Liverpool Skylilne

Sport and Exercise Sciences

Dr Tori Sprung

Dr Tori Sprung

Telephone: 0151 231 8162

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Biography

Tori is a Lecturer who works across the Physical Activity and Cardiovascular teaching teams in the School of Sport and Exercise Sciences. Similarly, Tori is a member of both the Physical Activity Exchange and the Cardiovascular Health Research Group within the Research Institute of Sport and Exercise Sciences (RISES). Tori is also a member of the Liverpool Centre for Cardiovascular Sciences (LCCS); a strategic research collaboration between Liverpool Heart & Chest Hospital, Liverpool John Moores University, Liverpool Health Partners, and the University of Liverpool. Tori's research interests centre around obesity, and lifestyle related conditions. Tori's research specifically focuses on the implementation of physical activity/exercise as a therapeutic management strategy in clinical populations.

Tori completed her PhD in RISES IN 2012, following which she spent several months in the University of Western Australia completing a lab-based visit before returning to Liverpool in 2013. At this time, Tori accepted a 6 year research fellow appointment at the University of Liverpool for which her main role was the coordination of large scale Phase IV Clinical Trials.

In addition to her academic commitments, Tori is an active member of the Athena Swan working group and has co-lead the departmental Bronze application. Tori volunteers for several charities and initiatives that promote gender equality in science; a field where women have been historically underrepresented.

Degrees

2012, Liverpool John Moores University, United Kingdom, PhD
2009, Liverpool John Moores University, United Kingdom, BSc (Hons) Sport Science (Physiology) Class I

Academic appointments

Postdoctoral Research Fellow, Institute of Ageing and Chronic Disease, University of Livrpool, 2013 - 2018
Research Associate, School of Sport Science, Exercise and Helath, University of Western Australia, 2012 - 2012

Postgraduate training

Microneurography Competency, Australia, Western Sydney University, 2015 - 2015

Publications

Journal article

Maxwell JD, Carter HH, Hellsten Y, Miller GD, Sprung VS, Cuthbertson DJ, Thijssen DHJ, Jones H. 2019. Seven-day remote ischaemic preconditioning improves endothelial function in patients with type 2 diabetes mellitus: a randomised pilot study EUROPEAN JOURNAL OF ENDOCRINOLOGY, 181 :659-669 DOI Author Url Public Url

Davies KAB, Pickles S, Sprung VS, Kemp GJ, Alam U, Moore DR, Tahrani AA, Cuthbertson DJ. 2019. Reduced physical activity in young and older adults: metabolic and musculoskeletal implications THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM, 10 DOI Author Url

Holder SM, Brislane Á, Dawson EA, Hopkins ND, Hopman MTE, Cable NT, Jones H, Schreuder THA, Sprung VS, Naylor L, Maiorana A, Thompson A, Thijssen DHJ, Green DJ. 2019. Relationship Between Endothelial Function and the Eliciting Shear Stress Stimulus in Women: Changes Across the Lifespan Differ to Men. Journal of the American Heart Association, 8 :e010994-e010994 DOI Author Url Publisher Url Public Url

Bowden Davies KA, Sprung VS, Norman JA, Thompson A, Mitchell KL, Harrold JA, Finlayson G, Gibbons C, Wilding JPH, Kemp GJ, Hamer M, Cuthbertson DJ. 2019. Physical Activity and Sedentary Time: Association with Metabolic Health and Liver Fat. Medicine and Science in Sports and Exercise, DOI Author Url Publisher Url Public Url

Bowden Davies KA, Sprung VS, Norman JA, Thompson A, Mitchell KL, Halford JCG, Harrold JA, Wilding JPH, Kemp GJ, Cuthbertson DJ. 2018. Short-term decreased physical activity with increased sedentary behaviour causes metabolic derangements and altered body composition: effects in individuals with and without a first-degree relative with type 2 diabetes Diabetologia, 61 :1282-1294 DOI Author Url Publisher Url Public Url

Cuthbertson DJ, Sprung VS. 2017. High-intensity exercise offers no additional benefit to moderate-intensity exercise in reducing liver fat in patients with non-alcoholic fatty liver disease Evidence-Based Medicine, 22 :103-103 DOI Author Url

