocal bladder cancer. Eur J Cancer, 36 :1441-1451 >Link

Wada T, Louhelainen J, Hemminki K, Adolfsson J, Wijkström H, Norming U, Borgström E, Hansson J, Sandstedt B, Steineck G. 2000. Bladder cancer: allelic deletions at and around the retinoblastoma tumor suppressor gene in relation to stage and grade. Clin Cancer Res, 6 :610-615 >Link

Szyfter K, Szmeja Z, Szyfter W, Hemminki K, Banaszewski J, Jaskuła-Sztul R, Louhelainen J. 1999. Molecular and cellular alterations in tobacco smoke-associated larynx cancer. Mutat Res, 445 :259-274 >Link

Louhelainen J, Lindström E, Hemminki K, Toftgård R. 1998. Dinucleotide repeat polymorphism within the tumor suppressor gene PTCH at 9q22. Clin Genet, 54 :239-241 >Link

Kumar R, Lundh Rozell B, Louhelainen J, Hemminki K. 1998. Mutations in the CDKN2A (p16INK4a) gene in microdissected sporadic primary melanomas. Int J Cancer, 75 :193-198 >Link

Louhelainen J, Szyfter K, Szyfter W, Hemminki K. 1997. Loss of heterozygosity and microsatellite instability in larynx cancer INTERNATIONAL JOURNAL OF ONCOLOGY, 10 :247-252 >Link

Hemminki K, Kumar R, Bykov VJ, Louhelainen J, Vodicka P. 1996. Future research directions in the use of biomarkers. Environ Health Perspect, 104 Suppl 3 :459-464 >DOI >Link

Kumar R, Hanekamp JS, Louhelainen J, Burvall K, Onfelt A, Hemminki K, Thilly WG. 1995. Separation of transforming amino acid-substituting mutations in codons 12, 13 and 61 the N-ras gene by constant denaturant capillary electrophoresis (CDCE). Carcinogenesis, 16 :2667-2673 >Link

Nevalainen LT, Louhelainen J, Makarow M. 1989. Post-translational modifications in mitotic yeast cells. Eur J Biochem, 184 :165-172 >Link

RAUDASKOSKI M, ASTROM H, PERTTILA K, VIRTANEN I, LOUHELAINEN J. 1987. ROLE OF THE MICROTUBULE CYTOSKELETON IN POLLEN TUBES - AN IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL APPROACH BIOLOGY OF THE CELL, 61 :177-188 >Link

Engagement & Impact

Conference presentation:

DNA Analysis Of Washed Blood Stained Clothing – How Far We Can Reach?, 2nd Annual Genetics in Forensics Congress, London, UK, Oral presentation 14/03/2017

Finding Jack The Ripper, ThinkFest, Helsinki, Finland, Oral presentation 06/10/2016

”Applications of genetic tools for solving crimes, including medieval murders and the case of Jack The Ripper”, Millenium Talk, Aalto University, Helsinki, Finland, Oral presentation 14/09/2016

Science behind the case “Jack the Ripper” and future prospects of genetic analysis, Nokia Campus Open University Day, Nokia Open University, Oral presentation 13/09/2016

Effect of washing on DNA analysis from blood stained clothing, 7th European Academy of Forensic Science Conference, Oral presentation 10/09/2015

Analysis of novel human sex determination genes, 7th European Academy of Forensic Science Conference, Prague, Czech Republic, Oral presentation 08/09/2015

The use of micro-organism profiling for determination the cause and location of death by drowning, 7th European Academy of Forensic Science Conference, Prague, Czech Republic, Oral presentation 08/09/2015

The science behind high-profile historic cold case: Jack the Ripper, 7th European Academy of Forensic Science Conference, Prague, Czech Republic, Oral presentation 07/09/2015

The growth and development of Lucillia and Calliphora sp. in the presence of a range of drugs, 7th European Academy of Forensic Science Conference, Prague, Czech Republic, Oral presentation 07/09/2015

External collaboration:

Biochemistry Department, College of Medicine, University of Tikrit, Iraq., Sami Zbaar (Visiting PhD student)