Research participant study

Cardiovascular Health and Care Interest Group

Institute for Health Research

Providing solutions from bench to bedside

Cardiovascular (heart and circulatory) disease causes over 150,000 deaths each year in the UK. This equates to around 420 people dying each day from a mainly preventable condition. Moreover, around seven million people living with the condition require ongoing healthcare at a cost to the NHS of around £9 billion.

This research group, co-ordinated by Professor Ian Jones and Dr Ellen Dawson, brings together staff from seven different schools across the University with a diverse range of expertise that includes all aspects of health and care, ranging from biomedical science, health science, nursing, nutrition, pharmacology, psychology and sports science. This multi-disciplinary approach recognises that cardiovascular disease cannot be defeated without a joined up approach that includes prevention, treatment, care and rehabilitation. Our real-world applied research aims to provide healthcare solutions from bench to bedside.

We have established relationships with external stakeholders developing new collaborative projects with consultant cardiologists, cardiac surgeons, advanced cardiovascular nurses, public health professionals, healthcare scientists and cardiac physiologists in the region. This group has a long term aim of developing a Liverpool Research Centre for Excellence in cardiovascular research.

Research themes

Cardiovascular disease prevention and rehabilitation

  • Co-creating a new model of cardiac rehabilitation for South Asians
  • Physical activity and self-efficacy during early recovery phase in acute myocardial infarction patients not attending cardiac rehabilitation: a Jordanian study
  • Co-development and evaluation of a physical activity referral scheme for individuals with health conditions (includes phase 4 cardiac patients)
  • Family factors that influence physical activity adherence in post-MI patients
  • Mixed-method evaluation of exercise referral provision at Austin Rawlinson Leisure Centre, Speke
  • CALIBER study – carbohydrates, lipids and biomarkers of traditional and emerging cardiometabolic risk factors
  • Small molecules, big questions. Investigating the complexity of the LDL particle (small molecules attached to the LDL surface, using ultracentrifugation and LC-MS based metabolomics
  • Effects of a high-fat diet and supplementation with 2-hydroxyoleic acid and n-3 PUFA in mice
  • Polyphenol-rich beverages and cardiometabolic risk
  • Investigating the properties of nutraceuticals in the prevention of cardiovascular disease and metabolic syndromes
  • Lipoproteins related to cardiovascular risk of bodybuilders using anabolic steroids versus their non-using counterparts
  • Investigating the role of Lycopene in the prevention of chronic diseases
  • Daphnia as a model of cardiovascular therapeutics
  • Hepsense: development of heparin-type-carbohydrate sensors: for open heart surgery and beyond

Sub theme – Metabolic conditions: Diabetes/CVD prevention

  • The development of a new theoretical framework to explore type-2-diabetes self-management behaviours in UK South Asian patients: recommendations for healthcare practice
  • Prevention of diabetes: using mHealth applications for South Asian adults at risk
  • The effects of positive emotional HbA1c feedback on blood sugar control in multi-ethnic diabetes patients
  • Development of diabetes psychological platform evaluating a digital platform integrating psychological methods into diabetes care

Cardiovascular physiology

  • Cold as ice: does the cold pressor test predict risk and survival in cardiac surgery
  • Examining the impact of exercise on cardiovascular responses and the relationship to chronic training-induced adaptations
  • Determining the arterial in vivo and in vitro responses to catheterisation-induced damage in patients and exploring the effects of acute/chronic exercise to counteract these effects
  • Micro CT imaging revealing cardiac structure at high resolution
  • Using clinical archives to Investigate the structure of congenitally malformed hearts
  • Autonomic activity associated with listening effort: examining the sympathetic and parasympathetic responses associated with effortful listening
  • Achievement motive impact on effort-related cardiovascular responses: examining the moderating impact of the achievement motive on the link between task demand and effort-related cardiovascular responses
  • Changes in brain vascular flow and reactivity under physiologic and non-physiologic conditions
  • Long term effect on cerebral blood flow of ligation or repair of ICA after ECMO cannulation
  • Athletic pre-participation cardiac screening for the detection of inherited cardiac conditions
  • Novel echocardiography detailing complex cardiac mechanics in health and disease

Understanding the impact of cardiovascular disease on patients and families

  • How do patients make sense of a diagnosis of cardiomyopathy?
  • CASSPER – congenital cardiac surgery and parental perception of risk
  • Healthcare professionals decision making when managing the care of patients diagnosed with end stage heart failure
  • What are the barriers and influencers to cardiac rehabilitation for South Asian patients?
  • A cross-cultural translation and adaptation of the cardiac self-efficacy questionnaire for Arabic speaking people diagnosed with coronary heart disease
  • Development of an assessment tool to predict risk of sternal wound breakdown post cardiac surgery
  • Co-creation of a sternal wound support device to reduce incidence of sternal wound breakdown in overweight patients
  • Exploring the impact of care transition on adolescents with congenital heart disease

Congenital heart disease

  • Neuro protection – vascular reactivity in neonatal arch surgery
  • CASSPER – congenital cardiac surgery and parental perception of risk
  • Exploring the impact of care transition on adolescents with congenital heart disease
  • Cerebral perfusion and ECMO
  • Patent ductus arteriosus
  • NIHR – modelling predictors of outcome in adult congenital

Research impact

  • Collaborative funded research projects between the Faculty of Education, Health and Community and the Faculty of Science
  • PhD supervision including formal cross Faculty funded and supervised students
  • Co-authorship of academic papers in a number of high profile journals
  • Further joint bids for PGR students
  • Contribution to existing research projects

Key external partners

  • Alder Hey Children's NHS Foundation Trust
  • Aarhus University Hospital, Denmark
  • Bridgewater Community Healthcare NHS Foundation Trust Cardiomyopathy UK
  • Damibu Ltd
  • Inspiring Healthy Lifestyles, Wigan
  • Liverpool Clinical Commissioning Group
  • Liverpool City Council
  • Liverpool Heart and Chest Hospital NHS Foundation Trust
  • Liverpool Medical Institute
  • Liverpool Women’s NHS Foundation Trust
  • Royal Liverpool and Broadgreen University Hospital NHS Trust

Contact us

For further information about the Cardiovascular Health and Care Interest Group, please contact Professor Ian Jones or Dr Ellen Dawson.

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