Rajeev SP, Sprung VS, Roberts C, Harrold JA, Halford JCG, Stancak A, Boyland EJ, Kemp GJ, Cuthbertson DJ, Wilding JPH. 2017. Compensatory changes in energy balance during dapagliflozin treatment in type 2 diabetes mellitus: A randomised double-blind, placebo-controlled, cross-over trial (ENERGIZE) - Study protocol BMJ Open, 7 DOI Author Url Public Url

Pugh CJ, Sprung VS, Jones H, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Trenell MI, Kemp GJ, Cuthbertson DJ. 2016. Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in non-alcoholic fatty liver disease (NAFLD). International journal of obesity (2005), 40 :1927-1930 DOI Author Url Public Url

Jones H, Bailey TG, Cable NT, Sprung VS, Low DA, Miller GD . 2016. Repeated Warm Water Immersion Induces Similar Cerebrovascular Adaptations to 8 Weeks of Moderate-Intensity Exercise Training in Females INTERNATIONAL JOURNAL OF SPORTS MEDICINE, :1-9 DOI Author Url Public Url

Jones H, Cable NT, Aziz N, Dobson R , Sprung VS, Low DA, Bailey TG. 2016. Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control Menopause: The Journal of the North American Menopause Society, 23 :708-718 DOI Author Url Public Url

Dobson R, Burgess MI, Sprung VS, Irwin A, Hamer M, Jones J, Daousi C, Adams V, Kemp GJ, Shojaee-Moradie F, Umpleby M, Cuthbertson DJ. 2016. Metabolically healthy and unhealthy obesity: differential effects on myocardial function according to metabolic syndrome, rather than obesity. International Journal of Obesity, 40 :153-161 DOI Author Url Public Url

Cuthbertson DJ, Shojaee-Moradie F, Sprung VS, Jones H, Pugh CJ, Richardson P, Kemp GJ, Barrett M, Jackson NC, Thomas EL, Bell JD, Umpleby AM. 2015. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease. Clinical science (London, England : 1979), 130 :93-104 DOI Author Url Public Url

Jones H, Nyakayiru J, Bailey TG, Green DJ, Cable NT, Sprung VS, Hopkins ND, Thijssen DHJ. 2015. Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 22 :1083-1087 DOI Author Url Public Url

Pugh CJA, Sprung VS, Ono K, Spence AL, Thijssen DHJ, Carter HH, Green DJ. 2015. The Effect of Water Immersion during Exercise on Cerebral Blood Flow MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 47 :299-306 DOI Author Url Public Url

Cuthbertson DJ, Irwin A, Sprung VS, Jones H, Pugh CJA, Daousi C, Adams VL, Bimson WE, Shojaee Moradie F, Richardson P, Umpleby AM, Wilding JP, Kemp GJ. 2014. Ectopic lipid storage in non-alcoholic fatty liver disease is not mediated by impaired mitochondrial oxidative capacity in skeletal muscle CLINICAL SCIENCE, 127 :655-663 DOI Author Url Public Url

Pugh CJA, Sprung VS, Kemp GJ, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Jones H, Cuthbertson DJ. 2014. Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 307 :H1298-H1306 DOI Author Url Public Url

Cuthbertson DJ, Weickert MO, Lythgoe D, Sprung VS, Dobson R, Shoajee-Moradie F, Umpleby M, Pfeiffer AFH, Thomas EL, Bell JD, Jones H, Kemp GJ. 2014. External validation of the fatty liver index and lipid accumulation product indices, using H-1-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals EUROPEAN JOURNAL OF ENDOCRINOLOGY, 171 :561-569 DOI Author Url Public Url

Green DJ, Eijsvogels T, Bouts YM, Maiorana AJ, Naylor LH, Scholten RR, Spaanderman MEA, Pugh CJA, Sprung VS, Schreuder T, Jones H, Cable T, Hopman MTE, Thijssen DHJ. 2014. Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors JOURNAL OF APPLIED PHYSIOLOGY, 117 :345-352 DOI Author Url

Thijssen DHJ, Atkinson CL, Ono K, Sprung VS, Spence AL, Pugh CJA, Green DJ. 2014. Sympathetic nervous system activation, arterial shear rate, and flow-mediated dilation JOURNAL OF APPLIED PHYSIOLOGY, 116 :1300-1307 DOI Author Url

Sprung VS, Jones H, Pugh CJA, Aziz NF, Daousi C, Kemp GJ, Green DJ, Cable NT, Cuthbertson DJ. 2014. Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition CLINICAL SCIENCE, 126 :67-74 DOI Author Url

Pugh CJA, Cuthbertson DJ, Sprung VS, Kemp GJ, Richardson P, Umpleby AM, Green DJ, Cable NT, Jones H. 2013. Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease. Am J Physiol Endocrinol Metab, 305 :E50-E58 DOI Author Url

Sprung VS, Cuthbertson DJ, Pugh CJ, Aziz N, Kemp GJ, Daousi C, Green DJ, Tim Cable N, Jones H. 2013. Exercise Training in PCOS Enhances FMD in the Absence of Changes in Fatness. Med Sci Sports Exerc, DOI Author Url

Sprung VS, Cuthbertson DJ, Pugh CJA, Daousi C, Atkinson G, Aziz NF, Kemp GJ, Green DJ, Cable NT, Jones H. 2013. Nitric oxide-mediated cutaneous microvascular function is impaired in polycystic ovary sydrome but can be improved by exercise training. J Physiol, 591 :1475-1487 DOI Author Url

Mehta R, Gaze D, Mohan S, Williams KL, Sprung V, George K, Jeffries R, Hudson Z, Perry M, Shave R. 2012. Post-exercise cardiac troponin release is related to exercise training history International Journal of Sports Medicine, 33 :333-337 DOI

Sprung VS, Atkinson G, Cuthbertson DJ, Pugh CJA, Aziz N, Green DJ, Cable NT, Jones H. Endothelial function measured using flow-mediated dilation in polycystic ovary syndrome: a meta-analysis of the observational studies. Clin Endocrinol (Oxf), 78 :438-446 DOI Author Url

Sprung VS, Cuthbertson DJ, Pugh CJA, Aziz N, Kemp GJ, Daousi C, Green DJ, Cable NT, Jones H. Exercise training in polycystic ovarian syndrome enhances flow-mediated dilation in the absence of changes in fatness. Med Sci Sports Exerc, 45 :2234-2242 DOI Author Url

Jones H, Sprung VS, Pugh CJA, Daousi C, Irwin A, Aziz N, Adams VL, Thomas EL, Bell JD, Kemp GJ, Cuthbertson DJ. Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance. J Clin Endocrinol Metab, 97 :3709-3716 DOI Author Url

Mehta R, Gaze D, Mohan S, Williams KL, Sprung V, George K, Jeffries R, Hudson Z, Perry M, Shave R. Post-exercise cardiac troponin release is related to exercise training history. Int J Sports Med, 33 :333-337 DOI Author Url

Conference publication

Davies KAB, Norman JA, Thompson A, Mitchell KL, Halford JCG, Harrold JA, Wilding JPH, Kemp GJ, Cuthbertson DJ, Sprung VS. 2019. Short-term physical inactivity, with increased sedentary behaviour, causes a decline in endothelial function DIABETOLOGIA, 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) 62 :S552-S552 Author Url

Sprung VS, Davies KAB, Norman JA, Mitchell KL, Wilding JPH, Kemp GJ, Cuthbertson DJ. 2019. Metabolic health, rather than obesity status, contributes to endothelial dysfunction: a comparison of obesity/metabolic health related phenotypes DIABETOLOGIA, 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) 62 :S552-S552 Author Url

Sprung VS, Davies KAB, Norman JA, Thompson A, Wilding JPH, Jones H, Kemp GJ, Cuthbertson DJ. 2018. Metabolically healthy and unhealthy obesity: Metabolic health status rather than obesity is a more accurate prognostic marker for cardiovascular health DIABETIC MEDICINE, 35 :53-53 Author Url

Pugh C, Jones H, Sprung V, Richardson P, Shojaee-Moradie F, Umpleby AM, Irwin A, Green D, Cable NT, Kemp G, Cuthbertson D. 2016. Improvements In Liver Fat And Endothelial Function Following Supervised Exercise Training Are Not Sustained One-Year After The Cessation Of Supervision In Non-Alcoholic Fatty Liver Disease MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Annual Meeting of the American-College-of-Sports-Medicine (ACSM) 48 :539-539 DOI Author Url

Sprung VS, Green DJ, Cuthbertson DJ, Aziz NMD, Cable NT, Jones H. 2012. EXERCISE TRAINING IMPROVES CUTANEOUS MICROVASCULAR NITRIC OXIDE DYSFUNCTION IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME FERTILITY AND STERILITY, 98 :S209-S209 DOI Author Url

Sprung VS, Cuthbertson DJ, Pugh CJA, Aziz N, Kemp GJ, Green DJ, Atkinson G, Cable T, Jones H. 2012. Endothelial Dysfunction In Polycystic Ovarian Syndrome Is Not Explained By Poor Fitness Or Increased Fatness MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44 :582-583 Author Url

Sprung VS, Cuthbertson DJ, Pugh CJA, Aziz NF, Green DJ, Jones H. 2011. ENDOTHELIAL FUNCTION IS IMPAIRED IN POLYCYSTIC OVARIAN SYNDROME AND CAN BE IMPROVED WITH EXERCISE TRAINING FERTILITY AND STERILITY, Annual Meeting of the American-Society-for-Reproductive-Medicine 96 :S128-S128 DOI Author Url

Pugh CJA, Jones H, Sprung VS, Kemp GJ, Irwin A, Adams VL, Green DJ, Cable NT, Richardson P, Umpleby AM, Cuthbertson DJ. 2011. Exercise as a treatment strategy for non-alcoholic fatty liver disease: impact on vascular health and hepatic steatosis DIABETOLOGIA, 47th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) 54 :S247-S247 Author Url

Aziz N, Jones H, Sprung VS, Irwin A, Kemp GJ, Cuthbertson D. 2010. DOES ELEVATED ALANINE AMINOTRANSFERASE PREDICT COMPONENTS OF THE METABOLIC SYNDROME IN POLYCYSTIC OVARIAN SYNDROME? FERTILITY AND STERILITY, Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010) 94 :S198-S198 DOI Author Url

Pugh CJ, Jones H, Sprung VS, Kemp GJ, Irwin A, Adams VL, Bimson WE, Cable NT, Green DJ, Richardson P, Cuthbertson DJ. 2010. Exercise-induced reduction in liver fat is accompanied by improvements in vascular function in non-alcoholic fatty liver disease DIABETOLOGIA, 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53 :S30-S30 Author Url

Sprung VS, Cuthbertson DJ, Pugh CJ, Atkinson G, Irwin A, Aziz N, Kemp GJ, Jones H. 2010. The extent of endothelial dysfunction in polycystic ovarian syndrome is moderated by obesity status DIABETOLOGIA, 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53 Author Url

Jones H, Sprung VS, Pugh CJ, Irwin A, Aziz N, Kemp GJ, Adams VL, Bimson WF, Cuthbertson DJ. 2010. Increased intramyocellular lipid but normal intrahepatocellular lipid content characterises polycystic ovary syndrome compared with age- and BMI-matched healthy controls DIABETOLOGIA, 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53 Author Url

Pugh CJA, Jones H, Sprung VS, Kemp GJ, Irwin A, Adams VL, Cable NT, Umpleby AM, Richardson P, Cuthbertson DJ. A 16-week moderate intensity exercise intervention reduces body mass, hepatic triglyceride and abdominal subcutaneous fat in NAFLD patients The Journal of Diabetes, Prediabetes and the Metabolic Syndrome 3 :201-201

Sprung VS, Jones H, Irwin A, Aziz N, Kemp GJ, Adams VL, Cable NT, Bing C, Cuthbertson DJ. Elevated hepatic and visceral fat in Polycystic Ovarian Syndrome is associated with biochemical hyperandrogenism Diabetic Medicine, Diabetes UK 28 :92-92

Sprung VS, Cuthbertson DJ, Pugh CJA, Irwin A, Aziz N, Kemp GJ, Green DJ, Cable NT, Jones H. Endothelial function in polycystic ovarian syndrome: impact of exercise training Daibetic Medicine, Diabetes UK 29 :87-87

Sprung VS, Cuthbertson DJ, Aziz N, Green DJ, Cable NT, Jones H. Exercise training improves cutaneous microvascular nitric oxide dysfunction in women with PCOS Fertility and Sterility, American Society for Reproductive Medicine 98 :209-209

Editorial/letter to the editor

Bailey TG, Cable T, Aziz N, Dobson R, Sprung VS, Low DA, Jones H. 2017. Untitled Reply MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 24 :118-120 DOI Author Url

Bailey TG, Cable T, Aziz N, Dobson R, Sprung VS, Low DA, Jones H. 2017. In reply Menopause, 24 :118-120 DOI

Bailey TG, Cable T, Aziz N, Dobson R, Sprung VS, Low DA, Jones H. In Reply. Menopause (New York, N.Y.), 24 :118-120 DOI Author Url

Engagement & Impact

Industrial connections:

Performance Sleep, http://performancesleep.co.uk/about/. 2018

NovoNordisk, Project coordinator A randomised, controlled multi-centre trial of 26 weeks of subcutaneous Liraglutide (a GLP-1 receptor agonist), with or without continuous positive airway pressure (CPAP) in patients with type 2 Diabetes Mellitus (T2DM) and Obstructive Sleep Apnoes (OSA), https://www.lctu.org.uk/LCTU_NET/frontend/core/Features/trialinfo.aspx?Data=W1tkSEpwWVd4bmNtOTFjQT09XV1bTVRNPV1bW2RISnBZV3hwWkE9PV1dW01qRTBdW1tiRzlqWVd4bF1dW01RPT1d. 2013

Award:

PDRA Podium Best Presentation Prize, Universiy of Liverpool, Faculty of Health and Life Sciences. 2016

David Ellams Award for Outstanding Contribution (Athena Swan), University of Liverpool. 2016

Best Oral Presentation, British Association of Sport and Exercise Sciences. 2013

Young Investigator Award, European College of Sport Science. 2011

Best Oral Presentation, LJMU, Faculty of Science. 2011

Best Poster Presentation, LJMU, Faculty of Science. 2010

Research Grants Awarded:

AstraZeneca, RESILIENT, Dr Daniel Cuthbertson, Professor John Wilding, Professor Graham Kemp, Grant value (£): 999,999, Duration of research project: 48months. 2016

European Foundation for the Study of Diabetes (EFSD), Collaboration Grant- University of Western Sydney, Grant value (£): 8000euro. 2015

SANOFI- Diabetes Research, Characterise changes in physical activity level, correlated against changes in body composition, in obese patients with type 2 diabetes treated with the GLP1 receptor agonist, Dr Daniel Cuthbertson, Grant value (£): 12,500. 2014

Novo-Nordisk, ROMANCE: A randomised, controlled multi-centre trial of 26 weeks of subcutaneous Liraglutide (a GLP1 receptor agonist), with or without continuous positive airway pressure (CPAP), in patients with Type 2 Diabetes Mellitus (T2DM) and Obstructive Sleep Apnoea (OSA), Dr Daniel Cuthbertson, Dr Sonya Craig, Professor John Wilding, Grant value (£): £406,650. 2013

Pfizer, Evaluation of the effects of growth hormone deficiency and growth hormone replacement on serum fibroblast growth factor 21 concentration in patients with growth hormone deficiency, Dr Daniel Cuthbertson, Grant value (£): 40,200. 2013

British Foundation for Women Graduates, The impact of obesity and fitness on endothelial function in Polycystic Ovary Syndrome, Grant value (£): 6,000, Duration of research project: 12 months. 2011

Weight Matters- Personal Funding, Metabolic and Vacular Health in PCOS, Grant value (£): £6000, Duration of research project: 2. 2010

Conference organisation:

European College of Sport Science, Organising Committee. 2011

External collaboration:

Liverpool Women's Hospital, Nabil Aziz. 2009

University Hospital Aintree, Daniel Cuthbertson. 2009